scholarly journals Supplementation with three macular carotenoids in patients with early stage age-related macular degeneration

2019 ◽  
Vol 72 (9-10) ◽  
pp. 291-296
Author(s):  
Sandra Jovanovic ◽  
Sofija Davidovic ◽  
Aleksandar Miljkovic ◽  
Milica Atanackovic-Krstonosic ◽  
Darija Sazdanic ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Contrast Sensitivity ◽  
Early Stage ◽  
Visual Quality ◽  
Age Related Macular Degeneration ◽  
Visual Performance ◽  
Early Age ◽  
Age Related ◽  
Glare Sensitivity

Introduction. Macula lutea is the central part of the retina and it houses carotenoid macular pigments - lutein, zeaxanthin, and meso-zeaxanthin. It is considered that carotenoids can prevent or slow down the progression of the early age-related macular degeneration in some patients. Therefore, the aim of this study was to examine the effects of supplementation with all three macular pigments on vision quality in patients with early agerelated macular degeneration. Material and Methods. This prospective study included 15 patients (25 eyes in total) with early age-related macular degeneration. All visual tests - visual acuity, glare sensation and contrast sensitivity, were performed at baseline and after 6 months of continuous supplementation with 10 mg lutein, 2 mg zeaxanthin, and 10 mg mesozeaxanthin. Results. The results showed that glare sensitivity improved in 20% of cases. Most of the examined eyes (76%) presented without visual acuity deterioration. Similar results were obtained for the contrast sensitivity test, where in 80% of cases vision quality remained stable or improved. There were no statistically significant differences between average values of examined parameters at baseline and after 6 months of supplementation. Conclusion. In most of the examined eyes (over 75%) visual quality remained stable or improvement of measured parameters was observed. This type of supplementation may improve visual performance or its preservation in patients with early age-related macular degeneration.

Visual acuity and contrast sensitivity in patients with neovascular age-related macular degeneration

2003 ◽  
Vol 241 (12) ◽  
pp. 968-974 ◽  
Author(s):  
Caren Bellmann ◽  
Kristina Unnebrink ◽  
Gary S. Rubin ◽  
Daniel Miller ◽  
Frank G. Holz
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Contrast Sensitivity ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration

2016 ◽  
Vol 95 (4) ◽  
pp. e270-e277 ◽  
Author(s):  
Graham F. Merry ◽  
Marion R. Munk ◽  
Robert S. Dotson ◽  
Michael G. Walker ◽  
Robert G. Devenyi
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Contrast Sensitivity ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Visual Function and Macular Carotenoid Changes in Eyes with Retinal Drusen—An Open Label Randomized Controlled Trial to Compare a Micronized Lipid-Based Carotenoid Liquid Supplementation and AREDS-2 Formula

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3271
Author(s):  
Pinakin Gunvant Davey ◽  
Thomas Henderson ◽  
Drake W. Lem ◽  
Rebecca Weis ◽  
Stephanie Amonoo-Monney ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Contrast Sensitivity ◽  
Dark Adaptation ◽  
Age Related Macular Degeneration ◽  
Visual Performance ◽  
Control Group ◽  
Open Label ◽  
Treatment Groups ◽  
Age Related ◽  
Retinal Drusen

