The Authorship of Ancient Bounds

1953 ◽  
Vol 22 (3) ◽  
pp. 192-196 ◽  
Author(s):  
Barbara Kiefer
Keyword(s):  
Conclusive Evidence ◽  
Religious Toleration ◽  
History Of ◽  
Army Chaplain ◽  
Member Of Parliament

This unsigned tract published in 1645 is one of the most interesting and historically significant documents in the polemic literature of the Puritan Revolution; it has also been described as “one of the halfdozen most important contributions ever made to the theory of religious toleration in England.” The authorship has never been established, though some speculation has attributed the work to Francis Rous, Puritan mystic and leading member of Parliament. But certain references in contemporary documents, together with considerations of thought and style provide conclusive evidence that the pamphlet is from the pen of Joshua Sprigge, army chaplain, Fellow of All Souls College, constant advocate of toleration, and author of several sermons and political tracts, among them the important history of the army under Fairfax, Anglia Rediviva.

scholarly journals CHEK2∗1100delC Mutation and Risk of Prostate Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Victoria Hale ◽  
Maren Weischer ◽  
Jong Y. Park
Keyword(s):  
Prostate Cancer ◽  
Current Knowledge ◽  
Prostate Cancer Screening ◽  
Critical Role ◽  
Prostate Cancer Risk ◽  
Conclusive Evidence ◽  
Increased Risk ◽  
History Of ◽  
Cancer Studies

Although the causes of prostate cancer are largely unknown, previous studies support the role of genetic factors in the development of prostate cancer.CHEK2plays a critical role in DNA replication by responding to double-stranded breaks. In this review, we provide an overview of the current knowledge of the role of a genetic variant, 1100delC, ofCHEK2on prostate cancer risk and discuss the implication for potential translation of this knowledge into clinical practice. Currently, twelve articles that discussedCHEK2∗1100delC and its association with prostate cancer were identified. Of the twelve prostate cancer studies, five studies had independent data to draw conclusive evidence from. The pooled results of OR and 95% CI were 1.98 (1.23–3.18) for unselected cases and 3.39 (1.78–6.47) for familial cases, indicating thatCHEK2∗1100delC mutation is associated with increased risk of prostate cancer. Screening for CHEK2∗1100delC should be considered in men with a familial history of prostate cancer.

Isaac Nelson

2018 ◽  
Author(s):  
Daniel Ritchie
Keyword(s):  
Frederick Douglass ◽  
Home Rule ◽  
Church Of Scotland ◽  
Free Church ◽  
William Lloyd Garrison ◽  
History Of ◽  
County Mayo ◽  
Member Of Parliament

This book reconsiders the career of an important, controversial, but neglected figure in this history of Irish Presbyterianism. The Revd Isaac Nelson is mostly remembered for his opposition to the evangelical revival of 1859, but this book demonstrates that there was much more to Nelson’s career. Nelson started out as a protégé of Henry Cooke and as an exemplary young evangelical minister. Upon aligning himself with the Belfast Anti-Slavery Society and joining forces with American abolitionists such as Frederick Douglass and William Lloyd Garrison, Nelson emerged as a powerful voice against compromise with slaveholders. One of the central objectives of this book is to show that anti-slavery, especially his involvement with the ‘Send Back the Money’ controversy in the Free Church of Scotland and the debate over fellowship with slaveholders at the Evangelical Alliance, was crucially important to the development of Nelson into one of Irish Presbyterianism’s most controversial figures. His later opposition to the 1859 Revival has often been understood as being indicative of Nelson’s opposition to evangelicalism. This book argues that such a conclusion is mistaken and that Nelson opposed the Revival as a Presbyterian evangelical. His later involvement with the Land League and the Irish Home Rule movement, including his tenure as the Member of Parliament for County Mayo, could be easily dismissed as an entirely discreditable affair. While avoiding romantic nostalgia in relation to Nelson’s nationalism, this book argues that Nelson’s basis for advocating Home Rule was not as peculiar as it might first appear.

