scholarly journals Determination of extraction conditions of Ginkgo biloba L. leaves by supercritical CO2 using response surface methodology

2011 ◽  
Vol 65 (2) ◽  
pp. 147-157 ◽  
Author(s):  
Svetlana Milosevic ◽  
Zika Lepojevic ◽  
Zoran Zekovic ◽  
Senka Vidovic
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Response Surface ◽  
Process Parameters ◽  
Ginkgo Biloba ◽  
Supercritical Co2 ◽  
Extraction Yield ◽  
Extraction Time ◽  
Order Polynomial ◽  
Supercritical Carbon

The effects of process parameters on the extraction of Ginkgo biloba L. leaves with supercritical carbon dioxide were investigated. The investigated parameters include particle size (mean particle diameter 0.19, 0.467 and 1.009 mm), solvent flow rate (1.5810-3, 3.2210-3 and 4.1610-3 kg CO2/min) and pressure (100-300 bar), which were obtained by the response surface methodology (RSM) under the following condition ranges: temperature 40-50-60?C, pressure 100-140-180 bar and extraction time of 2-3-4 h at the flow rate of 3.2210-3 kg/min. Based on the experimental results of kinetics of Ginkgo biloba leaves extraction with supercritical carbon dioxide, modeling of the extraction system of Ginkgo biloba-supercritical CO2 was done. Two mathematical models (Reverchon-Sesti Osseo and Sovov?) were applied to correlate the experimental data. RSM was applied to optimize the process parameters of supercritical carbon dioxide extraction of Ginkgo biloba L. leaves. A second-order polynomial response surface equation was developed indicating the effect of variables on Ginkgo biloba extraction yield. The statistical analysis of the experiment indicated that pressure (X1), extraction time (X3), the quadratic of temperature (X22), and the interaction between pressure and extraction time (X1X3), show significant effect on the extraction yield. The results showed that the data were adequately fitted into the second-order polynomial model. It was predicted that the optimum extraction process parameters within the experimental ranges would be the extraction temperature of 52.7?C, the pressure of 184.4 bar, and the extraction time of 3.86 h. Under these conditions, the predicted extraction yield is 2.39% (g/100 g drug).

scholarly journals Determination of Oleanolic and Ursolic Acids inHedyotis diffusaUsing Hyphenated Ultrasound-Assisted Supercritical Carbon Dioxide Extraction and Chromatography

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Ming-Chi Wei ◽  
Yu-Chiao Yang ◽  
Show-Jen Hong
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
High Performance ◽  
Extraction Yield ◽  
Extraction Time ◽  
Different Temperatures ◽  
Ultrasound Assisted ◽  
High Concentrations ◽  
Static Extraction ◽  
Supercritical Carbon

Oleanolic acid (OA) and ursolic acid (UA) were extracted fromHedyotis diffusausing a hyphenated procedure of ultrasound-assisted and supercritical carbon dioxide (HSC–CO2) extraction at different temperatures, pressures, cosolvent percentages, and SC–CO2flow rates. The results indicated that these parameters significantly affected the extraction yield. The maximal yields of OA (0.917 mg/g of dry plant) and UA (3.540 mg/g of dry plant) were obtained at a dynamic extraction time of 110 min, a static extraction time of 15 min, 28.2 MPa, and 56°C with a 12.5% (v/v) cosolvent (ethanol/water = 82/18, v/v) and SC–CO2flowing at 2.3 mL/min (STP). The extracted yields were then analyzed by high performance liquid chromatography (HPLC) to quantify the OA and UA. The present findings revealed thatH. diffusais a potential source of OA and UA. In addition, using the hyphenated procedure for extraction is a promising and alternative process for recovering OA and UA fromH. diffusaat high concentrations.

scholarly journals Process optimization for the supercritical carbondioxide extraction of lycopene from ripe grapefruit (Citrus paradisi) endocarp

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Supriya Priyadarsani ◽  
Avinash Singh Patel ◽  
Abhijit Kar ◽  
Sukanta Dash
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Flow Rate ◽  
Polynomial Regression ◽  
Operating Parameter ◽  
Extraction Yield ◽  
Extraction Time ◽  
Citrus Paradisi ◽  
Polynomial Regression Models ◽  
Supercritical Carbon

