scholarly journals Pneumococcal meningitis associated with glomerulonephritis: A case report

2017 ◽  
Vol 74 (7) ◽  
pp. 693-698
Author(s):  
Biljana Vuletic ◽  
Andjelka Stojkovic ◽  
Zoran Igrutinovic ◽  
Lidija Stankovic ◽  
Rasa Medovic ◽  
...  
Keyword(s):  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Central Nervous System Involvement ◽  
Young Male ◽  
Clinical Form ◽  
Adequate Treatment ◽  
Postinfectious Glomerulonephritis ◽  
Meningitis In Children ◽  
Gross Haematuria

Introduction. Streptococcus pneumoniae is the second most common cause of meningitis in children, producing more serious complications than other bacteria. Streptococcus pneumoniae infections are a rare trigger of glomerulonephritis. We presented a case of glomerulonephritis developing concurrently with meningitis in a young male child. Case report. Gross haematuria, significant proteinuria, hypertension and decreased level of C3 alongside the signs of central nervous system involvement occurred in a male patient of 5 years and 3 months of age. Spontaneous resolution of renal affliction parameters followed the successful treatment of meningitis. The disease course was strongly suggestive of postinfectious glomerulonephritis, although it manifested at the same time as meningitis. The absence of the latent period might point to the development of IgA nephropathy, but since the renal function was stable, without any abnormalities in urine tests documented during follow-up, our opinion is that this was rather the case of postinfectious nephropathy. Conclusion. The presented case is a unique clinical form of postinfectious glomerulonephritis. An accurate diagnosis of this entity should ensure the adequate treatment and follow-up of these patients.

scholarly journals Mandibular Full-Arch Rehabilitation over 3 Straight Immediately Loaded Implants: 8 Years of Follow-Up

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Márcio de Carvalho Formiga ◽  
Magda Nagasawa ◽  
Jamil Awad Shibli
Keyword(s):  
Case Report ◽  
Dental Implants ◽  
Treatment Option ◽  
Successful Treatment ◽  
Treatment Plan ◽  
Adequate Treatment ◽  
The Past ◽  
Technical Complications ◽  
Edentulous Patients

Mandibular full-arch restoration is a good and successful treatment option for totally edentulous patients. In the past years, several studies have described the placement of 4 to 6 implants to restore this type of case; however, an option using 3 dental implants placed in strategic and specific positions could also be an alternative. Therefore, this case report describes a full-arch rehabilitation on 3 straight, immediately loaded implants after 8 years of follow-up. The restoration presented no biological or technical complications during this follow-up period, showing that an adequate treatment plan was able to allow good results using this treatment option.

Kimura’s disease: case report of an Italian young male and response to oral cyclosporine A in an 8 years follow-up

2010 ◽  
Vol 32 (S1) ◽  
pp. 55-57 ◽  
Author(s):  
Enrico Beccastrini ◽  
Giacomo Emmi ◽  
Michela Chiodi ◽  
Camilla Di Paolo ◽  
Elena Benedetta Silvestri ◽  
...  
Keyword(s):  
Case Report ◽  
Cyclosporine A ◽  
Young Male ◽  
Kimura’S Disease ◽  
Disease Case

scholarly journals Specific Guidelines Including Multidisciplinary Approach Is Critical of Management of Langerhans Cell Histiocytosis in Adults

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 1041-1041
Author(s):  
Lorenzo Rizzo ◽  
Michelina Santopietro ◽  
Gianluca Sfaciotti ◽  
Marco Brunori ◽  
Luisa Cardarelli ◽  
...  
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Multidisciplinary Approach ◽  
Central Nervous System Involvement ◽  
Langerhans Cell ◽  
Age At Diagnosis ◽  
Braf V600e ◽  
Adequate Treatment ◽  
Previously Treated ◽  
Over Time

