Periodontal Wound Healing with Biodegradable Guided Tissue Regeneration Barriers

This study evaluates the influence of early healing on clinical and radiological outcomes of guided tissue regeneration (GTR) procedures of vertical intrabony defects in patients with aggressive periodontitis (AgP) in a 12-month follow-up. The influence of patient-related, site-specific and technical aspects on optimal early wound healing was also assessed. This analysis included 25 patients with 61 intrabony defects. All sites were treated according to guidelines of minimally invasive surgical technique with the use of bone grafts and collagen membranes. Early post-operative healing was evaluated using the Early Wound-Healing Index (EHI). Changes in clinical and radiological parameters were assessed 12 months postoperatively. After 2 weeks, primary healing (EHI ≤3) was observed in 44 sites (72.13%) and secondary healing was present in 17 sites (22.87%) (EHI = 4). The presence of thin gingival phenotype was significantly associated with an increased risk of secondary healing (OR = 0.203; p = 0.014). At 12 months, GTR resulted in a significant clinical attachment level gain, as well as probing pocket depth reduction and radiographic defect depth reduction. Primary or secondary healing did not affect these outcomes. Thick gingival biotype might be a prerequisite for optimal early wound healing. However, the type of early healing seems not to affect the long-term outcomes after regenerative treatment in aggressive periodontitis patients.

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The Effects of Guided Tissue Regeneration and Fixation Technique on Osseous Wound Healing in Rabbit Zygomatic Arch Osteotomies

Journal of Craniofacial Surgery ◽

10.1097/00001665-199601000-00011 ◽

1996 ◽

Vol 7 (1) ◽

pp. 46-53 ◽

Cited By ~ 16

Author(s):

Mark P. Mooney ◽

Robert D. Mundell ◽

Kraig Stetzer ◽

Mark W. Ochs ◽

Eric A. Milch ◽

...

Keyword(s):

Wound Healing ◽

Tissue Regeneration ◽

Guided Tissue Regeneration ◽

Zygomatic Arch ◽

Fixation Technique

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Periodontal Wound Healing and Tissue Regeneration: A Narrative Review

Pharmaceuticals ◽

10.3390/ph14050456 ◽

2021 ◽

Vol 14 (5) ◽

pp. 456

Author(s):

Young-Dan Cho ◽

Kyoung-Hwa Kim ◽

Yong-Moo Lee ◽

Young Ku ◽

Yang-Jo Seol

Keyword(s):

Wound Healing ◽

Tissue Regeneration ◽

Alveolar Bone ◽

Healing Process ◽

Complex Structure ◽

Limiting Factors ◽

Public Health Issue ◽

Wound Healing Process ◽

Periodontal Tissues ◽

Periodontal Wound Healing

Periodontal disease is a major public health issue, and various periodontal therapies have been performed to regenerate periodontal tissues. The periodontium is a complex structure composed of specialized tissues that support the teeth, and most periodontal surgeries are invasive procedures, including a resection of the gingiva or the alveolar bone. The periodontal wound healing process is slightly different from cutaneous wound healing and is similar to fetal healing, being almost scar-free. The aim of this review article is to provide an overview of periodontal wound healing and discuss various surgical and pharmaceutical approaches to achieve stable wound healing and improve the treatment outcomes. In addition, detrimental and limiting factors that induce a compromised prognosis are discussed, along with the perspective and future direction for successful periodontal tissue regeneration.

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