Modified Dermoscopic Algorithm for the Differentiation between Melanocytic and Nonmelanocytic Skin Tumors

2006 ◽  
Vol 10 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Andreas Blum ◽  
Jennifer Clemens ◽  
Giuseppe Argenziano
Keyword(s):  
Diagnostic Accuracy ◽  
Basal Cell ◽  
Skin Lesions ◽  
Skin Tumors ◽  
Melanocytic Tumors ◽  
Melanocytic Tumor ◽  
Clinical Diagnostic ◽  
Basal Cell Carcinomas ◽  
Surface Microscopy

Background: The use of dermoscopy (dermatoscopy, epiluminescence microscopy, surface microscopy) improves the clinical diagnostic accuracy of skin tumors by applying different algorithms or scores. The first step in the dermoscopic evaluation is the differentiation between melanocytic and nonmelanocytic skin tumors. Objective: To evaluate the diagnostic accuracy of the established dermoscopic algorithm (EDA) and the modified dermoscopic algorithm (MDA) for melanocytic versus nonmelanocytic skin tumors. Methods: Two hundred forty-nine patients with melanocytic and nonmelanocytic skin lesions were included. Dermoscopic images of the tumors were taken with 10-fold magnification, followed by surgery and histopathology at the departments of Dermatology at the universities of Tuebingen, in Germany, and Naples, in Italy. Each lesion was classified using the EDA and MDA. In the MDA, accessory nipples and dermatofibromas were considered in particular. Results: With the EDA, 225 of 249 (90.4%) skin tumors were correctly classified in one of the six groups. With the MDA, 237 of 249 (95.2%) were correctly classified. Improvement was achieved in 12 (4.8%) better classified skin tumors. In both algorithms, no melanoma was classified as a nonmalignant melanocytic tumor. All melanomas were classified in the group of melanocytic tumors and one melanoma was classified in the group of basal cell carcinomas. Conclusion: Both dermoscopic algorithms for the differentiation between melanocytic and nonmelanocytic skin tumors were simple and effective when applied step by step. The MDA is an improvement on the EDA with the classification of accessory nipples and dermatofibromas.

scholarly journals Medical images classification for skin cancer using quantitative image features with optical coherence tomography

2016 ◽  
Vol 09 (02) ◽  
pp. 1650003 ◽  
Author(s):  
Wei Gao ◽  
Valery P. Zakharov ◽  
Oleg O. Myakinin ◽  
Ivan A. Bratchenko ◽  
Dmitry N. Artemyev ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Skin Cancer ◽  
Basal Cell ◽  
Image Features ◽  
Skin Tumors ◽  
P Value ◽  
Optical Coherence ◽  
Quantitative Image ◽  
Basal Cell Carcinomas

Optical coherence tomography (OCT) is employed in the diagnosis of skin cancer. Particularly, quantitative image features extracted from OCT images might be used as indicators to classify the skin tumors. In the present paper, we investigated intensity-based, texture-based and fractal-based features for automatically classifying the melanomas, basal cell carcinomas and pigment nevi. Generalized estimating equations were used to test for differences between the skin tumors. A modified p value of [Formula: see text][Formula: see text]0.001 was considered statistically significant. Significant increase of mean and median of intensity and significant decrease of mean and median of absolute gradient were observed in basal cell carcinomas and pigment nevi as compared with melanomas. Significant decrease of contrast, entropy and fractal dimension was also observed in basal cell carcinomas and pigment nevi as compared with melanomas. Our results suggest that the selected quantitative image features of OCT images could provide useful information to differentiate basal cell carcinomas and pigment nevi from the melanomas. Further research is warranted to determine how this approach may be used to improve the classification of skin tumors.

Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors

2019 ◽  
Vol 152 (4) ◽  
pp. 446-457 ◽  
Author(s):  
Giovana Osorio ◽  
Teresa Zulueta-Dorado ◽  
Patricia González-Rodríguez ◽  
José Bernabéu-Wittel ◽  
Julian Conejo-Mir ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Skin Tumors ◽  
Aquaporin 3 ◽  
Melanocytic Nevi ◽  
Aquaporin 1 ◽  
Melanocytic Tumors ◽  
Basal Cell Carcinomas ◽  
Molecular Therapeutic ◽  
Molecular Therapeutic Targets ◽  
Atypical Nevi

Abstract Objectives Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. Methods Analysis of AQP1 and AQP3 expression by immunohistochemistry of 72 skin biopsy specimens from melanocytic skin tumors, nonmelanocytic tumors, or healthy samples. Results AQP1 showed strong labeling in 100% of benign common melanocytic nevi. Small blood vessels, stroma, and melanophages surrounding different types of melanomas tumors also were positive. Tumoral melanocytes in atypical nevi and melanomas were negative for AQP1. AQP3 showed strong labeling in 100% of melanocytic nevi, 100% of atypical melanocytic nevi, and 100% of melanomas. In all basal cell carcinomas and squamous cell carcinomas, staining for AQP3 was positive. Conclusions To our knowledge, this work represents the first demonstration of AQP1/AQP3 expression in human melanocytic skin tumors. More studies are needed to understand the underlying molecular mechanisms of expression of both AQPs in melanocytic tumors and their potential as molecular therapeutic targets.