Toleration and the Cromwellian Protectorate

1984 ◽  
Vol 21 ◽  
pp. 199-233 ◽  
Author(s):  
Blair Worden
Keyword(s):  
Nineteenth Century ◽  
Religious Toleration ◽  
Moral Foundations ◽  
The Past ◽  
History Of ◽  
The Subject ◽  
Late Nineteenth

Toleration is a Victorian subject, a monument to Victorian liberalism. ‘To us who have been educated in the nineteenth century’, proclaimed F. A. Inderwick in his book on the Interregnum, ‘any declaration inconsistent with religious toleration would be abhorrent and inadmissible’. His sentiment would not have seemed controversial to a generation raised on such best-selling works as Buckle’s History of Civilisation in England and Lecky’s History of the Rise and Influence of the Spirit of Rationalism. It may be that the Victorians, enquiring into the origins of the toleration which they had achieved, were prone to congratulate the past on becoming more like the present. Yet in the late nineteenth and early twentieth centuries, when interest in the subject was perhaps at its peak, we can also detect, in the statements on toleration of a Creighton or a Figgis, a fear that the present might become more like the past: that materialism and religious indifference might destroy the moral foundations of toleration, and foster a new barbarism which would persecute Christians afresh.

A 55-Year-Old Female with a History of Right Foot Drop and Left Hand Weakness

2016 ◽  
Author(s):  
Jeffrey A. Cohen ◽  
Justin J. Mowchun ◽  
Victoria H. Lawson ◽  
Nathaniel M. Robbins
Keyword(s):  
Systemic Vasculitis ◽  
Immunosuppressive Treatment ◽  
Abrupt Onset ◽  
Conclusive Evidence ◽  
Foot Drop ◽  
Mononeuritis Multiplex ◽  
Vasculitic Neuropathy ◽  
Left Hand ◽  
Serologic Markers ◽  
History Of

Vasculitic neuropathy often presents as a mononeuritis multiplex pattern. Ischemic nerve injury can lead to abrupt-onset, painful, and multifocal sensorimotor neuropathy. This chapter emphasizes the diagnostic considerations of vasculitic neuropathy, which includes the significant limitations of serologic markers in non-systemic vasculitic neuropathy. Nerve and muscle biopsy are important investigations to consider to make the diagnosis. Keys to management are also reviewed. It is important to manage systemic vasculitis with a rheumatologist. Nonsystemic vasculitis has a much better prognosis; immunosuppressive treatment is less aggressive, but it is recommended to have a rheumatologist’s input. There is no conclusive evidence on how to treat nonsystemic vasculitis. Mild cases may be treated with steroids alone.

The conservation of number and location of 18S sites indicates the relative stability of rDNA in species of Pentatomomorpha (Heteroptera)

Genome ◽  
2013 ◽  
Vol 56 (7) ◽  
pp. 425-429 ◽  
Author(s):  
Vanessa Bellini Bardella ◽  
Thiago Fernandes ◽  
André Luís Laforga Vanzela
Keyword(s):  
Sex Chromosomes ◽  
18S Rdna ◽  
Fluorescent In Situ Hybridization ◽  
Evolutionary History ◽  
Conclusive Evidence ◽  
Fish Analysis ◽  
Comparative Cytogenetics ◽  
Rdna Sites ◽  
History Of

Fluorescent in situ hybridization (FISH) with rDNA probes has been used for comparative cytogenetics studies in different groups of organisms. Although heteropterans are a large suborder within Hemiptera, studies using rDNA are limited to the infraorder Cimicomorpha, in which rDNA sites are present in the autosomes or sex chromosomes. We isolated and sequenced a conserved 18S rDNA region of Antiteuchus tripterus (Pentatomidae) and used it as a probe against chromosomes of 25 species belonging to five different families of Pentatomomorpha. The clone pAt05, with a length of 736 bp, exhibited a conserved stretch of 590 bp. FISH analysis with the probe pAt05 always demonstrated hybridization signals in sub-terminal positions, except for Euschistus heros. Apparently, there is a tendency for 18S rDNA sites to locate in autosomes, except for Leptoglossus gonagra and Euryophthalmus rufipennis, which showed signals in the m- and sex chromosomes, respectively. Although FISH has produced evidence that rearrangements are involved in rDNA repositioning, whether in different autosomes or between sex and m-chromosomes, we have no conclusive evidence of what were the pathways of these rearrangements based on the evolutionary history of the species studied here. Nevertheless, the diversity in the number of species analyzed here showed a tendency of 18S rDNA to remain among the autosomes.

