KOMPARASI EFEK PEMBERIAN MINYAK JINTAN HITAM (Nigella sativa) DENGAN MINYAK ZAITUN (Olea europea) TERHADAP PENURUNAN GLUKOSA DARAH PADA MENCIT (Mus musculus) STRAIN Balb/c

Diabetes mellitus is a disease in humans characterized by an increase in blood glucose levels exceeds the normal limits. Cumin oil and olive oil is an alternative drug to a decrease in blood glucose levels for people with diabetes mellitus. Cumin oil and olive oil has several compounds that can lower blood glucose levels in excess. This study was conducted in January 2015 for 3 weeks in PUSVETMA Surabaya. Animals used in the study were female mice 2-3 months old with an average weight of 20-25 grams of a much as 30 individuals. At a dosage of dextrose 40% is 0.4 cc/ head/ day and the dosage of cumin oil and olive oil is 0.7 cc/ head/ day. This a study conducted of mice that had been induced dextrose 40% by using a sample of a much as 30 female mice. The results of statistical independent t-test, there was no difference or both of the test sample may lower blood glucose levels among female mice were treated with cumin oil and treated with olive oil. While the results of the data was tested using SPSS statistical Paired t-test showed that effectively lower blood glucose levels are olive oil, because there is a significant difference between before and after administration of olive oil after 7 days of dosing.

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Autonomic neuropathy - a complication less pronounced in patients with Type 1 diabetes mellitus who have lower blood glucose levels

Diabetic Medicine ◽

10.1046/j.1464-5491.2000.00398.x ◽

2000 ◽

Vol 17 (12) ◽

pp. 860-866 ◽

Cited By ~ 18

Author(s):

P. Reichard ◽

K. Jensen-Urstad ◽

M. Ericsson ◽

M. Jensen-Urstad ◽

L. E. Lindblad

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Blood Glucose ◽

Type 1 Diabetes Mellitus ◽

Autonomic Neuropathy ◽

Lower Blood Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Lower Blood

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Konseling Gizi, Kualitas Diit Berbasis Pangan Lokal Dengan Kadar Glukosa Darah Penderita Diabetes Mellitus Tipe Ii Di Wilayah Kerja Puskesmas Bahu

Jurnal GIZIDO ◽

10.47718/gizi.v10i2.744 ◽

2018 ◽

Vol 10 (2) ◽

pp. 108-112

Author(s):

Rivolta G,M, Walalangi ◽

Muksin Pasambuna ◽

Rudolf B. Purba ◽

Agung Suryohadi

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Local Food ◽

T Test ◽

The Body ◽

Significance Level ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference ◽

Before And After

Diabetes Mellitus is a group of chronic disease which is characterized by increased levels of glucose in the blood due to disorders of the body's metabolism system, in which the pancreas organ incapable of producing the hormone insulin according to needs of the body. Nutritional counselling with quality local food based diit can help control blood glucose levels. This research aims to identify the difference in blood glucose levels and the value of quality diit type II diabetes mellitus patients before and after given nutritional counseling with quality local food based diit. This type of research is Pre Experimental research using one group pretest-posttest design. The number of samples is determined by purposive sampling counted 31 people. Data analysis using Wilcoxon and T-test analysis. The Wilcoxon analysis with significance level of 95% can be seen to produce significant difference in pre-post glycemic index component with p=0,000 (p<0,05) and diversity of pre-post food with p=0,002 (p<0,05). In the result of T-test for pre-post blood glucose variable, there was no significant difference p=0,105 (p>0,05). However, there was a range of decreased glucose levels before and after in 22 respondents with an average decrease of 11.42 mg/dL. Conclusion there was no difference of blood glucose level before and after nutrition counseling with quality of diet based on local food.

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EFFECT OF AEROBIC EXERCISES AND RESISTANCE TRAINING ON GLUCOSE LEVELS IN TYPE 2 DIABETIC SUBJECTS.

