scholarly journals Antimicrobial activity of Hypericum annulatum moris and Hypericum elegans stephan ex willd. essential oils from Serbia

2013 ◽  
Vol 19 (1) ◽  
pp. 7-11
Author(s):  
Aleksandra Djordjevic ◽  
Jelena Lazarevic ◽  
Violeta Mitic ◽  
Radosav Palic ◽  
Gordana Stojanovic
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Antibacterial And Antifungal Activity ◽  
Significant Difference ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Hypericum Species

The in vitro antimicrobial activity of Hypericum annulatum and Hypericum elegans essential oils was evaluated against a panel of standardized bacteria and fungi using broth microdilution assay. Both essential oils showed antimicrobial activity against all the tested microorganisms. Hypericum annulatum essential oil showed better antibacterial than antifungal activity, being more effective against Pseudomonas aeruginosa and Escherichia coli while H. elegans essential oil showed no significant difference between antibacterial and antifungal activity. Antimicrobial testing of ?-pinene, ?-pinene and ?-myrcene compounds was also performed. All the compounds were active against all the tested microorganisms, however, based on the MIC, MBC and MFC values, none of these compounds could be thought of as the main bearer of the oils? antimicrobial activity. This is the first report regarding the antimicrobial activity of the essential oils of the two Hypericum species.

scholarly journals Chemical constituents, in vitro antibacterial and antifungal activity of Mentha×Piperita L. (peppermint) essential oils

2019 ◽  
Vol 31 (4) ◽  
pp. 528-533 ◽  
Author(s):  
Nagarjuna Reddy Desam ◽  
Abdul Jabbar Al-Rajab ◽  
Mukul Sharma ◽  
Mary Moses Mylabathula ◽  
Ramachandra Reddy Gowkanapalli ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Mentha Piperita ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

scholarly journals In VitroAntimicrobial Activity of Essential Oil ofThymus schimperi,Matricaria chamomilla,Eucalyptus globulus, andRosmarinus officinalis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Awol Mekonnen ◽  
Berhanu Yitayew ◽  
Alemnesh Tesema ◽  
Solomon Taddese
Keyword(s):  
Antimicrobial Activity ◽  
Minimum Inhibitory Concentration ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibitory Concentration ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Drug Preparation ◽  
Bacteria And Fungi

In this study, thein vitroantimicrobial activities of four plant essential oils (T. schimperi,E. globulus,R. officinalis, andM. Chamomilla) were evaluated against bacteria and fungi. The studies were carried out using agar diffusion method for screening the most effective essential oils and agar dilution to determine minimum inhibitory concentration of the essential oils. Results of this study revealed that essential oils ofT. schimperi,E. globulus, andR. officinaliswere active against bacteria and some fungi. The antimicrobial effect ofM. chamomillawas found to be weaker and did not show any antimicrobial activity. The minimum inhibitory concentration values ofT. schimperiwere<15.75 mg/mL for most of the bacteria and fungi used in this study. The minimum inhibitory concentration values of the other essential oils were in the range of 15.75–36.33 mg/mL against tested bacteria. This study highlighted the antimicrobial activity of the essential oil ofE. globulus,M. chamomilla,T. Schimperi, andR. officinalis. The results indicated thatT. schimperihave shown strong antimicrobial activity which could be potential candidates for preparation of antimicrobial drug preparation.

scholarly journals Antimicrobial Activity of Essential Oils and Solvent Extracts from Zieria species (Rutaceae)

2013 ◽  
Vol 8 (6) ◽  
pp. 1934578X1300800
Author(s):  
Nicholas J. Sadgrove ◽  
Graham L. Jones
Keyword(s):  
Antifungal Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Essential Oil Composition ◽  
Antibacterial And Antifungal Activity ◽  
Oil Composition ◽  
Pharmaceutical Development ◽  
Antibacterial And Antifungal ◽  
Broth Dilution ◽  
Nutraceutical Products

Essential oils were hydrodistilled from six Zieria species, including two previously not investigated: Z. floydii and Z. odorifera subsp. williamsii, and characterized using GC-MS. Additionally, solvent extracts of leaf material from five of these species were prepared using n-hexane, acetone and methanol as solvents, respectively. These solvent extracts were examined, along with essential oils, for antibacterial activity using micro titer plate broth dilution assays. Antifungal activity against pathogenic Trichophyton species responsible for dermal infections such as Tinea and Kangaroo Pox (uncommon), was examined using a similar method. Results of essential oil characterizations are relatively consistent with those previously reported. Interestingly, the essential oil composition of Z. floydii showed car-3-en-2-one at a concentration of 71%, similar to that observed in a previous study for Z. furfuracea and Z. granulata, thus complementing the observations of A.G. Floyd that Z. floydii is morphologically allied with these two species (CANB 598758). Antimicrobial assays demonstrated relatively high antibacterial and antifungal activity, using both essential oils and solvent extracts. This is particularly true for the n-hexane extract from Z. smithii. We therefore conclude that Zieria species may be a useful source for the development of antiseptic, cosmaceutical and/or topical nutraceutical products. In addition, they may well serve as a source of further novel, purified compounds providing scaffolds for pharmaceutical development in the future.

