scholarly journals Development of Hot Melt Coating Technique for Taste Masking of Chloroquine Phosphate Tablets

2019 ◽  
Vol 9 (4-s) ◽  
pp. 562-568
Author(s):  
Ashwini R. Madgulkar ◽  
Mangesh R. Bhalekar ◽  
Aishwarya Deepak Vaidya ◽  
Pauroosh Kaushal ◽  
R. P. Mudalwadkar
Keyword(s):  
Application Rate ◽  
Taste Masking ◽  
Wet Granulation ◽  
Coating Process ◽  
Coating Agent ◽  
Coating Technique ◽  
Taste Evaluation ◽  
Good Uniformity ◽  
Hot Melt ◽  
Reduced Risk

In the present study to mask the unpleasant taste of chloroquine phosphate, hot melt coating technique was used as a taste masking tool. Hot melt coating is a solvent free technology grants rapid, additionally economical coating process with reduced risk of dissolving drug during process and provide uniform application rate of coating agent. Precirol ATO 5 was used as hot melt coating material for taste masking. Tablets were prepared by wet granulation method and coated using hot melt coating technique. Coated tablets exhibited good uniformity of drug content. Amount of drug release from all batches were evaluated. Taste evaluation of hot melt coated tablets was done by using electronic tongue.PrecirolATO5 was found to be a better taste masking agent when used by hot melt coating technique. Keywords: Precirol ATO 5, Hot melt coating, taste masking.

Formulation and Evaluation of Baclofen Orally Disintegrating Tablets

1970 ◽  
Vol 2 (4) ◽  
pp. 733-738
Author(s):  
Dumpeti Janardhan ◽  
Joginapally Sreekanth ◽  
P.Theja Pavan Kumar ◽  
M.Vamshi Krishna
Keyword(s):  
Pilot Scale ◽  
Taste Masking ◽  
Wet Granulation ◽  
Physical Parameters ◽  
Disintegration Time ◽  
Granulation Process ◽  
Good Taste ◽  
Orally Disintegrating Tablets ◽  
Human Volunteers ◽  
Eudragit Epo

The purpose of this study was to evaluate the potential of polymers for masking the taste of bitter drugs when incorporated into orally disintegrating tablets. The tablets were produced by simple wet granulation technique with a model compound (baclofen) which is moderately bitter. The formulating procedure had two variables to obtain good taste masking with desirable characteristics. The optimal granulation process parameters were polymer selection and its concentration (w/w), suitable for pilot scale level. Dextrates, β- cyclodextrin, eudragit EPO and PVP K-30 were used in preparation of granules by using water and iso-propyl alcohol. Crospovidone was used intra and extra granularly as superdisintegrant.  Sodium bicarbonate and citric acid were used as effervescent for fast disintegration of tablets, which also optionally act as desensitizer of taste buds. Results from evaluation of tablets indicated a disintegration time (avg) of 30-35 sec and 100% drug release was achieved within 5 min. But taste masking was achieved by only with eudragit EPO. Results from an evaluation by a panel of six human volunteers demonstrated that the orally disintegrating tablets which are prepared by using polymer Eudragit EPO (5% and 7.5% w/w of tablet) and PVP (7.5% w/w of tablet) improved taste, significantly. On studying physical parameters, F9 formulation demonstrated acceptable level of hardness and friability with good taste masking and it was thus considered as an optimized formulation

scholarly journals FORMULATION, IN VITRO, AND IN VIVO EVALUATION OF TASTE-MASKED ORAL DISINTEGRATING TABLETS OF FEXOFENADINE HYDROCHLORIDE USING SEMISYNTHETIC AND NATURAL SUPERDISINTEGRANTS

2021 ◽  
pp. 99-108
Author(s):  
NAGADANI SWARNALATHA ◽  
VIDYAVATHI MARAVAJHALA
Keyword(s):  
Desirability Function ◽  
Research Work ◽  
In Vivo Studies ◽  
Taste Masking ◽  
Wet Granulation ◽  
Maximum Plasma ◽  
In Vivo Evaluation ◽  
Eudragit Epo