Diagnosing Basal Cell Carcinoma by Dermatoscopy

1998 ◽  
Vol 3 (2) ◽  
pp. 62-67 ◽  
Author(s):  
David M. Carroll ◽  
Elizabeth M. Billingsley ◽  
Klaus F. Helm
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Blood Vessels ◽  
Basal Cell ◽  
Skin Surface ◽  
Skin Lesions ◽  
Noninvasive Technique ◽  
Cutaneous Malignancy ◽  
Basal Cell Carcinomas ◽  
Pigmented Skin Lesions

Background: Dermatoscopy (DS) has been used primarily to evaluate pigmented skin lesions. Little information is available on DS findings of basal cell carcinoma (BCC). Dermatoscopy is a noninvasive technique that allows visualization of cutaneous features from the skin surface to the papillary dermis. Basal cell carcinoma, the most common cutaneous malignancy, is traditionally diagnosed clinically and confirmed with biopsy. Objective: To determine the dermatoscopic features of non-pigmented basal cell carcinomas. Methods: The dermatoscopic findings of 27 lesions that clinically were suspicious for BCC were analyzed. Results: Of these 27 clinically suspect lesions, the biopsies revealed BCC in 20 specimens and squamous cell carcinoma (SCC) in two specimens. Twenty of these 22 specimens had dermatoscopic findings of BCC: diffusely distributed, branching blood vessels, asymmetric, and narrow blood vessels distributed deeper in the dermis, or a milky-red corona with superficial wide blood vessels. One nodular BCC in our study showed no distinct findings. Conclusions: Many BCCs have characteristic DS findings; however, dermatoscopic examination of some tumours will not demonstrate any known characteristic findings. As such, the DS criteria we propose for BCC are best utilized as an adjunctive study of clinical impressions. Biopsy remains the definitive diagnostic tool.

Clinical Diagnostic Accuracy of Early/Advanced Parkinson Disease: Updated Clinicopathologic Study

2020 ◽  
pp. 10.1212/CPJ.0000000000001016
Author(s):  
Charles H. Adler ◽  
Thomas G. Beach ◽  
Nan Zhang ◽  
Holly A. Shill ◽  
Erika Driver-Dunckley ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Clinical Diagnosis ◽  
Gold Standard ◽  
Disease Duration ◽  
Clinical Signs ◽  
Confidence Levels ◽  
Clinicopathologic Study ◽  
Clinical Diagnostic ◽  
Neuropathological Diagnosis

AbstractObjectives:Update data for diagnostic accuracy of a clinical diagnosis of Parkinson’s disease (PD) using neuropathological diagnosis as the gold standard.Methods:Data from the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) was used to determine the predictive value of a clinical PD diagnosis. Two clinical diagnostic confidence levels were used, Possible PD (PossPD, never treated or not responsive) and Probable PD (ProbPD, 2/3 cardinal clinical signs + responsive to dopaminergic medications). Neuropathological diagnosis was the gold standard.Results:Based on first visit to AZSAND, 15/54 (27.8%) PossPD cases and 138/163 (84.7%) ProbPD had confirmed PD. PD was confirmed in 24/34 (70.6%) ProbPD with <5 yrs and 114/128 (89.1%) with >5 yrs disease duration. Using the consensus final clinical diagnosis following death, 161/187 (86.1%) ProbPD had neuropathologically confirmed PD. Diagnostic accuracy for ProbPD improved if included motor fluctuations, dyskinesias, and hyposmia, and hyposmia for PossPD.Conclusions:This updated study confirmed lower clinical diagnostic accuracy for elderly, untreated or poorly responsive PossPD participants and for ProbPD with <5 yr disease duration, even when medication responsive. Caution continues to be needed when interpreting clinical studies of PD, especially studies of early disease, that do not have autopsy confirmation.Classification of Evidence:This study provides Class II evidence that a clinical diagnosis of probable PD at first visit identifies patients who will have pathologically confirmed PD with a sensitivity of 82.6% and specificity of 86.0%.

scholarly journals Assessment of clinical diagnostic accuracy compared with pathological diagnosis of basal cell carcinoma

2015 ◽  
Vol 6 (4) ◽  
pp. 258 ◽  
Author(s):  
Kafaie Parichehr ◽  
Dehghani Farideh ◽  
Rashidi Amirhossein ◽  
Shojaoddiny-Ardekani Ahmad ◽  
Ebrahimzadeh-Ardakani Mohammad ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Diagnostic Accuracy ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Pathological Diagnosis ◽  
Clinical Diagnostic

scholarly journals Radiological Findings of Gorlin Syndrome-A Case Report

2013 ◽  
Vol 3 (1) ◽  
pp. 94-98
Author(s):  
S Maohakud ◽  
G Sharma ◽  
Hira Lal ◽  
J Mohanty
Keyword(s):  
Basal Cell ◽  
Autosomal Dominant ◽  
Sella Turcica ◽  
Skin Lesions ◽  
Chest Wall Deformity ◽  
Radiological Findings ◽  
Autosomal Dominant Disorder ◽  
Falx Cerebri ◽  
Goltz Syndrome ◽  
Basal Cell Carcinomas

Basal cell nevus (Gorlin-Goltz) syndrome is a rare autosomal dominant disorder with multiple developmental anomalies and predisposition to various neoplasms. We present a 60 year old male with pigmented, ulcerated skin lesions in face, neck and trunk, histologically proved to be basal cell carcinomas. Mild exopthalmos, hypertelorism, chest wall deformity & scoliosis were noted. Radiological imaging showed calcification of falx cerebri & tentorium cerebelli, bridging of sella turcica, right third, fourth and fifth bifid ribs, scoliosis of lumbar spine, odontogenic keratocyst of mandible and flame shaped lucencies in hands. Nepalese Journal of Radiology / Vol.3 / No.1 / Issue 4 / Jan-June, 2013 / 94-98 DOI: http://dx.doi.org/10.3126/njr.v3i1.8821

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