scholarly journals Laparoscopic enucleation of a neuroendocrine tumor at the back wall of the pancreas - case report and literature review

2020 ◽  
pp. 115-115
Author(s):  
Dragan Eric ◽  
Vladimir Milosavljevic ◽  
Boris Tadic ◽  
Dragan Gunjic ◽  
Milos Bjelovic
Keyword(s):  
Neuroendocrine Tumor ◽  
Histopathological Examination ◽  
Incidental Finding ◽  
Pancreatic Neuroendocrine Tumor ◽  
Dorsal Side ◽  
The Body ◽  
Diagnostic Challenge ◽  
Back Wall ◽  
Efficient Manner ◽  
Laparoscopic Enucleation

Introduction Introduction. Neuroendocrine tumors of the pancreas are rare neoplasms. They are divided into two groups: functional and non-functional. Non-functional tumors represent a diagnostic challenge, given that they often remain asymptomatic and are diagnosed as an incidental finding. Case outline. We present a patient in whom the tumor was discovered at the junction of the body and the tail of the pancreas on the dorsal side. The patient had no specific symptomatology, with no loss in body weight. Considering the conducted diagnostics and the condition of the patient, we decided to perform a laparoscopic enucleation. This procedure has been applied in a safe and efficient manner, so the operative and postoperative course passed without complications. The definitive histopathological examination confirmed the finding that it was a non-functional pancreatic neuroendocrine tumor. Conclusion. Laparoscopic enucleation is an effective and safe treatment modality of these tumors with well-known advantages compared to open surgery, but there is always a tending to improve already existing results and thus to contribute not only to treatment but to greater and better comfort of the patient

scholarly journals Pancreatic Neuroendocrine Tumor with Benign Serous Cystadenoma: A Rare Entity

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Randhir Sagar Yadav ◽  
Ashik Pokharel ◽  
Shumneva Shrestha ◽  
Ashbita Pokharel ◽  
Deepshikha Gaire ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Histopathological Examination ◽  
Epigastric Pain ◽  
Pancreatic Neuroendocrine Tumor ◽  
Serous Cystadenoma ◽  
Neuroendocrine Neoplasm ◽  
Management Approach ◽  
Cystic Neoplasms ◽  
Distal Pancreas

Mixed serous-neuroendocrine neoplasm constitutes pancreatic serous cystic neoplasms and pancreatic neuroendocrine tumor, two tumor components with different underlying pathologies. The differentiation of these tumors is important as the management and prognosis depend on the pancreatic neuroendocrine tumor component. We report a case of mixed serous-neuroendocrine neoplasm in a 47-year-old female who presented with epigastric pain abdomen for two years. Imaging studies, tumor markers, thorough systemic evaluation, surgical resection, histopathological examination, and timely follow-up constituted our management approach. A 4 cm × 4 cm mass in the distal pancreas with multiple cysts in the pancreatic parenchyma containing serous fluid on distal pancreatectomy and splenectomy was found. The histopathological examination revealed combined benign serous cystadenoma and neuroendocrine tumor. She did not have any recurrence or metastasis by four years of follow-up.

scholarly journals The Impact of Repeating Endosonography with Confocal Endomicroscopy for the Diagnosis of Cystic Neuroendocrine Tumor

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Iqra Haq ◽  
Somashekar G. Krishna ◽  
Bhaveshkumar Patel ◽  
Thavam Thambi-Pillai ◽  
Chencheng Xie ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Pancreatic Pseudocyst ◽  
Incidental Finding ◽  
Pancreatic Neuroendocrine Tumor ◽  
Needle Aspiration ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
The Impact

Cystic pancreatic neuroendocrine tumors represent around 13% of all neuroendocrine tumors (Hurtado-Pardo 2017). There has been an increase in the incidence of cases due to improvement in imaging modalities. This is a case of a 68-year-old male with the incidental finding of a pancreatic cyst on CT. Initial Endoscopic Ultrasound with Fine Needle Aspiration (EUS-FNA) showed sonographic and cytology features suggestive of a pancreatic pseudocyst. However the cyst persisted with no change in size after aspiration leading to a follow-up EUS- FNA, which was combined with needle based confocal laser endomicroscopy (nCLE). The nCLE features were consistent with a cystic pancreatic neuroendocrine tumor, which was later confirmed on histology after surgical resection.

