scholarly journals COMPONENT COMPOSITION OF THE EXTRACTS AND ESSENTIAL OILS FROM THE ALHAGI PERSARUM, GROWING IN UZBEKISTAN AND THEIR ANTIMICROBIAL ACTIVITY

2018 ◽  
pp. 125-132
Author(s):  
Сабир (Sabir) Зарипбаевич (Zaripbaevich) Нишанбаев (Nishanbaev) ◽  
Хайрулла (Khairulla) Мамадиевич (Mamadievich) Бобакулов (Bobakulov) ◽  
Баходир (Bakhodir) Сотволдиевич (Sotvoldievich) Охундедаев (Okhundedaev) ◽  
Собирджан (Sobirjan) Анарматович (Anarmatovich) Сасмаков (Sasmakov) ◽  
Насрулла (Nasrullah) Джалилович (Dzhalilovich) Абдуллаев (Abdullayev) ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oils ◽  
Aerial Part ◽  
Component Composition ◽  
Flowering Period ◽  
Antibacterial And Antifungal Activity ◽  
Hexahydrofarnesyl Acetone ◽  
The Republic ◽  
Antibacterial And Antifungal

The volatile compounds of hexane and benzene extracts were studied by GC-MS analysis, as well as were investigated the composition of essential oils obtained by steam and hydrodistillation from the aerial part of Alhagi persarum Boiss. & Buhse, collected during the flowering period in the Fergana region of the Republic of Uzbekistan. As a result of the studies, 44 components were found in the hexane and benzene extracts, among them the neophytadiene (44.0%), hexahydrofarnesyl acetone (20.5%), phytol (17.1%), dihydroactinidiolide (2.0%), a-thujone (32.1%) and b-thujone (9.8%), camphor (30.5%) are dominated. In the composition of essential oils isolated by steam and hydrodistillation methods, were identified 69 and 56 compounds, respectively. The dominating components are eucalyptol (4.7% and 2.9%), a-thujone (44.0% and 35.3%) and b-thujone (17.1% and 14.3%), camphor (12.7% and 28.2%). In vitro screening for antibacterial and antifungal activity of extracts were carried out, as well as EО from Alhagi persarum. Among the samples studied, EO, obtained by steamdistillation, possesses the highest antimicrobial activity against Bacillus subtilis (15 mm), Staphylococcus aureus (13 mm), Escherichia coli (11 mm) and Candida albicans (8 mm).

scholarly journals Antimicrobial activity of Hypericum annulatum moris and Hypericum elegans stephan ex willd. essential oils from Serbia

2013 ◽  
Vol 19 (1) ◽  
pp. 7-11
Author(s):  
Aleksandra Djordjevic ◽  
Jelena Lazarevic ◽  
Violeta Mitic ◽  
Radosav Palic ◽  
Gordana Stojanovic
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Antibacterial And Antifungal Activity ◽  
Significant Difference ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Hypericum Species

The in vitro antimicrobial activity of Hypericum annulatum and Hypericum elegans essential oils was evaluated against a panel of standardized bacteria and fungi using broth microdilution assay. Both essential oils showed antimicrobial activity against all the tested microorganisms. Hypericum annulatum essential oil showed better antibacterial than antifungal activity, being more effective against Pseudomonas aeruginosa and Escherichia coli while H. elegans essential oil showed no significant difference between antibacterial and antifungal activity. Antimicrobial testing of ?-pinene, ?-pinene and ?-myrcene compounds was also performed. All the compounds were active against all the tested microorganisms, however, based on the MIC, MBC and MFC values, none of these compounds could be thought of as the main bearer of the oils? antimicrobial activity. This is the first report regarding the antimicrobial activity of the essential oils of the two Hypericum species.

scholarly journals Chemical constituents, in vitro antibacterial and antifungal activity of Mentha×Piperita L. (peppermint) essential oils

2019 ◽  
Vol 31 (4) ◽  
pp. 528-533 ◽  
Author(s):  
Nagarjuna Reddy Desam ◽  
Abdul Jabbar Al-Rajab ◽  
Mukul Sharma ◽  
Mary Moses Mylabathula ◽  
Ramachandra Reddy Gowkanapalli ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Mentha Piperita ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

scholarly journals Composition Chimique Et Activité Antimicrobienne Des Huiles Essentielles De Deux Espèces De Lavande : Lavandula Dentata Spp. Dentata Et Lavandula Peduncultata Spp. Pedunculata

2017 ◽  
Vol 13 (21) ◽  
pp. 293
Author(s):  
Lamia Bachiri ◽  
Mohamed Bammou ◽  
Ghizlane Echchegadda ◽  
Jamal Ibijbijen ◽  
Lhoussaine El Rhaffari ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Aerial Part ◽  
Phytopathogenic Fungi ◽  
Penicillium Expansum ◽  
Antibacterial And Antifungal Activity ◽  
Composition Chimique ◽  
Methanol Fraction ◽  
Aspergillus Brasiliensis ◽  
Antibacterial And Antifungal