The knowledge of Langerhans Cell Histiocytosis (LCH) is based on pediatric studies. Adults with LCH are usually treated with pediatric protocols. In 2001, guidelines for adults with LCH (GIMEMA LCH 2001) were proposed, in order to standardize the diagnostic and therapeutic approaches for this category of patients. The aims of this retrospective study are: a) to evaluate the role of a multidisciplinary assessment in adults with LCH, according to the GIMEMA LCH 2001 guidelines, and b) to analyze the results obtained with the GIMEMA LCH 2001 guidelines and those obtained with pediatric protocols. Pts aged >18 years with a diagnosis of LCH (S-100+, CD1a+, CD207+) managed at our Institution since 1985 to 2018 were considered. As diagnostic and treatment approaches, two different strategies were used over time: the GIMEMA LCH 2001 guidelines and the pediatric protocols. The GIMEMA LCH 2001 guidelines included a multidisciplinary diagnostic work-up with complete odontostomatologic, pulmonary and endocrinologic assessments; treatment strategy consisted of: wait and see or local therapy in unifocal single system (SS), indomethacin in bone multifocal SS and vinblastine combined with low-dose prednisone (PDN) in multi-system (MS), PDN in pulmonary honey-combing disease (PHCD) and cladribine in central nervous system involvement. DAL-HX 83 and 90, LCH-I and LCH II were the pediatric protocols utilized over time. Response to treatment was defined as complete (CR) or intermediate (IR). Persistence of the symptoms and/or appearance of new lesions were defined no response (NR). Progression was considered the appearance of symptoms and/or new lesions after initial response. One-hundred-thirty-one LCH pts (females 72, males 59) with a median age at diagnosis of 36 years (range 18 - 71) were considered. Median follow up was 43 months (range 12 - 330). One-hundred-seven patients were managed according to the GIMEMA LCH 2001 guidelines, 16 of them previously treated with a pediatric protocol. Pulmonary and/or oral involvements were identified in 31/107 (29%) and 12/107 (11%) patients, respectively, 5/16 (31%) and 3/16 (19%), respectively, of previously treated asymptomatic patients. Ninety-one newly diagnosed patients (median age at diagnosis: 36 years) were treated according to the GIMEMA LCH 2001 guidelines and 40 (median age at diagnosis: 33 years) were managed with pediatric protocols. All patients treated with the GIMEMA LCH 2001 were evaluable for response. In particular, all patients with SS-LCH achieved a response (100%), that was complete in 20/26 (76.9%) unifocal-SS and in 10/14 (71.4%) multifocal-SS. All but one patient with MS-LCH reached a response that was complete in 22/45 (48.9%). Of 6 pts with PHCD, 5 had a IR and one a CR. No pt presented CNS involvement at initial diagnosis. Thirty-nine of 40 pts managed with pediatric protocols were evaluable for response. All 13 pts with SS-LCH had a response that was complete in 6 (46.1%). Among 26 patients with MS-LCH, 3 of them with organ risk involvement achieved a response, that was complete in 1, while among 23 patients without organ risk, 12 (52.2%), 8 (34.8%) and 3 (13%) had a CR, IR and NR, respectively. Overall, 12 patients were lost to follow-up. Disease progression was recorded in 47/95 pts (49.5%) after a median time of 19 months (range: 6-147 months). The progression-free survival at 43 months was significantly better for patients treated according to the GIMEMA LCH 2001 guidelines compared to those managed with pediatric protocols, 67% (IC95% 53.14 - 80.86%) vs 48% (IC95% 31.37 - 64.63%), respectively (p 0.005). Overall, 7 deaths were recorded, 5 in patients treated with the pediatric protocols. The overall survival at 43 months, was similar in patients managed with the GIMEMA LCH 2001 guidelines and in those treated with pediatric protocols (97.9%, CI 95%: 93.75% - 100% and 97.3%, (IC95% 91.96% - 100%). BRAF V600E mutation was found in 13/35 (37%) evaluable cases. No differences in response and outcome between BRAFV600E-mutated patients and those not-mutated were found. Our experience in a large cohort of LCH adults shows that a multidisciplinary approach is useful in identifying organ involvement in adults, including those asymptomatic. This is critical for an adequate treatment. Moreover, guidelines specific for adults with LCH proved efficacy in improving the outcome in this category of patients. Disclosures No relevant conflicts of interest to declare.

scholarly journals Mandibular Ameloblastoma with Lung Metastasis 10 Years after Resection

2016 ◽  
Vol 31 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Justin Iohanne Siy Rabo ◽  
Allan B. Carpela ◽  
Eutrapio S. Guevara ◽  
Joel A. Romualdez
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Lung Metastasis ◽  
Private Hospital ◽  
Primary Lesion ◽  
Standard Protocol ◽  
Adequate Treatment ◽  
High Propensity ◽  
Design Case

Objective:  To present a case of mandibular ameloblastoma with pulmonary metastasis after ten years and discuss the possible pathophysiology, diagnostic and therapeutic options. Methods: Study Design: Case Report Setting:           Tertiary Private Hospital Subject:          One Conclusion: Though benign, ameloblastoma has a high propensity for local invasion and may metastasize. It is difficult to predict metastasis, even with adequate treatment of the primary lesion. There is no standard protocol to prevent or detect metastatic ameloblastoma, but regular and close follow up may ensure early diagnosis. Keywords: ameloblastoma, metastatic ameloblastoma, lung metastasis, follicular type ameloblastoma, odontogenic tumor

scholarly journals Acute Thyroiditis Associated with Brucellosis: A Case Report

PRILOZI ◽  
2019 ◽  
Vol 40 (2) ◽  
pp. 113-117
Author(s):  
Marija Cvetkova ◽  
Iskra Bitoska ◽  
Kostadin Poposki ◽  
Dejan Jakimovski ◽  
Mile Bosilkovski
Keyword(s):  
Case Report ◽  
Early Recognition ◽  
Subsequent Development ◽  
Favorable Outcome ◽  
Peripheral Arthritis ◽  
Suppurative Thyroiditis ◽  
Adequate Treatment ◽  
Ultrasound Investigation ◽  
Acute Thyroiditis

