US database study: burden and healthcare resource utilization in adults with systemic endemic mycoses and aspergillosis

2020 ◽  
Vol 9 (8) ◽  
pp. 573-584
Author(s):  
Anna Forsythe ◽  
Gareth Lewis ◽  
Robyn Jordan ◽  
George R Thompson
Keyword(s):  
Resource Utilization ◽  
Antifungal Therapy ◽  
Healthcare Resource ◽  
Burden Of Illness ◽  
Cross Sectional Study ◽  
Healthcare Resource Utilization ◽  
Transplant Recipients ◽  
Cross Sectional ◽  
Itraconazole Treatment ◽  
Endemic Mycoses

Aim: This study evaluated burden of illness in immunocompromised patients with systemic mycoses (SM) eligible for itraconazole treatment, specifically, histoplasmosis, blastomycosis and aspergillosis. Methods: A cross-sectional study used an electronic medical record network integrating information from 30 US hospitals, including >34 million patients, to evaluate burden and healthcare resource utilization over 6 months following initiation of antifungal therapy. Results: Symptomatic burden experienced by each of the otherwise healthy or age >65 or immunosuppressed cohorts receiving antifungal therapy for SM was comparable but significantly greater in cancer or HIV patients and transplant recipients. Across groups, there was substantially higher healthcare resource utilization in patients with SM versus matched controls without SM. Conclusion: The total impact of SM is particularly severe in high-risk or vulnerable populations.

scholarly journals Pulmonary embolism in Europe - Burden of illness in relationship to healthcare resource utilization and return to work

2018 ◽  
Vol 170 ◽  
pp. 181-191 ◽  
Author(s):  
Stefan N. Willich ◽  
Ling-Hsiang Chuang ◽  
Ben van Hout ◽  
Pearl Gumbs ◽  
David Jimenez ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Return To Work ◽  
Resource Utilization ◽  
Healthcare Resource ◽  
Burden Of Illness ◽  
Healthcare Resource Utilization

scholarly journals Clinical Characteristics and HealthCare Resource Utilization in Patients With Generalized Pustular Psoriasis: Real-World Evidence From a Large Claims-Based Dataset

2021 ◽  
pp. 247553032110217
Author(s):  
Jeffrey Crowley ◽  
Amanda K. Golembesky ◽  
Nirali Kotowsky ◽  
Ran Gao ◽  
Rhonda L. Bohn ◽  
...  
Keyword(s):  
Resource Utilization ◽  
Plaque Psoriasis ◽  
Healthcare Resource ◽  
Burden Of Illness ◽  
Medication Use ◽  
International Classification Of Diseases ◽  
Healthcare Resource Utilization ◽  
Pustular Psoriasis ◽  
Administrative Claims ◽  
Generalized Pustular Psoriasis

Background: Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin disease with significant unmet clinical need. Historically, GPP has not been well characterized; however, the advent of the International Classification of Diseases, 10th revision, has made it possible to more accurately characterize patients with GPP. Objective: To describe the characteristics and estimate the burden of disease in patients with GPP compared with those with plaque psoriasis. Methods: A retrospective study was conducted using a US administrative claims database, Optum® Clinformatics® Data Mart, between October 1, 2015, and March 31, 2019. Patients with at least 1 inpatient or 2 outpatient diagnosis codes for GPP (L40.1) or psoriasis vulgaris (L40.0) were included. The main outcome measures included the percentage of individuals with comorbidities, medication use, and healthcare resource utilization (HCRU), which were compared between patients with GPP and those with plaque psoriasis and a general population comparator control cohort. Results: Overall, 1,669 patients with GPP were identified at baseline; most patients were female (67.6%). Patients with GPP had more comorbidities than those with plaque psoriasis, specifically metabolic disorders: hyperlipidemia and type 2 diabetes. Medication use for patients with GPP differed from those with plaque psoriasis—patients with GPP required more frequent use of antihypertensives and antibiotics than those with plaque psoriasis. Patients with GPP also had higher HCRU than those with plaque psoriasis. Conclusion: Although this study has limitations, it shows that patients with GPP have a high burden of illness that differs from patients with plaque psoriasis.

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