Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts: The two cases report

Introduction. Coagulation and blood clot formation in bone defects is sometimes followed by retraction of a blood clot and serum extrusion, thus producing peripheral serum-filled spaces between bony wall and coagulum. This can result in a higher incidence of postoperative complications. Stabilization of blood coagulum, which enables successful primary healing, may be accomplished by autotransplantation, allotransplantation, xenotransplantation, or application of autologous platelet concentrate and concentrated growth factors (CGF). Case report. Two patients with large cystic lesions in the upper and lower jaw were presented. In both patients postoperative bony defects were filled with autologous fibrin rich blocks containing CGF. Postoperative course passed uneventfully. Conclusion. Application of fibrin rich blocks containing CGF is one of the possible methods for reconstruction of bone defects. CGF can be applied alone or mixed with a bone graft. The method is relatively simple, without risk of transmissible and allergic diseases and economically feasible.

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Application of fibrin rich blocks with concentrated growth factors in pre-implant augmentation procedures

Medicinski pregled ◽

10.2298/mpns1406177t ◽

2014 ◽

Vol 67 (5-6) ◽

pp. 177-180 ◽

Cited By ~ 5

Author(s):

Ana Tadic ◽

Tatjana Puskar ◽

Branislava Petronijevic

Keyword(s):

Growth Factors ◽

Soft Tissues ◽

Dental Materials ◽

Cost Effective ◽

Allergic Diseases ◽

Alveolar Ridge ◽

Cell Proliferation And Differentiation ◽

Inflammatory Processes ◽

Concentrated Growth Factors ◽

Endosteal Implants

Introduction. Growth factors are mediators regulating the key processes of tissue regeneration, including cell proliferation and differentiation, extracellular matrix synthesis, chemotaxis and angiogenesis. In addition to the role they play in haemostasis and inflammatory processes, thrombocytes are of major importance in the reparation of mineralized and soft tissues. Application of fibrin rich blocks with concentrated growth factors is one of the latest approaches to guided bone regeneration and augmentation of lost bony structures of the alveolar ridge. Case report. This paper presents a case of a female patient who underwent reconstruction of the defect of residual alveolar ridge of the upper jaw by applying fibrin rich blocks with concentrated growth factors and subsequent placement of two titanium endosteal implants five months after wound healing. Conclusion. The loss of a single tooth or several teeth sometimes entails the augmentation of lost bony structures in order to provide optimal conditions for dental implant placement and subsequent prosthetic rehabilitation. A range of contemporary surgical procedures and a variety of dental materials for reconstruction of bony defects of the upper and lower jaws are available nowadays. The method described in this paper, i.e. the application of concentrated growth factors is one of the latest approaches which poses no risk of transmissible and allergic diseases and is at the same time cost effective.

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Growth factors and cytokines in autologous platelet concentrate and their correlation to periodontal regeneration outcomes

Journal Of Clinical Periodontology ◽

10.1111/j.1600-051x.2006.00991.x ◽

2006 ◽

Vol 33 (11) ◽

pp. 837-845 ◽

Cited By ~ 60

Author(s):

M. Christgau ◽

D. Moder ◽

K.-A. Hiller ◽

A. Dada ◽

G. Schmitz ◽

...

Keyword(s):

Growth Factors ◽

Periodontal Regeneration ◽

Platelet Concentrate ◽

Autologous Platelet Concentrate ◽

Autologous Platelet

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Concentrated Growth Factors as an Ingenious Biomaterial in Regeneration of Bony Defects after Periapical Surgery: A Report of Two Cases

Case Reports in Dentistry ◽

10.1155/2019/7046203 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Nivedhitha Malli Sureshbabu ◽

Kathiravan Selvarasu ◽

Jayanth Kumar V ◽

Mahalakshmi Nandakumar ◽

Deepak Selvam

Keyword(s):