Efficacy of nasopancreatic stenting prior to laparoscopic enucleation of pancreatic neuroendocrine tumor

2013 ◽  
Vol 6 (2) ◽  
pp. 140-142 ◽  
Author(s):  
Takeyuki Misawa ◽  
Hiroo Imazu ◽  
Yuki Fujiwara ◽  
Hiroaki Kitamura ◽  
Nobuhiro Tsutsui ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Laparoscopic Enucleation

scholarly journals Complete Surgical Enucleation of a Giant Chylous Mesenteric Cyst

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Maria Isaia ◽  
Maria Erodotou ◽  
Georgios Nakos ◽  
Nikolaos Nikolaou
Keyword(s):  
Bowel Resection ◽  
Histopathological Examination ◽  
Incidental Finding ◽  
Abdominal Mass ◽  
Mesenteric Cyst ◽  
Abdominal Tumors ◽  
Mesenteric Cysts ◽  
Laparoscopic Enucleation ◽  
Chylous Mesenteric Cyst ◽  
Palpable Abdominal Mass

Mesenteric cysts are rare benign abdominal tumors, and they can appear anywhere in the mesentery of the gastrointestinal tract, from the duodenum to the rectum. They are generally asymptomatic and may present as an incidental finding. The diagnosis is confirmed by the laparotomy findings and the results of the histopathological examination. Complete surgical (open or laparoscopic) enucleation of the cyst is the treatment of choice. We present a case of a female patient who presented with abdominal pain and a giant palpable abdominal mass. The patient underwent a surgical exploration which showed a giant mesenteric cyst. A complete surgical enucleation of the cyst was successfully performed without the need of bowel resection. The histopathological examination of the cyst was compatible with the diagnosis of chylous mesenteric cyst.

scholarly journals Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl

2021 ◽  
Vol 28 (3) ◽  
pp. 373-386
Author(s):  
Elżbieta Sowińska-Przepiera ◽  
Dariusz Starzyński ◽  
Anhelli Syrenicz ◽  
Ireneusz Dziuba ◽  
Barbara Wiszniewska ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Histopathological Examination ◽  
Mature Teratoma ◽  
Young Patients ◽  
The Body ◽  
Systemic Review ◽  
Neuroendocrine Neoplasm ◽  
Neuroendocrine Neoplasms ◽  
Heterogeneous Structure

A mature teratoma is a germinal neoplasm that differentiates from embryonic multipotent cells into three germ layers. There may also be glandular tissue. The literature describes a total of 658 cases of ovarian neuroendocrine neoplasms, mainly in women over 40 years of age. The authors, together with a systemic review, present a case of a 16-year-old girl diagnosed with and treated for a neuroendocrine tumor. Case description: A 16-year-old girl visited the Paediatric Gynaecology Outpatient Clinic because of abdominal pains that intensified during menstruation. Standard painkillers and diastolic drugs were ineffective. An ultrasound examination revealed a large tumor with a heterogeneous structure in her right ovary. A sparing operation was carried out. During laparotomy, the lesion was enucleated, leaving healthy tissue. Histopathological examination revealed the typical features of teratoma, as well as the coexistence of a G1 neuroendocrine tumor. Immunohistochemical examination (IHC) showed the presence of markers characteristic for this type of tumor. The patient requires constant monitoring in the Endocrinology and Oncological Gynaecology Clinic. Conclusion: Tissue of neuroendocrine neoplasm within a teratoma is rare in this age group of patients; thus, there are currently no standards for long-term follow-up. This case adds to the body of evidence and demonstrates a possible good prognosis with non-aggressive behavior in G1 neuroendocrine tumors and teratomas in young patients.

