Formulation and Development of Aceclofenac loaded Microsponges Topical Drug Delivery System using quality by Design Approach

2021 ◽  
pp. 185-192
Author(s):  
Urvish M. Choudhary ◽  
Rinku Y. Mistree ◽  
Disha N. Patel ◽  
Shreyas V. Desai ◽  
Naimish A. Patoliya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Liquid Paraffin ◽  
Systemic Exposure ◽  
Diffusion Method ◽  
Topical Drug Delivery ◽  
Phase Volume

The proposed study is focussed at developing Aceclofenacmicrosponges for topic drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment was to prepare a safe, efficacious, stable and patient compliant microsponge dosage form of Aceclofenac. Materials and methods: Pre-formulation studies were carried out which helped in developing an accurate dosage form. UV, FTIR, DSC, and SEM studies were done for pre-formulation and post-formulation evaluations. These study deals with the design and optimization of Aceclofenacmicrosponges loaded topical drug delivery system to the controlled release of active drug into the skin in order to minimize the systemic exposure and minimize local cutaneous reactions to active drugs by DoE method of QbD Approach. AceclofenacMicrosponges were prepared by quasi emulsion solvent diffusion method using Eudragit-RS100 as a polymer, polyvinyl alcohol, Ethanol as Internal phase volume and Liquid paraffin as External phase volume. In this study, we found that the controlled release of aceclofenac microsponges.

Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

2020 ◽  
Vol 14 (4) ◽  
pp. 351-359
Author(s):  
Shubham Shrestha ◽  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Structure ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Carrier System ◽  
Current Review ◽  
Long Time ◽  
Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

scholarly journals Microsponge as an Emerging Technique in Novel Drug Delivery System

2021 ◽  
Vol 11 (1) ◽  
pp. 171-182
Author(s):  
Payal D Borawake ◽  
Arumugam Kauslya ◽  
Jitendra V Shinde ◽  
Rajashree S Chavan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Product Performance ◽  
Topical Drug Delivery ◽  
Polymeric Microspheres ◽  
Current Review ◽  
Improved Stability ◽  
Novel Drug

Numbers of developments are implemented in drug delivery system to achieve the goals of optimized efficacy, cost effectiveness of therapy. One of the latest, novel and highly evolving technologies is microsponge drug delivery system which gives controlled release and site specific delivery of active ingredients. They are highly cross linked, porous and polymeric microspheres with size range of 5-300µm. This system is emerging as valuable option for topical delivery of drugs due to characteristics like decreased side effects, improved stability, better formulation flexibility, superior product performance. It is having number of applications in oral, topical, ocular and biopharmaceuticals delivery. The current review describes microsponge technology and details of the formulation methods, evaluation, programmable release mechanisms and applications.   Keywords: Microsponges; Controlled release; Quasi emulsion solvent diffusion; Programmable drug release; Oral administration; Topical drug delivery.

scholarly journals INNOVATIVE AND NOVEL STRATEGY: MICROSPONGES FOR TOPICAL DRUG DELIVERY

2018 ◽  
Vol 8 (5) ◽  
pp. 28-34 ◽  
Author(s):  
Jyoti Jyoti ◽  
Sandeep Kumar
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
Systemic Exposure ◽  
Spherical Particles ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Novel Strategy

Microsponge type of drug delivery is the latest technology which has been introduced in topical skin care, drug products to facilitate the controlled release of the active medicament into the skin in order to reduce systemic exposure and control local cutaneous reactions to active drugs. Microsponge can be loaded into a topical route of drug delivery system for the residue of dosage form of skin and thus controlled release drug delivery system is achieved and in return improving the patient compliance by providing target drug delivery system and prolonging dosage intervals. Microsponge is polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles and posses large porous surface area. Furthermore, they may enhance stability, reduce side effects, improve patient compliance and modify drug release. Microsponges are the polymer-based microspheres system that has the capacity to entrap a wide variety of substances, and can then be incorporated into a different formulation. Keywords: Microsponge Delivery System, Quasi- emulsion solvent diffusion.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

Recent Applications of Nanoemulsion Based Drug Delivery System: A Review

2021 ◽  
pp. 2852-2858
Author(s):  
Asif Eqbal ◽  
Vaseem Ahamad Ansari ◽  
Abdul Hafeez ◽  
Farogh Ahsan ◽  
Mohd Imran ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Therapeutic Agents ◽  
Topical Drug Delivery ◽  
Transdermal Drug Delivery System ◽  
Small Droplet ◽  
Pharmaceutical Application ◽  
System A

