FORMULATION DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF TRAZODONE HYDROCHLORIDE

Objective: Focus of the study was to formulate Design expert Software assisted floating tablet of Bisoprolol Fumarate. Bisoprolol Fumarate is a Beta adrenergic blocking agent, used to treat cardiac diseases favorable characters to be formulated as sustained release Gastro retentive floating tablets. Methods: Floating Tablets of Bisoprolol Fumarate were prepared by using polymers such as Polyox N 12 K and Carbapol 940 P. Formulations were prepared by using direct compression method and evaluated for various parameters like Hradness, thickness, weight variations, Floating lag time Total floating time,% drug release and Stability Study etc. Results: FTIR spectroscopic study indicates no drug-excipients interaction in the prepared formulations. Hardness or crushing strength of the tablets of all the formulation was found between 5.8 and 6.5 kg/cm2. Floating lag time of all batches is in range of 1.18±2.0 to 2.43±1.6 (minutes). All other parameters of all batches are within an acceptable range. The polymer Carbopol 940 P had the significant negative effect of on the floating lag times. The In vitro dissolution profiles of optimized A3 Floating formulation of Bisoprolol Fumarate were found to sustain drug release 99.25 % up to 12 h with floating lag time of 1.45 min; Designed formulation was stable after Stability study. Optimization study was carried out by using 32 factorial designs to fabricate formulations. Conclusion: It can be conclude that reproducible results of various parameters in this developed formulation can easily scale up. Furthermore designed formulation will be very effective for controlling blood pressure.

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Formulation Development and In vitro Evaluation of Floating Tablets of Lafutidine by Employing Effervescent Technology

Asian Journal of Pharmaceutical Research ◽

10.5958/2231-5691.2017.00029.6 ◽

2017 ◽

Vol 7 (3) ◽

pp. 189

Author(s):

N. M. Vageesh ◽

Ramya Sri Sura ◽

K Gulijar Begum ◽

B Swathi

Keyword(s):

Formulation Development ◽

In Vitro Evaluation ◽

Floating Tablets

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FORMULATION DEVELOPMENT AND EVALUATION OF CARVEDILOL PHOSPHATE GASTRO RETENTIVE FLOATING TABLETS

International Research Journal of Pharmacy ◽

10.7897/2230-8407.0718 ◽

2016 ◽

Vol 7 (1) ◽

pp. 44-51

Author(s):

Raghavendra Kumar Gunda ◽

J N Suresh Kumar ◽

Satyanarayana V ◽

Ramanjaneyulu K V ◽

B Satya Prasad

Keyword(s):

Formulation Development ◽

Floating Tablets ◽

Gastro Retentive

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FORMULATION DEVELOPMENT AND EVALUATION OF DILTIAZEM HYDROCHLORIDE GASTRO RETENTIVE FLOATING TABLETS

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v3i3.509 ◽

2013 ◽

Vol 3 (3) ◽

Author(s):

Hardik Patel ◽

Manish Jaimini

Keyword(s):

Diltiazem Hydrochloride ◽

Formulation Development ◽

Floating Tablets ◽

Gastro Retentive

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FORMULATION DEVELOPMENT AND EVALUATION OF MATRIX TABLET TRAZODONE HYDROCHLORIDE USING NATURAL POLYMER

International Research Journal of Pharmacy ◽

10.7897/2230-8407.1208156 ◽

2021 ◽

Vol 12 (8) ◽

pp. 46-51

Author(s):

Jeetendra Kushwaha ◽

Dev Sharan Chaturvedi ◽

Manisha Verma ◽

Kuldeep Kumar Tiwari ◽

Neelesh Anuragi

Keyword(s):

Drug Release ◽

Sustained Release ◽

Research Work ◽

In Vitro Release ◽

Matrix Tablets ◽

Average Weight ◽

Release Kinetic ◽

Matrix Tablet ◽

Formulation Development ◽

Trazodone Hydrochloride

Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Trazodone Hydrochloride (TRZ) is a well-known chemical compound that is used as an antidepressant that belongs to a selective serotonin reuptake inhibitor (SARI). The objective of present work was to develop and evaluated oral sustained release matrix tablet of TRZ. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. No interactions were observed between TRZ and excipients from the Fourier transform infrared spectroscopy. The present research work was successful in improving the efficacy TRZ oral therapy as the drug release was extended for 12 hours thus reducing dosing frequency thereby improving patient compliance. The study also revealed the applicability of HPMC K-15, Gaur gum and PVP K30 as rate-controlling polymers in matrix tablets. The hydrophilic matrix of HPMC alone cannot control the release TRZ effective for 12 h while when combined with guar gum, may slow down the release of the drug and therefore, can be successfully employed for the formulation of matrix tablets SR. It may be concluded from the study that; the optimized formulation F-8 was shown maximum drug release 99.12 % in 12 h of dissolution. The release kinetic data of formulation F-8 shown first order release kinetics (R2 = 0.980).

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FORMULATION DEVELOPMENT, CHARACTERIZATION AND IN- VITRO EVALUATION OF FLOATING MATRIX DOSAGE FORM OF TRAMADOL HYDROCHLORIDE USING VARIOUS POLYMERS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i2.15587 ◽

2017 ◽

Vol 10 (2) ◽

pp. 281

Author(s):

Sarada Anepu ◽

Lohithasu Duppala ◽

Soma Sundari M

Keyword(s):

Methyl Cellulose ◽

Formulation Development ◽

Scanning Calorimetry ◽

Tramadol Hydrochloride ◽

Floating Tablets ◽

Gastric Residence Time ◽

Weight Variation ◽

Floating Drug Delivery ◽

Release Studies

Objective: The purpose of present study was to formulate the gastro retentive floating tablets of tramadol hydrochloride for enhancement of the gastric residence time.Methods: The floating tablets were prepared by direct compression method and evaluated for hardness, thickness, and friability of the tablets. The in vitro drug release studies were performed for different formulations and to optimize the best formulae based on the dissolution profiles.Results: Fourier transform infrared spectroscopy and differential scanning calorimetry studies revealed that there was no interaction between tramodol hydrocholride and excipients. The formulated tablets were evaluated for properties like weight variation, hardness, thickness, friability, drug content, density and floating properties, matrix integrity and complied with USP requirements. The tablets of optimized formula had floating lag time of 120, 72 and 96 seconds and the tablets remained in the floating condition for more than 12 h. The results of drug excipients compatibility studies suggest that there was no significant change in the physical appearance of these blends, when stored at 40 °C/75% RH for a period of 4 weeks. Among various trial formulations developed with different concentration of polymer F3 (HPMC K4 M with 120mg of polymer), F5 (HPMC K15 M with 100 mg polymer), F11 (PEO WSR 303 with 100mg polymer), were chosen as the optimized formulations based on the release profile.Conclusion: Tramodol HCl floating tablets were successfully made using various polymers for the enhancement of the gastric residence time. From the present study it was concluded that hydroxy propyl methyl cellulose K 4 M can be used as effective polymer for the formulation of floating effervescent tablets of highly soluble drug indicating successful development of sustained release floating drug delivery system.Key words: Tramodol HCl, floating tablets, PEO 303 WSR, PEO N60, HPMC K 4 M, HPMC K15 M and HPMC K 100 M.

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