scholarly journals The role of cytological evaluation of pleural fluid in diagnosing malignant mesothelioma

2012 ◽  
Vol 65 (1-2) ◽  
pp. 5-8
Author(s):  
Aleksandra Lovrenski ◽  
Milana Panjkovic ◽  
Dragana Tegeltija ◽  
Ljiljana Tadic-Latinovic ◽  
Jelena Krcedinac
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Malignant Mesothelioma ◽  
Lung Diseases ◽  
Clinical Symptoms ◽  
X Rays ◽  
Malignant Cells ◽  
Cytological Evaluation ◽  
Low Sensitivity

Malignant mesothelioma is the most significant pleural tumour and it can be divided into three types: epithelial, sarcomatoid and biphasic mesothelioma. The most significant clinical manifestation of this tumour is pleural effusion. This paper was aimed at determining the role of cytological evaluation of pleural fluid in the diagnosis of malignant mesothelioma. This retrospective study included 33 medical records of patients with pleural malignant mesothelioma referred to the Institute for Lung Diseases of Vojvodina, in Sremska Kamenica in the period from 2004 to 2009. In 24 out of 33 patients, x-rays confirmed pleural effusion, thoracentesis was performed and specimens of effusion were cytologically examined at the Department of Pathology of the Institute for Lung Diseases of Vojvodina. Forty-nine cytological examinations were done. Only 2 of the first specimens were positive for malignant cells and 6 were suspicious. In repeated cytological examinations, 5 out of 6 initially suspicious specimens were positive for malignant cells, and the remaining 1 was negative. To sum up, 7 of 49 cytological examinations were positive and the sensitivity of our cytological study for the diagnosis of malignancy was 29%. Due to the low sensitivity of the cytological examinations, it has been recommended to perform biopsy of the pleura for definitive diagnosis in every patient with clinical symptoms and suspicious radiography.

scholarly journals Pleural Fluid Mesothelin as an Adjunct to the Diagnosis of Pleural Malignant Mesothelioma

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Jenette Creaney ◽  
Amanda Segal ◽  
Nola Olsen ◽  
Ian M. Dick ◽  
A. W(Bill) Musk ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Clinical Diagnosis ◽  
Malignant Mesothelioma ◽  
Definitive Diagnosis ◽  
Malignant Cells ◽  
Clinical Value ◽  
Clinical Role ◽  
Pleural Malignant Mesothelioma ◽  
Malignant Diagnosis

Rationale. The diagnosis of pleural malignant mesothelioma (MM) by effusion cytology may be difficult and is currently controversial. Effusion mesothelin levels are increased in patients with MM but the clinical role of this test is uncertain.Objectives. To determine the clinical value of measuring mesothelin levels in pleural effusion supernatant to aid diagnosis of MM.Methods and Measurements. Pleural effusion samples were collected prospectively from 1331 consecutive patients. Mesothelin levels were determined by commercial ELISA in effusions and their relationship to concurrent pathology reporting and final clinical diagnosis was determined.Results. 2156 pleural effusion samples from 1331 individuals were analysed. The final clinical diagnosis was 183 MM, 436 non-MM malignancy, and 712 nonmalignant effusions. Effusion mesothelin had a sensitivity of 67% for MM at 95% specificity. Mesothelin was elevated in over 47% of MM cases in effusions obtained before definitive diagnosis of MM was established. In the setting of inconclusive effusion cytology, effusion mesothelin had a positive predictive value of 79% for MM and 94% for malignancy.Conclusions. A mesothelin-positive pleural effusion, irrespective of the identification of malignant cells, indicates the likely presence of malignancy and adds weight to the clinical rationale for further investigation to establish a malignant diagnosis.

