scholarly journals Left Bundle Branch Area Pacing guided by Continuous Uninterrupted Monitoring of the unipolar Pacing Characteristics.

2021 ◽  
Author(s):  
Kris Gillis ◽  
Jean-Yves Wielandts ◽  
Gabriela Hilfiker ◽  
Louisa O'Neill ◽  
Alina Vlase ◽  
...  
Keyword(s):  
Real Time ◽  
Group Performance ◽  
Accurate Determination ◽  
Septal Perforation ◽  
Validation Group ◽  
Pacing Lead ◽  
Qrs Morphology ◽  
Qrs Duration ◽  
Highly Correlated

Introduction. During left bundle branch area pacing (LBBAP) lead implantation, intermittent monitoring of unipolar pacing characteristics validates LBB capture and can detect septal perforation. We aimed to demonstrate that continuous uninterrupted unipolar pacing from an inserted lead stylet (LS) is feasible and facilitates LBBAP implantation. Methods. Thirty patients (mean age 76 ± 14 years) were implanted with stylet-driven pacing lead (Biotronik Solia S60). In 10 patients (validation-group) conventional, interrupted implantation was performed, with comparison of unipolar pacing characteristics between LS and connector-pin (CP)-pacing after each rotation step. In 20 patients (feasibility-group) performance and safety of uninterrupted implantation during continuous pacing from the LS were analyzed. Results. In the validation-group, LS and CP-pacing impedances were highly correlated (R=0.95, p<0.0001, bias 12±37Ω). Pacing characteristics from LS and CP showed comparable sensed electrograms and paced QRS morphologies. In the feasibility-group, continuous LS-pacing allowed beat-to-beat monitoring of impedance and QRS morphology to guide implantation. This resulted in successful LBBAP in all patients, after a mean of 1±0 attempts, with mean threshold 0.81 ± 0.4V, median sensing 6.5mV [IQR 4.4-9.5] and mean impedance 624 ± 101Ω, and positive LBBAP-criteria with median paced QRS duration 120ms [IQR 112-152ms] and median pLVAT 73ms [IQR 68-80.5ms]. No septal perforation occurred. Conclusion. Unipolar pacing from the LS allows accurate determination of pacing impedance and generates similar paced QRS morphologies and equal sensed electrograms, compared to CP pacing. Continuous LS pacing allows real-time monitoring of impedance and paced QRS morphology, which facilitates a safe and successful LBBAP lead implantation.

scholarly journals A Method for Real Time Detection of Reaction Endpoints Using a Moving Window T-Test of in Situ Time Course Data

2020 ◽  
Author(s):  
Elyse N. Towns ◽  
John Guo ◽  
Alexander O'Brien ◽  
Robert W. Bondi
Keyword(s):  
Real Time ◽  
Process Parameters ◽  
Time Course ◽  
Accurate Determination ◽  
Scale Up ◽  
Feasibility Studies ◽  
T Test ◽  
Moving Window ◽  
Test Algorithm

In-line mid-infrared spectroscopy (FTIR) was used to monitor a reaction which had a highly inconsistent rate due to sensitivity to changes in process parameters and the quality of the starting materials. Accurate determination of the endpoint in real time was needed to prevent formation of an impurity by degradation of the product. A moving window t-test algorithm was used to predict and determine the endpoint by analysis of FTIR trends during the reaction. The method was selected because it determined the endpoint in the correct range for reactions with different process parameters and data collected with different FTIR instruments. During development, the FTIR and t-test algorithm were used to monitor reactions for feasibility studies, process optimization, use tests, robustness DoE, and scale up to pilot plant. The method for monitoring the reaction may be useful in a GMP manufacturing environment where sampling and analysis are time consuming. <br>

scholarly journals Comparison Of Urinary Bladder Volume In Children Using Suprapubic Ultrasonic Bi-Planner Technique With Voided Urine Volume

