scholarly journals BCG Induced Cold Abscess as a Complication of Inadvertent Vaccine Injection, a Case Series

2021 ◽  
Author(s):  
Parinaz Sedighi ◽  
Taravat Sadrosadat ◽  
Mahsa Movahedi ◽  
Iraj Sedighi
Keyword(s):  
Case Series ◽  
Final Diagnosis ◽  
Left Thigh ◽  
Bcg Vaccine ◽  
Thigh Muscle ◽  
Vaccine Injection ◽  
Cold Abscess ◽  
Thigh Swelling

We report a four-month-old girl with a right thigh swelling, an eight-month-old girl with a left thigh swelling, and a five-month-old boy with a left thigh swelling with the final diagnosis of BCG-induced cold abscess as a result of erroneous injection of BCG vaccine into the infants’ thigh muscle.

scholarly journals Man With Left Thigh Swelling and Pain

2021 ◽  
Vol 77 (6) ◽  
pp. e117-e118
Author(s):  
Jun Huang ◽  
Li Li ◽  
Tao Wang
Keyword(s):  
Left Thigh ◽  
Thigh Swelling

scholarly journals Epidermolysis Bullosa Acquisita in Children: Case Series

2019 ◽  
Vol 18 (1) ◽  
pp. 56-64
Author(s):  
Nikolay N. Murashkin ◽  
Leonid A. Opryatin ◽  
Alexander I. Materikin ◽  
Eduard T. Ambarchyan ◽  
Roman V. Epishev ◽  
...  
Keyword(s):  
Epidermolysis Bullosa ◽  
Case Series ◽  
Basal Membrane ◽  
Final Diagnosis ◽  
Epidermolysis Bullosa Acquisita ◽  
Type Vii Collagen ◽  
Bullous Dermatosis ◽  
Medical Drug ◽  
Line Drug

Background. Epidermolysis bullosa acquisita (EBA) is chronic disease accompanied with subepidermal blistering on skin and mucous membranes as a result of autoimmune aggression to type VII collagen. EBA diagnostics in children is complicated due to similarity of clinical presentation with other bullous dermatosis in children.Clinical Case Description. The description of three clinical cases of EBA in children is provided. It is shown that for establishing the diagnosis it is necessary to estimate clinical evidence and to define the depth of blisters according to the results of histological examination of skin biopsy sample. Determination of IgG deposition positions relatively to the skin basal membrane due to performed indirect immunofluorescence test helps us to establish final diagnosis and specify patient management. Medical drug Dapsone was used in children with EBA, it has shown to be effective and safe to use as the first-line drug in management of such patients.Conclusion. The algorithm for EBA differential diagnosis with other bullous dermatosis in children is provided. Successful results of medical treatment are described. 

Scar Formation and Tuberculin Conversion Following BCG

2021 ◽  
Vol 15 (11) ◽  
pp. 3056-3057
Author(s):  
Muhammad Sarfraz ◽  
Zahid Jamil ◽  
Muhammad Naim Ashraf ◽  
Saima Arshad ◽  
Zirwa Sarfraz ◽  
...  
Keyword(s):  
Skin Testing ◽  
Case Series ◽  
Operational Definition ◽  
Scar Formation ◽  
Bcg Vaccine ◽  
Base Line ◽  
Positive Skin ◽  
Post Vaccination ◽  
Vaccination Programs ◽  
Bcg Vaccination

