Fatty Acids and Inflammatory Skin Diseases

2018 ◽  
Vol 80 (1) ◽  
pp. 5-8
Author(s):  
Tetsuya HONDA
Keyword(s):  
Fatty Acids ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

2020 ◽  
Vol 21 (3) ◽  
pp. 741 ◽  
Author(s):  
Anamaria Balić ◽  
Domagoj Vlašić ◽  
Kristina Žužul ◽  
Branka Marinović ◽  
Zrinka Bukvić Mokos
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Skin Diseases ◽  
Inflammatory Responses ◽  
Omega 3 ◽  
Inflammatory Skin Diseases ◽  
Prevention And Treatment ◽  
Omega 6 ◽  
Inflammatory Skin

Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.

scholarly journals Experimental and clinical study of the efficacy of medicines containing omega-3 and 6 polyunsaturated fatty acids, in the treatment of inflammatory skin diseases

2018 ◽  
Vol 4 (2) ◽  
pp. 84-92
Author(s):  
Svetlana Grebennikova ◽  
Yurij Maklyakov
Keyword(s):  
Fatty Acids ◽  
Contact Dermatitis ◽  
Polyunsaturated Fatty Acids ◽  
Skin Diseases ◽  
Irritant Contact Dermatitis ◽  
Omega 3 ◽  
Inflammatory Skin Diseases ◽  
White Rats ◽  
Inflammatory Skin ◽  
Anti Inflammatory

Introduction: Over the recent years, the attention of scientists regarding the search for alternative means of treatment, including local therapy, of inflammatory skin diseases, has been focused in recent years on medicines containing omega-3 and 6 polyunsaturated fatty acids (PUFA). Objectives: to substantiate the feasibility of using medicines containing omega-3 and 6 polyunsaturated fatty acids and antioxidants in the treatment of inflammatory skin diseases. Methods:The studies were carried out on 224 conventional white rats of the Wistar line in compliance with the international principles of the European Convention for the Protection of Vertebrates. A burn injury was used to cause experimental simple irritant contact dermatitis. After trying various treatment options with using Omegaven, histopathological examinations of 18 fragments of affected skin of white rats with cross sections stained with hematoxylin–eosin and pikrofuxin by Van Gieson’s method. The state of lipid peroxidation (LPO) in blood and affected skin was evaluated in the animals. One hundred forty-six patients with inflammatory skin diseases (dermatitis simple irritant contact, allergic contact dermatitis, atopic dermatitis, neurodermatitis, psoriasis, cutaneous mastocytosis in children) were observed. In treatment, there were used medicines with omega-3 and 6 PUFA or an antioxidant medicines. Results and discussion: Skin reactions of dermatitis simple irritant contact in rats after burn injury were evaluated at different points of time. The observations showed higher efficacy of medicines containing PUFA than standard anti-inflammatory agents in the treatment of simple irritant contact dermatitis. Histopathological examination of the skin of white rats with simple irritant contact dermatitis after the 11-day treatment revealed that the expression and composition of the cellular reaction in the lesions with a predominating lymphocytes and macrophages (mainly cell response) differ significantly from those trated with Radevit ointment (segmented neutrophil leukocytes, eosinophils – delay in the acute phase of inflammation). There was identified a smaller thickness (up to 1/3) of the strips of granulation tissue under the actively proliferating cells of the epidermis. It was possible to demonstrate the superiority with respect to reducing the activity of LPO medicines containing omega-3 and 6 PUFA, over those with anti-inflammatory action. The clinical observations of patients showed high efficacy of the local treatment with medicines containing omega-3 and 6 PUFA, or antioxidant. Conclusion: For the first time, the mechanism of implementing an anti-inflammatory effect of the experimental medicines containing omega-3 and 6 polyunsaturated fatty acids (Omegaven, Vitamin F99 cream rich), – an antioxidant effect - when treating simple irritant contact dermatitis when treating simple irritant contact dermatitis; that is the weakening of the severity of oxidative stress. For the first time, the greatest contribution of an increased activity of catalase to the weakening of oxidative stress in the affected skin is shown.

Use of Natural Components Derived from Oil Seed Plants for Treatment of Inflammatory Skin Diseases

2019 ◽  
Vol 25 (20) ◽  
pp. 2241-2263 ◽  
Author(s):  
Monika Styrczewska ◽  
Magdalena Zuk ◽  
Aleksandra Boba ◽  
Iwan Zalewski ◽  
Anna Kulma
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Cultivated Plants ◽  
Seed Plants ◽  
Inflammatory Skin Diseases ◽  
Oil Seed ◽  
Tailored Approach ◽  
Inflammatory Skin

The incidence of inflammatory skin diseases is increasing, so the search for relevant therapeutics is of major concern. Plants are rich in phytochemicals which can alleviate many symptoms. In this review, we concentrate on compounds found in the seeds of widely cultivated plants, regularly used for oil production. The oils from these plants are often used to alleviate the symptoms of inflammatory diseases through synergetic action of unsaturated fatty acids and other phytochemicals most commonly derived from the terpenoid pathway. The knowledge of the chemical composition of oil seeds and the understanding of the mechanisms of action of single components should allow for a more tailored approach for the treatment for many diseases. In many cases, these seeds could serve as an efficient material for the isolation of pure phytochemicals. Here we present the content of phytochemicals, assumed to be responsible for healing properties of plant oils in a widely cultivated oil seed plants and review the proposed mechanism of action for fatty acids, selected mono-, sesqui-, di- and triterpenes, carotenoids, tocopherol and polyphenols.

scholarly journals High prevalence and little awareness in patients with chronic inflammatory skin diseases and genital involvement

2021 ◽  
Author(s):  
Petra Staubach ◽  
Natascha Plavic‐Radeka ◽  
Adriane Peveling‐Oberhag ◽  
Anna Sohn ◽  
Sebastian Zimmer ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
High Prevalence ◽  
Inflammatory Skin
Sign in / Sign up

Export Citation Format

Share Document