An ‘Unnatural Alliance’ for Religious Toleration: The Philosophes and the Outlawed Pastors of the ‘Church of the Desert’

1973 ◽  
Vol 42 (4) ◽  
pp. 505-523
Author(s):  
John Dunning Woodbridge
Keyword(s):  
Eighteenth Century ◽  
Roman Catholic ◽  
Religious Toleration ◽  
Life Imprisonment ◽  
Southern France ◽  
Protestant Church ◽  
Religious Services ◽  
History Of ◽  
Reformed Churches ◽  
The Church

The struggles and sacrifices of those pastors and laymen who reconstructed the Reformed churches in southern France during the eighteenth century compose one of the intriguing chapters of the history of the “Church of the Desert.” Members of an outlawed Protestant church in a country which was overwhelmingly Roman Catholic by religion, these pastors and their flocks ran great risks in holding open-air religious services in the secluded and rugged countryside of the Midi—or the “Desert”—in southern France. Attendance at their services was punishable by perpetual service in the king's galleys for the men and life imprisonment for the women; the Reformed pastors who led these meetings did so on pain of death. Not a few of these Calvinists suffered extreme physical and mental anguish because of their obstinate refusal to abandon the faith of their fathers.

John Tucker, M.P., and Mid-Eighteenth-Century British Politics

1997 ◽  
Vol 29 (1) ◽  
pp. 15-38
Author(s):  
Bob Harris ◽  
Jeremy Black
Keyword(s):  
Eighteenth Century ◽  
British Politics ◽  
Bodleian Library ◽  
Political World ◽  
Political Views ◽  
Political Stance ◽  
History Of ◽  
Member Of Parliament

John Tucker was a member of Parliament for the borough of Weymouth between 1735–47 and again between 1754–78. The relevant entries for him in the volumes of the History of Parliament are exiguous. He appears to have made only two interventions in Commons debates, on 27 February 1771 and 30 April 1772. In John Brooke's words, both were “slight and short.” According to the History of Parliament, Tucker's political stance was determined largely by his relationship with George Bubb Dodington, although the evidence is capable, as we shall see, of being read in a different way. Romney Sedgwick quotes from a letter Dodington wrote to Sir Robert Walpole in 1737, following the famous division on the Prince of Wales's allowance, that “the connexion between these gentlemen [those identified with his interest, including Tucker] and me was such that we should not have differed in opinion” even had he decided to vote for the motion. Tucker emerges from the History of Parliament volumes as a man without political views of his own and as an individual tightly caught up in a politics shaped principally by interest and management.This article exploits a hitherto neglected source to reconstruct more fully John Tucker's political world and views, to present a different account of his political stance and importance, and thus to throw considerable light on politics in the mid-eighteenth century. This source is a manuscript collection that the Bodleian Library acquired in 1969 and 1970. The collection mostly comprises the papers of John Tucker's father, Edward, his brother, Richard, and John himself.

Thomas Hobbes, Heresy, and the Theological Project of Leviathan

2013 ◽  
Vol 26 (1) ◽  
pp. 6-33 ◽  
Author(s):  
Jeffrey R. Collins
Keyword(s):  
Thomas Hobbes ◽  
Latin Translation ◽  
Religious Toleration ◽  
History Of ◽  
English Law ◽  
Church Politics

In the later years of his life, Thomas Hobbes developed an intense interest in the history of Christian heresy, an interest which informed half a dozen of his manuscripts and publications. These heresy writings have typically been studied within the context of Restoration church politics. This article offers a broader account of the significance of these writings. It reads them as extensions of Hobbes’s longstanding project of theological reform. Hobbes’s heresy writings were not merely intended to defend him from prosecution under English law. They also constituted an audacious and risky reassertion of the assault on Trinitarian orthodoxy that Hobbes had supposedly retracted in the Latin translation of Leviathan. The article concludes by considering what this interpretation might tell us about Hobbes’s vacillating commitment to religious toleration.

scholarly journals Childhood Adversity Linked to Neurological Circuitry Changes and Mental Health Disorders. Narrative Review

2021 ◽  
Vol 9 (1) ◽  
pp. 43-51
Author(s):  
Alexander Shand
Keyword(s):  
Psychiatric Disorders ◽  
Preventive Medicine ◽  
Brain Connectivity ◽  
Childhood Adversity ◽  
Neural Circuitry ◽  
Conclusive Evidence ◽  
Medicine Research ◽  
Increased Risk ◽  
History Of ◽  
The Brain

Children who experience adversity have increased risk for psychiatric disorders. However, little is known about the exact alterations that occur in the neural circuitry and how that information may help lead to early diagnosis or preventive medicine. Research has shown that there are specific changes in neurological functional connectivity in the brain associated with childhood adversity. This review will examine recent papers that have investigated the correlation between these changes in brain connectivity and specific psychiatric disorders. Understanding the changes may help with preventive medicine by ensuring clinicians monitor patients with more severe history of adversity who are therefore at higher risk for developing a psychiatric disorder. This paper will also address potential recommendations that could be implemented in the future as research offers more conclusive evidence. Research is now beginning to address the questions of whether these changes can be attenuated, either during childhood or as adults.

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