The aim of the present work is to compare the chemical composition, antibacterial and antifungal activity of two spontaneous species of lavender "Lavandula stoechas L." and "Lavandula dentata L." in Morocco. A phytochemical screening was performed on the aerial part of invested plants. The qualitative variation was revealed in the secondary metabolites of the species studied. Subsequently, the dosage of the crude organic extracts showed that the polyphenol content was higher in the methanol fraction, with an important yield in L. dentata. Also, the essential oils of the aerial part, obtained by hydrodistillation gave higher yields in L. dentata than L. pedunculata. Finally, tests of the antibacterial and antifungal activity of the essential oils of the two species were performed on four strains of bacterial pathogens (Staphylococcus aureus "Gram+," and Escherichia coli; Klebsiella pneumoniae and Proteus mirabilis which are Gram-), and three phytopathogenic fungi : Rhizopus stolonifer, Aspergillus brasiliensis and Penicillium expansum, The results obtained showed that the essential oil of L. dentata showed a strong antibacterial activity against the studied strains, particularly against S. aureus. While the antifungal activity revealed that L. pedunculata has a remarkable antifungal power against the fungi tested in comparison with L. dentata.

Synthesis, Reactions and Antimicrobial Activity of Thieno[2,3-c]pyridazine Derivatives

2009 ◽  
Vol 2009 (10) ◽  
pp. 593-598 ◽  
Author(s):  
Fatma El Mariah
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Spectroscopic Studies ◽  
Antibacterial And Antifungal Activity ◽  
Pyridazine Derivatives ◽  
Antibacterial And Antifungal ◽  
Synthesis Reactions

The reaction of N1-(un)substituted 4-aminosulfonamide with 6-chloropyridothienopyridazine (5) and 8-chloro-pyrimidothienopyridazine (14) gave 6-substituted aminopyridothienopyridazine (9) and 8-substituted amino-pyrimidothienopyridazine (16) respectively. All of the derivatives have been characterised by analytical and spectroscopic studies and also tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

scholarly journals Screening of Antimicrobial Activity of Siddha drug Kukkiladhi Choornam

2018 ◽  
Vol 10 (1) ◽  
pp. 40-42
Author(s):  
Marimuthu Revathi ◽  
Murugesan Karthikeyan ◽  
Ashok Gnanasekaran ◽  
Ranjith MS
Keyword(s):  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Streptococcus Pyogenes ◽  
Shigella Flexneri ◽  
Salmonella Typhi ◽  
Antibacterial And Antifungal Activity ◽  
Proteus Vulgaris ◽  
Solid Media ◽  
Antibacterial And Antifungal

Plan: Kukkiladhi choornam is one of the Siddha drugs, which has been indicated for its anti-microbial properties. The aim of the present study was to validate the antibacterial and antifungal activity of Kukkiladhi choornam extract against various microorganisms. Preface: The present study examined the in-vitro screening of antimicrobial activity of Siddha drug Kukkiladhi choornam. Methodology: The extracts were tested for antimicrobial activity using agar well diffusion on solid media. The microorganisms used in the present study include Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Shigella flexneri, Proteus vulgaris, and Candida albicans. Outcome: The study revealed that 50µl extract of Kukkiladhichoornam had significant inhibiting activity against Shigellaflexneri (17mm), Streptococcus pyogenes (17mm) and Candida albicans (18mm).

scholarly journals Design, synthesis and antimicrobial activity of new biquinoline derivatives

2012 ◽  
Vol 77 (3) ◽  
pp. 279-286 ◽  
Author(s):  
Nirav Shah ◽  
Nimesh Shah ◽  
Manish Patel ◽  
Ranjan Patel
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Efficient Method ◽  
Ethyl Cyanoacetate ◽  
Catalytic Amount ◽  
Antibacterial And Antifungal Activity ◽  
Design Synthesis ◽  
Antibacterial And Antifungal

A simple and efficient method has been developed for the synthesis of some novel biquinoline derivatives bearing a thiazole moiety through a onepot three-component condensation of 2-chlro-3-formylquinolines, ethyl cyanoacetate and ?-enaminone using catalytic amount of piperidine in refluxing ethanol. These molecules were evaluated in vitro for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antibacterial and antifungal activity against all the tested strains.

scholarly journals Antibacterial and antifungal activity of zinc(II) complexes with some 2-methylbenzimidazole derivatives

2005 ◽  
pp. 231-238 ◽  
Author(s):  
Sanja Podunavac-Kuzmanovic ◽  
Dragoljub Cvetkovic ◽  
Gordana Cetkovic
Keyword(s):  
Antimicrobial Activity ◽  
Inhibitory Concentration ◽  
Complex Structure ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Yeast Growth ◽  
In Vitro Antimicrobial Activity ◽  
Antibacterial And Antifungal ◽  
Candida Pseudotropicalis

