CHEMICAL CONTAMINATION IN PACKAGING MATERIAL OF PHARMACEUTICAL USE

The use of packaging materials is important in the pharmaceutical industry. The pharmaceutical industry uses, as primary packaging materials, glass bottles, blister packs, caps and closures, glass vials, sealed tubes. The aim of this study is to perform global component migration analyses on these types of packaging, to see if there is a possibility of migration of components from the pharmaceutical package into the drug, so as not to alter in any way its therapeutic properties. The results obtained from the processing of the extracts obtained were below the maximum limits allowed for each category of packaging, respectively, plastic, paper and cardboard, glass.

Rheological and Component Characterization of an Innovative Bio-Binder Using Guayule Resin in Partial and Entire Asphalt Replacement

Asphalt cement will not last for a long time as the world encounters a diminishment in the crude oil. For sustainable, flexible pavement development, new resources can provide a contribution to replace it partially or entirely. In this study, asphalt was partially and entirely replaced by guayule resin as a bioresource by-product, extracted during the guayule natural rubber production. Crumb rubber modifier (CRM) was used as an asphalt enhancer. The Superpave grading system was followed at high, intermediate, and low temperatures to evaluate such innovative binder for rutting, fatigue, and thermal cracking, respectively, in addition to viscosity. Therefore, the original, short-term aging and long-term aging were simulated using tank, rolling thin film oven, and pressure aging vessel materials. Additionally, component analysis using Fourier-transform infrared spectroscopy was provided to link the rheological properties with the chemical changes. Outcomes showed a relatively much lower viscosity of guayule in the same high-temperature asphalt grade indicating savings in plant energy consumption and reduced environmental emissions. CRM enhanced guayule, but not as much as asphalt, proven by polymeric component migration through liquid binder. This enhancement was reflected in the rheological performance besides other factors. As-received guayule seems to have high oxygen content proven by strong absorption peak intensities of oxidative bonds (e.g., Carbonyl and sulfoxide). Such pre-oxidation was negatively reflected in the intermediate- and low-temperature performance of guayule and guayule-based binders. However, the investigated guayule had potential to compensate for asphalt replacement in the presence of CRM by 23–42% by weight of blend.

Vitamin E-doped total hip arthroplasty liners show similar head penetration to highly cross-linked polyethylene at five years: a multi-arm randomized controlled trial

Aims The most frequent indication for revision surgery in total hip arthroplasty (THA) is aseptic loosening. Aseptic loosening is associated with polyethylene liner wear, and wear may be reduced by using vitamin E-doped liners. The primary objective of this study was to compare proximal femoral head penetration into the liner between a) two cross-linked polyethylene (XLPE) liners (vitamin E-doped (vE-PE)) versus standard XLPE liners, and b) two modular femoral head diameters (32 mm and 36 mm). Methods Patients scheduled for a THA were randomized to receive a vE-PE or XLPE liner with a 32 mm or 36 mm metal head (four intervention groups in a 2 × 2 factorial design). Head penetration and acetabular component migration were measured using radiostereometric analysis at baseline, three, 12, 24, and 60 months postoperatively. The Harris Hip Score, University of California, Los Angeles (UCLA) Activity Score, EuroQol five-dimension questionnaire (EQ-5D), and 36-Item Short-Form Health Survey questionnaire (SF-36) were assessed at baseline, three, 12, 36, and 60 months. Results Of 220 screened patients, 127 were included in this study. In all, 116 received the allocated intervention, and 94 had their results analyzed at five years. Head penetration was similar between liner materials and head sizes at five years, vE-PE versus XLPE was -0.084 mm (95% confidence interval (CI) -0.173 to 0.005; p = 0.064), and 32 mm versus 36 mm was -0.020 mm (95% CI -0.110 to 0.071; p = 0.671), respectively. No differences were found in acetabular component migration or in the patient-reported outcome measures. Conclusion No significant difference in head penetration was found at five years between vE-PE and XLPE liners, nor between 32 mm and 36 mm heads. Cite this article: Bone Joint J 2020;102-B(10):1303–1310.

Kajian Terhadap Migrasi Plastik Hasil Induksi Panas pada Beberapa pH dan Jenis Asam Organik

In Indonesian street food vendor, most of hot acidic food and drinks are served with plastic packaging and plastic cutlery. This research is aimed to study about the presence of plastic’s component migration as a result of heat induction in the presence of various pHs and organic acid, and to identify the types of migrated plastic components through its functional groups. In this research, the samples were 10 plastic packaging and cutlery made from LDPE, HDPE, PP, PE, and PS plastic. Acetic acid, citric acid, and lactic acid and three levels of pH which were pH 4, 5, and 6. Temperatures of 80 and 100 ? were used as representation of food and drinks served warm. Each samples were conditioned in each organic acids solutions with different pH (pH 4, 5, and 6) and thermal treatments were carried out for 1 hour in each temperature. The plastic migrations were detected using UV-Visible spectroscopy, followed by FTIR spectroscopy to identify functional groups of the migrated plastic components, followed by prediction of the migrated compound. The results suggested that plastic component migration were detected in all samples, and using lactic acid pH 4, 5, and 6 an antistatic diethanolamides was ruled plausible released from white plastic glass sample. Keywords : plastic migration, organic acids, pH, spectroscopy, temperature.

Deteksi Migrasi Material Pembungkus Makanan ke Air karena Pemanasan

This research was aimed to detect if migration of additives or other components from plastic material used as packaging of hot food/drinks were occurred in warm-hot cooked temperature. In this works, plastic samples as like spoon, packaging, and wraps were taken directly from mainly street food vendors and shops. Pure water and plastics samples were mixed, and heat were introduced to induced migration. Three temperature of 60 °C, 80 °C, dan 100 °C, were each applied to induced migration for one hour. Migrations were detected using UV-Visible Spectroscopy, Fourier Transform InfraRed, and Gas Chromatography. Migrated polymer materials from plastics were detected through peaks of UV-visible absorption with water as background spectra were subtracted, and its functional groups were detected using FTIR spectroscopy. Gas chromatography was used to confirm if UV-visible and FTIR results were result from single component migration. Keywords: polymer, migration, temperature, plastics, wavelength.