scholarly journals Implementing multidisciplinary tumor boards in oncology: a narrative review

2021 ◽  
Author(s):  
Max S Mano ◽  
Fadil T Çitaku ◽  
Paul Barach

The healthcare industry compares unfavorably with other ultra-safe industries such as aviation and nuclear power plants, which address complexity by reducing the vulnerability of a single person and promoting teams and strong systems. A multidisciplinary tumor board (MTB) is an evidence-based organizational approach to implementing a more effective concept in oncology practice. Studies addressing the correlation between MTBs and cancer outcomes show promising results, and other potential benefits are also addressed. The objectives of this article are to define and characterize MTBs in modern oncology practice, review the current literature on MTBs effectiveness and address challenges to the implementation and maintenance of MTBs. In this commentary-type narrative review, the authors present their opinions and, whenever possible, substantiate recommendations by citing supportive literature.

2013 ◽  
Vol 7 (2) ◽  
pp. 201-214 ◽  
Author(s):  
James M. Shultz ◽  
David Forbes ◽  
David Wald ◽  
Fiona Kelly ◽  
Helena M. Solo-Gabriele ◽  
...  

AbstractObjectivesOn March 11, 2011, Japan experienced the largest earthquake in its history. The undersea earthquake launched a tsunami that inundated much of Japan's eastern coastline and damaged nuclear power plants, precipitating multiple reactor meltdowns. We examined open-source disaster situation reports, news accounts, and disaster-monitoring websites to gather event-specific data to conduct a trauma signature analysis of the event.MethodsThe trauma signature analysis included a review of disaster situation reports; the construction of a hazard profile for the earthquake, tsunami, and radiation threats; enumeration of disaster stressors by disaster phase; identification of salient evidence-based psychological risk factors; summation of the trauma signature based on exposure to hazards, loss, and change; and review of the mental health and psychosocial support responses in relation to the analysis.ResultsExposure to this triple-hazard event resulted in extensive damage, significant loss of life, and massive population displacement. Many citizens were exposed to multiple hazards. The extremity of these exposures was partially mitigated by Japan's timely, expert-coordinated, and unified activation of an evidence-based mental health response.ConclusionsThe eastern Japan disaster was notable for its unique constellation of compounding exposures. Examination of the trauma signature of this event provided insights and guidance regarding optimal mental health and psychosocial responses. Japan orchestrated a model response that reinforced community resilience. (Disaster Med Public Health Preparedness. 2013;0:1-14)


2020 ◽  
Vol 10 (4) ◽  
pp. 252
Author(s):  
Ari VanderWalde ◽  
Axel Grothey ◽  
Daniel Vaena ◽  
Gregory Vidal ◽  
Adam ElNaggar ◽  
...  

In the precision medicine era, molecular testing in advanced cancer is foundational to patient management. Molecular tumor boards (MTBs) can be effective in processing comprehensive genomic profiling (CGP) results and providing expert recommendations. We assessed an MTB and its role in a community setting. This retrospective analysis included patients with MTB recommendations at a community-based oncology practice January 2015 to December 2018; exclusions were death within 60 days of the MTB and/or no metastatic disease. Potentially actionable genomic alterations from CGP (immunohistochemistry, in-situ hybridization, next-generation sequencing) were reviewed bi-weekly by MTB practice experts, pathologists, genetic counselors, and other support staff, and clinical care recommendations were provided. Subsequent chart reviews determined implementation rates of recommendations. In 613 patients, the most common cancers were lung (23%), breast (19%), and colorectal (17%); others included ovarian, endometrial, bladder, and melanoma. Patients received 837 actionable recommendations: standard therapy (37%), clinical trial (31%), germline testing and genetic counseling (17%), off-label therapy (10%), subspecialty multidisciplinary tumor board review (2%), and advice for classifying tumor of unknown origin (2%). Of these recommendations, 36% to 78% were followed by the treating physician. For clinical trial recommendations (n = 262), 13% of patients enrolled in a clinical trial. The median time between CPG result availability and MTB presentation was 12 days. A community oncology-based comprehensive and high-throughput MTB provided useful clinical guidance in various treatment domains within an acceptable timeframe for patients with cancer in a large community setting.