AbstractIn this study, an underutilized citrus family fruit named grapefruit was explored for the extraction of lycopene using supercritical carbon dioxide (CO2) extraction technique. An experimental design was developed using response surface methodology to investigate the effect of supercritical carbon dioxide (CO2) operating parameter viz., pressure, temperature, CO2 flow rate, and extraction time on the extraction yield of lycopene yield from grapefruit. A total of 30 sets of experiments were conducted with six central points. The statistical model indicated that extraction pressure and extraction time individually, and their interaction, significantly affected the lycopene yield. The central composite design showed that the polynomial regression models developed were in agreement with the experimental results, with R2 of 0.9885. The optimum conditions for extraction of lycopene from grapefruit were 305 bar pressure, 35 g/min CO2 flow rate, 135 min of extraction time, and 70 °C temperature.

scholarly journals Extraction of β-sitosterol from Swietenia mahagoni seeds by using supercritical carbon dioxide (SC-CO2) extraction

2018 ◽  
Vol 14 (3) ◽  
pp. 411-417
Author(s):  
Nur Salsabila Md Norodin ◽  
Liza Md Salleh ◽  
Siti Machmudah ◽  
Nik Musaadah Mustafa ◽  
Hartati Hartati ◽  
...  
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Response Surface Methodology ◽  
Supercritical Carbon Dioxide ◽  
Response Surface ◽  
Oil Yield ◽  
High Concentration ◽  
Order Polynomial ◽  
Swietenia Mahagoni ◽  
Supercritical Carbon

This work investigates the effect of supercritical carbon dioxide (SC-CO2) extraction conditions (pressure and temperature) on the oil yield and β-sitosterol content extracted from Swietenia mahagoni seeds by using response surface methodology (RSM). The experimental data obtained were fitted to a second-order polynomial model and the obtained oil yields were 1.49-14.45%, while β-sitosterol content obtained were 3.12-9.20 mg/g. The best conditions within the ranges studied were 30 MPa and 40°C to extract β-sitosterol in the highest amount. The present findings show that S. mahagoni seeds extract has a high concentration of β-sitosterol.

scholarly journals Extraction of Cecropia Pachystachya Leaves by Supercritical Carbon Dioxide: Kinetics, Phytochemical Characterization, Antibacterial and Antioxidant Activities

2020 ◽  
Vol 8 (4) ◽  
pp. 570
Author(s):  
Jaqueline Hoscheid ◽  
Joice Karina Otenio ◽  
Emerson Luiz Botelho Lourenço ◽  
Elissandro Jair Klein ◽  
Camila Da Silva ◽  
...  
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Co2 ◽  
Antioxidant Activities ◽  
Extraction Yield ◽  
Pharmacological Activities ◽  
Supercritical Fluid Technology ◽  
Carbon Dioxide Co2 ◽  
Supercritical Carbon

Cecropia pachystachya Trécul is popularly known in Brazil as embaúva or embaúba. Pharmacological activities were reported in extant studies including the development of anxiolytic, antidepressant, hypoglycemic, antioxidant, cardiotonic, sedative, anti-inflammatory, antimicrobial and leishmanicidal properties for aqueous and alcoholic extracts prepared by infusion or maceration of C. pachystachya leaves. However, there is a paucity of studies examining extracts of leaves of C. pachystachya obtained by supercritical fluid technology. This study evaluated the extraction of Cecropia pachystachya oil using supercritical carbon dioxide (CO2). Extractions were performed at 35 °C, 45 °C, and 55 °C and 14 MPa, 17 MPa, and 20 MPa. The extraction yield, characteristics of the oil, antioxidant and antibacterial potentials were evaluated. The highest extraction yield obtained from C. pachystachya leaves was 1.48% using supercritical CO2 at 55 °C and 20 MPa. The main identified compounds include terpenoids (ursolic and pomolic acids, squalene and β-sitosterol). The most promising results for antibacterial activity relative to Staphylococcus aureus and antioxidant potentials were observed on the extract obtained at 55 °C and 14 MPa. The mathematical Sovová model satisfactorily represented the experimental data.

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