scholarly journals Effect of influenza vaccine on prevention of acute attack of chronic airway disease in elderly population：a randomized controlled trail.

2021 ◽  
Author(s):  
Kun Gao ◽  
Guangbo Qu ◽  
Cuihong Zhang ◽  
Huaibiao Li ◽  
Liang Sun
Keyword(s):  
Influenza Vaccine ◽  
Elderly Patients ◽  
Influenza Vaccination ◽  
Airway Disease ◽  
Acute Attack ◽  
Outpatient Visits ◽  
Significant Difference ◽  
Chronic Airway Disease ◽  
The Cost ◽  
Chronic Airway

Objective To investigate the effect of influenza vaccination on prevention of acute attack in elderly patients with chronic airway disease, and to provide evidence for the prevention and control strategy of chronic airway disease in elderly population. Methods Elderly patients in Linquan County of Anhui Province of China who under stationary phase of chronic airway disease were selected and randomly vaccinated with tetravalent or trivalent influenza vaccine. The number of patients with acute attack, the number of outpatients with acute attack, the number of outpatients, the number of inpatients, the number of inpatients, the total cost of patients, the cost of outpatients, the cost of hospitalization and the length of hospitalization were collected before vaccination and after one year follow up. Results A total of 348 subjects were included in this study, 248 were vaccinated with trivalent vaccination and 100 were vaccinated with tetravalent vaccination. There was no significant difference in age and sex ratio among two vaccination groups. The ratios of acute attack, outpatient visits and hospitalization, and number of outpatient visits, number of hospitalizations, total medical expenses, outpatient expenses and hospitalization expenses were significantly higher before vaccination than those after vaccination in both trivalent vaccination group and tetravalent vaccination group. While, there was no significant difference in the length of stay between before and after vaccination in neither trivalent vaccination group nor tetravalent vaccination group. The protection effect between trivalent vaccination group and tetravalent vaccination group was not significant. Conclusion Influenza vaccination can effectively prevent the acute attack of chronic airway disease and delay the progress of the chronic airway disease.

scholarly journals Immunogenicity of high-dose influenza vaccination in patients with primary central nervous system malignancy

2018 ◽  
Vol 5 (3) ◽  
pp. 176-183
Author(s):  
Roy E Strowd ◽  
Gregory Russell ◽  
Fang-Chi Hsu ◽  
Annette F Carter ◽  
Michael Chan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Influenza Vaccine ◽  
Elderly Patients ◽  
Influenza Vaccination ◽  
Standard Dose ◽  
High Grade Glioma ◽  
Cns Lymphoma ◽  
High Dose ◽  
Central Nervous System Malignancy

Abstract Background For cancer patients, rates of influenza-associated hospitalization and death are 4 times greater than that of the general population. Previously, we reported reduced immunogenicity to the standard-dose influenza vaccine in patients with central nervous system malignancy. In other poorly responding populations (eg, elderly patients), high-dose vaccination has improved efficacy and immunogenicity. Methods A prospective cohort study was designed to evaluate the immunogenicity of the Fluzone® high-dose influenza vaccine in brain tumor patients. Data on diagnosis, active oncologic treatment, and immunologic status (eg, CD4 count, CD8 count, CD4:CD8 ratio) were collected. All patients received the high-dose vaccine (180 µg). Hemagglutination inhibition titers were measured at baseline, day 28, and 3 months following vaccination to determine seroconversion (≥4-fold rise) and seroprotection (titer ≥1:40), which were compared to our prior results. Results Twenty-seven patients enrolled. Diagnoses included high-grade glioma (85%), CNS lymphoma (11%), and meningioma (4%). Treatment at enrollment included glucocorticoids (n = 8, 30%), radiation (n = 2, 7%), and chemotherapy (n = 9, 33%). Posttreatment lymphopenia (PTL, CD4 ≤ 200) was observed in 4 patients (15%). High-dose vaccination was well tolerated with no grade III-IV toxicity. Overall, seroconversion rates for the A/H1N1, A/H3N2, and B vaccine strains were significantly higher than in our prior study: 65% vs 37%, 69% vs 23%, and 50% vs 23%, respectively (all P < .04). Seroconversion was universally poor in patients with PTL. While seroprotection at 3 months declined in our prior study, no drop was observed following high-dose vaccination in this cohort. Conclusions The immunologic response to HD influenza vaccination was higher in this cohort than standard-dose influenza vaccination in our prior report. These findings mirror those in elderly patients where high-dose vaccination is the standard of care and raise the possibility of an immunosenescence phenotype.