2012 ◽  
Vol 17 (2) ◽  
pp. 4-7
Author(s):  
S Sadek ◽  
M Hossain ◽  
H Akther ◽  
A Sikdar
Keyword(s):  
Real Time ◽  
Accurate Determination ◽  
Urine Volume ◽  
Bladder Capacity ◽  
Bladder Volume ◽  
Bladder Function ◽  
Urethral Trauma ◽  
Fear And Anxiety ◽  
Real Time Ultrasonography

Accurate determination of intravesical residual urine volume as well as bladder capacity is of significant importance in children. The ability to confirm these measurements non invasively in children avoids discomfort, urethral trauma and the introduction of urinary tract infection. Also, by avoiding the need for catheterization this technique permits more physiological assessment and allows for repeated examinations without fear and anxiety on the part of the patients. In this prospective study we assess the accuracy of the real time, hand held, ultrasonic device using suprapubic views and biplanar technique to determine intravesical volumes. Real time ultrasonography with suprapubic views and the described bi-planar technique to determine intravesical urine volume is simple, accurate and reproducible. It also is rapid and noninvasive, and can detect accurately an empty bladder in children. A strong correlation was found between the estimated bladder volume with our method and voided urine volume (0 ml, residual volume) .This study concluded that the modality used in this study has the potential to provide useful and reproducible information in the clinical evaluation of bladder function in children.DOI: http://dx.doi.org/10.3329/jdnmch.v17i2.12199 J. Dhaka National Med. Coll. Hos. 2011; 17 (02): 4-7

Extremely fast retrieval of volcanic SO2 layer heights from UV satellite data using inverse learning machines

2021 ◽  
Author(s):  
Pascal Hedelt ◽  
MariLiza Koukouli ◽  
Konstantinos Michaelidis ◽  
Taylor Isabelle ◽  
Dimitris Balis ◽  
...  
Keyword(s):  
Real Time ◽  
Accurate Determination ◽  
Principal Component ◽  
Volcanic Eruptions ◽  
Neural Network Approach ◽  
Layer Height ◽  
Precise Knowledge ◽  
Innovation Project ◽  
Learning Machine

&lt;p&gt;Precise knowledge of the location and height of the volcanic sulfur dioxide (SO&lt;sub&gt;2&lt;/sub&gt;) plume is essential for accurate determination of SO&lt;sub&gt;2&lt;/sub&gt; emitted by volcanic eruptions, however so far not available in operational near-real time UV satellite retrievals. The FP_ILM algorithm (Full-Physics Inverse Learning Machine) enables for the first time to extract the SO&lt;sub&gt;2&lt;/sub&gt; layer height information in a matter of seconds for current UV satellites and is thus applicable in NRT environments.&lt;/p&gt;&lt;p&gt;The FP_ILM combines a principal component analysis (PCA) and a neural network approach (NN) to extract the information about the volcanic SO&lt;sub&gt;2&lt;/sub&gt; layer height from high-resolution UV satellite backscatter measurements. So far, UV based SO&lt;sub&gt;2 &lt;/sub&gt;layer height retrieval algorithms were very time-consuming and therefore not suitable for near-real-time applications like aviation control, although the SO&lt;sub&gt;2&lt;/sub&gt; LH is essential for accurate determination of SO&lt;sub&gt;2&lt;/sub&gt; emitted by volcanic eruptions.&lt;/p&gt;&lt;p&gt;In this presentation, we will present the latest FP_ILM algorithm improvements and show results of recent volcanic eruptions.&lt;/p&gt;&lt;p&gt;The SO&lt;sub&gt;2&lt;/sub&gt; layer height product for Sentinel-5p/TROPOMI is developed in the framework of the SO&lt;sub&gt;2&lt;/sub&gt;&amp;#160;Layer Height (S5P+I: SO&lt;sub&gt;2&lt;/sub&gt; LH)&amp;#160;project, which is part of ESA Sentinel-5p+ Innovation project (S5P+I). The S5P+I project aims to develop novel scientific and operational products to exploit the potential of the S5P/TROPOMI capabilities. The S5P+I: SO&lt;sub&gt;2&lt;/sub&gt; LH&amp;#160;project is dedicated to the generation of an SO&lt;sub&gt;2&lt;/sub&gt;&amp;#160;LH product and its extensive verification with collocated ground- and space-born measurements.&lt;/p&gt;