Objective: To determine frequency of scar formation and positive tuberculin conversion test following BCG vaccine administered within 0-28 days of life in children in 6 months to 6 years of age presenting at outpatient department of Fauji Foundation Hospital Lahore. Study Design: Descriptive case series. Place and Duration of Study: Outdoor Department of Pediatrics, Fauji Foundation Hospital, Lahore from 1st July 2020 to 30th December 2020. Methodology: Ninety seven children were included. Base line demographic information of patients (age, gender, weight on weight machine) was recorded. 0.5 ml BCG was administered in right arm. Tuberculin skin test was assessed as per operational definition. After 48 to 72 hours, scar formation was assessed after 1 month. Data regarding scar formation and positive tuberculin conversion test was recorded. Results: The mean age was 3.20±1.46 years, 39 (40.21%) were male whereas 58 (59.79%) were females. The scar formation following BCG vaccine administered within 0-28 days of life in children in 6 months to 6 years of age was 59 (60.82%) and positive tuberculin conversion test following BCG vaccine administered within 0-28 days of life in children in 6 months to 6 years was recorded in 47 (48.45%). Conclusion: Most babies have developed a post-vaccination scar. The combination of the BCG scar and the positive skin testing tuberculin was very important. The development of BCG scars had no effect on age or sex. Greater trials are advised in order to detect the true extent of the problem and to evaluate regularly the BCG vaccination programs. Keywords: Infants, Tuberculosis, BCG vaccination, Scar formation, Positive tuberculin conversion test

scholarly journals Scaphoid Fractures below the Age of 10: Case Series and Review of the Literature

2020 ◽  
Vol 9 (06) ◽  
pp. 458-464
Author(s):  
Rachana Tataria ◽  
Jeannette Ting ◽  
Andrea Jester ◽  
Tommy R. Lindau ◽  
Kerstin Oestreich
Keyword(s):  
Pediatric Population ◽  
Age Groups ◽  
Case Series ◽  
Final Diagnosis ◽  
Scaphoid Bone ◽  
Age Group ◽  
Level Of Evidence ◽  
Scaphoid Fractures ◽  
Fractures In Children ◽  
Common Location

Abstract Background Scaphoid fractures are relatively uncommon in children, especially below the age of 10 due to the ossification of the scaphoid bone, which starts around 4 to 6 years of age and continues until 13 to 15 years of age, where pediatric scaphoid fractures peak. This makes the diagnoses challenging in this age group. Methods The primary aim of this study was to analyze prospectively collected data in managing scaphoid fractures. All cases in children up to the age of 10 years, treated in a tertiary pediatric hand and upper limb from January 2014 to June 2018 were included. Parameters studied were patient demographics, clinical presentation, mechanism of injury, investigations, type of fracture, associated injuries, treatment offered, outcomes and complications. The secondary aim was to review the literature due to the limited knowledge about these fractures in these low age groups. Results A total of 23 patients with documented scaphoid fractures in children up to the age of 10 years were found. Final diagnosis in all these patients was done with magnetic resonance imaging (MRI). The mean age was 9.8 years, with female preponderance. Scaphoid waist was the most common location. Five patients had associated fractures of the capitate and one patient had associated second metacarpal base fracture. All patients were managed nonoperatively. The average time of immobilization was 6.6 weeks (range: 4–10 weeks). A majority of patients had minor symptoms after the fracture, most likely due to the immobilization time. Conclusion Scaphoid fractures are rare in the pediatric population up to the age of 10. MRI is most often needed to confirm diagnosis. Nonoperative management of most scaphoid fractures in this age group is safe and feasible with no significant long-term morbidity. Surgical management of scaphoid fractures might be required in very selected cases. Level of Evidence This is a Level IV study.

scholarly journals Cold Abscess of the Thigh in an Infant

2014 ◽  
Vol 11 (1) ◽  
pp. 86-87 ◽  
Author(s):  
D Mishra ◽  
A Mohta ◽  
P Arora
Keyword(s):  
Medical Journal ◽  
Adverse Reactions ◽  
Final Diagnosis ◽  
Rare Association ◽  
Cold Abscess ◽  
Tuberculous Abscess

Local and minor adverse reactions to diphtheria–pertussis–tetanus (DPT) vaccination are usually mild and appear within 48 hours of vaccination. We herein report a rare association with intramuscular DPT injection and discuss pertinent issues. Primary tuberculous abscess was the final diagnosis. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11035 Kathmandu University Medical Journal Vol.11(1) 2013: 86-87

scholarly journals Three female patients with Danon disease presenting with predominant cardiac phenotype: a case series

