scholarly journals Intravascular lymphoma - The creepy crawler: A case series and brief literature review

2021 ◽  
Author(s):  
Kainat Saleem ◽  
Azadeh Nasrazadani ◽  
Chaoyuan Kuang ◽  
Vanya Jaitly ◽  
Jonhan Ho ◽  
...  
Keyword(s):  
Cell Lymphoma ◽  
Diagnostic Yield ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Diagnostic Tools ◽  
Large B Cell Lymphoma ◽  
Improved Outcomes ◽  
Rare Malignancy ◽  
Poor Outcomes ◽  
Large B Cell

We present four cases of intravascular large B-cell lymphoma (IVLBCL), a rare malignancy with poor outcomes. The exclusive presence of lymphoma cells in blood vessels leads to a heterogenous presentation and poor diagnostic yield with traditional initial diagnostic tools. Timely diagnosis and treatment can lead to improved outcomes.

scholarly journals Circulating long non-coding RNAs HOTAIR, Linc-p21, GAS5 and XIST expression profiles in diffuse large B-cell lymphoma: association with R-CHOP responsiveness

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mahmoud A. Senousy ◽  
Aya M. El-Abd ◽  
Raafat R. Abdel-Malek ◽  
Sherine M. Rizk
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Expression Profiles ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
B Cell Lymphoma ◽  
Diagnostic Tools ◽  
Large B Cell Lymphoma ◽  
Non Coding Rnas ◽  
Large B Cell

AbstractThe reliable identification of diffuse large B-cell lymphoma (DLBCL)-specific targets owns huge implications for its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are implicated in DLBCL pathogenesis; however, circulating DLBCL-related lncRNAs are barely investigated. We investigated plasma lncRNAs; HOTAIR, Linc-p21, GAS5 and XIST as biomarkers for DLBCL diagnosis and responsiveness to R-CHOP therapy. Eighty-four DLBCL patients and thirty-three healthy controls were included. Only plasma HOTAIR, XIST and GAS5 were differentially expressed in DLBCL patients compared to controls. Pretreatment plasma HOTAIR was higher, whereas GAS5 was lower in non-responders than responders to R-CHOP. Plasma GAS5 demonstrated superior diagnostic accuracy (AUC = 0.97) whereas a panel of HOTAIR + GAS5 superiorly discriminated responders from non-responders by ROC analysis. In multivariate analysis, HOTAIR was an independent predictor of non-response. Among patients, plasma HOTAIR, Linc-p21 and XIST were correlated. Plasma GAS5 negatively correlated with International Prognostic Index, whereas HOTAIR positively correlated with performance status, denoting their prognostic potential. We constructed the lncRNAs-related protein–protein interaction networks linked to drug response via bioinformatics analysis. In conclusion, we introduce plasma HOTAIR, GAS5 and XIST as potential non-invasive diagnostic tools for DLBCL, and pretreatment HOTAIR and GAS5 as candidates for evaluating therapy response, with HOTAIR as a predictor of R-CHOP failure. We provide novel surrogates for future predictive studies in personalized medicine.

scholarly journals UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma

Blood ◽  
2016 ◽  
Vol 127 (12) ◽  
pp. 1564-1574 ◽  
Author(s):  
Tibor Bedekovics ◽  
Sajjad Hussain ◽  
Andrew L. Feldman ◽  
Paul J. Galardy
Keyword(s):  
B Cell ◽  
Germinal Center ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Neuronal Marker ◽  
Large B Cell Lymphoma ◽  
Increased Risk ◽  
Key Points ◽  
Poor Outcomes ◽  
Large B Cell

Key Points The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene-induced transformation of, GCB cells. High levels of UCHL1 identify patients with GC DLBCL with an increased risk for poor outcomes.

scholarly journals Primary Diffuse Large B-cell Lymphoma involving the Mandible

2015 ◽  
Vol 16 (10) ◽  
pp. 840-844 ◽  
Author(s):  
Zeeshan H Ahmad ◽  
Sukumaran Anil ◽  
Abdulsalam S Aljabab ◽  
Ibraheem HM Motabi ◽  
Abdullah Alrashed
Keyword(s):  
B Cell ◽  
Clinical Presentation ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoid Cells ◽  
Large B Cell Lymphoma ◽  
Rare Malignancy ◽  
B Lymphoid ◽  
Immunologic Profile ◽  
Large B Cell