scholarly journals Chemical and Biological Studies of the Essential Oils of Micromelum hirsutum

2007 ◽  
Vol 2 (6) ◽  
pp. 1934578X0700200
Author(s):  
Pham Thi Minh Diep ◽  
Agata Maria Pawlowska ◽  
Pier Luigi Cioni ◽  
Do Huu Nghi ◽  
Le Mai Huong ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Cytotoxic Effect ◽  
In Vitro Assay ◽  
Vitro Assay ◽  
Biological Studies ◽  
Bacteria And Fungi ◽  
Positive Results

Essential oils of the branches and leaves, flowers, and fruits of Micromelum hirsutum (Rutaceae) collected in Vietnam were investigated. Essential oils were obtained by hydrodistillation and analyzed by GC and GC/MS techniques. Essential oils yields were 0.07%, 0.125%, and 0.22% (w/w), respectively, and in each oil 43, 49, and 37 components were identified, comprising 86.0, 86.3, and 96.4% of the total amount, respectively. All the essential oils were screened for antimicrobial activity, showing positive results against various strains of bacteria and fungi. The essential oil of the flowers was also found to have cytotoxic effect against three cancer lines by in vitro assay.

Synthesis, Reactions and Antimicrobial Activity of Thieno[2,3-c]pyridazine Derivatives

2009 ◽  
Vol 2009 (10) ◽  
pp. 593-598 ◽  
Author(s):  
Fatma El Mariah
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Spectroscopic Studies ◽  
Antibacterial And Antifungal Activity ◽  
Pyridazine Derivatives ◽  
Antibacterial And Antifungal ◽  
Synthesis Reactions

The reaction of N1-(un)substituted 4-aminosulfonamide with 6-chloropyridothienopyridazine (5) and 8-chloro-pyrimidothienopyridazine (14) gave 6-substituted aminopyridothienopyridazine (9) and 8-substituted amino-pyrimidothienopyridazine (16) respectively. All of the derivatives have been characterised by analytical and spectroscopic studies and also tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

scholarly journals COMPONENT COMPOSITION OF THE EXTRACTS AND ESSENTIAL OILS FROM THE ALHAGI PERSARUM, GROWING IN UZBEKISTAN AND THEIR ANTIMICROBIAL ACTIVITY

2018 ◽  
pp. 125-132
Author(s):  
Сабир (Sabir) Зарипбаевич (Zaripbaevich) Нишанбаев (Nishanbaev) ◽  
Хайрулла (Khairulla) Мамадиевич (Mamadievich) Бобакулов (Bobakulov) ◽  
Баходир (Bakhodir) Сотволдиевич (Sotvoldievich) Охундедаев (Okhundedaev) ◽  
Собирджан (Sobirjan) Анарматович (Anarmatovich) Сасмаков (Sasmakov) ◽  
Насрулла (Nasrullah) Джалилович (Dzhalilovich) Абдуллаев (Abdullayev) ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oils ◽  
Aerial Part ◽  
Component Composition ◽  
Flowering Period ◽  
Antibacterial And Antifungal Activity ◽  
Hexahydrofarnesyl Acetone ◽  
The Republic ◽  
Antibacterial And Antifungal

The volatile compounds of hexane and benzene extracts were studied by GC-MS analysis, as well as were investigated the composition of essential oils obtained by steam and hydrodistillation from the aerial part of Alhagi persarum Boiss. & Buhse, collected during the flowering period in the Fergana region of the Republic of Uzbekistan. As a result of the studies, 44 components were found in the hexane and benzene extracts, among them the neophytadiene (44.0%), hexahydrofarnesyl acetone (20.5%), phytol (17.1%), dihydroactinidiolide (2.0%), a-thujone (32.1%) and b-thujone (9.8%), camphor (30.5%) are dominated. In the composition of essential oils isolated by steam and hydrodistillation methods, were identified 69 and 56 compounds, respectively. The dominating components are eucalyptol (4.7% and 2.9%), a-thujone (44.0% and 35.3%) and b-thujone (17.1% and 14.3%), camphor (12.7% and 28.2%). In vitro screening for antibacterial and antifungal activity of extracts were carried out, as well as EО from Alhagi persarum. Among the samples studied, EO, obtained by steamdistillation, possesses the highest antimicrobial activity against Bacillus subtilis (15 mm), Staphylococcus aureus (13 mm), Escherichia coli (11 mm) and Candida albicans (8 mm).

