2061-P: Inflammation Status Is Independent Risk Factor for the Development of Metabolic Syndrome in Both Metabolically Healthy Obese and Nonobese Adults

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2061-P
Author(s):  
KYU YEON HUR ◽  
MIN SUN CHOI ◽  
SUNG WOON PARK ◽  
SEUNG-EUN LEE ◽  
JIYEON AHN ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy

scholarly journals The prevalence of metabolically healthy obesity according to the sample of the Moscow region

2017 ◽  
Vol 14 (4) ◽  
pp. 51-56 ◽  
Author(s):  
Elena V. Ostrovskaya ◽  
Tatiana I. Romantsova ◽  
Andrei N. Gerasimov ◽  
Tamara E. Novoselova
Keyword(s):  
Metabolic Syndrome ◽  
Carbohydrate Metabolism ◽  
Medical Records ◽  
Density Lipoprotein ◽  
Homa Index ◽  
Obese Patients ◽  
Hip Circumference ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy

Introduction. Obesity is a major factor for cardiometabolic risk. However, there is a category of obese patients without disorders of lipid, carbohydrate metabolism and cardiovascular disease metabolically healthy obese (MHO). Aim. Our goal was to investigate the prevalence and characteristics of this phenotype compared to patients with metabolic syndrome (MS). Materials and methods. To evaluate the prevalence of the MHO phenotype we analyzed 389 medical records of females aged 1860 years with obesity. Three types of MHO criteria were used: 1) HOMA index (2.7); 2) IDF-criteria of metabolic syndrome, 2005; 3) the BioSHaRE-EU 2013 criteria (obese patients without any symptoms of MS). We conducted a comparative analysis of anthropometry, status of lipid and carbohydrate metabolism, the functional state of the liver. Results. The MHO prevalence was: 34.5% according to HOMA index, according to the definitions of MS 2005 38.6%, in BioSHaRE-EU 9.6%. In groups of MHO and MS dyslipidemia was observed in 27.3 and 49.5% (p0.05), hypertension in 25% and 71.6% (p0.05), steatogepatosis in 47.7% vs 51.3% (p0.05) of observations, respectively. Among comorbidities the gynecological pathology was most prevalent - 50.8 and 61.4% (p0.05), disorders of carbohydrate metabolism differed significantly in frequency- 6.82 and 39.1% of patients (p0.05). Patients with MHO had a shorter duration of the existence of obesity than MS (18.7 vs. 24 years) (p=0.0004) and less likely to have attempted to reduce weight 85.8% and 91.6%. Average BMI, waist circumference, hip circumference, fasting glucose, total cholesterol, insulin basal, basal C-peptide, HOMA index in groups of MHO and MS differed significantly (p0.05). Median ALT was 20 and 23.2 U/l, AST 20 and 23 U/l, triglycerides 1.1 and 1.8 mmol/l, high-density lipoprotein 1.4 and 1.1 mmol/l, respectively. Conclusions. The MHO prevalence was maximal according to the MS definitions from 2005, and minimal with BioSHaRE-EU criteria. The main analyzed indicators differed significantly in groups MHO and MS. Longer obesity existence in the MS group may suggest an instability of MHO phenotype over time.

scholarly journals Increased Heart Failure Risk in Normal-Weight People With Metabolic Syndrome Compared With Metabolically Healthy Obese Individuals

2011 ◽  
Vol 58 (13) ◽  
pp. 1343-1350 ◽  
Author(s):  
Christina Voulgari ◽  
Nicholas Tentolouris ◽  
Polychronis Dilaveris ◽  
Dimitris Tousoulis ◽  
Nicholas Katsilambros ◽  
...  
Keyword(s):  
Heart Failure ◽  
Metabolic Syndrome ◽  
Normal Weight ◽  
Metabolically Healthy Obese ◽  
Failure Risk ◽  
Healthy Obese ◽  
Metabolically Healthy

scholarly journals Metabolically healthy obese and metabolic syndrome of the lean: the importance of diet quality. Analysis of MAGNETIC cohort

