Association of PON1 gene polymorphisms and enzymatic activity with risk of coronary artery disease

2021 ◽  
Vol 17 (1) ◽  
pp. 119-126
Author(s):  
Charuta Godbole ◽  
Saket Thaker ◽  
Prafulla Kerkar ◽  
Milind Nadkar ◽  
Nithya Gogtay ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Enzymatic Activity ◽  
Gene Polymorphisms ◽  
Pon1 Activity ◽  
Pon1 Gene ◽  
Artery Disease ◽  
Pon1 Polymorphisms ◽  
Serum Pon1 Activity ◽  
Control Study

Background: The present case–control study evaluated the association of PON1 gene polymorphisms and enzyme activity in the western Indian population. Materials & methods: Angiographically proven coronary artery disease (CAD) formed the cases. PON1 polymorphisms (Q192R, L55M) and enzymatic activity (paraoxonase) were assessed. Results: A total of 502 participants (251 per group) were studied. PON1 Q192R and L55M polymorphisms were not associated with the risk of CAD. Notably, a weak association was observed between Q192R polymorphisms and the risk of CAD. CAD patients had significantly lower PON1 enzymatic activity (U/L) as compared with the controls regardless of the genotype. Conclusion: Low serum PON1 activity was confirmed to be an independent predictor for the risk of CAD.

Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study

2018 ◽  
Vol 9 (3) ◽  
pp. 115-122 ◽  
Author(s):  
Latheef Latheef K ◽  
Rajasekhar Rajasekhar D ◽  
Vanajakshamma Vanajakshamma V ◽  
Aparna Aparna BR ◽  
Chaudhury Chaudhury A ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
South Indian ◽  
Artery Disease ◽  
Control Study

scholarly journals Investigation of paraoxonase 1 activity of the workers at the plant, who have long-term contact with organophosphorus compounds

2017 ◽  
Vol 15 (1) ◽  
pp. 57
Author(s):  
Natalia D Razgildina ◽  
Valentina V Miroshnikova ◽  
Aleksey V Fomichev ◽  
Ekaterina V Malisheva ◽  
Alexandra A Panteleeva ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Organophosphorus Compounds ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Control Group ◽  
Pon1 Gene ◽  
Polymorphic Variants ◽  
Pon1 Polymorphisms ◽  
Serum Pon1 Activity

Background. Liver enzyme paraoxonase 1 (PON1) plays an important role in protection the organism from toxic effects of organophosphorus compounds (OPs) via their hydrolysis whose rate and efficiency depend on PON1 serum level activity. PON1 activity is largely determined by the polymorphic variants of the PON1 gene. Effect of long-term work with exposure to the toxic OPs on the PON1 activity is almost unknown. The aim of the present work was to study the effect of long-term work with exposure to the toxic OPs on PON1 serum enzymatic activity depending on polymorphisms Q191R, L54M, C(-108)T PON1 gene. Materials and methods. PON1 serum enzymatic activity and PON1 polymorphisms were determined in men, who were categorized in 2 groups: workers of companies providing storage and disposal of the OPs (68) and control group (37). The PON1 191, PON1 55 and PON1 108 polymorphisms were studied by polymerase chain reaction/restriction fragment length polymorphism. PON1 serum enzymatic activity was measured by a spectrophotometric method using paraoxon. Results. PON1 activity in workers with exposure to the toxic OPs relative was increased compared to the control group (p = 0,027). Differences in serum PON1 activity was shown for the carriers of certain genotypes of the PON1 gene: PON1 serum activity was higher in workers compared to controls only for LL genotype (L54M polymorphism) and C allele (C(-108)T polymorphism) carriers (p < 0,001 and p = 0,002, correspondently). Conclusion. We suggest that the increase in serum PON1 activity in workers providing storage and disposal of OPs could be modulated with the polymorphic variants of the PON1 gene.

scholarly journals Complement C3 gene polymorphisms are associated with lipid levels, but not the risk of coronary artery disease: a case-control study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Gaojun Cai ◽  
Li Li ◽  
Yifei Chen ◽  
Haomin Huang ◽  
Lei Yu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Apolipoprotein A1 ◽  
Lipid Levels ◽  
Artery Disease ◽  
Control Study

Abstract Background Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Previous studies have shown that complement component 3 (C3) is associated with atherosclerosis and cardiovascular risk factors. Methods We conducted this study to evaluate the associations between tagSNPs in the C3 gene locus and the CAD susceptibility and lipid levels in the Chinese population. A hospital-based case-control study, including 1017 subjects (580 CAD patients and 437 non-CAD controls), was conducted. TagSNPs in the C3 gene were searched and genotyped by using the polymerase chain reaction-ligase detection reaction method. Results The C3 levels were positively associated with the low-density lipoprotein cholesterol (LDL-C) levels (r = 0.269, P = 0.001). Compared with those in controls, the serum C3 levels in CAD patients were significantly higher (Control: 0.94 + 0.14 g/l; CAD: 1.10 + 0.19 g/l, P < 0.001). No significant differences in genotype or allele frequencies were observed between CAD patients and controls. The minor T allele of rs2287848 was associated with low apolipoprotein A1 (ApoA1) levels in controls (Bonferroni corrected P, Pc = 0.032). Linkage disequilibrium and haplotype analysis established two haplotype blocks (Block1: rs344555-rs2277984, Block 2: rs2287848-rs11672613) and six haplotypes. No significant associations between haplotypes and the risk of CAD were observed (all Pc > 0.05). Conclusions The results revealed that C3 gene polymorphisms were associated with the lipid levels, but not CAD susceptibility in the Chinese population.

scholarly journals Association of the ATG9B gene polymorphisms with coronary artery disease susceptibility: A case-control study

2019 ◽  
Vol 11 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Mahsa Mehrabi Pour ◽  
Mahboobeh Nasiri ◽  
Hajar Kamfiroozie ◽  
Mohammad Javad Zibaeenezhad
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Proper Function ◽  
Arms Pcr ◽  
Increased Risk ◽  
Artery Disease ◽  
Control Study

Introduction: Endothelial nitric oxide synthase (eNOS), the main regulator of cardiac cell functioning, is regulated post-transcriptionally by autophagy-related 9B (ATG9B) gene. The proper function of the heart is partly determined by the intact interaction of these molecules. The present study aimed to investigate the effects of ATG9B rs2373929 and rs7830 gene polymorphisms on the predisposition to coronary artery disease (CAD). Methods: In this hospital-based case-control study, 150 patients with CAD compared with 150 healthy subjects for the genotype distributions of rs2373929 and rs7830 polymorphisms using T-ARMS PCR and ARMS PCR, respectively. Results: Considering rs2373929 polymorphism, increased risk of CAD observed in the presence of TT genotype (OR: 3.65; 95% CI: 1.77-7.53; P < 0.001) and also in the recessive model for T allele (OR: 3.41; 95% CI: 1.76- 6.60; P < 0.001). The frequency of the T allele was higher in cases compared to controls (OR: 1.71; 95% CI: 1.24-2.28; P = 0.001). The genotype and allele frequencies of the rs7830 polymorphism did not differ between the two study groups. Conclusion: The ATG9B gene rs2373929 polymorphism might involve in the pathogenesis of the CAD and can be considered as a screening molecular marker in the subjects prone to CAD.

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