Objective: The aim of the present research work was to prepare and evaluate taste-masked oral disintegrating tablets (ODT) of Fexofenadine hydrochloride. Methods: In the present work, Eudragit EPO, a taste masking agent and Karaya gum (GK) (natural), Sodium starch glycolate, and Croscarmellose sodium (CCS) (semi-synthetic) super disintegrants in three ratios (3, 6,9%) were used. Taste masked granules were prepared by different ratios of the drug: Eudragit EPO (1:1, 1:1.5, 1:2) by wet granulation method. The optimized taste-masked granules (1:2) were selected by sensory evaluation test to prepare 9 Fexofenadine ODT (FH1-FH9) formulations. These were evaluated for different parameters. Then desirability function (DF) was calculated for all formulations using disintegration time (DT), time taken for the tablet to release 90% of the drug (t 90%), and % drug dissolved in 10 min (Q10) as significant parameters. Results: The best formulation (FH6) showed the highest DF value due to less DT and 100% in vitro drug release within 15 min. Thus, FH6 formulation containing 9% CCS was selected as the best among the prepared formulations to which in vivo studies were performed on rabbits to find maximum plasma concentration (Cmax), time taken to reach maximum concentration (tmax), area under the curve (AUC), rate of elimination (Kel), absorption rate (Ka) and half-life(t1/2) and compared with Fexofenadine (Allegra) marketed tablets. Total bioavailability was increased for the test formulation compared to the reference formulation. Conclusion: Fexofenadine was successfully prepared as ODT with increased AUC and decreased tmax to which stability studies were conducted which were found to be stable.

Hot melt extrusion of ion-exchange resin for taste masking

2018 ◽  
Vol 547 (1-2) ◽  
pp. 385-394 ◽  
Author(s):  
David Cheng Thiam Tan ◽  
Jeremy Jianming Ong ◽  
Rajeev Gokhale ◽  
Paul Wan Sia Heng
Keyword(s):  
Ion Exchange ◽  
Exchange Resin ◽  
Hot Melt Extrusion ◽  
Ion Exchange Resin ◽  
Taste Masking ◽  
Melt Extrusion ◽  
Hot Melt

DESIGN AND EVALUATION OF EUDRAGIT COATED LOSARTAN POTASSIUM CONTROLLED RELEASE PELLETS BY PAN COATING TECHNIQUE

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (10) ◽  
pp. 30-38
Author(s):  
S Vidyadhara ◽  
◽  
R. L. C. Sasidhar ◽  
P Thrilochani ◽  
L. K. Lavanya
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Methyl Cellulose ◽  
Losartan Potassium ◽  
Scanning Calorimetry ◽  
Coating Agent ◽  
Coating Technique ◽  
S 100 ◽  
Eudragit S 100

The present investigation was focused on the development and evaluation of controlled release pellets of losartan potassium with Eudragit S 100 and hydroxypropyl methyl cellulose phthalate (HPMCP) by employing pan coating technique. Eudragit S 100, a high viscosity grade controlled release polymer, was mainly used as coating agent for regulating the drug release from pellets. HPMCP, an enteric coating polymer was used in the present study to regulate the drug release at varied G.I. pH conditions. The prepared pellets were evaluated for particle size, drug content, friability and for in vitro drug release. The formulations were further characterized to identify any possible interactions by FTIR spectroscopy and differential scanning calorimetry. The surface morphology of the pellets was studied by scanning electron microscopy. From the results it was observed that due to increase in the concentration of Eudragit the drug release was extended up to 12 hours. The increase in the HPMCP polymeric concentration in formulations showed initial delay in drug release.

scholarly journals TASTE MASKING BY HOT MELT EXTRUSION WITHOUT LOSS OF BIOAVAILABILITY FOR PEDIATRICS

2019 ◽  
pp. 7-13
Author(s):  
Dhananjay M. ◽  
Pravin C. ◽  
Smita M.
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Drug Release ◽  
Fourier Transform Infrared Spectroscopy ◽  
Dosage Form ◽  
Bitter Taste ◽  
Taste Masking ◽  
Platform Technology ◽  
Eudragit Epo ◽  
Hot Melt