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Kamila Osadnik ◽  
Tadeusz Osadnik ◽  
Marta Lonnie ◽  
Mateusz Lejawa ◽  
Rafał Reguła ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Diet Quality ◽  
Quality Analysis ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy

scholarly journals Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0174945 ◽  
Author(s):  
Andrea E. Iglesias Molli ◽  
Julieta Panero ◽  
Patricia C. Dos Santos ◽  
Claudio D. González ◽  
Jorge Vilariño ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Telomere Length ◽  
Obese Women ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy

scholarly journals Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017

2020 ◽  
Vol 18 (1) ◽  
pp. 63
Author(s):  
Yongseok Seo ◽  
Seungyeon Lee ◽  
Joung-Sook Ahn ◽  
Seongho Min ◽  
Min-Hyuk Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Health Insurance ◽  
National Health Insurance ◽  
National Health ◽  
Metabolic Status ◽  
National Health Insurance System ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy

(1) Background: The health implications associated with the metabolically healthy obese (MHO) phenotype, in particular related to symptoms of depression, are still not clear. the purpose of this study is to check whether depression and metabolic status are relevant by classifying them into four groups in accordance with the MHO diagnostic standard. Other impressions seen were the differences between sexes and the effects of the MHO on the occurrence of depression. (2) Methods: A sample of 3,586,492 adult individuals from the National Health Insurance Database of Korea was classified into four categories by their metabolic status and body mass index: (1) metabolically healthy non-obese (MHN); (2) metabolically healthy obese (MHO); (3) metabolically unhealthy non-obese (MUN); and (4) metabolically unhealthy obese (MUO). Participants were followed for six to eight years for new incidences of depression. The statistical significance of the general characteristics of the four groups, as well as the mean differences in metabolic syndrome risk factors, was assessed with the use of a one-way analysis of variance (ANOVA). (3) Results: The MHN ratio in women was higher than in men (men 39.3%, women 55.2%). In both men and women, depression incidence was the highest among MUO participants (odds ratio (OR) = 1.01 in men; OR = 1.09 in women). It was concluded as well that, among the risk factors of metabolic syndrome, waist circumference was the most related to depression. Among the four groups, the MUO phenotype was the most related to depression. Furthermore, in women participants, MHO is also related to a higher risk of depressive symptoms. These findings indicate that MHO is not a totally benign condition in relation to depression in women. (4) Conclusion: Therefore, reducing metabolic syndrome and obesity patients in Korea will likely reduce the incidence of depression.

scholarly journals Metabolic profiles of obese women

2019 ◽  
Vol 6 (2) ◽  
pp. 93-96
Author(s):  
Mohamed Ridha GUEDJATI ◽  
◽  
Adeila Dalel Taibi ◽  
Ghania Hebboul ◽  
Khaoula Lachekhab ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Profiles ◽  
Obese Women ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
Surcharge Pondérale