Purpose: To compare the changes in visual and ocular parameters in individuals with retinal drusen who were treated with two commercially available nutritional supplements. Methods: An open-label, single-center, randomized, parallel-treatment with an observational control group design was utilized. The treatment groups included individuals with fine retinal drusen sub-clinical age-related macular degeneration (AMD), while the control group consisted of ocular normal individuals. The treatment groups were randomly assigned to the micronized lipid-based carotenoid supplement, Lumega-Z (LM), or the PreserVision Age-Related Eye Disease Study 2 (AREDS-2) soft gel (PV). Visual performance was evaluated using the techniques of visual acuity, dark adaptation recovery and contrast sensitivity, at baseline, three months, and six months. Additionally, the macular pigment optical density (MPOD) was measured. The control group was not assigned any carotenoid supplement. The right eye and left eye results were analyzed separately. Results: Seventy-nine participants were recruited for this study, of which 68 qualified and 56 participants had useable reliable data. Of the individuals who completed this study, 25 participants belonged to the LM group, 16 belonged to the PV group, and 15 to the control group. The LM group demonstrated statistically significant improvements in contrast sensitivity function (CSF) in both eyes at six months (p < 0.001). The LM group displayed a positive linear trend with treatment time in CSF (p < 0.001), with benefits visible after just three months of supplementation. Although there was a trend showing improvement in CSF in the PV group, the change was not significant after a Bonferroni-corrected p-value of p < 0.00625. Visual acuity, dark adaptation recovery and MPOD did not significantly improve in either treatment groups. Conclusion: The LM group demonstrated greater and faster benefits in visual performance as measured by CSF when compared to the PV group. This trial has been registered at clinicaltrials.gov (NCT03946085).

Relationship between macular pigment and visual acuity in eyes with early age-related macular degeneration

2013 ◽  
Vol 91 (4) ◽  
pp. e298-e303 ◽  
Author(s):  
María C. Puell ◽  
Catalina Palomo-Alvarez ◽  
Ana R. Barrio ◽  
Fernando J. Gómez-Sanz ◽  
María Jesús Pérez-Carrasco
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Age Related

scholarly journals Visual Function and Patient Satisfaction with Multifocal Intraocular Lenses in Patients with Glaucoma and Dry Age-Related Macular Degeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Carmen Sánchez-Sánchez ◽  
Laureano A. Rementería-Capelo ◽  
Beatriz Puerto ◽  
Cristina López-Caballero ◽  
Aida Morán ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Contrast Sensitivity ◽  
Visual Function ◽  
Intraocular Lenses ◽  
Age Related Macular Degeneration ◽  
Multifocal Intraocular Lenses ◽  
Age Related ◽  
Increased Risk ◽  
Preperimetric Glaucoma

Purpose. To report visual function and self-reported satisfaction of patients with glaucoma and dry age-related macular degeneration (dAMD) implanted with multifocal intraocular lenses (MIOL). Methods. Patients with glaucoma or dAMD as well as healthy individuals implanted with MIOL were invited to participate. Explorations performed were uncorrected and corrected distance visual acuity (UDVA and CDVA), low-contrast visual acuity (LCVA), binocular contrast sensitivity, and defocus curves. Patients completed the Catquest-9 questionnaire and reported on the presence of dysphotopsias and the need for spectacles. Results. 38 subjects were included: 11 in the healthy/control group and 9 each in the preperimetric glaucoma, perimetric glaucoma, and dAMD groups. Controls had statistically better monocular UDVA, CDVA, and LCVA than patients with glaucoma and dAMD, as well as better binocular acuity in the defocus curves between −2.00 D and +0.50 D. Differences between controls and patients with preperimetric glaucoma were not statistically significant. Between −3.0 D and +0.5 D, all groups except dAMD achieved acuities better than 0.2 logMAR. Patients with dAMD had worse contrast sensitivity than all others for 3 cycles per degree (cpd), and patients with glaucoma had worse values than all others for 12 cpd; other differences did not reach statistical significance. Healthy subjects and patients with preperimetric glaucoma perceived halos more often than patients with glaucoma or dAMD, while suffering less from glare. Patients with glaucoma and dAMD found more difficulties when driving at night and required spectacles for near more often than the other subjects. Patients with dAMD were less satisfied with their vision. Conclusions. MIOLs may be implanted in patients with preperimetric glaucoma with little fear of patient dissatisfaction. In glaucoma and dAMD, MIOLs might be considered with caution, after explaining the increased risk of glare and the higher need for spectacle correction for reading.