Objective: The aim of present work was to develop a platform technology for the pediatric dosage form to mask the bitter taste of Furosemide (FUR) and prepare a flexible solid oral dosage form. Methods: Excipient compatibility study was carried out by using Fourier-transform infrared spectroscopy (FTIR). Taste masking was done by hot melt extrusion (HME) technology. Eudragit EPO and Soluplus were used as a taste masking and solubilizing polymers respectively. The prepared solid dispersion and tablets were evaluated for their physicochemical parameters such as hardness, friability, disintegration, in vitro drug release. Results: Experimental data revealed that physical integrity, brittleness of granules, conversion of a drug in amorphous form was improved by combining Eudragit EPO with Soluplus. Plasticizer helped to complete HME at 80 °C. Less than 10% drug release in pH 6.8 medium revealed that release would be extremely limited in the saliva and thus avoiding bitterness. Animal study data revealed that bioavailability has been increased by 30%. Differential scanning calorimetry (DSC) and x-ray diffraction (XRD) tests confirmed the existence of molecularly dispersed drug. Fourier-transform infrared spectroscopy (FTIR) confirmed the unchanged functional groups of FUR after HME processing. Conclusion: Proposed platform technology masked the bitter taste and enhanced the bioavailability of FUR in D: P ratio of 1:2.

Influence of Intermittent Air Introduction on Formation of Zn Films by Mechanical Coating Technique

2013 ◽  
Vol 750 ◽  
pp. 138-141
Author(s):  
Liang Hao ◽  
Yun Lu ◽  
Hiromasa Sato ◽  
Hiroshi Asanuma ◽  
Fu Sheng Pan
Keyword(s):  
Zinc Oxide ◽  
Adhesion Strength ◽  
The Other ◽  
Coating Process ◽  
Sem Images ◽  
Coating Technique ◽  
Zno Nanocrystals ◽  
Other Hand ◽  
Mechanical Coating

The influence of intermittent air introduction on the formation of Zn films during mechanical coating process was investigated. A series of contrast experiments were carried out. The XRD and EDS results showed that Zn particles were slightly oxidized. The SEM images indicated that disk-like zinc oxide (ZnO) nanocrystals were formed. The formation of disk-like ZnO made the morphology of Zn films more uneven and irregular. On the other hand, it increased the adhesion strength of Zn films to Al2O3 balls and hence the exfoliation of Zn films was not found.

Taste masking of isoniazid by hot melt extrusion and spray drying – A comparative study

2016 ◽  
Vol 511 (2) ◽  
pp. 1142
Author(s):  
Alison Keating ◽  
Duncan Craig ◽  
Catherine Tuleu ◽  
Claire Forbes ◽  
Barry Aldous ◽  
...  
Keyword(s):  
Comparative Study ◽  
Spray Drying ◽  
Hot Melt Extrusion ◽  
Taste Masking ◽  
Melt Extrusion ◽  
Hot Melt

A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation

2013 ◽  
Vol 40 (2) ◽  
pp. 145-156 ◽  
Author(s):  
Mohammed Maniruzzaman ◽  
Joshua S. Boateng ◽  
Babur Z. Chowdhry ◽  
Martin J. Snowden ◽  
Dennis Douroumis
Keyword(s):  
Hot Melt Extrusion ◽  
Taste Masking ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating

2021 ◽  
Vol 71 (1) ◽  
pp. 35-54
Author(s):  
Jelisaveta Ignjatović ◽  
Jelena Đuriš ◽  
Mihal Đuriš ◽  
Teodora Bočarski ◽  
Vanja Vasilijević ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Liquid Paraffin ◽  
Practical Method ◽  
Coating Agent ◽  
Coated Particles ◽  
Coated Material ◽  
Model Substance ◽  
Coating Method ◽  
Coating Methods ◽  
Hot Melt

Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in the coated samples was high (99%), the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan-and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies.

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