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i7.18532 ◽

2017 ◽

Vol 10 (7) ◽

pp. 360

Author(s):

Aishwarya Pramod Benkar ◽

Smita Bhimrao Kanase

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Resistance Training ◽

Blood Glucose Level ◽

Glucose Level ◽

Postprandial Blood Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference

Objective: Diabetes mellitus is a leading cause of death and disability in the world and its prevalence is predicted to rise to 10% by 2030. Hence, this study is conducted with objectives to find out the effect of aerobic exercises and resisted exercises on blood glucose levels in type 2 diabetes mellitus (T2DM) subjects and to compare the effect of both exercises on blood glucose level.Method: The comparative study was conducted at Krishna Institute of Medical Sciences Deemed University, Physiotherapy department, Karad. 30 participants with age group between 30 and 65 years were taken. Subjects were selected as per inclusion and exclusion criteria. Group A (15) participants were given aerobic exercise on static bicycle, and Group B (15) participants were given resistance training using dumbbells and weight cuffs for 5 days/week for 4 weeks. Diet recommendations were given to every participant.Results: Statistical analysis was performed using paired and unpaired t-test. Analysis showed statistically extremely significant difference in fasting blood glucose level and postprandial blood glucose level in both the groups (p≤0.0001).Conclusion: Thus, this study concludes that both aerobic exercises and resistance training prove to be beneficial in controlling blood glucose levels in T2DM subjects.

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Self Instructional Training Methods to Reduce Blood Glucose Levels Type 2 Diabetes Mellitus

Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) ◽

10.26699/jnk.v4i1.art.p006-011 ◽

2017 ◽

Vol 4 (1) ◽

pp. 006-011

Author(s):

Nian Afrian Nuari

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

T Test ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Number Of Patients ◽

Patients With Diabetes ◽

Reduce Blood Glucose ◽

Instructional Training ◽

Paired T Test

Blood glucose levels uncontrolled is a problem that is often found in patients with Diabetes Mellitus. This has an impact on the health of the patient as it would appear some macrovascular and microvascular complications. Number of patients with DM in Indonesia has increased every year and only 50% of patients suffering from diabetes who are aware of, and around 30% of them take medication regularly. The purpose of this study to determine the effect of Self Instructional Training method on blood glucose levels of patients. The method used is pre experiment with purposive sampling technique and the sample size of 16 respondents. Measuring instrument used glucometers to measure blood glucose levels and analyzed with Paired T Test. Based on the results, the entire blood glucose levels before the intervention above 200 mg /dl. After Self Instructional Training Intervention average blood glucose level was 35.75 mg /dl. Blood glucose levels are highest when the post test was 253 mg /dl and the lowest is 197 mg /dl. Based on Paired T Test analysis obtained Self Instructional Training interventions can reduce blood glucose levels of patients with Diabetes Mellitus Type II (p value = 0.000). Diabetes Mellitus patients expected to be able to apply the SIT method to perform self-care so that the patient's blood glucose levels can be controlled. Patient can do this methods at home and needed support from their family and health professionals to treat the diseases.Keywords : Self, Instructional, Training, level, glucose, blood, DM

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Pengaruh Pemberian Konseling Gizi Terhadap Asupan Zat Gizi Dan Kadar Glukosa Darah Pada Pasien Diabetes Mellitus Tipe 2 Di Wilayah Kerja Puskesmas Motoling

Jurnal GIZIDO ◽

10.47718/gizi.v10i1.726 ◽

2018 ◽

Vol 10 (1) ◽

pp. 7-16

Author(s):

Ana B Montol ◽

Jufri Sineke ◽

Terema M.E. Kolompoy

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Carbohydrate Intake ◽

Fat Intake ◽

Nutritional Counseling ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference ◽

