scholarly journals Haplotypes of Transcription Factor 7–Like 2 (TCF7L2) Gene and Its Upstream Region Are Associated With Type 2 Diabetes and Age of Onset in Mexican Americans

Diabetes ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 389-393 ◽  
Author(s):  
Donna M. Lehman ◽  
Kelly J. Hunt ◽  
Robin J. Leach ◽  
Jeanette Hamlington ◽  
Rector Arya ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Mexican Americans ◽  
Age Of Onset ◽  
Upstream Region ◽  
Tcf7l2 Gene

scholarly journals Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men

Diabetes ◽  
2006 ◽  
Vol 55 (9) ◽  
pp. 2645-2648 ◽  
Author(s):  
Cuilin Zhang ◽  
Lu Qi ◽  
David J. Hunter ◽  
James B. Meigs ◽  
JoAnn E. Manson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Tcf7l2 Gene

scholarly journals Transcription factor regulation as a mechanism of confounding effects between distinct human traits

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 1349
Author(s):  
Milos Pjanic ◽  
Clint L. Miller ◽  
Thomas Quertermous
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Genetic Variants ◽  
Human Diseases ◽  
Upstream Region ◽  
Hair Color ◽  
Human Populations ◽  
Genome Wide Association Studies ◽  
Transcription Factor Regulation

Genome-wide association studies (GWAS) to date have discovered thousands of genetic variants linked to human diseases and traits, which hold the potential to unravel the mechanisms of complex phenotypes. However, given that the majority of these associated variants reside in non-coding genomic regions, their predicted cis and trans-regulatory functions remain largely undefined. Here we show that correlation between human diseases and traits can follow geographical distribution of human populations, and that the underlying mechanism is at least partly genetically based. We report two Type 2 Diabetes (T2D) GWAS variants (rs7903146 and rs12255372) in the TCF7L2 locus that regulate expression in skin tissues but not lymphoblastoid or adipose tissues, of the KITLG gene that encodes an important regulator of melanogenesis and light hair color in European populations. We also report extensive binding events of TCF7L2 protein in the promoter region, immediate upstream region and first intron of the KITLG gene, which supports a trans-interaction between TCF7L2 and KITLG. We further show that both light hair color and T2D genetic variants are correlated with geographic latitude. Taken together, our observations suggest that natural variation in transcription factor loci in European human populations may be an underlying and confounding factor for the geographical correlation between human phenotypes, such as type 2 diabetes and light hair color. We postulate that transcription factor regulation may confound the correlation between seemingly diverse human traits. Furthermore, our findings demonstrate the importance of dissecting the genomic architecture of GWAS loci using multiple genetic and genomic datasets.

scholarly journals Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population

Diabetes ◽  
2007 ◽  
Vol 56 (10) ◽  
pp. 2631-2637 ◽  
Author(s):  
Y.-C. Chang ◽  
T.-J. Chang ◽  
Y.-D. Jiang ◽  
S.-S. Kuo ◽  
K.-C. Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Association Study ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Tcf7l2 Gene

scholarly journals Polymorphism of Transcription Factor 7-Like 2 Gene and HOMA-β Level of Individuals With and Without Type 2 Diabetes Mellitus Family History

2016 ◽  
Vol 19 (2) ◽  
pp. 176
Author(s):  
Waode Astria Sahrani ◽  
Indwiani Astuti ◽  
Ahmad Hamim Sadewa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor ◽  
Insulin Secretion ◽  
Family History ◽  
Model Assessment ◽  
Tcf7l2 Gene ◽  
Type 2 Dm

Family history has considered as a risk factor of type 2 diabetes. Transcription factor-7 like 2 (TCF7L2) hasrole to regulates insulin secretion and blood glucose homeostasis. The aim of current study was to determine thers7903146 polymorphism of TCF7L2 gene and homeostatic model assessment-β (HOMA-β) level on individual withand without type 2 Diabetes Mellitus (DM) family history. This work is a case-control study. Thirty six subjectswith type 2 DM family history and 36 subjects without type 2 DM family history were recruited. HOMA-βmeasure to analyze the insulin secretion. Polymorphisms of TCF7L2 gene was analyzed by using PCR-RFLPmethod. Statistical analysis was performed by using T-test, Mann-Whitney and Chi-square with signifi cancelevel 0.05. The frequency of the T allele of the cases were 4.2% and the controls were 2.8% (p=0.500). The oddratio was 0.649 (CI;95%:0.106-4.055). The HOMA-β levels of the cases were signifi cant low (132.56±62.48)compared with the controls (266.09±1.68) with p=0.000. The subjects with type 2 DM family history have asimilar frequency of having T alleles and CT/TT genotypes. The subjects with type 2 DM family history hassignifi cantly lower HOMA-β levels than subject without DM family history.

scholarly journals GENETIC SUSCEPTIBILITY OF TRANSCRIPTION FACTOR 7-LIKE 2 GENE VARIANT AND RISK OF TYPE 2 DIABETES IN ASIAN INDIANS

2019 ◽  
pp. 151-155
Author(s):  
NAVNEET KAUR ◽  
GURJIT KAUR BHATTI ◽  
SANJAY KUMAR BHADADA ◽  
SAMER SINGH ◽  
JASVINDER SINGH BHATTI
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Indian Population ◽  
Human Subjects ◽  
Density Lipoprotein ◽  
Polymerase Chain Reaction Method ◽  
North Indian Population ◽  
Tcf7l2 Gene ◽  
Increased Risk

Background: The variants of transcription factor 7-like 2 (TCF7L2) gene have been shown to be associated with type 2 diabetes mellitus (T2DM) and its related complications. Objectives: We aimed to explore the possible association of rs7903146 (C/T) variant in TCF7L2 with the risk of T2DM in the North Indian population. Methods: The present case–control study included a total of 638 human subjects (318 T2DM subjects and 320 healthy controls). Various anthropometric, biochemical, and genetic parameters were studies in all the subjects. Genotyping of TCF7L2 gene was carried out using allele-specific polymerase chain reaction method. Results: The results of this study indicate significantly higher values of body mass index, waist circumference, waist-to-hip ratio, and body fat (%) in T2DM subjects than controls (p≤0.001). Dyslipidemia represented by higher levels of triglycerides and reduced values of high-density lipoprotein was more predominant in diabetic subjects compared to healthy subjects. The frequency of risk genotype (TT) frequency was significantly higher in T2DM subjects (16.4%) compared to controls (11.6%). The “T” allele was more dominant in diabetic subjects than controls. Logistic regression analysis of the data revealed a significant association of TT genotype with 2-fold (odds ratio with 95% of confidence interval; 2.09 [1.29–3.42] p=0.003) and CT genotype with 1.7-fold (1.73 [1.23–2.44] p=0.002) increased risk of developing T2DM. Conclusions: The present study demonstrated a significant association of rs7903146 (C/T) variant in TCF7L2 with the augmented risk of T2DM in North Indian population.

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