scholarly journals Potential Role of Androgens in the Treatment of Hypoactive Sexual Desire in Women

2005 ◽  
Vol 1 (2) ◽  
pp. 191-193 ◽  
Author(s):  
Anita H Clayton
Keyword(s):  
Treatment Group ◽  
Postmenopausal Women ◽  
Clinical Experience ◽  
Sexual Desire ◽  
Potential Role ◽  
Post Treatment ◽  
Salivary Testosterone ◽  
Testosterone Levels ◽  
Group Post

Evaluation of: van Anders SM, Chernick AB, Chernick BA et al.: Preliminary clinical experience with androgen administration for pre- and postmenopausal women with hypoactive sexual desire. J. Sex Marital Ther. 31, 173–185 (2005). There has been significant debate about the potential role of androgens in the treatment of hypoactive sexual desire in women. In this study, pre- and postmenopausal women with hypoactive sexual desire were age-matched with women without such complaints (n = 33). The treatment group received 100 mg of testosterone cypionate intramuscularly once a month for 3 months. Measures of salivary testosterone indicated no difference between groups at baseline, with an increase in testosterone levels in the hypoactive sexual desire group post-treatment. While significant differences existed between the two groups at baseline in scores on the Sexual Desire Inventory, the treated women demonstrated a significant increase in sexual desire post-treatment, with no difference in Sexual Desire Inventory scores at study end point. This study suggests that supplemental testosterone may improve sexual desire in women with hypoactive sexual desire without hypoandrogenism.

scholarly journals Transient sex-related changes in the mice hypothalamo–pituitary–adrenal (HPA) axis during the acute phase of the inflammatory process

1993 ◽  
Vol 2 (2) ◽  
pp. 123-127 ◽  
Author(s):  
T. Daneva ◽  
E. Spinedi ◽  
R. Hadid ◽  
M.-C. Jacquier ◽  
M. Giacomini ◽  
...  
Keyword(s):  
Sex Difference ◽  
Acute Phase ◽  
Hpa Axis ◽  
Plasma Levels ◽  
Potential Role ◽  
Post Treatment ◽  
Male Mice ◽  
Plasma Acth ◽  
Endogenous Sex Hormones

The potential role of endogenous sex hormones in regulating hypothalamo–pituitary–adrenal (HPA) axis function was investigated after a single injection of endotoxin in adult (8 week old) BALB/c mice of both sexes. The effect of LPS on plasma ACTH, corticosterone (B), testosterone and oestradiol (E) levels and on anterior pituitary (AP) ACTH and adrenal B contents at different times after treatment was studied. The results indicate that: (a) basal B but not ACTH plasma levels were significantly higher in female than in male mice; (b) LPS significantly increased both ACTH and B plasma levels over the baseline 2 h after injection, both hormone levels being higher in female than in male mice; (c) although plasma ACTH concentrations recovered the basal value at 72 h after LPS in animals of both sexes, plasma B levels returned to the baseline only at 120 h after treatment; (d) E plasma levels significantly increased 2 h after LPS and returned to the baseline at 72 h post-treatment, in both sexes; (e) at 2 h after LPS, testosterone plasma levels significantly decreased in male mice and increased in female mice, recovering the baseline level at 120 and 72 h after LPS, respectively; (f) AP ACTH content was similar in both sexes in basal condition and it was significantly diminished 72 h post-treatment without sex difference; whereas AP ACTH returned to basal content 120 h after LPS in males, it remained significantly decreased in females; (g) basal adrenal B content was higher in female than in male mice, and it significantly increased in both sexes 2 h post-LPS, maintaining this sex difference. Whereas adrenal B returned to basal content 72 h after treatment in male mice, it remained significantly enhanced up to 120 h post-LPS in female animals. The data demonstrate the existence of a clear sexual dimorphism in basal condition and during the acute phase response as well as in the recovery of the HPA axis function shortly after infection.

scholarly journals The potential role of testosterone in hypertension and target organ damage in hypertensive postmenopausal women

2019 ◽  
Vol Volume 14 ◽  
pp. 743-752
Author(s):  
Ningyin Li ◽  
Ruixin Ma ◽  
Shixiong Wang ◽  
Yang Zhao ◽  
Ping Wang ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Potential Role ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

Potential Role of Histone Deacetylase Inhibitors in Mesothelioma: Clinical Experience with Suberoylanilide Hydroxamic Acid