A Rare Case of Sclerosing Variant of Pancreatic Neuroendocrine Tumor-Expressing Glucagon

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S63-S63
Author(s):  
Rong Xia ◽  
Maryam Noori Koloori ◽  
Mohamed Alshal ◽  
Amir Dehghani ◽  
Qiang Xie ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Histopathological Examination ◽  
Single Cells ◽  
Pancreatic Head ◽  
Pancreatic Neuroendocrine Tumor ◽  
Neuroendocrine Cells ◽  
Histopathological Study ◽  
Low Grade ◽  
Pancreatic Parenchyma ◽  
Dermatology Clinic

Abstract Introduction Sclerosing variant of pancreatic neuroendocrine tumor (PanNET) is a rare variant of PanNET characterized by decreased tumor cellularity and prominent stromal fibrosis, and it is considered associated with serotonin expression. We herein present an unusual case of a sclerosing PanNET expressing glucagon. Methods The patient, a 75-year-old woman with refractory diabetes, scaly erythematous skin plaques in the eyelid, bilateral elbows and scalp, and episodes of nausea and poor appetite, presented to emergency department for acute abdominal pain. Abdominal computed tomography showed a 17-mm pancreatic head mass. Endoscopic ultrasound with fine-needle biopsy was performed for histopathological examination, followed by pancreaticoduodenectomy. Results Biopsy showed a background of predominantly blood and benign strips of pancreatic parenchyma and scanty fragments of fibrotic hyalinized stroma containing medium-sized atypical monotonous cells with round-to-ovoid nuclei, smooth borders, and inconspicuous nucleoli. These cells were difficult to characterize morphologically due to the scanty sampling. Immunohistochemical stains revealed the atypical cells were positive for AE1/AE2, synaptophysin, chromogranin, and glucagon and negative for insulin, serotonin, and pancreatic polypeptide. The lack of heterogeneous peptide cell composition supported a neoplastic proliferation of neuroendocrine cells. The pancreaticoduodenectomy specimen showed a 1.2-cm white firm mass in the pancreatic head. Histopathological study showed that, in a sclerotic background, the tumor cells grew mostly in trabecular patterns and occasionally in single cells, infiltrating into adjacent pancreatic parenchyma, and showed the same immunoprofile features as in the biopsy specimen. The proliferative index was <3%, supporting the diagnosis of low-grade sclerosing PanNET. The patient recovered well postsurgery. Moreover, the episodes of nausea and loss of appetite improved postsurgery. Patient did not show up for follow-up appointments in the dermatology clinic. Conclusion Sclerosing PanNET is challenging for diagnosis, especially on small biopsy specimens. Immunohistochemistry helps establish the diagnosis. Our case demonstrates a rare presentation of sclerosing PanNET expressing glucagon.

scholarly journals Renal Leiomyoma – A Rare Case Report

2021 ◽  
Vol 10 (21) ◽  
pp. 1633-1635
Author(s):  
Raju Kamlakarao Shinde ◽  
Harsh Dinesh Bhalsod ◽  
Sangita Jogdand Shinde
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Rare Case ◽  
Histopathological Examination ◽  
Incidental Finding ◽  
Benign Lesions ◽  
Diagnostic Challenge ◽  
Rare Case Report ◽  
Incidental Discovery ◽  
Malignant Lesions

Cases of renal leiomyomas are fewer than 100 in the literature and therefore possess a diagnostic challenge.1 By definition, leiomyomas are benign soft tissue neoplasms.2 that arise from smooth muscle cells.3 The most common sites of origin are the uterus, intestines and skin.4 One of the more unusual types of leiomyomas are the ones arising from the kidneys. They account for about 1.5 % benign lesions of kidneys.5 The methods of detection are through discovery during autopsy, incidental discovery during imaging or by clinical diagnosis in symptomatic lesions.6 Prevalence based on incidental finding at the time of autopsy is 4.2 - 5.2 %.7 Creating a differential diagnosis between leiomyomas and other malignant lesions is only possible by histopathological examination.8 We hereby report a case of 26-year-old female who presented with pain in abdomen and on histopathological examination was diagnosed as a case of renal leiomyoma.

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