Porous silicon nanomaterials: recent advances in surface engineering for controlled drug-delivery applications

Nanomedicine ◽  
2019 ◽  
Vol 14 (24) ◽  
pp. 3213-3230 ◽  
Author(s):  
De-Xiang Zhang ◽  
Lars Esser ◽  
Roshan B Vasani ◽  
Helmut Thissen ◽  
Nicolas H Voelcker
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Porous Silicon ◽  
Surface Engineering ◽  
Controlled Drug Delivery ◽  
Current Status ◽  
Polymer Grafting ◽  
Recent Advances ◽  
Drug Delivery Applications

Porous silicon (pSi) nanomaterials are increasingly attractive for biomedical applications due to their promising properties such as simple and feasible fabrication procedures, tunable morphology, versatile surface modification routes, biocompatibility and biodegradability. This review focuses on recent advances in surface modification of pSi for controlled drug delivery applications. A range of functionalization strategies and fabrication methods for pSi-polymer hybrids are summarized. Surface engineering solutions such as stimuli-responsive polymer grafting, stealth coatings and active targeting modifications are highlighted as examples to demonstrate what can be achieved. Finally, the current status of engineered pSi nanomaterials for in vivo applications is reviewed and future prospects and challenges in drug-delivery applications are discussed.

A Closer Look to Polyesters: Properties, Synthesis, Characterization, and Particle Drug Delivery Applications

2020 ◽  
Vol 10 ◽  
Author(s):  
Katherine Pazmiño V. ◽  
Karla Sofía Vizuete ◽  
Frank Alexis ◽  
Brajesh Kumar ◽  
Alexis Debut
Keyword(s):  
Drug Delivery ◽  
Glycolic Acid ◽  
Controlled Drug Delivery ◽  
Polymeric Materials ◽  
Synthetic Polymers ◽  
Future Application ◽  
In Vivo Tests ◽  
Drug Delivery Applications

Background: Natural and synthetic polymeric materials can be used in the fields of biomedicine and pharmaceuticals as a material for controlled drug delivery. Among the synthetic polymers, polyesters are synthesized from two natural monomers: lactic and glycolic acid, which are biocompatible and biodegradable. Objective: Here we review broad aspects of polyesters including its properties, synthesis, characterization, and particle drug delivery applications. Conclusion: Finally, we have concluded that polyesters are certainly very versatile material that is continuously reinvented for future application in new areas of science and medicine. However, several aspects must be considered when synthesizing polyesters, which have a direct influence on biodegradability and biocompatibility. These properties may limit the performance of in vitro and in vivo tests.

scholarly journals Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
De-Xiang Zhang ◽  
Chiaki Yoshikawa ◽  
Nicholas G. Welch ◽  
Paul Pasic ◽  
Helmut Thissen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Porous Silicon ◽  
Sustained Drug Delivery ◽  
Drug Delivery Applications

scholarly journals Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Maria Mir ◽  
Saba Ishtiaq ◽  
Samreen Rabia ◽  
Maryam Khatoon ◽  
Ahmad Zeb ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Imaging ◽  
Imaging System ◽  
Controlled Drug Delivery ◽  
In Vivo Imaging System

Versatile surface engineering of porous nanomaterials with bioinspired polyphenol coatings for targeted and controlled drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (16) ◽  
pp. 8600-8606 ◽  
Author(s):  
Juan Li ◽  
Shuxian Wu ◽  
Cuichen Wu ◽  
Liping Qiu ◽  
Guizhi Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Engineering ◽  
Controlled Drug Delivery ◽  
Porous Nanomaterials

scholarly journals A Mini Review: Recent Advances in Surface Modification of Porous Silicon

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2557 ◽  
Author(s):  
Seo Lee ◽  
Jae Kang ◽  
Dokyoung Kim
Keyword(s):  
Surface Modification ◽  
Porous Silicon ◽  
Wide Spectrum ◽  
Basic Research ◽  
Recent Advances ◽  
Developed Surface ◽  
The Many ◽  
Insight Into ◽  
Biomedical Fields

Porous silicon has been utilized within a wide spectrum of industries, as well as being used in basic research for engineering and biomedical fields. Recently, surface modification methods have been constantly coming under the spotlight, mostly in regard to maximizing its purpose of use. Within this review, we will introduce porous silicon, the experimentation preparatory methods, the properties of the surface of porous silicon, and both more conventional as well as newly developed surface modification methods that have assisted in attempting to overcome the many drawbacks we see in the existing methods. The main aim of this review is to highlight and give useful insight into improving the properties of porous silicon, and create a focused description of the surface modification methods.

scholarly journals Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 150 ◽  
Author(s):  
Elisabetta Mazzotta ◽  
Lorena Tavano ◽  
Rita Muzzalupo
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Controlled Drug Delivery ◽  
Solid Tumours ◽  
Site Specific ◽  
Mild Hyperthermia ◽  
Promising Tool ◽  
A Site

Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored.

Recent advances in polymeric and solid lipid–based nanoparticles for controlled drug delivery

2020 ◽  
pp. 131-158
Author(s):  
Manu Sharma ◽  
Namita Gupta ◽  
Ranju Soni ◽  
Ankita Gautam ◽  
Kakarla Raghava Reddy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Solid Lipid ◽  
Recent Advances
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