2006 ◽  
Vol 7 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Lee M. Krug ◽  
Tracy Curley ◽  
Lawrence Schwartz ◽  
Stacie Richardson ◽  
Paul Marks ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Clinical Experience ◽  
Hydroxamic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Potential Role ◽  
Suberoylanilide Hydroxamic Acid

Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: potential role of cytokine-mediated cell–cell interactions

2020 ◽  
Vol 11 (10) ◽  
pp. 9252-9262 ◽  
Author(s):  
Zhigang Zhang ◽  
Changming Guo ◽  
Huijie Jiang ◽  
Bing Han ◽  
Xiaoqiao Wang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Rat Liver ◽  
Potential Role ◽  
Arsenic Exposure ◽  
Post Treatment ◽  
Cell Interactions ◽  
Schematic Diagram ◽  
Inflammation Response ◽  
Chronic Arsenic Exposure

Schematic diagram of the mechanism of post treatment with natural astaxanthin attenuating arsenic-induced inflammatory response in rat liver.

Postmenopausal women with carotid atherosclerosis: Potential role of the serum calcium levels

2013 ◽  
Vol 23 (11) ◽  
pp. 1141-1146 ◽  
Author(s):  
T. Montalcini ◽  
R. Terracciano ◽  
S. Romeo ◽  
D. Foti ◽  
E. Gulletta ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Serum Calcium ◽  
Potential Role ◽  
Carotid Atherosclerosis

scholarly journals Potential role of post‑treatment follow‑up FDG‑PET CT to detect mandibular osteoradionecrosis: A case report

2017 ◽  
Author(s):  
Masaya Akashi ◽  
Satoshi Wanifuchi ◽  
Junya Kusumoto ◽  
Megumi Kishimoto ◽  
Yasumasa Kakei ◽  
...  
Keyword(s):  
Case Report ◽  
Fdg Pet ◽  
Potential Role ◽  
Post Treatment ◽  
Pet Ct ◽  
Fdg Pet Ct

IL10, An Independent Predictor of Outcome in HNSCC Patients

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P90-P90
Author(s):  
Osama Alhamarneh ◽  
Nicholas D. Stafford ◽  
John Greenman
Keyword(s):  
Treatment Group ◽  
Clinical Outcome ◽  
Oral Cavity ◽  
Potential Role ◽  
Tumor Stage ◽  
Post Treatment ◽  
Kaplan Meier ◽  
Tumor Load ◽  
Pre Treatment

Problem To determine the correlation between IL10, a Th2-type inhibitory cytokine, clinical outcome and survival in HNSCC patients. Methods IL10 levels in the serum of newly-presenting, untreated, patients with HNSCC were measured pre-treatment (n=107) and 4–6 weeks after treatment (n=43), and were compared with a cohort of healthy controls (n=40) of similar age and sex. A commercial IL10 ELISA (Biosource) with a minimum detectable level of 0.2 pg/ml was used. Statistical analysis of associations between the levels and detectability of IL10 and clinical outcome and survival were done. Results Both IL10 detectability and levels were significantly higher in patients than in controls (p=0.001). Post treatment, IL10 levels dropped significantly (p=0.02). Pretreatment, IL10 levels were significantly elevated in the advanced stage of the disease (III/IV vs. I/II), in node positive patients and in patients with bulkier tumor load (T3/T4 vs. T1/T2); p=0.005, 0.037 and 0.001 respectively. The larynx (n=36), oropharynx (n=25) and pharynx (n=16) showed significantly higher levels and increased detectability of IL10 in the pre-treatment group when compared to the post treatment group, however, oral cavity tumors (n=21) showed the opposite. Finally, the detectability of IL10 significantly correlated with poorer survival (Kaplan-Meier, p=0.026) after a mean follow up of 15 (range 1–36) months. Conclusion IL10 levels drop significantly once the tumor mass is removed suggesting that this is the most important source of the circulating cytokine. IL10, as well as the tumor bulk, the nodal status and the overall tumor stage, were shown to be independent factors in predicting a poorer clinical outcome and worse survival in tumors originating in the larynx, pharynx and oropharynx, but not oral cavity, suggesting distinct inter-tumour differences. Significance IL10 could play a potential role as a prognostic marker in HNSCC, in addition to the possible manipulation of IL10 in future immunotherapeutic agents.

