scholarly journals Microsponge as an Emerging Technique in Novel Drug Delivery System

2021 ◽  
Vol 11 (1) ◽  
pp. 171-182
Author(s):  
Payal D Borawake ◽  
Arumugam Kauslya ◽  
Jitendra V Shinde ◽  
Rajashree S Chavan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Product Performance ◽  
Topical Drug Delivery ◽  
Polymeric Microspheres ◽  
Current Review ◽  
Improved Stability ◽  
Novel Drug

Numbers of developments are implemented in drug delivery system to achieve the goals of optimized efficacy, cost effectiveness of therapy. One of the latest, novel and highly evolving technologies is microsponge drug delivery system which gives controlled release and site specific delivery of active ingredients. They are highly cross linked, porous and polymeric microspheres with size range of 5-300µm. This system is emerging as valuable option for topical delivery of drugs due to characteristics like decreased side effects, improved stability, better formulation flexibility, superior product performance. It is having number of applications in oral, topical, ocular and biopharmaceuticals delivery. The current review describes microsponge technology and details of the formulation methods, evaluation, programmable release mechanisms and applications.   Keywords: Microsponges; Controlled release; Quasi emulsion solvent diffusion; Programmable drug release; Oral administration; Topical drug delivery.

Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

2020 ◽  
Vol 14 (4) ◽  
pp. 351-359
Author(s):  
Shubham Shrestha ◽  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Structure ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Carrier System ◽  
Current Review ◽  
Long Time ◽  
Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

scholarly journals Development and characterization of polymeric microspheres for controlled release protein loaded drug delivery system

2008 ◽  
Vol 70 (3) ◽  
pp. 303 ◽  
Author(s):  
S Ravi ◽  
KK Peh ◽  
Yusrida Darwis ◽  
BKrishna Murthy ◽  
TRaghu Raj Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Microspheres

scholarly journals Microencapsulation: A potential and promising approach in drug delivery system

2016 ◽  
Vol 1 (1) ◽  
pp. 30-39
Author(s):  
Madiha Jabeen ◽  
Shireen Begum ◽  
Aroosa Siddique ◽  
Syeda Saniya Fatima
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Material ◽  
Wall Material ◽  
The Core ◽  
Novel Drug Delivery System ◽  
Reduced Toxicity ◽  
Novel Drug

Novel drug delivery system is a method by which drug delivered can have significant effect on its efficacy. There are several advantages of novel drug delivery system over conventional multi dose therapy, which include improved efficacy, reduced toxicity, improved patient compliance and convenience. Many efforts have been made in developing novel drug delivery system, which emphasizes on controlled and sustained release dosage forms to obtain optimum benefits. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres or microcapsules. Microencapsulation is a process by which solids, liquids or gases can be enclosed in microscopic particles by forming a thin coating of wall material around substances, which protects it from external environment and control the drug release yielding capsules ranging for one micron to several hundred microns in size (1µ- 800µ). There are different microencapsulation techniques, which are used to obtain microcapsules for controlled release of drug. The morphology of microcapsules depends on the core material and deposition of coating material. Substances may be microencapsulated for the purpose of confining core material within capsule wall for specific period of time. Core materials are also encapsulated so that the core material can be gradually released (controlled release or diffusion) or when external conditions trigger the capsule walls to rupture, melt, or dissolve. Microencapsulation has found many applications in science and technology.

Formulation and Development of Aceclofenac loaded Microsponges Topical Drug Delivery System using quality by Design Approach

2021 ◽  
pp. 185-192
Author(s):  
Urvish M. Choudhary ◽  
Rinku Y. Mistree ◽  
Disha N. Patel ◽  
Shreyas V. Desai ◽  
Naimish A. Patoliya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Liquid Paraffin ◽  
Systemic Exposure ◽  
Diffusion Method ◽  
Topical Drug Delivery ◽  
Phase Volume

The proposed study is focussed at developing Aceclofenacmicrosponges for topic drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment was to prepare a safe, efficacious, stable and patient compliant microsponge dosage form of Aceclofenac. Materials and methods: Pre-formulation studies were carried out which helped in developing an accurate dosage form. UV, FTIR, DSC, and SEM studies were done for pre-formulation and post-formulation evaluations. These study deals with the design and optimization of Aceclofenacmicrosponges loaded topical drug delivery system to the controlled release of active drug into the skin in order to minimize the systemic exposure and minimize local cutaneous reactions to active drugs by DoE method of QbD Approach. AceclofenacMicrosponges were prepared by quasi emulsion solvent diffusion method using Eudragit-RS100 as a polymer, polyvinyl alcohol, Ethanol as Internal phase volume and Liquid paraffin as External phase volume. In this study, we found that the controlled release of aceclofenac microsponges.

scholarly journals A comprehensive review on Liposomes: a novel drug delivery system

2018 ◽  
Vol 8 (6) ◽  
pp. 400-404
Author(s):  
Harshita Mishra ◽  
Vaishali Chauhan ◽  
Kapil Kumar ◽  
Deepak Teotia
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Liposomal Drug ◽  
Hydrophilic Drug ◽  
Site Of Action ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Lipophilic Character

Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character   they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug (amphiphatic nature) to its compartment and lead to   controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are used for the treatment of various diseases like tumors or cancer. This article provides an overview of Liposomal Drug Delivery System and various aspects related to liposome that can be studied. Keywords: Liposomes, novel delivery, amphiphatic, controlled release.

Review on Microsponges As a Novel Drug Delivery System

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Pankaj V. Ahire ◽  
A. B. Darekar ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
Release Mechanism ◽  
Topical Drug Delivery ◽  
Site Specific ◽  
Release Drug ◽  
Novel Drug Delivery System ◽  
Novel Drug

Microsponge can be effectively incorporated into oral delivery of drugs using bio erodible polymer’s especially for colon specific delivery and also use for topical drug delivery system for retention of dosage form on skin and controlled release drug delivery system thus improving patient compliance by proving site specific drug delivery system and prolonging dosage intervals. The microsponge consists of myriad of interconnecting voids within non- collapsible structures with a large porous surface. The size of Micro sponges can be varied usually from 5-300 μm in diameter. The outer surface is typically porous, allowing the sustained flow of substances out of the sphere. Microsponge delivery system (MDS) can provide increased efficacy for topically active agents with enhanced safety, extended product stability, enhanced formulation flexibility , reduced side effects and improved aesthetic properties in an efficient and novel manner In addition these are non-mutagenic, non allergic, and non-toxic . The present review introduces Microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of MDS

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