Palatability and oral cavity tolerability of THC:CBD oromucosal spray and possible improvement measures in multiple sclerosis patients with resistant spasticity: a pilot study

2018 ◽  
Vol 8 (2) ◽  
pp. 105-113 ◽  
Author(s):  
Giacomo Lus ◽  
Roberto Cantello ◽  
Maura Chiara Danni ◽  
Agusto Rini ◽  
Paola Sarchielli ◽  
...  
2020 ◽  
Vol 339 ◽  
pp. 577113
Author(s):  
Andreia Monteiro ◽  
Pedro Rosado ◽  
Luiza Rosado ◽  
Ana Mafalda Fonseca ◽  
Artur Paiva

2014 ◽  
Vol 1 ◽  
pp. 18-23
Author(s):  
Marian Simka ◽  
Tomasz Ludyga ◽  
Piotr Janas ◽  
Marek Kazibudzki ◽  
Paweł Latacz

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yee Ming Ching ◽  
Shanthi Viswanathan ◽  
Nurhanani Mohamed Nor ◽  
Shuwahida Shuib ◽  
Balqis Kamarudin ◽  
...  

Abstract Background Multiple sclerosis is an immune mediated disease targeting the central nervous system. Association of non-human leukocyte antigen gene, CD58, with multiple sclerosis has been reported in several populations but is unclear among Southeast Asians. This pilot study was conducted to explore the association between CD58 polymorphism and multiple sclerosis among the Malay population in Malaysia. Methods Blood samples were collected from 27 multiple sclerosis patients, and compared with 58 age- and gender matched healthy individuals. All patients were tested negative for anti-aquaporin 4. DNA was extracted from the blood and genotyped for 3 single nucleotide polymorphisms rs12044852, rs2300747 and rs1335532 of gene CD58 by real-time PCR. Results The majority of multiple sclerosis patients were female (85.2%). The general mean age of onset was 30.5 years. Genotyping results showed that frequencies of the alleles were between 40 and 50% for MS patients and healthy individuals. Association (allelic model) between multiple sclerosis and CD58 gene polymorphism alleles rs12044852 (p = 0.410), rs2300747 (p = 0.881) and rs1335532 (p = 0.407) were indistinct. Conclusions The impact of the CD58 gene polymorphism was not prominent in this pilot study, implying that genetic composition contributing to multiple sclerosis may be different between different populations, thus results in a heterogeneity of disease manifestation and distribution.


2005 ◽  
Vol 13 (1) ◽  
pp. 25-33 ◽  
Author(s):  
D. Aldridge ◽  
W. Schmid ◽  
M. Kaeder ◽  
C. Schmidt ◽  
T. Ostermann

2019 ◽  
Vol 24 (1) ◽  
pp. 105
Author(s):  
Fereshteh Shamsian ◽  
RoshanakMehdipour Dastjerdi ◽  
Arian Kavosh ◽  
Fereshteh Ashtari

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