Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model

Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing.

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Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

Applied Sciences ◽

10.3390/app10175750 ◽

2020 ◽

Vol 10 (17) ◽

pp. 5750 ◽

Cited By ~ 1

Author(s):

Vittorio Moraschini ◽

Carlos Fernando de Almeida Barros Mourão ◽

Rafael Coutinho de Mello Machado ◽

Jhonathan Raphaell Barros Nascimento ◽

Kayvon Javid ◽

...

Keyword(s):

Soft Tissue ◽

Bone Regeneration ◽

Systematic Reviews ◽

Selection Process ◽

Soft Tissue Healing ◽

Socket Preservation ◽

Platelet Rich Fibrin ◽

Dimensional Changes ◽

Tissue Healing ◽

The Impact

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets.

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Microbial adherence affinity and clinical characteristics of polypropylene versus silk sutures in oral surgery

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh170428184d ◽

2018 ◽

Vol 146 (5-6) ◽

pp. 258-263 ◽

Cited By ~ 1

Author(s):

Miroslav Dragovic ◽

Marko Pejovic ◽

Jelena Stepic ◽

Svetlana Dragovic ◽

Nadja Nikolic ◽

...

Keyword(s):

Soft Tissue ◽

Clinical Features ◽

Oral Surgery ◽

Statistical Significance ◽

Bacterial Adherence ◽

Silk Suture ◽

Soft Tissue Healing ◽

Tissue Healing ◽

The Impact ◽

Polypropylene Sutures

Introduction/Objective. The purpose of this study was to compare polypropylene and silk suture materials in terms of bacterial adherence and clinical features including the impact on soft tissue healing. Methods. Ten healthy patients were included in this study. Unilateral upper and lower wisdom teeth were extracted at the same time and wounds were sutured with different threads (one monofilament ? polypropylene ? and one multifilament ? silk suture). Stitches were removed seven days postoperatively. Real-time polymerase chain reaction was used to analyze bacterial adherence. Intraoperative handling and ease of removal were assessed with the help of Visual Analogue Scale. Landry healing index was used for evaluation of soft tissue healing. Results. Significantly more pronounced bacterial adherence was found on silk compared to polypropylene sutures (p = 0.005). Superior intraoperative handling properties were registered suturing with polypropylene compared to silk (p = 0.005). Soft tissue healing was significantly better around polypropylene sutures, both on the third and the seventh postoperative day (p = 0.016). Patient discomfort was slightly higher for polypropylene sutures, but without statistical significance. Conclusion. Polypropylene suture material showed significantly lower bacterial adherence and superior clinical features compared to silk, including better soft tissue healing.

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Immediate provisionalization with a CAD/CAM interim abutment and crown: A guided soft tissue healing technique

Journal of Prosthetic Dentistry ◽

10.1016/j.prosdent.2014.09.003 ◽

2015 ◽

Vol 113 (2) ◽

pp. 91-95 ◽

Cited By ~ 22

Author(s):

Periklis Proussaefs

Keyword(s):

Soft Tissue ◽

Soft Tissue Healing ◽

Tissue Healing ◽

Cad Cam

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Biomaterial-Stabilized Soft Tissue Healing for Healing of Critical-Sized Bone Defects: the Masquelet Technique

Advanced Healthcare Materials ◽

10.1002/adhm.201500793 ◽

2016 ◽

Vol 5 (6) ◽

pp. 630-640 ◽

Cited By ~ 12

Author(s):

Magdalena Tarchala ◽

Edward J. Harvey ◽

Jake Barralet

Keyword(s):

Soft Tissue ◽

Bone Defects ◽

Soft Tissue Healing ◽

Masquelet Technique ◽

Tissue Healing

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Tissue changes of extraction sockets in humans: a comparison of spontaneous healing vs. ridge preservation with secondary soft tissue healing

Clinical Oral Implants Research ◽

10.1111/j.1600-0501.2012.02535.x ◽

2012 ◽

pp. n/a-n/a ◽

Cited By ~ 16

Author(s):

Antonio Barone ◽

Massimiliano Ricci ◽

Paolo Tonelli ◽

Stefano Santini ◽

Ugo Covani

Keyword(s):

Soft Tissue ◽

Ridge Preservation ◽

Soft Tissue Healing ◽

Spontaneous Healing ◽

Tissue Healing ◽

Tissue Changes

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Effect of Platelet-Rich Plasma and Amniotic Membrane in Patients with Rotator Cuff Repair

Journal of Biomimetics Biomaterials and Biomedical Engineering ◽

10.4028/www.scientific.net/jbbbe.39.98 ◽

2018 ◽

Vol 39 ◽

pp. 98-102

Author(s):

Heri Suroto ◽

Ameria Pribadi ◽

Dwikora Novembri Utomo ◽

Ferdiansyah Mahyudin ◽

Lukas Widhiyanto

Keyword(s):

Soft Tissue ◽

Rotator Cuff ◽

Pain Score ◽

Amniotic Membrane ◽

Rotator Cuff Repair ◽

Platelet Rich Plasma ◽

Soft Tissue Healing ◽

Disability Score ◽

Tissue Healing ◽

Cuff Repair

Rotator cuff disorders are the most common source of shoulder problems, ranging from mild strain to massive tears. Platelet-rich plasma (PRP), an autologous blood with platelets concentration above baseline values represents a source of multiple growth factors that promotes tissue repair. This review examines the potential of using PRP to augment rotator cuff repair. Reporting 4 patients with impingement syndrome and supraspinatus tear who underwent decompression acromioplasty and supraspinatus repair augmented with platelet-rich plasma and amniotic membrane. An evaluation was made 3-24 months postoperative using Shoulder Pain and Disability Index (SPADI). Average preoperative pain score is 64%, disability score 54.58%, and total score 58.19%. Average postoperative pain score is 0%, disability score 0.42%, and total score 0.26% (Minimum Detectable Change at 90% confidence for pain score is 18%, disability score 13%, and total score 11%). This result is consequent with research by Luoay Fallouh, stating that improvement is caused by growth factor effects in platelet-rich plasma which promotes soft tissue healing. It can be concluded that platelet-rich plasma and amniotic membrane have promising effects to enhance soft tissue healing in patients with rotator cuff syndrome. Shoulder function is restored with no limitation on daily activity and pain is no longer present.

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