Growth Factors ◽

Bone Regeneration ◽

Healing Time ◽

Platelet Concentrates ◽

Periapical Lesions ◽

New Family ◽

Retrograde Filling ◽

Concentrated Growth Factors ◽

Autologous Platelet

The overall success of a periapical surgery is assessed in terms of regeneration of functional periradicular tissues. The regenerative potential of platelets has been well documented. This article describes the use of concentrated growth factors (CGF), a new family of autologous platelet concentrates, as a sole material for bone regeneration after periapical surgery. 32- and 35-year-old female patients diagnosed with Ellis Class IV, an open apex in 11 with apical periodontitis in 11 and 12 and previously root canal-treated 31 and 41 with a chronic apical abscess, respectively, were managed with endodontic surgery. Subsequent to apicectomy and retrograde filling, the CGF fibrin block and membrane were used before suturing. There was uneventful healing during the immediate post-op and the subsequent follow-up periods. CGF is produced by a differential centrifugation process that results in the formation of a denser fibrin matrix richer in growth factors than those observed in PRF. Reasonable osseous healing was seen as early as 6-month follow-up, thereby recommending the use of CGF as an alternative to bone grafts and membranes in extensive periapical lesions to enhance bone regeneration and to decrease the healing time.

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Кісткова репарація щелеп під впливом суміші біоактивного скла і аутологічного кісткового мозку

CLINICAL DENTISTRY ◽

10.11603/2311-9624.2018.1.8159 ◽

2018 ◽

Author(s):

Ya. V. Pyuryk ◽

Hr. V. Pohoretska ◽

L. O. Patskan

Keyword(s):

Bone Marrow ◽

Clinical Practice ◽

Bioactive Glass ◽

Blood Clot ◽

Maxillofacial Surgery ◽

Autologous Bone Marrow ◽

Bone Defects ◽

Odontogenic Cysts ◽

Jaw Cysts ◽

Autologous Bone

Summary. Operation on removing odontogenic jaw cysts is one of the most common surgical interventions. Patients with radicular cysts of the maxillary bones make up about 6 % in the overall structure of dental morbidity. After the removal of cysts the bone cavities are formed, the healing of which is accompanied by frequent suppuration and is long-lasting. To speed up the healing of bone cavity using various grafts made of native or synthetic bone.The aim of the study – to improve the efficacy of treatment for odontogenic cysts, we decided to combine autologous bone marrow with an artificial bone substitute, creating a mixture that, by replacing bone defects with it, would optimize reparative processes and thus restore the anatomical and functional properties of the dento-facial system.Materials and Methods. 60 patients aged 18–65 years who were operated on the basis of radicular jaw cysts were examined. The patients were on inpatient treatment at the Department of Maxillofacial Surgery of Ivano-Frankivsk Regional Clinical Hospital. The diagnosis of the disease was verified on the basis of the data of the X-ray examination. The radiographic dimensions of the cysts were within 1.5–3.5 cm. Depending on the type of material used to substitute postoperative bone cavities, patients were divided into III groups: I – in 20 patients restoration was made a blood clot; II – in 20 patients postoperative bone defects were replaced with bioactive glass, and ІІІ – in 20 patients postoperative bone defects were replaced with a mixture of autologous bone marrow and bioactive glass.Conclusions. The developed composite material of bioactive glass with the addition of an autologous bone marrow is an inductor and a source of osteogenesis, which allows to recommend it as a method of choice in the treatment of patients with bone defects of the jaws that are formed after the removal of odontogenic cysts. Thus, the prospectivity and importance of the use of bioplastic material in the clinical practice of marrow bioactive mixture in clinical practice will significantly expand the possibilities of modern reconstructive and restorative maxillofacial surgery.

