Laser-photobiomodulation on titanium implant bone healing in rat model: comparison between 660- and 808-nm wavelength

2022 ◽  
Author(s):  
Guilherme Aparecido Monteiro Duque da Fonseca ◽  
Marcos Fernando Xisto Braga Cavalcanti ◽  
José Daniel de Souza Maior ◽  
Juliana da Silva Pereira ◽  
Leandro augusto Pinto ◽  
...  
Keyword(s):  
Bone Healing ◽  
Rat Model ◽  
Model Comparison ◽  
Titanium Implant

A Combination Treatment of Raloxifene and Vitamin D Enhances Bone-to-Tendon Healing of the Rotator Cuff in a Rat Model

2020 ◽  
Vol 48 (9) ◽  
pp. 2161-2169
Author(s):  
Dong Min Kim ◽  
In Kyoung Shim ◽  
Myung Jin Shin ◽  
Jae Hee Choi ◽  
Yu Na Lee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Rat Model ◽  
Combination Treatment ◽  
Biomechanical Testing ◽  
Female Rats ◽  
Muscle Quality ◽  
Control Group ◽  
The Mean

Background: Tearing and degeneration of the rotator cuff at the tendon-to-bone junction are common in adults aged ≥50 years. Few studies have reported on the relationship between estrogen and the rotator cuff enthesis. In addition to preventing bone loss, selective estrogen receptor modulators have been shown to improve tendon and muscle quality. Purpose: To evaluate the effects of raloxifene (RLX) and vitamin D on rotator cuff tendon-to-bone healing in a rat model. Study Design: Controlled laboratory study. Methods: A total of 29 female rats (58 shoulders) were assigned to 4 groups: (1) control group, (2) ovariectomy (OVX)–only group, (3) no RLX group (OVX and rotator cuff repair [RCR]), and (4) RLX group (OVX, RCR, and RLX). Rats that did not undergo rotator cuff tear (RCT) surgery were divided into the control and OVX-only groups according to OVX surgery. Rats that underwent RCT surgery and RCR were divided into the no RLX and RLX groups according to RLX and vitamin D administration. An estrogen-deficient state was induced by OVX at 12 weeks of age. Bone mineral density (BMD) and trabecular bone characteristics were measured by micro–computed tomography, and healing of the tendon-to-bone junction was evaluated by biomechanical testing, histomorphometry, and micro–magnetic resonance imaging (MRI). Results: The mean final body weight (BW; 461.6 ± 47.3 g) of the OVX-only group was significantly higher and BMD (0.25 ± 0.07 g/cm3) was significantly lower ( P < .001) than the mean final BW (338.5 ± 35.1 g) and BMD (0.48 ± 0.05 g/cm3) of the control group. In contrast, the RLX group showed that the BW (369.6 ± 35.8 g) and BMD (0.41 ± 0.08 g/cm3) were not significantly different from the control group. The RLX group had a significantly higher histomorphometric total score (8.50 ± 1.05) than the no RLX group (4.83 ± 2.48). On biomechanical testing, the RLX group (29.7 ± 9.1 N) showed a significantly higher load to failure than the no RLX group (19.4 ± 8.8 N). On micro-MRI, the RLX group had a more homogeneous low signal and tendon continuity than the no RLX group. Conclusion: The combination treatment of RLX and vitamin D prevented a decrease in local BMD (greater tuberosity of the proximal humerus) and enhanced tendon-to-bone healing of the rotator cuff in a rat model. Clinical Relevance: This study induced an estrogen-deficient state similar to the human postmenopausal state and used drugs that are actually being prescribed in a clinical situation.

scholarly journals Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

2017 ◽  
Vol 13 (5) ◽  
pp. 1827-1831 ◽  
Author(s):  
Şeref Ezirganli ◽  
Hakki Oğuz Kazancioğlu ◽  
Ahmet Hüseyin Acar ◽  
Hakan Özdemir ◽  
Emre Kuzu ◽  
...  
Keyword(s):  
Bone Healing ◽  
Rat Model

scholarly journals A metaphyseal fracture rat model for mechanistic studies of osteoporotic bone healing