scholarly journals Design, synthesis and antimicrobial activity of new biquinoline derivatives

2012 ◽  
Vol 77 (3) ◽  
pp. 279-286 ◽  
Author(s):  
Nirav Shah ◽  
Nimesh Shah ◽  
Manish Patel ◽  
Ranjan Patel
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Efficient Method ◽  
Ethyl Cyanoacetate ◽  
Catalytic Amount ◽  
Antibacterial And Antifungal Activity ◽  
Design Synthesis ◽  
Antibacterial And Antifungal

A simple and efficient method has been developed for the synthesis of some novel biquinoline derivatives bearing a thiazole moiety through a onepot three-component condensation of 2-chlro-3-formylquinolines, ethyl cyanoacetate and ?-enaminone using catalytic amount of piperidine in refluxing ethanol. These molecules were evaluated in vitro for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antibacterial and antifungal activity against all the tested strains.

Synthesis, characterization, and antimicrobial activity of new benzoylthiourea ligands

2009 ◽  
Vol 63 (5) ◽  
Author(s):  
Gülşah Kurt ◽  
Fatih Sevgi ◽  
Bedrettin Mercimek
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

AbstractIn this study, new benzoylthiourea derivatives, (E)-N-[(2-benzamidomethyleneamino)ethylcarbamothioyl]benzamide H3L′, N-(1-(3-benzoylthioureido)propan-2-ylcarbamothioyl)-benzamide H4L″, (E)-N-[4-(benzamidomethyleneamino)phenylcarbamothioyl]benzamide H3L‴, were synthesized. Structures of the compounds were identified by spectroscopic techniques. In addition, all synthesized compounds were evaluated for in vitro antibacterial and antifungal activity. Compound H3L‴ exhibited antibacterial activity.

scholarly journals SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF PYRIMIDINE DERIVATIVES

2019 ◽  
pp. 156-163
Author(s):  
BHAGCHAND JAT ◽  
SWAPNA SANTRA ◽  
PRASANTA KUMAR SANTRA
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
High Performance ◽  
Functional Group ◽  
Analytical Data ◽  
Aromatic Aldehydes ◽  
Antibacterial And Antifungal Activity ◽  
Pyrimidine Derivatives ◽  
Antibacterial And Antifungal

Objectives: Synthesis, characterization, and evaluation of antimicrobial activity of novel pyrimidine derivatives containing O, N, and S in the ring. Methods: Pyrimidine derivatives were prepared in three steps. In the first step, chalcones containing -NO2 functional group were synthesized using Claisen-Schmidt condensation of aromatic aldehydes with 2-acetyl pyridine/3-acetylpyridine in methanol in the presence of aqueous NaOH. In the second step, -NO2 group was reduced to -NH2 group. Resulting compounds containing NH2 functional group were reacted with different dichlorothienopyrimidines and dichlorofuropyrimidines in the presence of N,N-diisopropylethylamine to obtain pyrimidine derivatives.Antibacterial and antifungal activity of pyrimidine derivatives were studied in vitro. Results: Pyrimidine derivatives were synthesized and purified using flash column chromatography. Purity of synthesized pyrimidines was determined by high-performance liquid chromatography. Pyrimidines were characterized by elemental analysis, infrared, nuclear magnetic resonance, and mass spectral analysis. Analytical data of synthesized pyrimidines supported the proposed structures. Significant antibacterial and antifungal activity were observed in the synthesized pyrimidine derivatives. Conclusion: Antibacterial and antifungal activity of the newly synthesized pyrimidine derivatives will definitely inspire future researchers for the preparation of new analogs.

scholarly journals Synthesis and antimicrobial activity of azepine and thiepine derivatives

2015 ◽  
Vol 80 (7) ◽  
pp. 839-852 ◽  
Author(s):  
Nina Bozinovic ◽  
Irena Novakovic ◽  
Sladjana Kostic-Rajacic ◽  
Igor Opsenica ◽  
Bogdan Solaja
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
In Vitro Antimicrobial Activity ◽  
Antibacterial And Antifungal ◽  
Weak Antibacterial Activity

A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The 5H-pyridobenzazepine derivatives showed better antibacterial and antifungal activity than corresponding 5H-dipyridoazepine analogs. Among the synthesized azepines, derivative 8 displayed potent activity against tested bacteria (MIC = 39-78 ?g/mL), while azepine 12 showed promising antifungal activity (MIC = 156-313 ?g/mL). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.

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