scholarly journals QSAR STUDIES OF SOME SUBSTITUTED IMIDAZOLE DERIVATIVES AS POTENT ANTIFUNGAL AGENTS

2021 ◽  
Vol 10 (4) ◽  
pp. 3346-3350
Author(s):  
Sumeet Prachand

Fracture of distal radius is the commonest fracture present in the upper limb. In fact, it is most commonly treated by the doctor. An outstretched hand is the most common cause of distal radius or wrist fractures. The fracture of distal radius can also lead to nerve injury mostly median nerve. Physical Therapy plays important role which provides positive effect in treating post fracture cases. A case of 45 years female is presented in this report who had a fall over right wrist joint and diagnosed with distal radius fracture and operated conservatively results into pain over wrist joint, decrease in physical activities. Rehabilitation protocol is explained below in the report. We report that there were improvement in patient outcomes level increases in muscles strength, provide pain relief and improvement in patient functional Independence.

2021 ◽  
Vol 10 (4) ◽  
pp. 3343-3345
Author(s):  
Ragini Dadgal

Fracture of distal radius is the commonest fracture present in the upper limb. In fact, it is most commonly treated by the doctor. An outstretched hand is the most common cause of distal radius or wrist fractures. The fracture of distal radius can also lead to nerve injury mostly median nerve. Physical Therapy plays important role which provides positive effect in treating post fracture cases. A case of 45 years female is presented in this report who had an fall over right wrist joint and diagnosed with distal radius fracture and operated conservatively results into pain over wrist joint, decrease in physical activities. Rehabilitation protocol is explained below in the report. We report that there were improvement in patient outcomes level increases in muscles strength, provide pain relief and improvement in patient functional Independence.


Author(s):  
Yanqing Zhou ◽  
Yanbin Zhu ◽  
Xiong Zhang ◽  
Dehu Tian ◽  
Bing Zhang

Abstract Purpose The aim of this study is to investigate the radiographic and functional results of die-punch fracture of distal radius treated by volar locking plate (VLP) or external fixation (EF). Methods Between January 2015 and June 2018, 87 patients who were treated with EF or VLP were included in this study. At postoperative 6 months and at least 12 months, radiographic and functional outcomes were evaluated, and compared between two groups using SPSS 21.0. Results The follow-up period was 15.6 months in average, and at the mean 8.5 weeks bony union was achieved in all patients. At 6-month visit, patients in VLP group had significantly better wrist flexion (79.2° vs. 71.8°) and pronation (79.5° vs. 75.2°) than those in EF group, but the difference was non-significant at the last visit (> 12 months); as for other parameters, no significant differences were observed. No significant difference was found between both groups in term of volar tilt, radial inclination, radial height, ulnar variance, or Gartland–Werley score and DASH. The articular step-off was significantly greater in EF than VLP group (0.6 mm vs. 0.3 mm, p < 0.001). The overall incidence of complications seemed higher in EF group (25% vs. 14%), but not approaching to the statistical significance level. Conclusions Patients with VLP fixation of die-punch fractures had better wrist flexion and pronation at 6-month visit and more favorable wrist joint congruence at the last visit, but ultimately their outcome was comparable with those treated by EF.


2016 ◽  
Vol 11 (4) ◽  
pp. 3-8 ◽  
Author(s):  
Prakash Bahadur Thapa ◽  
Rudra Prasad Marasini ◽  
Shrawan Kumar Thapa ◽  
Nabeesman Singh Pradhan ◽  
Shreekrishna Giri

