Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome

Introduction. Certains sujets obèses, parait-il, sont plus exposés à encourir des complications cardiométaboliques. Par ailleurs, d’autres sujets ne le sont peut-être pas. Objectif. Profiler les sujets obèses métaboliquement sains (Metabolically Healthy Obese ou MHO) et des sujets obèses métaboliquement malades (Metabolically UnHealthy Obese ou MUHO) en utilisant deux critères de définition. Méthode. 49 femmes en surcharge pondérale (IMC ≥ 25 Kg/m2) ou obèses (IMC ≥ 30 Kg/m2), ont été sélectionneés pour répondre à une identification de leur profil métabolique en utilisant deux types de critères, Les critères Wildman modifié avec Triglycérides ≥ 1,5 g/l, HDLc < 0,5 g/l, Glycémie à Jeun ≥ 1g/l. Les critères du Consensus Sociaties on Metabolic Syndrome avec, en plus, des mêmes valeurs glucido-lipidiques, la présence d’un diabète ou d’une HTA. Pour Wildman, il faut au moins 2 critères pour qu’un obèse soit métaboliquement sain (MHO). Pour le consensus, il faut au moins trois critères. Résultats. Chez les 49 femmes, le phénotype MHO représente 77 % (n=38) selon les critères du consensus vs 57 % (n=28) selon les critères de Wildman modifiés. En utilisant les critères du Consensus, 10 sujets MUHO (20 %) basculent dans le profil MHO. Discussion. Dans notre étude, la taille de l’échantillon étant très faible et les critères étant limités au bilan lipidique et aux antécédents personnels, nos résultats ne font qu’orienter l’instabilité d’un consensus fixant clairement les critères de définition des phénotypes métaboliques des sujets obèses notamment leur caractère sain. Conclusion. L’absence de consensus sur les critères de définition des MHO et des MUHO conditionne fortement la classification de ces deux catégories d’obèses.

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The prevalence of metabolically healthy obesity according to the sample of the Moscow region

Obesity and metabolism ◽

10.14341/omet2017451-56 ◽

2017 ◽

Vol 14 (4) ◽

pp. 51-56 ◽

Cited By ~ 2

Author(s):

Elena V. Ostrovskaya ◽

Tatiana I. Romantsova ◽

Andrei N. Gerasimov ◽

Tamara E. Novoselova

Keyword(s):

Metabolic Syndrome ◽

Carbohydrate Metabolism ◽

Medical Records ◽

Density Lipoprotein ◽

Homa Index ◽

Obese Patients ◽

Hip Circumference ◽

Metabolically Healthy Obese ◽

Healthy Obese ◽

Metabolically Healthy

Introduction. Obesity is a major factor for cardiometabolic risk. However, there is a category of obese patients without disorders of lipid, carbohydrate metabolism and cardiovascular disease metabolically healthy obese (MHO). Aim. Our goal was to investigate the prevalence and characteristics of this phenotype compared to patients with metabolic syndrome (MS). Materials and methods. To evaluate the prevalence of the MHO phenotype we analyzed 389 medical records of females aged 1860 years with obesity. Three types of MHO criteria were used: 1) HOMA index (2.7); 2) IDF-criteria of metabolic syndrome, 2005; 3) the BioSHaRE-EU 2013 criteria (obese patients without any symptoms of MS). We conducted a comparative analysis of anthropometry, status of lipid and carbohydrate metabolism, the functional state of the liver. Results. The MHO prevalence was: 34.5% according to HOMA index, according to the definitions of MS 2005 38.6%, in BioSHaRE-EU 9.6%. In groups of MHO and MS dyslipidemia was observed in 27.3 and 49.5% (p0.05), hypertension in 25% and 71.6% (p0.05), steatogepatosis in 47.7% vs 51.3% (p0.05) of observations, respectively. Among comorbidities the gynecological pathology was most prevalent - 50.8 and 61.4% (p0.05), disorders of carbohydrate metabolism differed significantly in frequency- 6.82 and 39.1% of patients (p0.05). Patients with MHO had a shorter duration of the existence of obesity than MS (18.7 vs. 24 years) (p=0.0004) and less likely to have attempted to reduce weight 85.8% and 91.6%. Average BMI, waist circumference, hip circumference, fasting glucose, total cholesterol, insulin basal, basal C-peptide, HOMA index in groups of MHO and MS differed significantly (p0.05). Median ALT was 20 and 23.2 U/l, AST 20 and 23 U/l, triglycerides 1.1 and 1.8 mmol/l, high-density lipoprotein 1.4 and 1.1 mmol/l, respectively. Conclusions. The MHO prevalence was maximal according to the MS definitions from 2005, and minimal with BioSHaRE-EU criteria. The main analyzed indicators differed significantly in groups MHO and MS. Longer obesity existence in the MS group may suggest an instability of MHO phenotype over time.