Abstract Brucella thyroiditis represents an extremely rare focal form of brucellosis. In this case report we describe a 55 years old male, diagnosed with brucellosis and peripheral arthritis with subsequent development of acute thyroiditis. The symptoms duration consistent with brucellosis started two weeks before establishing the diagnosis. Only a day after diagnosis and initiation of antibrucellar treatment, acute non-suppurative thyroiditis suddenly manifested. Thyroiditis was diagnosed with clinical inspection and confirmed by ultrasound investigation. With the appropriate antibrucellar treatment, complete cure of thyroid affection was reached in ten days and the patient remained well during the follow-up period of two and a half years. In conclusion, in brucellosis endemic regions brucellosis should be included in the diagnostic consideration in patients with acute non-suppurative thyroiditis. Early recognition and adequate treatment of brucella thyroiditis results in favorable outcome.

scholarly journals Progressive disseminated histoplasmosis with pulmonary and central nervous system involvement: a case report

2021 ◽  
Author(s):  
Matheus Fellipe Nascimento de Souza ◽  
Ana Paula Teixeira da Silva ◽  
Gabriela Santos Bianchin ◽  
Maria Eduarda Angelo de Mendonça Fileti ◽  
Raddib Eduardo Noleto da Nóbrega de Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Systemic Disease ◽  
Central Nervous System Involvement ◽  
Tnf Alpha ◽  
Cns Involvement ◽  
Necrosis Factor Alpha ◽  
Adequate Treatment ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Context: Histoplasmosis (Histoplasma capsulatum) is a systemic disease that affects the lung and immune system1. The severity of histoplasmosis is directly related to the individual’s immune response since it is an opportunistic pathogen2. It is one of the most prevalent infections in immunocompromised patients due to the use of tumor necrosis factor-alpha (TNF-alpha) inhibitors, resulting in a mortality rate of 20%. The evolution to CNS occurs in 5-10% of patients with disseminated symptoms3. Case Report: M.G.M, a woman, 67 years, was admitted with bilateral tonicclonic seizure with focal onset in the right upper limb. The patient had hypertension, diabetes and rheumatoid arthritis, and was use ASA, glibenclamide, hydrochlorothiazide, losartan, amlodipine, adalimumab and methotrexate. Complementary exams were performed that showed lesions suggestive of microangiopathy on cranial CT; nodular lesions in the pulmonary right upper lobe and prominent lymph nodes in the hilum and mediastinum on chest CT; CSF with increased cytology (monomorphonuclear predominance), without glucose consumption. The biopsy of lung lesions identified Histoplasma capsulatum, confirming the diagnosis of progressive disseminated histoplasmosis with pulmonary and CNS involvement. Thus, treatment with amphotericin B was started, however, the patient died. Conclusions: Histoplasmosis is the most prevalent invasive fungal infection in users of TNF-alpha inhibitors. In these cases, the disease can be more aggressive and have a rapid evolution, with CNS involvement - which confers a worse prognosis. Early diagnosis, suspension of the immunomodulator and adequate treatment for infection control are required.

scholarly journals 880 Rare Benign Chondromyxoid Fibroma of Rib, A Case Report; Is It Really Benign?

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
B Basak ◽  
A Haragan ◽  
M Shackcloth ◽  
J Thekkudan
Keyword(s):  
Benign Tumor ◽  
Young Male ◽  
Rare Condition ◽  
Benign Tumors ◽  
High Recurrence Rate ◽  
Chondromyxoid Fibroma ◽  
Movement Restriction ◽  
Adequate Treatment ◽  
High Index Of Suspicion

Abstract Chondromyxoid Fibroma is a benign chondrogenic lesion accounting for less than one percent of the bone tumor; hence, likely to be misdiagnosed. Its presentation can vary from asymptomatic to pain, swelling, and movement restriction. The typical presentation includes a young male with a lesion commonly around the knee joint. However, we detail here an unusual presentation of this benign tumor in a 61-year male referred with chest pain and swelling. Histopathology can be very helpful in diagnosing this rare condition showing the characteristic patterns. Besides, as the tumor is locally aggressive, it can often be misinterpreted and treated as sarcoma. Moreover, it has a high recurrence rate. These characteristics make this rare tumor standout from the other benign tumors. Therefore, these cases need to be viewed thoroughly with a high index of suspicion pre-diagnosis and ensure adequate treatment and follow-up for successful management.

Intensive Stuttering Therapy With Telepractice Follow-up: A Case Study

2011 ◽  
Vol 21 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Farzan Irani ◽  
Rodney Gabel
Keyword(s):  
Case Report ◽  
Therapeutic Intervention ◽  
Intensive Therapy ◽  
Positive Outcome ◽  
Eclectic Approach

This case report describes the positive outcome of a therapeutic intervention that integrated an intensive, residential component with follow-up telepractice for a 21 year old male who stutters. This therapy utilized an eclectic approach to intensive therapy in conjunction with a 12-month follow-up via video telepractice. The results indicated that the client benefited from the program as demonstrated by a reduction in percent stuttered syllables, a reduction in stuttering severity, and a change in attitudes and feelings related to stuttering and speaking.

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