Renal Excretion of Gastrografin after Oral Administration: Clinical Significance in Gastric Resection Patients

Evaluation of the efficacy of methanolic extract of Cucumis melo in urolithiasis induced by gentamycin and calculi producing diet on Wistar rats. Gentamycin (40 mg/kg, subcutaneously) and calculi-producing diet (CPD) was fed to induce urolithiasis on Wistar rats. The effect of oral administration of methanolic extract of Cucumis melo seed on calcium oxalate urolithiasis has been studied and is compared with the effect of oral administration of Cystone as standard on Wistar rats. Gentamycin and CPD feeding resulted in hyperoxaluria and calcium oxalate deposition as well as increased renal excretion of calcium and oxalate. Supplementation with methanolic extract of Cucumis melo seed reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the seed of Cucumis melo is endowed with antiurolithiatic activity. Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

Download Full-text

Hyperthyroidism and the Dynamics of Distribution and Renal Excretion of Epinephrine in the Dog

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1958.193.2.375 ◽

1958 ◽

Vol 193 (2) ◽

pp. 375-378 ◽

Cited By ~ 12

Author(s):

Richard T. Jones ◽

William D. Blake

Keyword(s):

Plasma Concentration ◽

Oral Administration ◽

Renal Excretion ◽

Volume Of Distribution ◽

Constant Infusion ◽

Thyroid Extract ◽

Anesthetized Dogs

Several parameters related to the dynamics of distribution and renal excretion of epinephrine were studied in anesthetized dogs before and during oral administration of thyroid extract. These parameters include: a) plasma concentration and renal excretion of epinephrine during constant infusion of l-epinephrine bitartrate, b) the rate of disappearance from plasma and volume of distribution of epinephrine, and c) the resting excretion of endogenous epinephrine before and during thyroid feeding. Except for an increase in the percentage of infused epinephrine excreted in the urine, there were essentially no changes in these parameters after feeding thyroid.

Download Full-text

Tissue Distribution and Renal Excretion of Ormetoprim after Intravascular and Oral Administration in the Channel Catfish (Ictalurus punctatus)

Canadian Journal of Fisheries and Aquatic Sciences ◽

10.1139/f90-088 ◽

1990 ◽

Vol 47 (4) ◽

pp. 766-771 ◽

Cited By ~ 28

Author(s):

S. M. Plakas ◽

R. W. Dickey ◽

M. G. Barron ◽

A. M. Guarino

Keyword(s):

Oral Administration ◽

Ictalurus Punctatus ◽

Channel Catfish ◽

Renal Excretion ◽

Peak Plasma ◽

Parent Compound ◽

Head Kidney ◽

Peak Plasma Level ◽

Bacterial Diseases ◽

A Minor

Ormetoprim is used to potentiate sulfadimethoxine in treating certain bacterial diseases of aquatic species. The tissue disposition and renal excretion of ormetoprim and metabolites were examined after intravascular and oral administration (4 mg∙kg−1) in channel catfish (Ictalurus punctatus). Peak plasma level (0.66 μg∙mL−1) of 14C-ormetoprim occurred at 6 h after oral dosing. The oral bioavailability was estimated at 52%. Ormetoprim and metabolites were widely distributed in the tissues. The tissue concentrations were highest in the liver, trunk kidney, head kidney, and spleen. Clearance of the radiolabel from tissues was rapid. The muscle contained 49.3% of the intravascularly administered dose at 2 h; however, at 72 h, less than 1% of the dose remained in this tissue. 14C-Ormetoprim was more persistent in the skin than in the muscle. Ormetoprim was extensively metabolized in catfish. After intravascular administration, 21.1% of the dose of 14C-ormetoprim was eliminated in the urine in 48 h, predominantly as polar metabolites; less than 4% of the dose was eliminated as the parent compound. Biliary excretion was a minor route of elimination (5–6% of the dose). The data suggest branchial excretion of ormetoprim and/or metabolites.

Download Full-text