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Bart A Mulder ◽  
Yvonne M Hoedemaekers ◽  
Maarten P van den Berg ◽  
Rosa L E van Loon ◽  
Anna M Wind ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Accessory Pathway ◽  
Disease Onset ◽  
Case Series ◽  
Final Diagnosis ◽  
Left Ventricular ◽  
Danon Disease ◽  
Female Patients ◽  
Cardiac Phenotype ◽  
Male Patients

Abstract Background Danon disease is a rare X-linked multisystemic disorder that has primarily been described in male patients. Case summary We present three female patients with Danon disease with a predominantly cardiac phenotype in whom disease onset and expression was very different from that of male patients. Case 1 was first admitted for acute heart failure and then readmitted a few months later for cardiac shock, necessitating mechanical support, and heart transplantation. Case 2 had complex arrhythmias for which many antiarrhythmic drugs were tried with only limited success. Her disease accelerated after her first pregnancy, and she showed reduced left ventricular function and dilated cardiomyopathy. Case 3 was referred for near syncope and ablated for an accessory pathway; she had extensive left ventricular hypertrophy. In all three cases, a final diagnosis of Danon disease was only made after genetic testing that identified a causal variant in the lysosome-associated membrane protein 2 gene. Discussion Danon disease in female patients is a challenging diagnosis that may not be identified until genetic testing has been performed.

A COMPARISON BETWEEN 6-POINT DIXON MRI AND MR SPECTROSCOPY TO QUANTIFY MUSCLE FAT IN THE THIGH OF SUBJECTS WITH SARCOPENIA

2018 ◽  
pp. 1-6
Author(s):  
A. GRIMM ◽  
H. MEYER ◽  
M.D. NICKEL ◽  
M. NITTKA ◽  
E. RAITHEL ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
High Speed ◽  
Left Thigh ◽  
Thigh Muscle ◽  
Proton Density ◽  
Resonance Spectroscopy ◽  
Semitendinosus Muscle ◽  
Proton Density Fat Fraction ◽  
Fat Fraction

Background: Changes in muscle fat composition as for example observed in sarcopenia, affect physical performance and muscular function, like strength and power. Objectives: The purpose of this study was to compare 6-point Dixon magnetic resonance imaging and multi-echo magnetic resonance spectroscopy sequences to quantify muscle fat. Setting, participants and measurements: Two groups were recruited (G1: 23 healthy young men (28 ± 4 years), G2: 56 men with sarcopenia (80 ± 5 years)). Proton density fat fraction was measured with a 6-point product and a 6-point prototype Dixon sequence in the left thigh muscle and with a high-speed multi-echo T2*-corrected H1 magnetic resonance spectroscopy sequence within the semitendinosus muscle of the left thigh. To evaluate the comparability among the different methods, Bland-Altman and linear regression analyses of the proton density fat fraction results were performed. Results: Mean differences ± 1.96 * standard deviation between spectroscopy and 6pt Dixon sequences were 1.9 ± 3.3% and 1.5 ± 3.6% for the product and prototype sequences, respectively. High correlations were measured between the proton density fat fraction results of the 6-point Dixon sequences and spectroscopy (R = 0.95 for the product sequence and R = 0.97 for the prototype sequence). Conclusions: Dixon imaging and spectroscopy sequences show comparable accuracy for fat measurements in the thigh. Spectroscopy is a local measurement, whereas Dixon sequences provide maps of the fat distribution. The high correlations of the 6-point Dixon sequences with spectroscopy support their clinical use. They provide higher spatial resolution than spectroscopy, but are not suitable for a more complicated spectral analysis to separate extra- and intramyocellular lipids.

scholarly journals Tuberculous brain abscesses: Case series and review of literature

2011 ◽  
Vol 02 (02) ◽  
pp. 153-157 ◽  
Author(s):  
Sarala Menon ◽  
Renu Bharadwaj ◽  
A.S. Chowdhary ◽  
D.V. Kaundinya ◽  
D.A. Palande
Keyword(s):  
Brain Abscess ◽  
Mr Spectroscopy ◽  
Case Series ◽  
Final Diagnosis ◽  
Diagnostic Dilemma ◽  
Proton Mr Spectroscopy ◽  
Microbiological Culture ◽  
Brain Abscesses ◽  
Tuberculous Brain Abscess

