scholarly journals Effect of calcitonin on bone healing following titanium implant insertion.

1999 ◽  
Vol 41 (2) ◽  
pp. 77-80 ◽  
Author(s):  
F. H. Nociti Jr. ◽  
E. A. Sallum ◽  
S. Toledo ◽  
H. N. Newman ◽  
A. W. Sallum
Keyword(s):  
Bone Healing ◽  
Titanium Implant

Early Bone Healing Around 2 Different Experimental, HA Grit-Blasted, and Dual Acid-Etched Titanium Implant Surfaces. A Pilot Study in Rabbits

2012 ◽  
Vol 21 (6) ◽  
pp. 454-460 ◽  
Author(s):  
Luca Gobbato ◽  
Emilio Arguello ◽  
Ignacio Sanz Martin ◽  
Charles E. Hawley ◽  
Terrence J. Griffin
Keyword(s):  
Pilot Study ◽  
Bone Healing ◽  
Titanium Implant

Laser-photobiomodulation on titanium implant bone healing in rat model: comparison between 660- and 808-nm wavelength

2022 ◽  
Author(s):  
Guilherme Aparecido Monteiro Duque da Fonseca ◽  
Marcos Fernando Xisto Braga Cavalcanti ◽  
José Daniel de Souza Maior ◽  
Juliana da Silva Pereira ◽  
Leandro augusto Pinto ◽  
...  
Keyword(s):  
Bone Healing ◽  
Rat Model ◽  
Model Comparison ◽  
Titanium Implant

scholarly journals Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1318
Author(s):  
Faez Saleh Al-Hamed ◽  
Ola M. Maria ◽  
Jeff Phan ◽  
Ahmed Al Subaie ◽  
Qiman Gao ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Healing ◽  
Immune Cell ◽  
Acetylcholinesterase Inhibitor ◽  
Titanium Implant ◽  
Soft Tissue Healing ◽  
Tissue Healing ◽  
Custom Made ◽  
The Impact ◽  
Postoperative Administration

Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing.

Effect of adipose-derived stem cells on bone healing on titanium implant in tibia of diabetes mellitus induced rats

2010 ◽  
Vol 36 (5) ◽  
pp. 392 ◽  
Author(s):  
Min-Gu Kim ◽  
In-Kyo Jung ◽  
Sang-Hun Shin ◽  
Chul-Hoon Kim ◽  
Bok-Joo Kim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Bone Healing ◽  
Titanium Implant ◽  
Adipose Derived Stem Cells

Osteogenic differentiation of mesenchymal stem cells modulated by a chemically modified super-hydrophilic titanium implant surface

2018 ◽  
Vol 33 (2) ◽  
pp. 205-215 ◽  
Author(s):  
Yong-Su Kwon ◽  
Jin-Woo Park
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Bone Healing ◽  
Titanium Implant ◽  
Contact Angles ◽  
Mouse Bone Marrow ◽  
Implant Surface ◽  
Water Contact ◽  
Chemically Modified

This study investigated the osteogenic functionality of multipotent mesenchymal stem cells (MSCs) modulated by a chemically modified super-hydrophilic titanium (Ti) bone implant surface to elucidate the biological mechanism underlying the bone healing capacity of this modified Ti surface. A microstructured Ti surface incorporating bioactive ions (in this study, phosphate (P) ions) was prepared by wet chemical treatment. The results showed that the hydrothermally obtained crystalline P-incorporated Ti surface (P surface) displayed long-term super-hydrophilicity (water contact angles <5°) during a 36-week observation period. The hydrophilic P surface enhanced early cellular functions and osteogenic differentiation of multipotent MSCs derived from mouse bone marrow and human adipose tissue. The expression of critical integrins affecting subsequent osteoblast function and osteoblast phenotype genes was notably upregulated in multipotent MSCs grown on the P surface compared with the commercially available grit-blasted microrough clinical oral implant surface. The P surface supported better cell spreading, focal adhesion and ALP activity of MSCs. These results indicate that a super-hydrophilic P-incorporated Ti surface accelerates implant bone healing by enhancing the early osteogenesis functions of multipotent MSCs.

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