ABSTRACT Lymphomas of the oral cavity are rare and typically present as intraosseous lesions that are most commonly diffuse large B-cell type. Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma histologically characterized by diffuse proliferation of large neoplastic B-lymphoid cells with a nuclear size equal to or exceeding normal histiocytic nuclei. A case of DLBCL of the mandible in an 18 years old male patient is presented. This report discusses this rare malignancy, including clinical presentation, histopathologic features, immunologic profile, treatment and prognosis. Though lymphoma of mandible is rare, it must be considered in differential diagnosis of swellings arising in the region. How to cite this article Alshahrani FAA, Aljabab AS, Motabi IHM, Alrashed A, Anil S. Primary Diffuse Large B-cell Lymphoma involving the Mandible. J Contemp Dent Pract 2015;16(10):840-844.

Primary bone marrow diffuse large B cell lymphoma: a case series and review

2010 ◽  
Vol 90 (7) ◽  
pp. 791-796 ◽  
Author(s):  
Hung Chang ◽  
Yu-Shin Hung ◽  
Tung-Liang Lin ◽  
Po-Nan Wang ◽  
Ming-Chung Kuo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Cell Lymphoma ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Primary Bone Marrow ◽  
Large B Cell

scholarly journals Clinical manifestations of diffuse large B‑cell lymphoma in the skin and subcutaneous tissue a case series study

2020 ◽  
Vol 37 (5) ◽  
pp. 812-816
Author(s):  
Katarzyna Dulik ◽  
Grażyna Kamińska-Winciorek ◽  
Ryszard Swoboda ◽  
Anna Kwiatkowska-Pamula ◽  
Sebastian Giebel
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Subcutaneous Tissue ◽  
Clinical Manifestations ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Case Series Study ◽  
Series Study ◽  
Large B Cell

scholarly journals P024 The mighty mimic: intravascular large b-cell lymphoma masquerading as myositis: a case series

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Maria A Mirza
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Surrounding Tissue ◽  
Affected Area ◽  
Small Vessels ◽  
Large B Cell Lymphoma ◽  
Skin Biopsies ◽  
Large B Cell

Abstract Background/Aims  Intravascular large b-cell lymphoma (IVLBCL) is a rare and aggressive form of extranodal diffuse lymphoma which due to its heterogeneous manifestations is often diagnosed at post mortem. The disease is typically contained within the small vessels thus sparing the surrounding tissue. Indeed, the presentation of the disease will depend on the organ involved with classical involvement of the central nervous system and skin. Methods  We herein report two compelling cases of patients presenting with features of myositis, only to find on muscle biopsy evidence of IVBCL. Biopsy of the affected area and indeed random skin biopsies (RSB) may be a fundamental tool in establishing this elusive diagnosis. Results  Features of the two cases are discussed, along with their various presentations, investigations, treatment and overall trajectory. Conclusion  IVBCL is a rare disease that can present in various ways and often a delay in reaching a diagnosis leads to patient deterioration and death. A multidisciplinary approach involving the microbiologists, rheumatologists and haematologists led to a timely identification of the disease and subsequent management in these two cases. As the disease is characteristically contained within the blood vessels, the diagnosis is normally not confirmed from peripheral blood tests or even bone marrow biopsy. Biopsy of the affected area is what revealed the diagnosis in our two cases. Random skin biopsies may be very useful in establishing the diagnosis when suspecting IVBCL. Treatment may be very effective in controlling the disease as demonstrated by these two cases. Disclosure  M.A. Mirza: None.

scholarly journals Prognosis of Intravascular Large B Cell Lymphoma (IVLBCL): Analysis of 182 Patients from Global Case Series

2020 ◽  
Vol Volume 12 ◽  
pp. 10531-10540
Author(s):  
Ziyue Liu ◽  
Yuelun Zhang ◽  
Yicheng Zhu ◽  
Wei Zhang
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell
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