ABSTRACT Introduction: Tuberculous brain abscess (TBA) is a rare but serious condition. It resembles a pyogenic brain abscess clinically and radiologically and poses a problem in diagnosis and treatment. A final diagnosis is established by smear or culture demonstration of acid fast bacilli (AFB) within the abscess. Here, we report four such cases in our fiveyear study on brain abscesses, along with the different diagnostic modalities used. Materials and Methods: A total of 75 brain abscess pus specimens were collected during neurosurgery, either by burr hole or by craniotomy. These specimens were further subjected to Gram stain, Ziehl-Neelsen (ZN) stain, and conventional microbiological culture. Only those cases which showed presence of AFB on ZN stain along with the growth of Mycobacterium tuberculosis were considered as TBAs. Such TBA cases were further presented along with their In vitro Proton Magnetic Resonance (MR) Spectroscopic findings. Results: Of these four patients, three were males. Though this condition is more commonly seen in immunocompromised patients, three of the patients in this study were immunocompetent. All the four pus specimens showed presence of AFB in the ZN stain. Three of them grew M. tuberculosis as sole isolate. The fourth case was of concomitant tuberculous and pyogenic brain abscess. In vitro Proton MR spectroscopy of the pus specimens showed absence of multiple amino acids at 0.9 ppm, which was found to be hallmark of TBA. One patient died of four. Conclusions: TBA always poses a diagnostic dilemma. ZN stain and conventional microbiological culture for Mycobacteria always help to solve this dilemma. In vitro Proton MR Spectroscopy also seems to have the diagnostic utility.

scholarly journals 335. Staphylococcus aureus Bacteremia as a Potential and Severe Complication from Intramuscular COVID-19 Vaccine Injection

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S272-S272
Author(s):  
Miguel Sebastian Pedromingo Kus
Keyword(s):  
Staphylococcus Aureus ◽  
Preventive Measures ◽  
Case Series ◽  
Vaccine Injection ◽  
Staphylococcus Aureus Bacteremia ◽  
Intramuscular Injections ◽  
Vaccine Type ◽  
Rare Side Effect ◽  
Etiological Agents ◽  
The Relationship

Abstract Background Abscess formation and bacteremia following intramuscular injections are rare complications from vaccine injections, and they are most commonly seen in immunocompromised individuals. Staphylococcus aureus is one of the etiological agents that can be found during this complication. Spain started to vaccine its population at the beginning of 2021. We noticed an important increase in Staphylococcus aureus infections and bacteremia during this period of time, leading us to study the relationship with previous vaccination. Methods In this case series we present a cohort of twenty patients with Staphylococcus aureus bacteremia (SAB) during the study period (January 1, 2021 through May 31, 2021), attended in our Institution (Hospital Nuestra Señora de Sonsoles, Ávila, Spain). We tried to establish or at least create the debate of a possible relationship with a previous COVID-19 vaccine. Results From January 1, 2021 through May 31, 2021, 20 SAB were identified in our Institution. 13/20 patients were vaccinated (all of them with the mRNA vaccine type). 5/13 (38%) were male and 8/13 (62%) female. 10 of them (77%) received at least one dose of the vaccine before hospital admission, and 3 of them (23%) after admission. From the 10 previously COVID-19-vaccinated patients treated for SAB (CVPSAB), 4 died - 40% (2 deaths directly related to the SAB). Conclusion Although SAB may be a rare side effect after intramuscular injections or vaccines, it always implies an outstanding risk due to potential complications. Even if our study is not able to directly establish a link between SAB and previous vaccination, it implies a possible association between the vaccine injection and a threating disease (SAB). We should be aware of this probable relationship, so that we can maximize preventive measures. Disclosures All Authors: No reported disclosures

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