Zinc(II) chloride reacts with 2-methylbenzimidazole derivatives to give complexes of the formula ZnL2Cl2-nH2O, where L=2-methylbenzimidazole l-benzyl-2-methylbenzimida-zole and l-(4-methylbenzyl)-2-methylbenzimidazole n=0, 0.5 or 1. All the ligands and their zinc(II) complexes were evaluated for their in vitro antimicrobial activity against Pseudomonas aeruginosa Bacillus sp., Staphylococcus aureus, Sarcina lutea and Candida pseudotropicalis. It was found that the majority of the investigated compounds displayed in vitro antimicrobial activity against very persistent microorganisms, except for the starting ligand, 2-methylbenzimidazole and its zinc(II) complex which were active only against gram-negative bacteria. None of the compounds was significantly effective against Candida pseudotropicalis, except for l-(4-methylbenzyl)-2-methylbenzimidazoleandits complex, which very slightly or slightly inhibited the yeast growth. The minimum inhibitory concentration (MIC) was determined for all the ligands and their complexes. The effect of ligand and complex structure on the antimicrobial activity was discussed.

Synthesis, characterization, and antimicrobial activity of new benzoylthiourea ligands

2009 ◽  
Vol 63 (5) ◽  
Author(s):  
Gülşah Kurt ◽  
Fatih Sevgi ◽  
Bedrettin Mercimek
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

AbstractIn this study, new benzoylthiourea derivatives, (E)-N-[(2-benzamidomethyleneamino)ethylcarbamothioyl]benzamide H3L′, N-(1-(3-benzoylthioureido)propan-2-ylcarbamothioyl)-benzamide H4L″, (E)-N-[4-(benzamidomethyleneamino)phenylcarbamothioyl]benzamide H3L‴, were synthesized. Structures of the compounds were identified by spectroscopic techniques. In addition, all synthesized compounds were evaluated for in vitro antibacterial and antifungal activity. Compound H3L‴ exhibited antibacterial activity.

scholarly journals SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF PYRIMIDINE DERIVATIVES

2019 ◽  
pp. 156-163
Author(s):  
BHAGCHAND JAT ◽  
SWAPNA SANTRA ◽  
PRASANTA KUMAR SANTRA
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
High Performance ◽  
Functional Group ◽  
Analytical Data ◽  
Aromatic Aldehydes ◽  
Antibacterial And Antifungal Activity ◽  
Pyrimidine Derivatives ◽  
Antibacterial And Antifungal

Objectives: Synthesis, characterization, and evaluation of antimicrobial activity of novel pyrimidine derivatives containing O, N, and S in the ring. Methods: Pyrimidine derivatives were prepared in three steps. In the first step, chalcones containing -NO2 functional group were synthesized using Claisen-Schmidt condensation of aromatic aldehydes with 2-acetyl pyridine/3-acetylpyridine in methanol in the presence of aqueous NaOH. In the second step, -NO2 group was reduced to -NH2 group. Resulting compounds containing NH2 functional group were reacted with different dichlorothienopyrimidines and dichlorofuropyrimidines in the presence of N,N-diisopropylethylamine to obtain pyrimidine derivatives.Antibacterial and antifungal activity of pyrimidine derivatives were studied in vitro. Results: Pyrimidine derivatives were synthesized and purified using flash column chromatography. Purity of synthesized pyrimidines was determined by high-performance liquid chromatography. Pyrimidines were characterized by elemental analysis, infrared, nuclear magnetic resonance, and mass spectral analysis. Analytical data of synthesized pyrimidines supported the proposed structures. Significant antibacterial and antifungal activity were observed in the synthesized pyrimidine derivatives. Conclusion: Antibacterial and antifungal activity of the newly synthesized pyrimidine derivatives will definitely inspire future researchers for the preparation of new analogs.

scholarly journals Synthesis and antimicrobial activity of azepine and thiepine derivatives

2015 ◽  
Vol 80 (7) ◽  
pp. 839-852 ◽  
Author(s):  
Nina Bozinovic ◽  
Irena Novakovic ◽  
Sladjana Kostic-Rajacic ◽  
Igor Opsenica ◽  
Bogdan Solaja
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
In Vitro Antimicrobial Activity ◽  
Antibacterial And Antifungal ◽  
Weak Antibacterial Activity

A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The 5H-pyridobenzazepine derivatives showed better antibacterial and antifungal activity than corresponding 5H-dipyridoazepine analogs. Among the synthesized azepines, derivative 8 displayed potent activity against tested bacteria (MIC = 39-78 ?g/mL), while azepine 12 showed promising antifungal activity (MIC = 156-313 ?g/mL). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.

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