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Enhancement of Syndesmotic Fusion Rates in Total Ankle Arthroplasty with the Use of Autologous Platelet Concentrate

Foot & Ankle International ◽

10.1177/107110070502600606 ◽

2005 ◽

Vol 26 (6) ◽

pp. 458-461 ◽

Cited By ~ 22

Author(s):

Craig R. Barrow ◽

Gregory C. Pomeroy

Keyword(s):

Growth Factors ◽

Tibial Component ◽

Fusion Rate ◽

Total Ankle Arthroplasty ◽

Platelet Concentrate ◽

Ankle Arthroplasty ◽

Autologous Platelet Concentrate ◽

Tibiofibular Joint ◽

Component Migration ◽

Autologous Platelet

Background: One of the challenges of total ankle arthroplasty continues to be achieving a solid distal fusion of the tibiofibular joint. Delayed union rates of 29% to 38% and the nonunion rates of 9% to 18% for syndesmotic fusion have been documented. The risk of tibial component migration has been reported to increase 8.5 times if a solid syndesmotic fusion is absent. Growth factors have been shown to accelerate bone healing and may enhance the fusion of the syndesmosis and, thereby, decrease the frequency of nonunion and subsequent tibial component migration. Methods: An autologous platelet concentrate was used to increase the amount of growth factors at the site of the distal tibiofibular joint fusion in 20 total ankle arthroplasties. Results: Our 6-month fusion rate was 100%. When compared to historical controls (6-month fusion rate of 62%) the difference was statistically significant ( p < 0.0001). Conclusion: The improved rate of distal tibiofibular fusion may be attributable to the increased presence of growth factors provided by an autologous platelet concentrate.

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Utilization of Concentrated Growth Factors (CGF) Following Explantation of a Failed Dental Implant: A Case Report

10.26226/morressier.5ac383182afeeb00097a3e81 ◽

2018 ◽

Author(s):

Nurul Ain Mohamed Yusof

Keyword(s):

Case Report ◽

Growth Factors ◽

Dental Implant ◽

Concentrated Growth Factors

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Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation—A Narrative Review

Biology ◽

10.3390/biology10040317 ◽

2021 ◽

Vol 10 (4) ◽

pp. 317

Author(s):

Eitan Mijiritsky ◽

Haya Drora Assaf ◽

Oren Peleg ◽

Maayan Shacham ◽

Loredana Cerroni ◽

...

Keyword(s):

Growth Factors ◽

Platelet Rich Plasma ◽

Periodontal Regeneration ◽

Clinical Work ◽

Gingival Recession ◽

Vital Role ◽

Facial Rejuvenation ◽

Cochrane Library ◽

The Past ◽

Autologous Platelet

Growth factors (GFs) play a vital role in cell proliferation, migration, differentiation and angiogenesis. Autologous platelet concentrates (APCs) which contain high levels of GFs make them especially suitable for periodontal regeneration and facial rejuvenation. The main generations of APCs presented are platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) techniques. The purpose of this review is to provide the clinician with an overview of APCs’ evolution over the past decade in order to give reliable and useful information to be used in clinical work. This review summarizes the most interesting and novel articles published between 1997 and 2020. Electronic and manual searches were conducted in the following databases: Pubmed, Scopus, Cochrane Library and Embase. The following keywords were used: growth factors, VEGF, TGF-b1, PRP, PRF, CGF and periodontal regeneration and/or facial rejuvenation. A total of 73 articles were finally included. The review then addresses the uses of the three different techniques in the two disciplines, as well as the advantages and limitations of each technique. Overall, PRP is mainly used in cases of hard and soft tissue procedures, while PRF is used in gingival recession and the treatment of furcation and intrabony defects; CGF is mainly used in bone regeneration.

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Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study

Applied Sciences ◽

10.3390/app11010395 ◽

2021 ◽

Vol 11 (1) ◽

pp. 395

Author(s):

Antonio Scarano ◽

Francesco Inchingolo ◽

Biagio Rapone ◽

Alberta Greco Lucchina ◽

Erda Qorri ◽

...

Keyword(s):

Critical Size ◽

Bone Defects ◽

New Bone Formation ◽

Platelet Gel ◽

Woven Bone ◽

Rapid Healing ◽

Rabbit Bone ◽

Autologous Platelet ◽

New Zealand Rabbits

Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (p < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.

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