Background & Objectives: Various methods of immobilization have been recommended for the treatment of torus fracture of distal radius in children. The purpose of this study is to determine if soft bandage is as effective and safe as below elbow circumferential casts in the treatment of torus fracture of the distal radius in the children.Materials & Methods: Children from 4 to 14 years of age, who presented to emergency and outpatient department of orthopaedics and trauma at National Academy of Medical Sciences with an isolated torus fracture of distal radius, were randomized and treated with either soft bandage or below-elbow plaster cast by the same investigators. Patients with associated neurovascular injuries, bilateral torus fractures, concomitant physeal injuries and associated musculoskeletal injuries were excluded. The patients were followed up at weekly interval for 4 weeks and analyzed with VAS, ROM and outcome questionnaire and data were analyzed by using SPSS 18.Results: Among the 114 patients analyzed, 57 patients were kept in soft bandage group and 57 in below-elbow cast group. The mean age in soft bandage group was 8.29 year and the mean age in below-elbow cast group was 8.55 years. There was no significant difference between the two groups with regard to patient demographics, initial fracture characteristics and mechanism of injury.Conclusion: Treatment of distal radius torus fracture with soft bandage is a cost-effective and safe in the children below 14 years of age. These minor fractures are stable and not subject to the risks of late displacement which can be very effectively treated symptomatically to provide pain relief by using soft bandage only and educating the parents about the nature of this paediatrics fracture.Journal of College of Medical Sciences-Nepal, Vol.11(4) 2015: 3-8


2016 ◽  
Vol 24 (3) ◽  
pp. 179-184 ◽  
Author(s):  
Stephanie A Hicks ◽  
Verena R Cimarolli

Introduction Previous research has shown that home telehealth services can reduce hospitalisations and emergency department visits and improve clinical outcomes among older adults with chronic conditions. However, there is a lack of research on the impact of telehealth (TH) use on patient outcomes in post-acute rehabilitation settings. The current study examined the effects of TH for post-acute rehabilitation patient outcomes (i.e. discharge setting and change in functional independence) when controlling for other factors (e.g. cognitive functioning). Methods For this retrospective study, electronic medical records (EMRs) of 294 patients who were discharged from a post-acute rehabilitation unit at a skilled nursing facility were reviewed. Only patients with an admitting condition of a circulatory disease based on ICD-9 classification were included. Main EMR data extracted included use of TH, cognitive functioning, admission and discharge functional independence, and discharge setting (returning home vs. returning to acute care/re-hospitalisation). Results Results from a regression analysis showed that although TH use was unrelated to post-acute rehabilitation care transition, it was significantly related to change in functional independence. Patients who used TH during their stay had significantly more improvement in functional independence from admission to discharge when compared to those who did not use TH. Discussion Findings indicate that TH use during post-acute rehabilitation has the potential to improve patient physical functioning.


2013 ◽  
Vol 7 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Theresa J.C Pazionis ◽  
Hussain Alradwan ◽  
Benjamin M Deheshi ◽  
Robert Turcotte ◽  
Forough Farrokhyar ◽  
...  

Introduction: Surgical management of Giant Cell Tumor of Bone of the distal radius (GCTDR) remains controversial due to risk of local recurrence (LR) offset by functional limitations which result from en-bloc resection. This study aims to determine the oncologic and functional outcomes of wide excision (WE) vs intralesional curettage (IC) of GCTDR. Methods: A complete search of the applicable literature was done. Included studies reported on patients from the same cohort who were surgically treated for GCTDR with WE or IC. Two reviewers independently assessed all papers. The primary outcome measure was LR. Results: One-hundred-forty-one patients from six studies were included: 60 treated with WE, and 81 with IC. Five WE patients (8%) suffered LR whereas 25 IC patients (31%) did. The odds of LR were three times less in the WE group vs the IC group. MSTS1993 scores, where available, were on average 'good' with WE and 'excellent' with IC. Conclusions: Within statistical limitations the data support an attempt, where feasible, at wrist joint preservation and superior function with IC. Intralesional curettage is reasonable when the functional benefit outweighs the risk of recurrence as is the case in many cases of GCT of the distal radius.