scholarly journals Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration

2012 ◽  
Vol 53 (11) ◽  
pp. 7310 ◽  
Author(s):  
María C. Puell ◽  
Ana R. Barrio ◽  
Catalina Palomo-Alvarez ◽  
Fernando J. Gómez-Sanz ◽  
Amaya Clement-Corral ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Age Related

scholarly journals A Longitudinal Follow-Up Study of Saffron Supplementation in Early Age-Related Macular Degeneration: Sustained Benefits to Central Retinal Function

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
M. Piccardi ◽  
D. Marangoni ◽  
A. M. Minnella ◽  
M. C. Savastano ◽  
P. Valentini ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Open Label ◽  
Macular Function ◽  
Age Related ◽  
Baseline Values ◽  
Reciprocal Value

Objectives. In a previous randomized clinical trial (Falsini et al. (2010)), it was shown that short-term Saffron supplementation improves retinal flicker sensitivity in early age-related macular degeneration (AMD). The aim of this study was to evaluate whether the observed functional benefits from Saffron supplementation may extend over a longer follow-up duration.Design. Longitudinal, interventional open-label study.Setting. Outpatient ophthalmology setting.Participants. Twenty-nine early AMD patients (age range: 55–85 years) with a baseline visual acuity >0.3.Intervention. Saffron oral supplementation (20 mg/day) over an average period of treatment of 14 (±2) months.Measurements. Clinical examination and focal-electroretinogram-(fERG-) derived macular (18°) flicker sensitivity estimate (Falsini et al. (2010)) every three months over a followup of 14 (±2) months. Retinal sensitivity, the reciprocal value of the estimated fERG amplitude threshold, was the main outcome measure.Results. After three months of supplementation, mean fERG sensitivity improved by 0.3 log units compared to baseline values (P<0.01), and mean visual acuity improved by two Snellen lines compared to baseline values (0.75 to 0.9,P<0.01). These changes remained stable over the follow-up period.Conclusion. These results indicate that in early AMD Saffron supplementation induces macular function improvements from baseline that are extended over a long-term followup.

Near-infrared fundus autofluorescence in early age-related macular degeneration

2019 ◽  
Vol 30 (6) ◽  
pp. 1448-1453
Author(s):  
Maurizio Battaglia Parodi ◽  
Pierluigi Iacono ◽  
Alexandros Papayannis ◽  
Giorgio Alto ◽  
Alessio Buzzotta ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Short Wavelength ◽  
Near Infrared ◽  
Fundus Autofluorescence ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Corrected Visual Acuity ◽  
Age Related ◽  
Best Corrected Visual Acuity

Purpose: To describe the patterns on near-infrared fundus autofluorescence in eyes affected by early age-related macular degeneration. Design: Cross-sectional observational case series. Participants: A total of 84 eyes of 84 patients suffering from early age-related macular degeneration (>63 μm but <125 μm drusen and no-to-mild retinal pigment epithelium abnormalities) were enrolled. Methods: Patients underwent best-corrected visual acuity, biomicroscopy, infrared reflectance, short-wavelength fundus autofluorescence, and near-infrared fundus autofluorescence. Eyes were classified according to different patterns of near-infrared fundus autofluorescence. Main outcome was definition of relative prevalence and features of each near-infrared fundus autofluorescence pattern; secondary outcomes were correlation between near-infrared fundus autofluorescence and short-wavelength fundus autofluorescence and between near-infrared fundus autofluorescence patterns and best-corrected visual acuity. Results: Four different patterns of near-infrared fundus autofluorescence identified: normal foveal signal (Pattern A, 7%); normal foveal signal with hyperautofluorescent/hypoautofluorescent spots not involving the fovea (Pattern B, 65.5%); hyperautofluorescent/hypoautofluorescent spots involving the fovea (Pattern C, 15.5%); patchy pattern (Pattern D, 12%). best-corrected visual acuity was lower in eyes with foveal signal alteration (Patterns C and D). Conclusion: Near-infrared fundus autofluorescence pattern in early age-related macular degeneration might be suggestive of visual function deterioration when the fovea is involved. Longitudinal studies are warranted to confirm our preliminary results.

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