2019 ◽  
Vol 37 ◽  
pp. 420-430 ◽  
Author(s):  
RMY Wong ◽  
U Thormann ◽  
MHV Choy ◽  
NY Chim ◽  
MCM Li ◽  
...  
Keyword(s):  
Bone Healing ◽  
Rat Model ◽  
Osteoporotic Bone ◽  
Mechanistic Studies ◽  
Metaphyseal Fracture

Evaluation of the Effect of Platelet-Rich Fibrin on Long Bone Healing: An Experimental Rat Model

Orthopedics ◽  
2017 ◽  
Vol 40 (3) ◽  
pp. e479-e484 ◽  
Author(s):  
Turan Cihan Dülgeroglu ◽  
Hasan Metineren
Keyword(s):  
Bone Healing ◽  
Rat Model ◽  
Long Bone ◽  
Platelet Rich Fibrin ◽  
Experimental Rat Model

Fracture Healing and Biomarker Expression in a Diabetic Zucker Rat Model

2014 ◽  
Vol 104 (5) ◽  
pp. 428-433 ◽  
Author(s):  
Javier La Fontaine ◽  
Nathan A. Hunt ◽  
Stacey Curry ◽  
Tyler Kearney ◽  
Daniel Jupiter ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Fracture Healing ◽  
Bone Healing ◽  
Rat Model ◽  
Healing Process ◽  
Diabetic Rats ◽  
Vascular Endothelial ◽  
Delayed Healing ◽  
Endothelial Growth Factor

Background Persons with diabetes have a higher incidence of fractures compared with persons without diabetes. However, there is little published information concerning the deleterious effect of late-stage diabetes on fracture healing. There are no studies using animal models that evaluate the effect of advanced diabetes on fracture healing. The purpose of our study was to evaluate cytokine expression, specifically macrophage inflammatory protein 1 (MIP-1) and vascular endothelial growth factor, in fracture healing in a type 2 diabetes rat model. Methods We evaluated biomarker expression after femur fracture using a rat model. The two groups consisted of 24 Zucker diabetic rats (study group) and 12 Zucker lean rats (control group). An independent reviewer was used to assess delayed union. We evaluated serum samples 2, 4, 7, and 14 days after surgery for MIP-1, vascular endothelial growth factor, leptin, and other cytokine levels. Results At 3 weeks, Kaplan-Meier estimates showed that 45.8% of femur fractures in Zucker diabetic rats had healed, whereas 81.8% of those in Zucker lean rats had healed (P = .02). A logistic regression model to predict fast healing that included the three cytokines and diabetes status showed that the only factor achieving significance was MIP-1α. Vascular endothelial growth factor was the only biomarker to show significance compared with delayed healing. Conclusions These results confirm significant differences in biomarker expression between diabetic and nondiabetic rats during bone healing. The key factors for bone healing may appear early in the healing process, whereas differences in diabetes versus nondiabetes are seen later in the healing process. Increased levels of MIP-1α were associated with the likelihood of delayed healing.

scholarly journals The effects of chronic unloading and gap formation on tendon-to-bone healing in a rat model of massive rotator cuff tears

2013 ◽  
Vol 32 (3) ◽  
pp. 439-447 ◽  
Author(s):  
Megan L. Killian ◽  
Leonardo Cavinatto ◽  
Shivam A. Shah ◽  
Eugene J. Sato ◽  
Samuel R. Ward ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Bone Healing ◽  
Rat Model ◽  
Rotator Cuff Tears ◽  
Gap Formation ◽  
Massive Rotator Cuff Tears

scholarly journals Effect of calcitonin on bone healing following titanium implant insertion.

1999 ◽  
Vol 41 (2) ◽  
pp. 77-80 ◽  
Author(s):  
F. H. Nociti Jr. ◽  
E. A. Sallum ◽  
S. Toledo ◽  
H. N. Newman ◽  
A. W. Sallum
Keyword(s):  
Bone Healing ◽  
Titanium Implant

scholarly journals Quantitative Evaluation of Hepatic Steatosis Using Normalized Local Variance in a Rat Model: Comparison with Histopathology as the Reference Standard

2019 ◽  
Vol 20 (9) ◽  
pp. 1399
Author(s):  
Jae Seok Bae ◽  
Jae Young Lee ◽  
Dong Ho Lee ◽  
Haeryoung Kim ◽  
Youngeun Lee ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Quantitative Evaluation ◽  
Rat Model ◽  
Model Comparison ◽  
Reference Standard ◽  
Local Variance
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