The effect of antihypertensive treatment on the incidence of stroke and cognitive decline in the elderly: a meta-analysis

2016 ◽  
Vol 12 (2) ◽  
pp. 237-248 ◽  
Author(s):  
Christine Parsons ◽  
Mohammad Hassan Murad ◽  
Stuart Andersen ◽  
Farouk Mookadam ◽  
Helene Labonte
Keyword(s):  
Cognitive Decline ◽  
Antihypertensive Treatment ◽  
Meta Analysis ◽  
The Elderly

Is hospitalization a risk factor for cognitive decline in older age adults?

2020 ◽  
pp. 1-18
Author(s):  
Lucia Chinnappa-Quinn ◽  
Steve Robert Makkar ◽  
Michael Bennett ◽  
Ben C. P. Lam ◽  
Jessica W. Lo ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Meta Analysis ◽  
Severity Of Illness ◽  
The Elderly ◽  
Preliminary Evidence ◽  
Older Age ◽  
Future Research ◽  
Cognitive Changes ◽  
Newcastle Ottawa Scale ◽  
Meta Analyses

ABSTRACT Objectives: Many studies document cognitive decline following specific types of acute illness hospitalizations (AIH) such as surgery, critical care, or those complicated by delirium. However, cognitive decline may be a complication following all types of AIH. This systematic review will summarize longitudinal observational studies documenting cognitive changes following AIH in the majority admitted population and conduct meta-analysis (MA) to assess the quantitative effect of AIH on post-hospitalization cognitive decline (PHCD). Methods: We followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Selection criteria were defined to identify studies of older age adults exposed to AIH with cognitive measures. 6566 titles were screened. 46 reports were reviewed qualitatively, of which seven contributed data to the MA. Risk of bias was assessed using the Newcastle–Ottawa Scale. Results: The qualitative review suggested increased cognitive decline following AIH, but several reports were particularly vulnerable to bias. Domain-specific outcomes following AIH included declines in memory and processing speed. Increasing age and the severity of illness were the most consistent risk factors for PHCD. PHCD was supported by MA of seven eligible studies with 41,453 participants (Cohen’s d = −0.25, 95% CI [−0.02, −0.49] I2 35%). Conclusions: There is preliminary evidence that AIH exposure accelerates or triggers cognitive decline in the elderly patient. PHCD reported in specific contexts could be subsets of a larger phenomenon and caused by overlapping mechanisms. Future research must clarify the trajectory, clinical significance, and etiology of PHCD: a priority in the face of an aging population with increasing rates of both cognitive impairment and hospitalization.

scholarly journals Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

2021 ◽  
Vol 13 ◽  
Author(s):  
Mengzhao Cui ◽  
Siwen Zhang ◽  
Yujia Liu ◽  
Xiaokun Gang ◽  
Guixia Wang
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Grip Strength ◽  
Web Of Science ◽  
Meta Analysis ◽  
Clinical Work ◽  
The Elderly ◽  
Sensitivity Analyses ◽  
The Relationship

Purpose: Loss of grip strength and cognitive impairment are prevalent in the elderly, and they may share the pathogenesis in common. Several original studies have investigated the association between them, but the results remained controversial. In this systematic review and meta-analysis, we aimed to quantitatively determine the relationship between baseline grip strength and the risk of cognitive impairment and provide evidence for clinical work.Methods: We performed a systematic review using PubMed, EMBASE, Cochrane, and Web of Science up to March 23, 2020, and focused on the association between baseline grip strength and onset of cognitive impairment. Next, we conducted a meta-analysis using a hazard ratio (HR) and 95% confidence interval (CI) as effect measures. Heterogeneity between the studies was examined using I2 and p-value. Sensitivity analyses and subgroup analyses were also performed, and publication bias was assessed by Begg's and Egger's tests.Results: Fifteen studies were included in this systematic review. After sensitivity analyses, poorer grip strength was associated with more risk of cognitive decline and dementia (HR = 1.99, 95%CI: 1.71–2.32; HR = 1.54, 95%CI: 1.32–1.79, respectively). Furthermore, subgroup analysis indicated that people with poorer strength had more risk of Alzheimer's disease (AD) and non-AD dementia (HR = 1.41, 95%CI: 1.09–1.81; HR = 1.45, 95%CI: 1.10–1.91, respectively).Conclusions: Lower grip strength is associated with more risk of onset of cognitive decline and dementia despite of subtype of dementia. We should be alert for the individuals with poor grip strength and identify cognitive dysfunction early.

Informant Questionnaire on Cognitive Decline in the Elderly--Farsi Version

2019 ◽  
Author(s):  
Mahshid Foroughan ◽  
Zahra Jafari ◽  
Ida Ghaemmagham Farahani ◽  
Vahid Rashedi
Keyword(s):  
Cognitive Decline ◽  
The Elderly ◽  
Farsi Version

Web-based interventions aimed at improving the mental health effects of home caregivers for dementia: Meta-analysis (Preprint)

2019 ◽  
Author(s):  
Hui Feng ◽  
Yinan Zhao ◽  
Mingyue Hu ◽  
Hengyu Hu ◽  
Hui Li ◽  
...  
Keyword(s):  
Mental Health ◽  
Meta Analysis ◽  
The Elderly ◽  
Anxiety Symptoms ◽  
Average Score ◽  
Physical And Mental Health ◽  
Web Based ◽  
Negative Results ◽  
Cochrane Database ◽  
The Web

BACKGROUND Dementia is one of the major cause of disability and dependency among the elderly worldwide, and there are general psychological distresses among caregivers in dementia, such as depression and anxiety symptoms. The physical and mental health of the caregiver is a prerequisite and a promise to help the elderly stay alive and promote health. Web-based interventions can provide for a more convenient and efficient support and education, OBJECTIVE The purpose of this study was to examine the effect of internet-based interventions on mental health outcomes of family caregivers with dementia, and exploring which components of the web-based interventions play an important role.which are likely to reduce caregivers’ negative outcomes associated with care. METHODS A comprehensive literature search was conducted on PubMed, Embase, PsycINFO, Cochrane Database and CINAHL by using relevant terms such as web-based and caregiver as keywords, covering all studies published before June 2018. Two reviewers independently reviewed all published abstracts, according to the established inclusion and exclusion criteria ，we extracted the information about participants, interventions and results, respectively, and reviewed the quality of articles on the methods of randomized trials using the approach recommended by the Cochrane Handbook for systematic review for intervention. RESULTS A total of 815 caregivers participated in 6 articles, and 4 of the studies use depression as an outcome, according to the research after different interventions based on network after the intervention, depression scores average drop of 0.23 (95%CI -0.38 to -0.07, p<0.01), 2 studies show caregivers anxiety symptoms, the average score for anxiety dropped by 0.32 points (95% CI -0.50 to -0.14, p< 0.01), but in terms of coping, pain and stress, the web-based interventions have shown a poor effect. On the whole, the addition of professional psychological support on the basis of education can improve mental health of carers. CONCLUSIONS Internet-based interventions were generally effective in reducing anxiety and depression in dementia carers, although negative results were found in some studies. But in terms of burden and stress, further research is needed.

Sign in / Sign up

Export Citation Format

Share Document