Nanoemulsions are drug transporters for the delivery of therapeutic agents. They possess the small droplet size having the range of 20×10-9-200×10-9m. The main purpose of using Nanoemulsion is to enhance the drug bio- availability of transdermal drug delivery system. With the help of phase diagram, we can select the components of nanoemulsion depending upon formulas ratio of oil phase, surfactant/co-surfactant and water phase. Nanoemulsion directly used as a topical drug delivery in skin organs. The most useable pharmaceutical application has been developed till date to provide systemic effects to penetrating the full thickness of skin organ layer nanoemulsions can be administered through variety of routes such as percutaneous, perioral, topical, transdermal, ocular and parental administration of medicaments. Nanoemulsions are transparent and slightly opalescent. Nanoemulsion can be prepared through various methods. Nanoemulsions are transparent and slightly opalescent. Factor affecting nanoemulsions are surfactant, viscosity, lipophilic, drug content, pH, concentration of each component, and methodology of formulation. It is unfeasible to test all factors at the various levels. Design of formulation when it comes to experimental design it gives an excellent approach through reducing the time and money.

Peptide-functionalized and high drug loaded novel nanoparticles as dual-targeting drug delivery system for modulated and controlled release of paclitaxel to brain glioma

2018 ◽  
Vol 553 (1-2) ◽  
pp. 169-185 ◽  
Author(s):  
Primiano Pio Di Mauro ◽  
Anna Cascante ◽  
Pau Brugada Vilà ◽  
Vanessa Gómez-Vallejo ◽  
Jordi Llop ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Brain Glioma ◽  
High Drug ◽  
Dual Targeting

scholarly journals Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

2017 ◽  
Vol 2 (4) ◽  
pp. 269-280 ◽  
Author(s):  
Vivek Dave ◽  
Renu Bala Yadav ◽  
Kriti Kushwaha ◽  
Sachdev Yadav ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Statistical Optimization ◽  
Hybrid Nanoparticles ◽  
Topical Drug Delivery ◽  
Polymer Hybrid

scholarly journals A REVIEW: ANTI-CANCER NATURAL PRODUCT DRUG DELIVERY SYSTEM DOSAGE FORM AND EVALUATION

2021 ◽  
pp. 41-51
Author(s):  
RIZKA KHOIRUNNISA GUNTINA ◽  
IYAN SOPYAN ◽  
ADE ZUHROTUN
Keyword(s):  
Drug Delivery ◽  
Natural Product ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Dosage Forms ◽  
Primary Data ◽  
Pharmaceutical Dosage Form ◽  
New Drug

A drug delivery system is a system in which a drug is released from a pharmaceutical dosage form to achieve the desired pharmacological effect. The system consists of conventional and new drug delivery systems. In the new drug delivery system, polymers are used as a matrix. The aim of this article is to find out and understand the formulation and evaluation of natural ingredients that have anticancer activity with different dosage forms and the basis for developing these dosages. Journal searches in this review came from primary data sources on the internet. Journal searches were carried out using a search engine such as Google Scholar, PubMed, and ScienceDirect. In recent years, natural products, such as extract, fraction, and isolate, are getting attention to help treat cancer. Because of their low solubility and bioavailability, the effectiveness tends to be lower than synthetic drugs. Therefore, a dosage form with a new drug delivery system was made to overcome the problem. The dosage forms commonly made are patch, suspension, powder, and emulsion with a new drug delivery system. To ensure the product that has been made met the requirements, they need to be evaluated with various methods like In vitro Study, morphology study, particle size study, and others. Cancer treatment using the natural product can be delivered through several dosage forms like patch, suspension, powder, and emulsion, with specific formulation and manufacturing methods based on several considerations such as natural ingredients properties, dosage form selection, excipient properties, and the purpose of the formulation. Dosage forms that has been made are then evaluated using several evaluation methods.

Recent Update on Nanoemulgel as Topical Drug Delivery System

2017 ◽  
Vol 106 (7) ◽  
pp. 1736-1751 ◽  
Author(s):  
Hira Choudhury ◽  
Bapi Gorain ◽  
Manisha Pandey ◽  
Lipika Alok Chatterjee ◽  
Pinaki Sengupta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Topical Drug Delivery
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