New Method for Posttraumatic Elbow Contracture Correction

2004 ◽  
Vol 11 (2) ◽  
pp. 44-48
Author(s):  
S P Mironov ◽  
M B Tsykunov ◽  
O V Oganesyan ◽  
N V Seleznev ◽  
M A Eremushkin ◽  
...  
Keyword(s):  
Computer Program ◽  
Real Time ◽  
Elbow Joint ◽  
Accurate Determination ◽  
New Method ◽  
Short Term ◽  
Articular Surfaces ◽  
Elbow Function ◽  
Elbow Contracture

New method for elbow function restoration in posttraumatic contracture using apparatus complex «Raduga-CITO» is suggested. This complex enables to set, control and monitor the indicators of motion. Elaborated computer program provides accurate determination of articular angle values, the rate of articular ends movement, forces of articular surfaces interrelation by 6 main vectors and monitoring of these kinesiologic and dynamic patterns in real time. The program allows to determine adequate algorithm movement in elbow joint and thus to optimize the conditions for elbow function restoration in posttraumatic contractures. The method has been used in 17 patients with posttraumatic elbow contractures and good short term results have been achieved in all patients.

scholarly journals The "dual-spot" Aethalometer: an improved measurement of aerosol black carbon with real-time loading compensation

2015 ◽  
Vol 8 (5) ◽  
pp. 1965-1979 ◽  
Author(s):  
L. Drinovec ◽  
G. Močnik ◽  
P. Zotter ◽  
A. S. H. Prévôt ◽  
C. Ruckstuhl ◽  
...  
Keyword(s):  
Real Time ◽  
Black Carbon ◽  
Source Apportionment ◽  
Accurate Determination ◽  
Optical Measurements ◽  
Quality Data ◽  
Loading Effect ◽  
Adverse Health Effects ◽  
Compensation Algorithm

Abstract. Aerosol black carbon is a unique primary tracer for combustion emissions. It affects the optical properties of the atmosphere and is recognized as the second most important anthropogenic forcing agent for climate change. It is the primary tracer for adverse health effects caused by air pollution. For the accurate determination of mass equivalent black carbon concentrations in the air and for source apportionment of the concentrations, optical measurements by filter-based absorption photometers must take into account the "filter loading effect". We present a new real-time loading effect compensation algorithm based on a two parallel spot measurement of optical absorption. This algorithm has been incorporated into the new Aethalometer model AE33. Intercomparison studies show excellent reproducibility of the AE33 measurements and very good agreement with post-processed data obtained using earlier Aethalometer models and other filter-based absorption photometers. The real-time loading effect compensation algorithm provides the high-quality data necessary for real-time source apportionment and for determination of the temporal variation of the compensation parameter k.

scholarly journals The "dual-spot" Aethalometer: an improved measurement of aerosol black carbon with real-time loading compensation

2014 ◽  
Vol 7 (9) ◽  
pp. 10179-10220 ◽  
Author(s):  
L. Drinovec ◽  
G. Močnik ◽  
P. Zotter ◽  
A. S. H. Prévôt ◽  
C. Ruckstuhl ◽  
...  
Keyword(s):  
Real Time ◽  
Black Carbon ◽  
Source Apportionment ◽  
Accurate Determination ◽  
Optical Measurements ◽  
Quality Data ◽  
Loading Effect ◽  
Adverse Health Effects ◽  
Compensation Algorithm

Abstract. Aerosol black carbon is a unique primary tracer for combustion emissions. It affects the optical properties of the atmosphere and is recognized as the second most important anthropogenic forcing agent for climate change. It is the primary tracer for adverse health effects caused by air pollution. For the accurate determination of mass equivalent black carbon concentrations in the air and for source apportionment of the concentrations, optical measurements by filter-based absorption photometers must take into account the "filter loading effect". We present a new real-time loading effect compensation algorithm based on a two parallel spot measurement of optical absorption. This algorithm has been incorporated into the new Aethalometer model AE33. Intercomparison studies show excellent reproducibility of the AE33 measurements and very good agreement with post-processed data obtained using earlier Aethalometer models, and other filter-based absorption photometers. The real-time loading effect compensation algorithm provides the high-quality data necessary for real-time source apportionment, and for determination of the temporal variation of the compensation parameter k.

