Exploring the role of Th1 cytokines: interleukin-17 and interleukin-18 in periodontal health and disease

ABSTRACT Probiotics are live micro-organisms that when administered in adequate amounts confer health benefits upon the host. Although a lot of work has been done regarding the effects of probiotic applications on systemic health particularly gastro-intestinal, the impact of probiotics on oral health is relatively new with lots of research going on; the area of probiotics and periodontal disease is still in its infancy. The present article summarizes the role of probiotics in periodontal health and disease and its effectiveness in periodontal therapy.

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Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease

Journal of Indian Society of Periodontology ◽

10.4103/0972-124x.183098 ◽

2016 ◽

Vol 0 (0) ◽

pp. 0 ◽

Cited By ~ 2

Author(s):

Vineet Nair ◽

Prasanta Bandyopadhyay ◽

Debabrata Kundu ◽

Satadal Das

Keyword(s):

Gingival Crevicular Fluid ◽

Interleukin 18 ◽

Periodontal Health ◽

Health And Disease ◽

Crevicular Fluid

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The Role of NrF2 in the Regulation of Periodontal Health and Disease

Journal of Dental Research ◽

10.1177/0022034517715007 ◽

2017 ◽

Vol 96 (9) ◽

pp. 975-983 ◽

Cited By ~ 17

Author(s):

A.V. Chiu ◽

M. Al Saigh ◽

C.A. McCulloch ◽

M. Glogauer

Keyword(s):

Cell Types ◽

Related Factor ◽

Oxygen Species ◽

Tissue Destruction ◽

Concept Of Disease ◽

Periodontal Health ◽

Disease Tolerance ◽

Host Protection ◽

Health And Disease

Immune-related disease tolerance is an important defense strategy that facilitates the maintenance of health in organs and tissues that are commonly colonized by bacteria. Immune tolerance to dysbiotic, tooth-borne biofilms is a poorly understood yet clinically relevant concept in the immunopathological mechanisms that are involved in the pathogenesis of periodontitis, particularly those related to neutrophil and macrophage responses. In periodontal health, neutrophils and macrophages respond to the formation of pathogenic bacterial biofilms by the production of bactericidal reactive oxygen species (ROS). However, when released in excess, ROS cause tissue damage and exacerbate inflammation. To counter these destructive responses, many cell types, including neutrophils and macrophages, launch a dedicated antioxidant system that limits the cell and tissue-damaging effects of ROS. The expression of antioxidants is primarily regulated by genetic response elements in their promoters. Here we consider the roles of nuclear factor erythroid 2-related factor (NrF2), a transcription factor, and other key regulators of antioxidants. The concept of disease tolerance, neutrophil and macrophage-generated oxidative stress, and their relationship to the pathogenesis of periodontitis is reviewed. We focus on the regulation of NrF2 and recent evidence suggesting that NrF2 plays a central role in host protection against tissue destruction in periodontitis.

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Role of the polymorphonuclear leukocyte in periodontal health and disease

Journal Of Clinical Periodontology ◽

10.1111/j.1600-051x.1984.tb01303.x ◽

1984 ◽

Vol 11 (1) ◽

pp. 1-15 ◽

Cited By ~ 76

Author(s):

Danette R. Miller ◽

Ira B. Lamster ◽

Abram I. Chasens

Keyword(s):

Polymorphonuclear Leukocyte ◽

Periodontal Health ◽

Health And Disease

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Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-2180 ◽

2017 ◽

Vol 18 (11) ◽

pp. 1085-1089 ◽

Cited By ~ 4

Author(s):

Monica J Mahajani ◽

Varsha A Jadhao ◽

Pooja S Wankhade ◽

Emmanuel Samson ◽

Vishwas D Acharya ◽

...

Keyword(s):

Periodontal Disease ◽

Gingival Crevicular Fluid ◽

Periodontal Therapy ◽

Interleukin 18 ◽

Periodontal Health ◽

Group I ◽

Nonsurgical Periodontal Therapy ◽

Health And Disease ◽

Group Ii ◽

Crevicular Fluid

ABSTRACT Aim The incidence and progression of the periodontal disease depend on periodontal microflora and the multifaceted response of the host, and these interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study was the assessment of the periodontal therapy in IL-18 level in periodontal disease and health. Materials and methods Based on clinical attachment loss (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) patients were divided into three groups: Group I with healthy patients, group II with chronic periodontitis, and group III with posttreatment patients having periodontitis. Results Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) volume were significantly higher in groups II and III compared with group I. However, there were no significant differences between GI in groups I, II, and III. The total amount of IL-18 in GCF was significantly higher in group II when compared with groups I and III (p < 0.05). Conclusion The present study confirmed that the IL-18 level in GCF was lower in healthy patients, higher in periodontally involved patients, and reduced at baseline, 3 and 6 weeks after nonsurgical periodontal therapy. Clinical significance The IL-18 might be hypothetically beneficial in distinguishing health from disease and monitoring periodontal disease activity. How to cite this article Mahajani MJ, Jadhao VA, Wankhade PS, Samson E, Acharya VD, Tekale PD. Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population. J Contemp Dent Pract 2017;18(11):1085-1089.

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