Introduction. Certains sujets obèses, parait-il, sont plus exposés à encourir des complications cardiométaboliques. Par ailleurs, d’autres sujets ne le sont peut-être pas. Objectif. Profiler les sujets obèses métaboliquement sains (Metabolically Healthy Obese ou MHO) et des sujets obèses métaboliquement malades (Metabolically UnHealthy Obese ou MUHO) en utilisant deux critères de définition. Méthode. 49 femmes en surcharge pondérale (IMC ≥ 25 Kg/m2) ou obèses (IMC ≥ 30 Kg/m2), ont été sélectionneés pour répondre à une identification de leur profil métabolique en utilisant deux types de critères, Les critères Wildman modifié avec Triglycérides ≥ 1,5 g/l, HDLc < 0,5 g/l, Glycémie à Jeun ≥ 1g/l. Les critères du Consensus Sociaties on Metabolic Syndrome avec, en plus, des mêmes valeurs glucido-lipidiques, la présence d’un diabète ou d’une HTA. Pour Wildman, il faut au moins 2 critères pour qu’un obèse soit métaboliquement sain (MHO). Pour le consensus, il faut au moins trois critères. Résultats. Chez les 49 femmes, le phénotype MHO représente 77 % (n=38) selon les critères du consensus vs 57 % (n=28) selon les critères de Wildman modifiés. En utilisant les critères du Consensus, 10 sujets MUHO (20 %) basculent dans le profil MHO. Discussion. Dans notre étude, la taille de l’échantillon étant très faible et les critères étant limités au bilan lipidique et aux antécédents personnels, nos résultats ne font qu’orienter l’instabilité d’un consensus fixant clairement les critères de définition des phénotypes métaboliques des sujets obèses notamment leur caractère sain. Conclusion. L’absence de consensus sur les critères de définition des MHO et des MUHO conditionne fortement la classification de ces deux catégories d’obèses.

scholarly journals Metabolically healthy obese individuals present similar chronic inflammation level but less insulin-resistance than obese individuals with metabolic syndrome

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0190528 ◽  
Author(s):  
Andrea Elena Iglesias Molli ◽  
Alberto Penas Steinhardt ◽  
Ariel Pablo López ◽  
Claudio Daniel González ◽  
Jorge Vilariño ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Chronic Inflammation ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy

scholarly journals Metabolically healthy obesity and physical fitness in military males in the CHIEF study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sheng-Huei Wang ◽  
Pei-Shou Chung ◽  
Yen-Po Lin ◽  
Kun-Zhe Tsai ◽  
Ssu-Chin Lin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
International Diabetes Federation ◽  
Analysis Of Covariance ◽  
Physically Active ◽  
Metabolically Healthy Obese ◽  
The Metabolic Syndrome ◽  
Male Cohort ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
The Difference

AbstractThe metabolically healthy obese (MHO) characterized by the absence of metabolic syndrome have shown superior cardiorespiratory fitness (CRF) and similar muscular strength as compared with the metabolically unhealthy obese (MUO). However, this finding might be biased by the baseline sedentary behavior in the general population. This study utilized 3669 physically active military males aged 18–50 years in Taiwan. Obesity and metabolically unhealthy were respectively defined as body mass index ≥ 27.5 kg/m2 and presence of at least two major components of the metabolic syndrome, according to the International Diabetes Federation criteria for Asian male adults. Four groups were accordingly classified as the metabolically healthy lean (MHL, n = 2510), metabolically unhealthy lean (MUL, n = 331), MHO (n = 181) and MUO (n = 647). CRF was evaluated by time for a 3-km run, and muscular strengths were separately assessed by numbers of push-up and sit-up within 2 min. Analysis of covariance was utilized to compare the difference in each exercise performance between groups adjusting for age, service specialty, smoking, alcohol intake and physical activity. The metabolic syndrome prevalence in MUL and MUO was 49.8% and 47.6%, respectively. The performance of CRF did not differ between MHO and MUO (892.3 ± 5.4 s and 892.6 ± 3.0 s, p = 0.97) which were both inferior to MUL and MHL (875.2 ± 4.0 s and 848.6 ± 1.3 s, all p values < 0.05). The performance of muscular strengths evaluated by 2-min push-ups did not differ between MUL and MUO (45.3 ± 0.6 and 45.2 ± 0.4, p = 0.78) which were both less than MHO and MHL (48.4 ± 0.8 and 50.6 ± 0.2, all p values < 0.05). However, the performance of 2-min sit-ups were only superior in MHL (48.1 ± 0.1) as compared with MUL, MHO and MUO (45.9 ± 0.4, 46.7 ± 0.5 and 46.1 ± 0.3, respectively, all p values < 0.05). Our findings suggested that in a physically active male cohort, the MHO might have greater muscle strengths, but have similar CRF level compared with the MUO.

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