Rapid and accurate prediction of the frequencies of Bursaphelenchus xylophilus and B. mucronatus in mixed nematode samples using real-time species-specific PCR

Nematology ◽  
2009 ◽  
Vol 11 (2) ◽  
pp. 289-299 ◽  
Author(s):  
Si Hyeock Lee ◽  
Il Sung Moon ◽  
Jae Soon Kang ◽  
Sang Chul Shin ◽  
Sang Gil Lee
Keyword(s):  
Real Time ◽  
Detection System ◽  
Accurate Determination ◽  
Marker Gene ◽  
Threshold Value ◽  
Nematode Species ◽  
Bursaphelenchus Xylophilus ◽  
Specific Pcr ◽  
Species Specific

AbstractAccurate detection of Bursaphelenchus xylophilus and prediction of its frequency in crude nematode samples is often hindered by the coexistence of related nematode species, such as B. mucronatus, that are morphologically similar but non-pathogenic. To establish a detection system enabling determination of the relative frequencies of B. xylophilus and B. mucronatus from field nematode samples, we developed a real-time species-specific PCR (rtssPCR) protocol which targets the substantial sequence differences in the 5S rRNA marker gene between the two nematode species. Using standard DNA mixtures of B. xylophilus and B. mucronatus in various ratios, plots of percent species proportion vs cycle threshold value (Ct value) were generated for the prediction of species frequency. The rtssPCR protocol enables the detection of target nematode frequencies as low as 0.16% at the 95% confidence level. When nematode DNA samples were extracted from the mixed specimens of B. xylophilus and B. mucronatus in various ratios and analysed by rtssPCR, the semi-log plot was nearly identical to the plot generated from standard mixed DNA samples, demonstrating that field populations of the nematodes can be directly used for rtssPCR analysis. The rapid and accurate determination of B. xylophilus or B. mucronatus frequencies by this rtssPCR protocol makes it ideal for routine monitoring and quarantine of B. xylophilus in the field.

scholarly journals A Method for Real Time Detection of Reaction Endpoints Using a Moving Window T-Test of in Situ Time Course Data

2020 ◽  
Author(s):  
Elyse N. Towns ◽  
John Guo ◽  
Alexander O'Brien ◽  
Robert W. Bondi
Keyword(s):  
Real Time ◽  
Process Parameters ◽  
Time Course ◽  
Accurate Determination ◽  
Scale Up ◽  
Feasibility Studies ◽  
T Test ◽  
Moving Window ◽  
Test Algorithm

In-line mid-infrared spectroscopy (FTIR) was used to monitor a reaction which had a highly inconsistent rate due to sensitivity to changes in process parameters and the quality of the starting materials. Accurate determination of the endpoint in real time was needed to prevent formation of an impurity by degradation of the product. A moving window t-test algorithm was used to predict and determine the endpoint by analysis of FTIR trends during the reaction. The method was selected because it determined the endpoint in the correct range for reactions with different process parameters and data collected with different FTIR instruments. During development, the FTIR and t-test algorithm were used to monitor reactions for feasibility studies, process optimization, use tests, robustness DoE, and scale up to pilot plant. The method for monitoring the reaction may be useful in a GMP manufacturing environment where sampling and analysis are time consuming. <br>

Rapid and accurate determination of zygosity in transgenic animals by real-time quantitative PCR

2002 ◽  
Vol 11 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Laurent Tesson ◽  
Jean-Marie Heslan ◽  
Séverine Ménoret ◽  
Ignacio Anegon
Keyword(s):  
Real Time ◽  
Quantitative Pcr ◽  
Accurate Determination ◽  
Transgenic Animals ◽  
Real Time Quantitative Pcr
Sign in / Sign up

Export Citation Format

Share Document