CLINICAL SYMPTOMS, BIOCHEMISTRY AND CYTOLOGY OF PLEURAL, PERITONEAL EFFUSIONS

2016 ◽  
pp. 66-71
Author(s):  
Van Mao Nguyen ◽  
Huyen Quynh Trang Pham
Keyword(s):  
Pleural Effusion ◽  
Clinical Symptoms ◽  
Cross Sectional Study ◽  
Malignant Cells ◽  
Sectional Study ◽  
Pleural Effusions ◽  
Cross Sectional ◽  
Breath Sounds ◽  
Peritoneal Effusion ◽  
Neutrophil Leukocytes

Background: The cytology and the support of clinical symptoms, biochemistry for diagnosis of the cases of effusions are very important. Objectives: - To describe some of clinical symptoms and biochemistry of effusions. - To compare the results between cytology and biochemistry by the causes of pleural, peritoneal fluids. Material & Method: A cross-sectional study to describe all of 47 patients with pleural, peritoneal effusions examinated by cytology in the Hospital of Hue University of Medicine and Pharmacy from April 2013 to January 2014. Results: In 47 cases with effusions, pleural effusion accounting for 55.32%, following peritoneal effusions 29.79% and 14.89% with both of them. The most common symptoms in patients with pleural effusions were diminished or absent tactile fremitus, dull percussion, diminished or absent breath sounds (100%), in patients with peritoneal effusions was ascites (95.24%). 100% cases with pleural effusions, 50% cases with peritoneal effusions and 80% cases with pleural and peritoneal effusions were exudates. The percentage of malignant cells in patients with pleural effusions was 26.92%, in peritoneal effusions was 28.57%, in pleural and peritoneal effusions was 42.86%. The percentage of detecting the malignant cells in patients with suspected cancer in the first test was 57.14%, in the second was 9.53% and 33.33% undetectable. Most of cases which had malignant cells and inflammatory were exudates, all of the cases which had a few cells were transudates. Besides, 7.5% cases which had high neutrophil leukocytes were transudates. Conclusion: Cytology should be carry out adding to the clinical examinations and biochemistry tests to have an exact diagnosis, especially for the malignant ones. For the case with suspected cancer, we should repeat cytology test one more time to increase the ability to detect malignant cells. Key words: Effusion, pleural effusion, peritoneal effusion, cytology, biochemistry

scholarly journals The relation of the pleural thickening in tuberculosis pleurisy with the activity of adenosine deaminase

2005 ◽  
Vol 63 (2) ◽  
Author(s):  
B. Uskul ◽  
H. Turker ◽  
C. Ulman ◽  
M. Ertugrul ◽  
A. Selvi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Clinical Findings ◽  
X Rays ◽  
Biochemical Tests ◽  
Pleural Thickening ◽  
Group I ◽  
Immunological Mechanisms ◽  
Tuberculosis Pleurisy

Selvi, A. Kant, S. Arslan, M. Ozgel. Background: Residual pleural thickening (RPT) still occurs in most patients with tuberculosis pleurisy despite advances in the treatment of tuberculosis. The aim of this study was to evaluate the significance of RPT in tuberculosis pleurisy with the patients clinical findings, biochemical and microbiological properties of pleural effusion and with the total adenosine deaminase (ADA) and isoenzymes levels. Methods: 121 tuberculosis pleurisy patients were evaluated retrospectively. According to posteroanterior chest x-rays, the 63 (52%) cases with the thickness 2 mm or more in lower lateral hemithorax were grouped as I and the 58 (48%) cases without pleural thickness were grouped as II. The amount of pleural effusion was classified into small, medium or massive according to their chest x-rays. In both groups; sex, age, symptoms score, bacteriological and biochemical tests and ADA levels were recorded. Results: 81 (67%) male and 40 (33%) female, overall 121 patients were enrolled into the study. RPT was found higher in males (p=0.014) and the increase ran parallel with the amount of cigarette smoking (p=0.014). RPT was found to be lower in small effusions (p=0.001). The group with RPT, the serum albumin was found lower (p=0.002), pleural fluid total protein (p=0.047) and the ratio of pleural fluid protein to serum protein (p=0.002) were found higher. In group I, total ADA: 69.5±38.9 IU/L and ADA2: 41.3±31.6 IU/L were higher than the cases without RPT (p=0.032, p=0.017, respectively). Conclusions: We suggest that the immunological mechanisms are effective in the development of pleural thickening.