Before And After

Diabetes Mellitus is a group of heterogeneous disorders characterized by elevated blood glucose levels or hyperglycemia. Counseling to people with Diabetes Mellitus about nutrition and healthy lifestyle is a method to raise awareness of Diabetes Mellitus patients to change food intake so as to improve blood glucose levels. The purpose of this study is to determine the effect of nutrition counseling on nutrient intake and blood glucose levels in patients with type 2 Diabetes Mellitus in the work area of Motoling Puskesmas. The research type is pre experiment design with one group pretest and posttest approach. The population in this study were 55 outpatient Diabetes Mellitus patients at Motoling Puskesmas, a sample of 23 outpatient Diabetes Mellitus Type 2 patients at Motoling Puskesmas. Nutrition counseling using media leaflets is given four times a month. Data Food intake was taken by using food recall 24 hours, data of glucose level of patient was taken by doing autocheck blood sugar test and for characteristic data of respondent using questioner. To determine the difference of glucose level with carbohydrate and fat intake before and after nutritional counseling was analyzed by using paired test of T test and Wilcoxon test. The results showed that there was a significant difference between carbohydrate intake before and after nutritional counseling (p = 0.002 <α 0.05). Average carbohydrate intake before counseling 359.52 g and after counseling 290.09 g a decrease of 69.43 g. For fat intake showed no significant difference in carbohydrate intake before and after nutritional counseling (p = 0.009 <α 0.05). Average fat intake before counseling 128.61 g and after counseling 75.04 g decreased 53.56 g. While blood glucose levels showed no significant difference in carbohydrate intake before and after nutritional counseling (p = 0.000 <α 0.05). Mean blood glucose levels before counseling 255 mg / dl to 202.39 mg / dl decreased 52.60 mg / dl. Conclusion, there is a significant difference between nutrient intake and blood glucose levels in patients with Diabetes Mellitus type 2 in the work area of Motoling Puskesmas.

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PENGARUH EKSTRAK BAWANG HITAM TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT

THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST ◽

10.30651/jmlt.v4i1.7269 ◽

2021 ◽

Vol 4 (1) ◽

pp. 49

Author(s):

Pipit Festi W

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Mus Musculus ◽

T Test ◽

Control Group ◽

Control Group Design ◽

Significance Level ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Reduce Blood Glucose

Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000 It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000 that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus

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Application of Diabetes Self Management Education (DSME) in Patients with Type 2 Diabetes Mellitus based on Blood Glucose Levels

Journal of Asian Multicultural Research for Medical and Health Science Study ◽

10.47616/jamrmhss.v1i2.43 ◽

2020 ◽

Vol 1 (2) ◽

pp. 42-46

Author(s):

Andi Akifa Sudirman ◽

Dewi Modjo

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Management Education ◽

T Test ◽

Self Management ◽

Glucose Levels ◽

Blood Glucose Levels

Diabetes Self Management Education (DSME) uses guidelines, counseling, and behavioral intervention methods to increase knowledge about diabetes and improve individual and family skills in managing diabetes mellitus (DM). This research is a quantitative study using a pre-experimental design that provides treatment or intervention to the research subjects then the effect of the treatment is measured and analyzed. This design is used to compare the results of the intervention of the application of Diabetes Self Management Education (DSME) on controlling blood glucose levels in patients with type 2 diabetes mellitus. The analysis used the dependent t-test / paired t-test. The results showed that there were significant differences in blood glucose levels in the measurement after giving DSME to the respondents, indicating that the measurement of blood glucose levels after treatment was smaller than the measurement before treatment. It is necessary to develop a program to increase the competence of nurses in nursing care for diabetic clients and education related to diabetic self-care to increase the knowledge and skills of nurses in managing diabetes.

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Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models

Nutrients ◽

10.3390/nu11102330 ◽

2019 ◽

Vol 11 (10) ◽

pp. 2330 ◽

Cited By ~ 3

Author(s):

Ari ◽

Murdun ◽

Koutnik ◽

Goldhagen ◽

Rogers ◽

...

