<p>The OT4CLIMA project, funded by the Italian Ministry of Education, University and Research, within the PON 2014-2020 Industrial Research program, &#8220;Aerospace&#8221; thematic domain, aims at developing advanced Earth Observation (EO) technologies and methodologies for improving our capability to better understand the effects of Climate Change (CC) and our capability to mitigate them at the regional and sub-regional scale. Both medium-to-long term impacts (e.g. vegetation stress, drought) and extreme events with rapid dynamics (e.g. intense meteorological phenomena, fires) will be investigated, trying a twofold (i.e. interesting both &#8220;products&#8221; and &#8220;processes&#8221;) technological innovation: a) through the design and the implementation of advanced sensors to be mounted on multiplatform EO systems; b) through the development of advanced methodologies for EO data analysis, interpretation, integration and fusion.</p><p>Activities will focus on two of the major natural processes strictly related to Climate Change, namely the Carbon and Water Cycles by using an inter-disciplinary approach.</p><p>As an example, the project will make it possible the measurements, with an unprecedented accuracy of atmospheric (e.g. OCS, carbon-sulphide) and surface (e.g. soil moisture) parameters that are crucial in determining the vegetation contribution to the CO2 balance, suggesting at the same time solutions based on the analysis and integration of satellite, airborne and unmanned data, in order to significantly improve the capability of local communities to face the short- and long-term CC-related effects.</p><p>OT4CLIMA benefits from a strong scientific expertise (14 CNR institutes, ASI, INGV, CIRA, 3 Universities), considerable research infrastructures and a wide industrial partnership (including both big national players, i.e. E-Geos and IDS companies and well-established italian SMEs consortia, i.e. CREATEC, CORISTA and SIIT, and a spin-off company, Survey Lab) specifically focused on the technological innovation frontier.</p><p>This contribution would summarize the project main objectives and show some activities so far carried out.</p>