Wnt Pathway Inhibitor DKK1—A Potential Novel Biomarker for Ectopic Skeletal Muscle Adiposity

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2100-P
Author(s):  
HIRA ALI ◽  
JOSEPH M. ZMUDA ◽  
RYAN CVEJKUS ◽  
ERIN E. KERSHAW ◽  
ALLISON L. KUIPERS ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wnt Pathway ◽  
Muscle Adiposity

scholarly journals Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity

2019 ◽  
Vol 3 (2) ◽  
pp. 488-495 ◽  
Author(s):  
Hira Ali ◽  
Joseph M Zmuda ◽  
Ryan K Cvejkus ◽  
Erin E Kershaw ◽  
Allison L Kuipers ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wnt Pathway ◽  
African Ancestry ◽  
Model Assessment ◽  
Fasting Serum ◽  
Muscle Area ◽  
Muscle Density ◽  
Muscle Adiposity ◽  
Total Body

Abstract Emerging evidence indicates that ectopic skeletal muscle adiposity may be a risk factor for type 2 diabetes (T2D), especially in persons of African ancestry. In vitro studies suggest that a Wnt pathway inhibitor, Dickkopf-related protein 1 (DKK1), plays a role in adiposity regulation and could be a biomarker for adiposity in humans. The objective of this study was to test whether serum DKK1 levels relate to adiposity measures in a cohort from an African ancestry population at high risk for T2D. Fasting serum DKK1 was measured in a sample of 159 men of African ancestry aged ≥40 years (mean age ± SD, 63.5 ± 8.2 years; mean body mass index, 27.8 ± 4.5 kg/m2). Anthropometrics included total-body and trunk adiposity measured by dual-energy x-ray absorptiometry and lower-leg skeletal muscle density measured by CT [which reflects the intramuscular adiposity content (mg/cm3)]. Serum DKK1 was positively correlated with BMI (r = 0.20; P = 0.01), waist circumference (r = 0.15; P = 0.046), DXA total-body adiposity (r = 0.24; P = 0.003), and DXA trunk adiposity (r = 0.21; P = 0.009), independent of age and height. In addition, serum DKK1 was inversely correlated with skeletal muscle density (r = −0.25; P = 0.002), independent of age, BMI, and calf muscle area. No significant correlation was found between serum DKK1 and fasting serum glucose or insulin levels or insulin resistance estimated by homeostasis model assessment. These findings suggest that higher levels of serum DKK1 may be associated with greater overall, central, and ectopic skeletal muscle adiposity. Further studies are needed to unravel the potential role of DKK1 in the regulation of adiposity in humans.

scholarly journals Markers of Inflammation Are Heritable and Associated with Subcutaneous and Ectopic Skeletal Muscle Adiposity in African Ancestry Families

2011 ◽  
Vol 9 (4) ◽  
pp. 319-326 ◽  
Author(s):  
Iva Miljkovic ◽  
Allison L. Kuipers ◽  
Candace M. Kammerer ◽  
Xiaojing Wang ◽  
Clareann H. Bunker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
African Ancestry ◽  
Markers Of Inflammation ◽  
Muscle Adiposity

scholarly journals Hepatic and Skeletal Muscle Adiposity Are Associated with Diabetes Independent of Visceral Adiposity in Nonobese African-Caribbean Men

2020 ◽  
Vol 18 (6) ◽  
pp. 275-283
Author(s):  
Iva Miljkovic ◽  
Allison L. Kuipers ◽  
Ryan K. Cvejkus ◽  
J. Jeffrey Carr ◽  
James G. Terry ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Visceral Adiposity ◽  
African Caribbean ◽  
Muscle Adiposity

scholarly journals Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men

Obesity ◽  
2013 ◽  
Vol 21 (9) ◽  
pp. 1900-1907 ◽  
Author(s):  
I. Miljkovic ◽  
A.L. Kuipers ◽  
L.H. Kuller ◽  
Y. Sheu ◽  
C.H. Bunker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Serum Lipid ◽  
Muscle Adiposity

scholarly journals Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD

2014 ◽  
Vol 44 (5) ◽  
pp. 1188-1198 ◽  
Author(s):  
Matthew Maddocks ◽  
Dinesh Shrikrishna ◽  
Simone Vitoriano ◽  
Samantha A. Natanek ◽  
Rebecca J. Tanner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Computed Tomography ◽  
Skeletal Muscle ◽  
Exercise Capacity ◽  
Intramuscular Fat ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Muscle Attenuation ◽  
Muscle Adiposity

Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population.In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU.Mean±sdpercentage intramuscular fat was higher in the patient group (6.7±3.5%versus4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95).Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes.

Abstract MP048: Ectopic Muscle and Liver Adiposity are Independently Associated with Type 2 Diabetes in African Ancestry Men

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Iva Miljkovic ◽  
Allison Kuipers ◽  
J Jeffrey Carr ◽  
James Terry ◽  
Sangeeta Nair ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Body Fat ◽  
African Ancestry ◽  
Ectopic Fat ◽  
Fat Depots ◽  
Total Body Fat ◽  
Muscle Adiposity ◽  
Total Body

Although obesity is a major driver of type 2 diabetes (T2D), many obese individuals do not develop T2D. Indeed, fat around and within non-adipose tissue organs (i.e., ectopic fat) is emerging as a strong risk factor for diabetes. The potential differential contribution of ectopic fat depots throughout the body on T2D risk is unclear because studies have mainly focused on visceral and/or liver fat. No study, to our knowledge, has addressed the potential independent association of visceral, liver, and skeletal muscle adiposity with T2D. Such studies are particularly needed among African ancestry populations, as generalized obesity and other risk factors do not appear to explain the high T2D burden in this population segment. To address this knowledge gap, we measured total body fat by DXA, and visceral, liver, and calf skeletal muscle adiposity by computed tomography in 490 Afro-Caribbean men, aged 50-91 years (mean age=64 years, mean BMI=27.5 kg/m 2 ). The prevalence of T2D in this population was 22.3%. We employed multiple logistic regression using total body fat percent and ectopic fat depots as predictors (Table). We found that each 7.9 HU decrease in liver attenuation (indicative of greater liver adiposity) was associated with a 33% increased odds of T2D (p=0.011). Similarly, each 4.2 mg/cm 3 decrease in muscle attenuation (indicative of greater intra-muscular adiposity) was associated with a 31% increased odds of T2D (p=0.04). These associations were independent of total and visceral adiposity. Our results support the “ectopic fat syndrome” theory, as opposed to the “portal theory”, in the pathogenesis of diabetes among African ancestry men. Longitudinal studies are needed to clarify the exact role of specific ectopic fat depots in T2D, particularly in high-risk African ancestry populations.

scholarly journals Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study

Thorax ◽  
2020 ◽  
Vol 75 (9) ◽  
pp. 801-804 ◽  
Author(s):  
Michaela R Anderson ◽  
Imaani Easthausen ◽  
Grace Gallagher ◽  
Jayaram Udupa ◽  
Yubing Tong ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Lung Transplant ◽  
Abdominal Muscle ◽  
Thigh Muscle ◽  
Risk Of Death ◽  
Increased Risk ◽  
Muscle Attenuation ◽  
Muscle Adiposity ◽  
Transplant Candidates

CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI −20 to −8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI −21 to −10). CT imaging may improve candidate risk stratification.

Sign in / Sign up

Export Citation Format

Share Document