scholarly journals Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice

Diabetes ◽  
2012 ◽  
Vol 61 (4) ◽  
pp. 857-865 ◽  
Author(s):  
M. Nakayama ◽  
T. Castoe ◽  
T. Sosinowski ◽  
X. He ◽  
K. Johnson ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Nod Mice ◽  
Cell Receptor

T Cell Receptor Gene Polymorphisms Associated with Anti-Insulin, Autoimmune T Cells in Diabetes-Prone NOD Mice

1997 ◽  
Vol 10 (3) ◽  
pp. 317-321 ◽  
Author(s):  
Eric A. Simone ◽  
Liping Yu ◽  
Dale R. Wegmann ◽  
George S. Eisenbarth
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Nod Mice ◽  
Cell Receptor ◽  
T Cell Receptor Gene ◽  
Receptor Gene Polymorphisms ◽  
Cell Receptor Gene

Anti-α/β T cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice

1991 ◽  
Vol 21 (5) ◽  
pp. 1163-1169 ◽  
Author(s):  
Pascal Sempé ◽  
Pierre Bédossa ◽  
Marie-Francoise Richard ◽  
Maria-Carme Villà ◽  
Jean-Francois Bach ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
T Cell Receptor ◽  
Autoimmune Diabetes ◽  
Nod Mice ◽  
Cell Receptor ◽  
Nonobese Diabetic ◽  
Receptor Monoclonal Antibody

scholarly journals Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization.

1996 ◽  
Vol 184 (5) ◽  
pp. 1755-1768 ◽  
Author(s):  
U McKeever ◽  
S Khandekar ◽  
J Newcomb ◽  
J Naylor ◽  
P Gregory ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Adoptive Transfer ◽  
Cell Clone ◽  
Nod Mice ◽  
Cell Receptor ◽  
Transfer Model ◽  
Maternal Immunization ◽  
Nonobese Diabetic ◽  
T Cell Clone

The BDC 2.5 T cell clone is specific for pancreatic beta-cell antigen presented by I-Ag7, and greatly accelerates diabetes when injected into 10-21-d-old nonobese diabetic (NOD) mice. The BDC 2.5 T cell receptor (TCR) has been solubilized as a TCR-IgG1 chimeric protein. All NOD mice immunized against BDC 2.5 TCR-IgG1 produced antibodies recognizing TCR C alpha/C beta epitopes that were inaccessible on the T cell surface. 56% of the mice produced antibodies against the BDC 2.5 clonotype that specifically blocked antigen activation of BDC 2.5 cells. We have used the adoptive transfer model of diabetes to demonstrate that maternal immunization with soluble TCR protects young mice from diabetes induced by the BDC 2.5 T cell clone.

Molecular Analysis of the T-cell Receptor Vβ5 and Vβ8 Repertoire in Pancreatic Lesions of Autoimmune Diabetic NOD Mice

1993 ◽  
Vol 6 (4) ◽  
pp. 405-422 ◽  
Author(s):  
Peter Berschick ◽  
Karin Fehsel ◽  
Hans Ulrich Weltzien ◽  
Hubert Kolb
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Molecular Analysis ◽  
Nod Mice ◽  
Cell Receptor

Limited heterogeneity of T-cell receptor Vβ gene expression in the early stage of insulitis in NOD mice

1993 ◽  
Vol 37 (2-3) ◽  
pp. 187-196 ◽  
Author(s):  
Klaus Drexler ◽  
Sally Burtles ◽  
Ursula Hurtenbach
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
T Cell Receptor ◽  
Early Stage ◽  
Nod Mice ◽  
Cell Receptor ◽  
T Cell Receptor Vβ

scholarly journals Autoreactive Effector/Memory CD4+ and CD8+ T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52054 ◽  
Author(s):  
Ramiro Diz ◽  
Alaina Garland ◽  
Benjamin G. Vincent ◽  
Mark C. Johnson ◽  
Nicholas Spidale ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Nod Mice ◽  
Cell Receptor ◽  
Effector Memory ◽  
Receptor Usage

scholarly journals Reduction of T Cell Receptor Diversity in NOD Mice Prevents Development of Type 1 Diabetes but Not Sjögren’s Syndrome

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112467 ◽  
Author(s):  
Joanna Kern ◽  
Robert Drutel ◽  
Silvia Leanhart ◽  
Marek Bogacz ◽  
Rafal Pacholczyk
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Receptor ◽  
Sjögren's Syndrome ◽  
Nod Mice ◽  
Cell Receptor ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice

Diabetes ◽  
1999 ◽  
Vol 48 (1) ◽  
pp. 34-42 ◽  
Author(s):  
H. S. Jun ◽  
P. Santamaria ◽  
H. W. Lim ◽  
M. L. Zhang ◽  
J. W. Yoon
Keyword(s):  
T Cells ◽  
T Cell ◽  
Beta Cell ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Nod Mice ◽  
Cell Receptor ◽  
Absolute Requirement

scholarly journals T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice.

1991 ◽  
Vol 173 (5) ◽  
pp. 1091-1097 ◽  
Author(s):  
N Nakano ◽  
H Kikutani ◽  
H Nishimoto ◽  
T Kishimoto
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Islet Cells ◽  
Cell Clone ◽  
Nod Mice ◽  
Cell Receptor ◽  
Cell Clones ◽  
T Cell Clone ◽  
Gene Usage

Five islet-reactive T cell clones were established from islet-infiltrating T cells of non-obese diabetic (NOD) mice. All clones expressed CD4, but not CD8, and responded to islet cells from various strains of mice in the context of I-ANOD. They could induce insulitis when transferred into disease-resistant I-E+ transgenic NOD mice. The T cell receptor (TCR) sequences utilized by the clones were determined. Their usage of TCR V and J segments was not restricted but was rather diverse. One of the clones utilized V beta 16. The expression of V beta 16 was significantly reduced in I-E+ transgenic NOD, suggesting the possibility that the islet-reactive T cell clone expressing V beta 16 may be deleted or inactivated by I-E molecules. This clone might be one of the candidates that triggers insulitis.

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