Keyword(s):

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Rodent Models ◽

Lower Blood Glucose ◽

Post Exercise ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Lower Blood Glucose Level ◽

Lower Blood

Diseases involving inflammation and oxidative stress can be exacerbated by high blood glucose levels. Due to tight metabolic regulation, safely reducing blood glucose can prove difficult. The ketogenic diet (KD) reduces absolute glucose and insulin, while increasing fatty acid oxidation, ketogenesis, and circulating levels of β-hydroxybutyrate (βHB), acetoacetate (AcAc), and acetone. Compliance to KD can be difficult, so alternative therapies that help reduce glucose levels are needed. Exogenous ketones provide an alternative method to elevate blood ketone levels without strict dietary requirements. In this study, we tested the changes in blood glucose and ketone (βHB) levels in response to acute, sub-chronic, and chronic administration of various ketogenic compounds in either a post-exercise or rested state. WAG/Rij (WR) rats, a rodent model of human absence epilepsy, GLUT1 deficiency syndrome mice (GLUT1D), and wild type Sprague Dawley rats (SPD) were assessed. Non-pathological animals were also assessed across different age ranges. Experimental groups included KD, standard diet (SD) supplemented with water (Control, C) or with exogenous ketones: 1, 3-butanediol (BD), βHB mineral salt (KS), KS with medium chain triglyceride/MCT (KSMCT), BD acetoacetate diester (KE), KE with MCT (KEMCT), and KE with KS (KEKS). In rested WR rats, the KE, KS, KSMCT groups had lower blood glucose level after 1 h of treatment, and in KE and KSMCT groups after 24 h. After exercise, the KE, KSMCT, KEKS, and KEMCT groups had lowered glucose levels after 1 h, and in the KEKS and KEMCT groups after 7 days, compared to control. In GLUT1D mice without exercise, only KE resulted in significantly lower glucose levels at week 2 and week 6 during a 10 weeks long chronic feeding study. In 4-month and 1-year-old SPD rats in the post-exercise trials, blood glucose was significantly lower in KD and KE, and in KEMCT groups, respectively. After seven days, the KSMCT group had the most significantly reduced blood glucose levels, compared to control. These results indicate that exogenous ketones were efficacious in reducing blood glucose levels within and outside the context of exercise in various rodent models of different ages, with and without pathology.

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Protective effect of cyanidin-3-O-glucoside on neonatal porcine islets

Journal of Endocrinology ◽

10.1530/joe-17-0141 ◽

2017 ◽

Vol 235 (3) ◽

pp. 237-249 ◽

Cited By ~ 6

Author(s):

Chao Li ◽

Bin Yang ◽

Zhihao Xu ◽

Eric Boivin ◽

Mazzen Black ◽

...

Keyword(s):

Drinking Water ◽

Blood Glucose ◽

Related Factor ◽

Post Transplantation ◽

Lower Blood Glucose ◽

Glucose Levels ◽

Porcine Islets ◽

Blood Glucose Levels ◽

Lower Blood ◽

Neonatal Porcine Islets

Oxidative stress is a major cause of islet injury and dysfunction during isolation and transplantation procedures. Cyanidin-3-O-glucoside (C3G), which is present in various fruits and vegetables especially in Chinese bayberry, shows a potent antioxidant property. In this study, we determined whether C3G could protect neonatal porcine islets (NPI) from reactive oxygen species (H2O2)-induced injury in vitro and promote the function of NPI in diabetic mice. We found that C3G had no deleterious effect on NPI and that C3G protected NPI from damage induced by H2O2. Significantly higher hemeoxygenase-1 (HO1) gene expression was detected in C3G-treated NPI compared to untreated islets before and after transplantation (P < 0.05). Western blot analysis showed a significant increase in the levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3K/Akt) proteins in C3G-treated NPI compared to untreated islets. C3G induced the nuclear translocation of nuclear erythroid 2-related factor 2 (NRF2) and the significant elevation of HO1 protein. Recipients of C3G-treated NPI with or without C3G-supplemented drinking water achieved normoglycemia earlier compared to recipients of untreated islets. Mice that received C3G-treated islets with or without C3G-supplemented water displayed significantly lower blood glucose levels at 5–10 weeks post-transplantation compared to mice that received untreated islets. Mice that received C3G-treated NPI and C3G-supplemented drinking water had significantly (P < 0.05) lower blood glucose levels at 7 and 8 weeks post-transplantation compared to mice that received C3G-treated islets. These findings suggest that C3G has a beneficial effect on NPI through the activation of ERK1/2- and PI3K/AKT-induced NRF2-mediated HO1 signaling pathway.

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