Potential role of FRAX analysis in postmenopausal women with osteopenia

Open Medicine ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. 185-189
Author(s):  
Aleksandar Dimić ◽  
Stojanovic Sonja ◽  
Nedovic Jovan ◽  
Stankovic Aleksandra ◽  
Stamenkovic Bojana ◽  
...  
Keyword(s):  
Hip Fracture ◽  
High Risk ◽  
Postmenopausal Women ◽  
Hip Fractures ◽  
Potential Role ◽  
Osteoporotic Fractures ◽  
Significant Negative Correlation ◽  
Mineral Density ◽  
Fracture Development

AbstractEarly diagnosis of osteoporosis and estimation of subjects that are at high risk for fracture, is neccesary for osteoporosis treatment. Dual-energy X-ray absorptometry (DXA) is a modern method for bone mineral density (BMD) evaluation. However, along BMD, clinical risk factors may significantly influence fracture development. Therefore, FRAX algorithm was designed for the assessment of a ten-year risk for serious osteoporotic fractures (SOF), as well as hip fractures. In the current study, we tried to evaluate the possible lumbal spine and hip BMD influence on ten year risk for SOF and hip fractures and potential role of FRAX in predicting the therapy in postmenopausal women with osteopenia. We performed the study on 385 postmenopausal women. According to the DXA measurements, at the lumbal (L) spine (L1–L4) and hip (femor neck), patients were then classified as normal, osteopenic, or osteoporotic. BMD evaluation included the L spine and the hip (subgroup 1), and only on the L spine (subgroup 2). By filling up the FRAX questionnaire, a ten-year risk for SOF fracture and hip fracture was calculated. BMD evaluation, in complete patient’s group and in subgroup 1, resulted in the highest number of osteoporosis (61.04%, 48.08%, retrospectively), while ospeopenia was a main finding in subgroup 2. In the subgroup 1, a high risk for SOF and hip fracture was detected in 16.45% and with high risk for hip fracture in 11.38% subjects. In subgroup 2, only high risk for hip fracture was observed in 3.16% subjects, indicating the active medicament treatment. Simultaneously, correlation of BMD results with FRAX values for SOF and hip fracture, showed significant negative correlation (p<0.001). Obtained results showed significant role of femur neck BMD evaluation in predicting the future factors, which may, together with FRAX analysis, improve the therapy approach in postmenopausal women with ospeopenia.

scholarly journals Sexual Subversives Or Lonely Losers? Discourses Of Resistance And Containment In Women's Use Of Male Homoerotic Media

2021 ◽  
Author(s):  
Nicole Susann Cormier
Keyword(s):  
Sexual Desire ◽  
Potential Role ◽  
Academic Work ◽  
Analytic Framework ◽  
Subject Positions ◽  
Depth Analysis ◽  
Online Texts ◽  
Feminist Poststructuralist ◽  
Sexual Power

Very little academic work to date has investigated women’s use of male homoerotic media (for notable exceptions, see Marks, 1996; McCutcheon & Bishop, 2015; Neville, 2015; Ramsay, 2017; Salmon & Symons, 2004). The purpose of this dissertation is to examine the potential role of male homoerotic media, including gay pornography, slash fiction, and Yaoi, in facilitating women’s sexual desire, fantasy, and subjectivity – and the ways in which this expansion is circumscribed by dominant discourses regulating women’s gendered and sexual subjectivities. The dissertation begins with a review of the existing scholarship on women, pornography, and male homoerotic media, followed by an in-depth analysis of online texts discussing women’s use of these media. The analysis explores what subject positions are (un)available to women who use these media. Using a Foucauldian, feminist poststructuralist discourse analytic framework, online editorial articles and internet forum discussions were explored using an immersion/crystallization approach, revealing three broad thematic queries posed by online interlocutors: a) whether women as a generalized category use male homoerotic media, b) establishing boundaries constructing and constraining a normative woman user, and c) interrogating why women are drawn to male homoeroticism. A variety of discourses were deployed pertaining to each of these themes, some of which served to align women’s use with dominant heterosexual, patriarchal, postfeminist, and neoliberal imperatives, while others subverted these imperatives and broadened the availability of sexual subjectivities for women. The tensions between these competing discourses mark male homoerotic media as a fertile site of resistance and expansion of sexual power and possibility for women.

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