Author(s):  
Robert Pool

Things used to be so simple. In the old days, a thousand generations ago or so, human technology wasn’t much more complicated than the twigs stripped of leaves that some chimpanzees use to fish in anthills. A large bone for a club, a pointed stick for digging, a sharp rock to scrape animal skins—such were mankind’s only tools for most of its history. Even after the appearance of more sophisticated, multipiece devices—the bow and arrow, the potter’s wheel, the ox-drawn cart—nothing was difficult to understand or decipher. The logic of a tool was clear upon inspection, or perhaps after a little experimentation. No longer. No single person can comprehend the entire workings of, say, a Boeing 747. Not its pilot, not its maintenance chief, not any of the thousands of engineers who worked upon its design. The aircraft contains six million individual parts assembled into hundreds of components and systems, each with a role to play in getting the 165-ton behemoth from Singapore to San Francisco or Sidney to Saskatoon. There are structural components such as the wings and the six sections that are joined together to form the fuselage. There are the four 21,000-horsepower Pratt & Whitney engines. The landing gear. The radar and navigation systems. The instrumentation and controls. The maintenance computers. The fire-fighting system. The emergency oxygen in case the cabin loses pressure. Understanding how and why just one subassembly works demands years of study, and even so, the comprehension never seems as palpable, as tangible, as real as the feel for flight one gets by building a few hundred paper airplanes and launching them across the schoolyard. Such complexity makes modern technology fundamentally different from anything that has gone before. Large, complex systems such as commercial airliners and nuclear power plants require large, complex organizations for their design, construction, and operation. This opens up the technology to a variety of social and organizational influences, such as the business factors described in chapter 3. More importantly, complex systems are not completely predictable.


Author(s):  
John D. Rubio

The degradation of steam generator tubing at nuclear power plants has become an important problem for the electric utilities generating nuclear power. The material used for the tubing, Inconel 600, has been found to be succeptible to intergranular attack (IGA). IGA is the selective dissolution of material along its grain boundaries. The author believes that the sensitivity of Inconel 600 to IGA can be minimized by homogenizing the near-surface region using ion implantation. The collisions between the implanted ions and the atoms in the grain boundary region would displace the atoms and thus effectively smear the grain boundary.To determine the validity of this hypothesis, an Inconel 600 sample was implanted with 100kV N2+ ions to a dose of 1x1016 ions/cm2 and electrolytically etched in a 5% Nital solution at 5V for 20 seconds. The etched sample was then examined using a JEOL JSM25S scanning electron microscope.


Author(s):  
Marjorie B. Bauman ◽  
Richard F. Pain ◽  
Harold P. Van Cott ◽  
Margery K. Davidson

2010 ◽  
pp. 50-56 ◽  
Author(s):  
Pablo T. León ◽  
Loreto Cuesta ◽  
Eduardo Serra ◽  
Luis Yagüe

2020 ◽  
Vol 39 (5) ◽  
pp. 6339-6350
Author(s):  
Esra Çakır ◽  
Ziya Ulukan

Due to the increase in energy demand, many countries suffer from energy poverty because of insufficient and expensive energy supply. Plans to use alternative power like nuclear power for electricity generation are being revived among developing countries. Decisions for installation of power plants need to be based on careful assessment of future energy supply and demand, economic and financial implications and requirements for technology transfer. Since the problem involves many vague parameters, a fuzzy model should be an appropriate approach for dealing with this problem. This study develops a Fuzzy Multi-Objective Linear Programming (FMOLP) model for solving the nuclear power plant installation problem in fuzzy environment. FMOLP approach is recommended for cases where the objective functions are imprecise and can only be stated within a certain threshold level. The proposed model attempts to minimize total duration time, total cost and maximize the total crash time of the installation project. By using FMOLP, the weighted additive technique can also be applied in order to transform the model into Fuzzy Multiple Weighted-Objective Linear Programming (FMWOLP) to control the objective values such that all decision makers target on each criterion can be met. The optimum solution with the achievement level for both of the models (FMOLP and FMWOLP) are compared with each other. FMWOLP results in better performance as the overall degree of satisfaction depends on the weight given to the objective functions. A numerical example demonstrates the feasibility of applying the proposed models to nuclear power plant installation problem.


Sign in / Sign up

Export Citation Format

Share Document