The role of CT in the diagnosis of sacro-iliitis

1998 ◽  
Vol 39 (3) ◽  
pp. 265-268 ◽  
Author(s):  
M. Geijer ◽  
H. Sihlbom ◽  
J. H. Göthlin ◽  
E. Nordborg
Keyword(s):  
Clinical Symptoms ◽  
Conventional Radiography ◽  
Symptom Duration ◽  
Radiological Findings ◽  
Early Start ◽  
Early Course ◽  
Low Sensitivity ◽  
Higher Sensitivity ◽  
Made In

Objective: Ankylosing spondylitis is a progressive, debilitating disease in which early diagnosis and early treatment can improve the prognosis. Radiographic confirmation is essential for diagnosis but conventional radiography has not proved useful, particularly in the early course of the disease. The aims of this study were to correlate the findings at conventional radiography with those at CT, and to correlate the duration of clinical symptoms with the radiological findings Material and Methods: Forty patients with clinical sacro-iliitis and 13 controls were evaluated by means of conventional radiography and CT Results: Conventional radiography was positive in 10/40 patients and CT in 30/40 patients. Conventional radiography was positive in only 2/14 patients with a symptom duration of less than 2 years while CT was positive in 10/14 such patients Conclusion: The study demonstrated a considerably higher sensitivity in CT than in conventional radiography in detecting the subtle changes necessary for the radiological diagnosis of sacro-iliitis, particularly in cases of short duration. CT allows an early start to be made in treatment with a consequently improved prognosis. The use of conventional radiography cannot be recommended because its low sensitivity delays diagnosis in many instances

The diagnostic role of pleural fluid and serum Pentraxin-3 levels in the determination of the etiology of pleural effusion

2017 ◽  
Author(s):  
Fatma Çiftci ◽  
Gulden Bilgin ◽  
Ayse Naz Ozcan ◽  
Ozlem Dogan ◽  
Aycan Yuksel ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Pentraxin 3 ◽  
Diagnostic Role

scholarly journals P3.03-009 Role of microRNAs as Biomarkers of Malignant Mesothelioma in Patients with Pleural Effusion

2017 ◽  
Vol 12 (1) ◽  
pp. S1348-S1349
Author(s):  
Alessandro Palleschi ◽  
Valentina Bollati ◽  
Chiara Favero ◽  
Carolina Mensi ◽  
Claudia Bareggi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Mesothelioma

Role of adenosine deaminase in pleural fluid in tubercular pleural effusion

2018 ◽  
Vol 13 (4) ◽  
pp. 163 ◽  
Author(s):  
SuchitaDilip Modi ◽  
AnilKalyandas Agrawal ◽  
ArvindS Bhake ◽  
VikasR Agrawal
Keyword(s):  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid

scholarly journals Diagnostic Performance of Xpert MTB/RIF in Tuberculous Pleural Effusion: Systematic Review and Meta-analysis

2016 ◽  
Vol 54 (4) ◽  
pp. 1133-1136 ◽  
Author(s):  
Inderpaul Singh Sehgal ◽  
Sahajal Dhooria ◽  
Ashutosh Nath Aggarwal ◽  
Digambar Behera ◽  
Ritesh Agarwal
Keyword(s):  
Systematic Review ◽  
Pleural Effusion ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Reference Standard ◽  
Tuberculous Pleural Effusion ◽  
Low Sensitivity ◽  
Composite Reference Standard

A systematic review investigating the role of Xpert MTB/RIF in the diagnosis of tuberculous pleural effusion (TPE) was conducted. The pooled sensitivities and specificities of Xpert MTB/RIF were 51.4% and 98.6%, respectively, with culture used as a reference standard and 22.7% and 99.8%, respectively, with a composite reference standard (CRS) used as the benchmark. Xpert MTB/RIF has low sensitivity but excellent specificity in the diagnosis of TPE.

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