Prevention of severe neonatal hyperbilirubinemia in healthy infants of 35 or more weeks of gestation: implementation of a systems-based approach

Twelve infants with neonatal hyperbilirubinemia caused by Rh or ABO incompatibility were followed for 1 year after birth. Antibodv determinations for diphtheria, tetanus, pertussis and three strains of E. coil (026, 055, and 079) were done. The results were compared with those from a control group of 25 healthy infants and from 40 infants who had received exchange transfusion after birth. The data suggests that bilirubin is a causative factor in the significant depression of antibody levels against diphtheria, tetanus, and pertussis in infants with hyperbilirubinemia when compared to healthy infants. [see pdf for figures]

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To study the effectiveness of cord blood Albumin as a predictor of neonatal jaundice

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20170724 ◽

2017 ◽

Vol 4 (2) ◽

pp. 645

Author(s):

Nithu A. George ◽

Shyam Sudhir M. K.

Keyword(s):

Cord Blood ◽

Neonatal Jaundice ◽

Mode Of Delivery ◽

The Body ◽

Neonatal Hyperbilirubinemia ◽

Healthy Infants ◽

Group 3 ◽

Blood Albumin ◽

Group 2 ◽

Group 1

Background: Neonatal hyperbilirubinemia is one of the commonest problems in newborn. It can be due to different etiologies. Most often it is physiological jaundice. The main reasons for physiological jaundice is that in an infant the liver is not mature enough to handle the freely circulating bilirubin due to higher volume of short life erythrocytes in the circulation and low level of albumin. Early detection of neonatal jaundice is essential to prevent developing kernicterus as well as discharge the babies early. Albumin is synthesized by liver and helps in the transport of unconjugated bilirubin by binding to bilirubin it and thus making it nontoxic to the body. Low levels of albumin make bilirubin free and toxic to the body. Hence, this study was done to evaluate effectiveness of cord blood albumin as a predictor of neonatal Hyperbilirubinemia.Methods: 50 term healthy newborns were included in the study with the term babies of both genders from any mode of delivery, birth weight >2.5 kg, APGAR score more than 7 at 1st and 5th minutes of life and without Rh incapability. Cord blood albumin levels were measured. Blood test for bilirubin was done when required and baby was managed accordingly.Results: Out of the total 50 neonates enrolled, 7 belonged to group 1 (albumin <2.8 g/dl), 34 to group 2 (2.8-3.3 g/dl), and 9 to group 3 (>3.3 g/dl). Out of the total 7 neonates in group 1, 6 (85.71%) was icteric at 24-48 hours and 1 (14.29%) was icteric at >72 hours. All the 7 neonates developed Hyperbilirubinemia requiring phototherapy. 3 (42.86%) out the 7-neonate required phototherapy for more than 24 hours. Out of the total 34 neonates in group 2, 20 (58.82%) was icteric at >72 hours, 12 (35.29%) at 48-72 hours and 2 (5.88%) at 24-48 hours. Only 12 (35.29%) neonates had Hyperbilirubinemia requiring phototherapy. Out of the total 9 neonates in group 3, 1 was icteric at 48 - 72 hours and 8 was icteric at >72 hours. But only 2 had Hyperbilirubinemia requiring phototherapy.Conclusions: Cord blood albumin is an effective way to predict neonatal Hyperbilirubinemia in term healthy infants.

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Correlation between the coagulation test and neonatal hyperbilirubinemia

10.21203/rs.3.rs-135247/v1 ◽

2020 ◽

Author(s):

fangye zhou ◽

Lei Li ◽

Rong Fu

Keyword(s):

Case Control Study ◽

Total Bilirubin ◽

Neonatal Hyperbilirubinemia ◽

Thrombin Time ◽

Coagulation Test ◽

Hematological Diseases ◽

Indirect Bilirubin ◽

Healthy Infants ◽

The Mean ◽

Control Study

Abstract Background The coagulation test is used to diagnose the hematological diseases. Little is known about correlation between the coagulation test and neonatal hyperbilirubinemia. The aim of the study was to describe neonatal coagulation test in infants with neonatal hyperbilirubinemia. Methods Data were collected from newborns who had neonatal hyperbilirubinemia and healthy in Chengdu Second People’s Hospital. Prothrombin time(PT), Thrombin time(TT), Fibrinogen(Fbg), activated partial thromboplastin time(APTT), and calculated international normalized ration(INR) values were recorded. Linear relationship between INR and level of total bilirubin and indirect bilirubin were analysed by linear regression. Comparisons of two groups were made by GraphPad Prism 8. Results In this case-control study, the mean PT, APTT level were significant higher in the infants with hyperbilirubinemia group compared to the healthy infants. We found the correlation between INR and total bilirubin(R = 0.3327; P < 0.0001). There was also correlation between INR and indirect bilirubin(R = 0.3402; P < 0.0001). Conclusions PT, APTT were significant high in neonatal hyperbilirubinemia group. Correlation were observed between the coagulation test and neonatal hyperbilirubinemia.

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Healthy Infants

PsycEXTRA Dataset ◽

10.1037/e378592004-003 ◽

1979 ◽

Author(s):

Keyword(s):

Healthy Infants

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Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

Journal of Pediatric Intensive Care ◽

10.1055/s-0040-1716857 ◽

2020 ◽

Author(s):

Adam Lee ◽

Adam Bajinting ◽

Abby Lunneen ◽

Colleen M. Fitzpatrick ◽

Gustavo A. Villalona

Keyword(s):

Literature Review ◽

Retrospective Review ◽

Review Of The Literature ◽

Rare Presentation ◽

Spontaneous Pneumomediastinum ◽

Nonaccidental Trauma ◽

Comprehensive Literature Review ◽

Healthy Infants ◽

History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

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