Eosinophilic inflammation and muscle mass in chronic airway disease

2021 ◽  
Author(s):  
Edith Visser ◽  
Kim De Jong ◽  
Tim Van Zutphen ◽  
Huib Kerstjens ◽  
Anneke Ten Brinke
Keyword(s):  
Muscle Mass ◽  
Airway Disease ◽  
Eosinophilic Inflammation ◽  
Chronic Airway Disease ◽  
Chronic Airway

scholarly journals The influence of a community intervention on influenza vaccination knowledge and behavior among diabetic patients

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lili Tao ◽  
Ming Lu ◽  
Xiaoning Wang ◽  
Xiaoyan Han ◽  
Shuming Li ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Community Intervention ◽  
Vaccination Rate ◽  
Control Group ◽  
Diabetic Patients ◽  
Vaccination Rates ◽  
Significant Difference ◽  
The Impact ◽  
Experimental Group

Abstract Background This study was conducted to evaluate the impact of a comprehensive community intervention on cognition and inoculation behaviors of diabetic patients immunized with influenza vaccine. Methods A total of 1538 diabetic patients aged 35 years and above for outpatient visits and follow-up treatments were selected from six community health service centers (three for the experimental group, and the other three for the control group) in Chaoyang District, Beijing. Comprehensive interventions applied to the experimental group include patient intervention and community climate interventions. We compared the total awareness of influenza vaccine knowledge and influenza vaccination rates between the two groups before and after the intervention. Results Before the intervention, the total awareness rate of influenza vaccine in the experimental group and the control group was similar (50.6 and 50.2%, respectively. P = 0.171). After the intervention, the awareness rate of influenza vaccine in the experimental group and the control group increased. The amplitude of the increase was similar (70.3 and 70.1%, respectively. P = 0.822,). Before the intervention, there was no significant difference in the influenza vaccination rate between the experimental group and the control group (29.0 and 26.8%, respectively. P = 0.334). After the intervention, the vaccination rate of the experimental group was higher than that of the control group. The difference was statistically significant (The vaccination rate 45.8 and 27.4% for the experimental group and the control group, respectively. P < 0.001). Conclusion Comprehensive community interventions had a positive effect on vaccination in diabetic patients. Trial registration ChiCTR1900025194, registered in Aug,16th, 2019. Retrospectively registered.

scholarly journals The clinical utility of long-term humidification therapy in chronic airway disease

2010 ◽  
Vol 104 (4) ◽  
pp. 525-533 ◽  
Author(s):  
Harold Rea ◽  
Sue McAuley ◽  
Lata Jayaram ◽  
Jeffrey Garrett ◽  
Hans Hockey ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Airway Disease ◽  
Chronic Airway Disease ◽  
Chronic Airway

Causes of Chronic Airway Disease

CHEST Journal ◽  
1999 ◽  
Vol 115 (1) ◽  
pp. 4-6 ◽  
Author(s):  
Michael C.F. Pain
Keyword(s):  
Airway Disease ◽  
Chronic Airway Disease ◽  
Chronic Airway

Changes in dyspnea, health status, and lung function in chronic airway disease.

1995 ◽  
Vol 151 (1) ◽  
pp. 61-65 ◽  
Author(s):  
D A Mahler ◽  
D Tomlinson ◽  
E M Olmstead ◽  
A N Tosteson ◽  
G T O'Connor
Keyword(s):  
Health Status ◽  
Lung Function ◽  
Airway Disease ◽  
Chronic Airway Disease ◽  
Chronic Airway
Sign in / Sign up

Export Citation Format

Share Document