Molecular Analysis of the T-cell Receptor Vβ5 and Vβ8 Repertoire in Pancreatic Lesions of Autoimmune Diabetic NOD Mice

1993 ◽  
Vol 6 (4) ◽  
pp. 405-422 ◽  
Author(s):  
Peter Berschick ◽  
Karin Fehsel ◽  
Hans Ulrich Weltzien ◽  
Hubert Kolb
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Molecular Analysis ◽  
Nod Mice ◽  
Cell Receptor

T Cell Receptor Gene Polymorphisms Associated with Anti-Insulin, Autoimmune T Cells in Diabetes-Prone NOD Mice

1997 ◽  
Vol 10 (3) ◽  
pp. 317-321 ◽  
Author(s):  
Eric A. Simone ◽  
Liping Yu ◽  
Dale R. Wegmann ◽  
George S. Eisenbarth
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Nod Mice ◽  
Cell Receptor ◽  
T Cell Receptor Gene ◽  
Receptor Gene Polymorphisms ◽  
Cell Receptor Gene

scholarly journals Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice

Diabetes ◽  
2012 ◽  
Vol 61 (4) ◽  
pp. 857-865 ◽  
Author(s):  
M. Nakayama ◽  
T. Castoe ◽  
T. Sosinowski ◽  
X. He ◽  
K. Johnson ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Nod Mice ◽  
Cell Receptor

Anti-α/β T cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice

1991 ◽  
Vol 21 (5) ◽  
pp. 1163-1169 ◽  
Author(s):  
Pascal Sempé ◽  
Pierre Bédossa ◽  
Marie-Francoise Richard ◽  
Maria-Carme Villà ◽  
Jean-Francois Bach ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
T Cell Receptor ◽  
Autoimmune Diabetes ◽  
Nod Mice ◽  
Cell Receptor ◽  
Nonobese Diabetic ◽  
Receptor Monoclonal Antibody

scholarly journals Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization.

1996 ◽  
Vol 184 (5) ◽  
pp. 1755-1768 ◽  
Author(s):  
U McKeever ◽  
S Khandekar ◽  
J Newcomb ◽  
J Naylor ◽  
P Gregory ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Adoptive Transfer ◽  
Cell Clone ◽  
Nod Mice ◽  
Cell Receptor ◽  
Transfer Model ◽  
Maternal Immunization ◽  
Nonobese Diabetic ◽  
T Cell Clone

The BDC 2.5 T cell clone is specific for pancreatic beta-cell antigen presented by I-Ag7, and greatly accelerates diabetes when injected into 10-21-d-old nonobese diabetic (NOD) mice. The BDC 2.5 T cell receptor (TCR) has been solubilized as a TCR-IgG1 chimeric protein. All NOD mice immunized against BDC 2.5 TCR-IgG1 produced antibodies recognizing TCR C alpha/C beta epitopes that were inaccessible on the T cell surface. 56% of the mice produced antibodies against the BDC 2.5 clonotype that specifically blocked antigen activation of BDC 2.5 cells. We have used the adoptive transfer model of diabetes to demonstrate that maternal immunization with soluble TCR protects young mice from diabetes induced by the BDC 2.5 T cell clone.

Limited heterogeneity of T-cell receptor Vβ gene expression in the early stage of insulitis in NOD mice

1993 ◽  
Vol 37 (2-3) ◽  
pp. 187-196 ◽  
Author(s):  
Klaus Drexler ◽  
Sally Burtles ◽  
Ursula Hurtenbach
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
T Cell Receptor ◽  
Early Stage ◽  
Nod Mice ◽  
Cell Receptor ◽  
T Cell Receptor Vβ

scholarly journals Autoreactive Effector/Memory CD4+ and CD8+ T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52054 ◽  
Author(s):  
Ramiro Diz ◽  
Alaina Garland ◽  
Benjamin G. Vincent ◽  
Mark C. Johnson ◽  
Nicholas Spidale ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Nod Mice ◽  
Cell Receptor ◽  
Effector Memory ◽  
Receptor Usage

Molecular analysis of T cell receptor Vβ chain to detect leukemia cell clonality in patients by adaptor ligation-mediated polymerase chain reaction

1994 ◽  
Vol 177 (1-2) ◽  
pp. 9-15 ◽  
Author(s):  
Takaji Matsutani ◽  
Chie Oishi ◽  
Toshihiko Kaneshige ◽  
Hirotsune Igimi ◽  
Kiyohisa Uchida ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
T Cell ◽  
T Cell Receptor ◽  
Molecular Analysis ◽  
Leukemia Cell ◽  
Cell Receptor ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
T Cell Receptor Vβ ◽  
Cell Clonality

scholarly journals Molecular Analysis of T-Cell Receptor β Genes in Cutaneous T-Cell Lymphoma Reveals Jβ1 Bias

2006 ◽  
Vol 126 (8) ◽  
pp. 1893-1899 ◽  
Author(s):  
Suzanne M. Morgan ◽  
Elizabeth Hodges ◽  
Tracey J. Mitchell ◽  
Susan Harris ◽  
Sean J. Whittaker ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Molecular Analysis ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma
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