2020 ◽  
Vol 41 (Supplement_1) ◽  
pp. S256-S256
Author(s):  
Leng Yang ◽  
Ascension Santoyo ◽  
Jeffery Hati ◽  
Nicole M Kopari

Abstract Introduction Burn injuries often result in functional mobility impairments limiting return to pre-burn activity. Early mobility within 24 hours of admission is recommended to minimize risks of joint and soft tissue contractures while promoting functional independence. To maximize these services, burn therapists undergo annual competency education to evaluate, develop a plan of care, and treat burn patients. Designated burn therapy staff coverage is often not 24/7 resulting in delayed times to early interventions. We identified a need to provide education within the therapy department specifically addressing burn rehab interventions. Methods An in-service presentation introducing Cutaneous Function Units (CFU) as a new functional assessment tool was developed and presented to the therapy department. An 8 question test was administered before and after the presentation to assess staff retention and application of learned techniques. A total of 15 therapist, both occupational and physical, attended the presentation with the results of the tests analyzed. Results Pre-test average scores were 73% with post-test average improved to 95%. Therapist learned 2 additional methods of assessing burn wounds. After analyzing the test results, we were able to identify specific areas that required further education. We used the pre- and post- test results to tailor further educational sessions focusing on hands-on education and small focus groups. Conclusions Despite annual burn rehab competencies with therapy staff, there continues to be a deficit in retention of education. This may result in delay of early mobility and burn rehab services in our burn population. With focused education tailored to specific areas of burn therapy competencies, we were able to impact burn patient therapy sessions. Applicability of Research to Practice Ongoing education can be tailored to specific ares of burn therapy competencies to improve overall patient outcomes.


2005 ◽  
Vol 54 (1) ◽  
pp. 143-146
Author(s):  
Manabu Taguchi ◽  
Hidechika Nakashima ◽  
Kenichiro Teramoto ◽  
Kanae Harada ◽  
Takushi Nagai ◽  
...  

2020 ◽  
Vol 10 (3) ◽  
pp. 147-157 ◽  
Author(s):  
Dustin Lash ◽  
Earl Frantz ◽  
Mark FB Hurdle

Aim: Cooled radiofrequency ablation (CRFA) has demonstrated efficacy in the management of knee pain caused by osteoarthritis. A typical procedure involves fluoroscopic placement of internally cooled radiofrequency probes to ensure the probes are located near target genicular nerves. Patients & methods: A new technique was developed to perform CRFA using ultrasound (US) guidance. Patient outcomes were reported using a telephone survey. Results: Ablation procedures were successfully performed using US guidance. A total of 51 patients were retrospectively identified for telephone screening. A total of 22 patients completed the telephone questionnaire. There were no safety concerns identified and the majority of patients reported satisfactory outcomes. Conclusion: Patient outcomes demonstrate that US-guided CRFA procedures provide pain relief and functional improvement. Further studies are needed to compare the efficacy of US-guided CRFA to fluoroscopy-guided CRFA procedures.


2019 ◽  
Vol 09 (02) ◽  
pp. 136-140
Author(s):  
C. A. Selles ◽  
M. A. M. Mulders ◽  
G. R. Roukema ◽  
C. H. van der Vlies ◽  
B. I. Cleffken ◽  
...  

Abstract Background Closed reduction and cast immobilization of displaced distal radius fractures carries the risk of secondary displacement, which could result in a symptomatic malunion. In patients with a symptomatic malunion, a corrective osteotomy can be performed to improve pain and functional impairment of the wrist joint. Objective The aim of this study was to assess the functional outcomes of children who underwent a corrective osteotomy due to a symptomatic malunion of the distal radius. Methods Between 2009 and 2016, all consecutive corrective osteotomies of the distal radius of patients younger than 18 years were reviewed. The primary outcome was functional outcome assessed with the ABILHAND-Kids score. Secondary outcomes were QuickDASH (Quick Disabilities of Arm, Shoulder, and Hand) score, range of motion, complications, and radiological outcomes. Results A total of 13 patients with a median age of 13 years (interquartile range [IQR]: 12.5–16) were included. The median time to follow-up was 31 months (IQR: 26–51). The median ABILHAND-Kids score was 42 (range: 37–42), and the median QuickDASH was 0 (range: 0–39). Range of motion did not differ significantly between the injured and the uninjured sides for all parameters. One patient had a nonunion requiring additional operative treatment. The postoperative radiological parameters showed an improvement of radial inclination, radial height, ulnar variance, dorsal tilt, and dorsal tilt. Conclusion Corrective osteotomy for children is an effective method for treating symptomatic malunions of the distal radius. Level of Evidence This is a Level IV study.


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