COVID-19 Evolution and Alternative Medicine- A Review

The current global health emergency, COVID-19, is not the first time that coronaviruses have posed a threat to human world shrinking our numbers by thousands. Before this SARS-CoV in 2003 and MERS-CoV in 2013 have caused epidemics. Four months in existence, and it has already affected 1,995,983 people and taken over 131,037 lives worldwide, yet we do not have any specific treatment available with us and the management is purely empirical. Looking at the similarities between SARS-CoV and SARS-CoV-2 in origin, genomics, pathogenesis and epidemiology, we can bring the researches done for SARS-CoV in use which can be our guide in finding an effective management strategy against SARS-CoV-2. There are various researches and studies reporting the use and effect of various phytochemical compounds in SARS-CoV treatment. Already, the thought has been put into action and in-silico screening for various natural plant compounds have been done to find a potential candidate compound. One such example is of curcumin, a secondary metabolite of turmeric, which is found to be effective against COVID-19 protease by molecular docking analysis.

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Molecular Docking Analysis Of Some Phytochemicals On Two SARS-CoV-2 Targets: Potential Lead Compounds Against Two Target Sites of SARS-CoV-2 Obtained from Plants

10.1101/2020.03.31.017657 ◽

2020 ◽

Cited By ~ 3

Author(s):

Amaka Ubani ◽

Francis Agwom ◽

Oluwatoyin RuthMorenikeji ◽

Shehu Nathan ◽

Pam Luka ◽

...

Keyword(s):

Molecular Docking ◽

Binding Affinity ◽

Potential Candidate ◽

Binding Affinities ◽

Protein Targets ◽

Docking Analysis ◽

Lead Compounds ◽

Target Sites ◽

Antiviral Activities ◽

Molecular Docking Analysis

AbstractCOV spike (S) glycoprotein and Mpro are two key targets that have been identified for vaccines and drug development against the COVID-19 disease. Virtual screening of some compounds of plants origin that have shown antiviral activities were carried out on the two targets, 6lu7 and 6vsb by docking with the PyRx software. The binding affinities were compared with other compounds and drugs already identified as potential ligands for 6lu7 and 6vsb as well as Chloroquine and hydroxychloroquine. The docked compounds with best binding affinities were also filtered for drug likeness using the SwissADME and PROTOX platforms on the basis of Physicochemical properties and toxicity respectively. The docking results revealed that scopodulcic acid and dammarenolic acid had the best binding affinity on the s-glycoprotein and Mpro protein targets respectively. Silybinin also demonstrated a good binding affinity to both protein targets making it a potential candidate for further evaluation as repurposed candidate for SARS COV2 with likelihood of having a multitarget activity.

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Evaluation of Different Phytochemicals Against BRCA2 Receptor

Biointerface Research in Applied Chemistry ◽

10.33263/briac122.16701681 ◽

2021 ◽

Vol 12 (2) ◽

pp. 1670-1681

Keyword(s):

Breast Cancer ◽

Molecular Docking ◽

Alternative Therapy ◽

Cancer Therapeutics ◽

Receptor Protein ◽

Effective Prevention ◽

Docking Analysis ◽

Cancer Tumor ◽

Phytochemical Compounds ◽

Molecular Docking Analysis

Cancer is one of the most common diseases and remains a leading cause of death worldwide. Breast cancer is one of the major causes of mortality in women. It is one of the most frequent cancers among others. Due to its high mortality, it requires effective prevention. Radiotherapy, immunotherapy, and chemotherapy are the most common methods used to treat breast cancer, but these techniques adversely affect healthy cells. Therefore, an alternative therapy is required to overcome this problem. Phytochemicals from different plant sources are an alternative way for curing infectious diseases and now they are being explored for their anti-cancer therapeutics. In the present study, the BRCA2 receptor protein, which is actively involved in breast cancer expression, was chosen for the molecular docking analysis. This study focuses on evaluating phytochemical compounds from 5 different plants against BRCA2 breast cancer tumor receptors. Prior to computational analysis, a theoretical ADME study was used to rule out a few compounds. Virtual screening of these compounds identified five-hit molecules, which could be further explored in the drug discovery pipeline. Molecular docking analysis revealed that isocolumbin possesses maximum negative binding energy against BRCA2 receptors. These hits were found to be well in range in the bioavailability radar test as well.

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Severe Acute Respiratory Syndrome Coronavirus-2 Emergence and Its Treatment with Alternative Medicines: A Review

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00967 ◽

2021 ◽

pp. 5551-5557

Author(s):

Arif Nur Muhammad Ansori ◽

Viol Dhea Kharisma ◽

Amaq Fadholly ◽

Martia Rani Tacharina ◽

Yulanda Antonius ◽

...

Keyword(s):

In Silico ◽

Natural Compound ◽

Specific Treatment ◽

In Silico Screening ◽

Transmitted Infection ◽

Positive Effects ◽

Alternative Medicines ◽

In Silico Studies ◽

The World ◽

Phytochemical Compounds

Known as the causal factor of the recent global COVID-19 pandemic, any SARS-CoV-2 is not the only coronavirus that has constituted a menace to society and taken thousands of human lives. Two previous pandemics were also led by coronaviruses; such as the MERS-CoV in 2012 and another SARS-CoV in 2002. Only five months into existence, SARS-CoV-2 transmitted infection to approximately 75 million people and it has led to more than 1.5 million of deaths all over the world. Unfortunately, there has not been any specific treatment yet for COVID-19 yet and its control is purely empirical. The examinations of the parity between SARS-CoV-2 and SARS-CoV, in terms of their genomics, origin, epidemiology, and pathogenesis, suggested that we may use the previous data of MERS-CoV or SARS-CoV as a guideline for uncovering the effective approach to strive against SARS-CoV-2. Various studies have reported the positive effects of numerous phytochemical compounds against SARS-CoV and MERS-CoV. Interestingly, this idea has been emplyed for SARS-CoV-2, and in silico screening of phytochemical compounds has been performed for identifying the potential candidates for COVID-19 treatment. Curcumin is an example of a natural compound which was demonstrated as potent candidate contrary to SARS-CoV-2 protease derived from the in silico studies. Herein, the occurrence of SARS-CoV-2 and the aplication of alternative medicines for treating coronavirus diseases are briefly reviewed.

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