Simulation of the long-term fate of superparamagnetic iron oxide-based nanoparticles using simulated biological fluids

Imaging-guided cancer theranostic is a promising strategy for cancer diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, is limited by the poor solubility and dispersion of photosensitizers (PS) in biological fluids. Herein, it is demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared by conjugated with Chlorin e6 (Ce6) and modified with folic acid (FA) on the surface, can be used as versatile drug delivery vehicles for effective PDT. The nanoparticles are great carriers for photosensitizer Ce6 with an extremely high loading efficiency. In vitro fluorescence imaging and in vivo magnetic resonance imaging (MRI) results indicated that SCFs selectively accumulated in tumor cells. Under near-infrared laser irradiation, SCFs were confirmed to be capable of inducing low cell viability of RM-1 cells In vitro and displaying efficient tumor ablation with negligible side effects in tumor-bearing mice models.

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Noninvasive Tracking of Implanted Cells: Superparamagnetic Iron Oxide Nanoparticles as a Long-Term, Multimodal Imaging Label

Cell Tracking - Methods in Molecular Biology ◽

10.1007/978-1-0716-0364-2_15 ◽

2020 ◽

pp. 167-175

Author(s):

Mughil Sriramvenugopal ◽

Christina A. Pacak

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Multimodal Imaging ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles

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Short-, middle- and long-term safety of superparamagnetic iron oxide-labeled allogeneic bone marrow stromal cell transplantation in rat model of lacunar infarction

Neuropathology ◽

10.1111/neup.12180 ◽

2014 ◽

Vol 35 (3) ◽

pp. 197-208 ◽

Cited By ~ 9

Author(s):

Chengbo Tan ◽

Hideo Shichinohe ◽

Takeo Abumiya ◽

Naoki Nakayama ◽

Ken Kazumata ◽

...

Keyword(s):

Bone Marrow ◽

Iron Oxide ◽

Cell Transplantation ◽

Rat Model ◽

Stromal Cell ◽

Bone Marrow Stromal Cell ◽

Superparamagnetic Iron Oxide ◽

Allogeneic Bone ◽

Marrow Stromal Cell

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In Vivo Distribution of Poly(ethylene glycol) Functionalized Iron Oxide Nanoclusters: An Ultrastructural Study

Nanomaterials ◽

10.3390/nano11092184 ◽

2021 ◽

Vol 11 (9) ◽

pp. 2184

Author(s):

Maria Suciu ◽

Claudiu Mirescu ◽

Izabell Crăciunescu ◽

Sergiu Gabriel Macavei ◽

Cristian Leoștean ◽

...

Keyword(s):

Iron Oxide ◽

De Novo ◽

Superparamagnetic Iron Oxide ◽

In Vivo Distribution ◽

Transmission Electron ◽

Blood And Urine Samples ◽

Poly Ethylene ◽

Exposure Evaluation

The in vivo distribution of 50 nm clusters of polyethylene glycol-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-PEG) was conducted in this study. SPIONs-PEG were synthesized de novo, and their structure and paramagnetic behaviors were analyzed by specific methods (TEM, DLS, XRD, VSM). Wistar rats were treated with 10 mg Fe/kg body weight SPIONs-PEG and their organs and blood were examined at two intervals for short-term (15, 30, 60, 180 min) and long-term (6, 12, 24 h) exposure evaluation. Most exposed organs were investigated through light and transmission electron microscopy, and blood and urine samples were examined through fluorescence spectrophotometry. SPIONs-PEG clusters entered the bloodstream after intraperitoneal and intravenous administrations and ended up in the urine, with the highest clearance at 12 h. The skin and spleen were within normal histological parameters, while the liver, kidney, brain, and lungs showed signs of transient local anoxia or other transient pathological affections. This study shows that once internalized, the synthesized SPIONs-PEG disperse well through the bloodstream with minor to nil induced tissue damage, are biocompatible, have good clearance, and are suited for biomedical applications.

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