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Reply to the letter to the editor: Lifestyle interventions on weight loss among metabolically healthy obese women

Clinical Nutrition ◽

10.1016/j.clnu.2020.07.017 ◽

2020 ◽

Vol 39 (9) ◽

pp. 2933-2934

Author(s):

M. Palau-Rodríguez ◽

M. Garcia-Aloy ◽

M. Rosa Bernal-Lopez ◽

R. Gómez-Huelgas ◽

F.J. Tinahones ◽

...

Keyword(s):

Weight Loss ◽

Lifestyle Interventions ◽

Obese Women ◽

Metabolically Healthy Obese ◽

Letter To The Editor ◽

Healthy Obese ◽

Metabolically Healthy

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Increased Heart Failure Risk in Normal-Weight People With Metabolic Syndrome Compared With Metabolically Healthy Obese Individuals

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2011.04.047 ◽

2011 ◽

Vol 58 (13) ◽

pp. 1343-1350 ◽

Cited By ~ 143

Author(s):

Christina Voulgari ◽

Nicholas Tentolouris ◽

Polychronis Dilaveris ◽

Dimitris Tousoulis ◽

Nicholas Katsilambros ◽

...

Keyword(s):

Heart Failure ◽

Metabolic Syndrome ◽

Normal Weight ◽

Metabolically Healthy Obese ◽

Failure Risk ◽

Healthy Obese ◽

Metabolically Healthy

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Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women

Journal of Proteome Research ◽

10.1021/acs.jproteome.8b00042 ◽

2018 ◽

Vol 17 (8) ◽

pp. 2600-2610 ◽

Cited By ~ 6

Author(s):

Enrique Almanza-Aguilera ◽

Carl Brunius ◽

M. Rosa Bernal-Lopez ◽

Mar Garcia-Aloy ◽

Francisco Madrid-Gambin ◽

...

Keyword(s):

Weight Loss ◽

Lifestyle Intervention ◽

Obese Women ◽

Metabolically Healthy Obese ◽

Plasma Metabolome ◽

Healthy Obese ◽

Metabolically Healthy

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Metabolically healthy obese and metabolic syndrome of the lean: the importance of diet quality. Analysis of MAGNETIC cohort

Nutrition Journal ◽

10.1186/s12937-020-00532-0 ◽

2020 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Kamila Osadnik ◽

Tadeusz Osadnik ◽

Marta Lonnie ◽

Mateusz Lejawa ◽

Rafał Reguła ◽

...

Keyword(s):

Metabolic Syndrome ◽

Diet Quality ◽

Quality Analysis ◽

Metabolically Healthy Obese ◽

Healthy Obese ◽

Metabolically Healthy

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2061-P: Inflammation Status Is Independent Risk Factor for the Development of Metabolic Syndrome in Both Metabolically Healthy Obese and Nonobese Adults

Diabetes ◽

10.2337/db19-2061-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2061-P

Author(s):

KYU YEON HUR ◽

MIN SUN CHOI ◽

SUNG WOON PARK ◽

SEUNG-EUN LEE ◽

JIYEON AHN ◽

...

Keyword(s):

Metabolic Syndrome ◽

Risk Factor ◽

Independent Risk Factor ◽

Metabolically Healthy Obese ◽

Healthy Obese ◽

Metabolically Healthy

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Characterization of lipid profile by nuclear magnetic resonance spectroscopy (1H NMR) of metabolically healthy obese women after weight loss with Mediterranean diet and physical exercise

Medicine ◽

10.1097/md.0000000000007040 ◽

2017 ◽

Vol 96 (27) ◽

pp. e7040 ◽

Cited By ~ 8

Author(s):

Enrique Rodriguez-Garcia ◽

Josefina Ruiz-Nava ◽

Sonia Santamaria-Fernandez ◽

Jose Carlos Fernandez-Garcia ◽

Antonio Vargas-Candela ◽

...

Keyword(s):

Nuclear Magnetic Resonance ◽

Weight Loss ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Obese Women ◽

Metabolically Healthy Obese ◽

Healthy Obese ◽

Metabolically Healthy

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Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles

Archives of Medical Science ◽

10.5114/aoms/92118 ◽

2021 ◽

Vol 17 (2) ◽

pp. 323-336

Author(s):

Aleksandra Korac ◽

Biljana Srdic-Galic ◽

Ana Stancic ◽

Vesna Otasevic ◽

Bato Korac ◽

...

Keyword(s):

Metabolic Syndrome ◽

At Risk ◽

Protein Expression ◽

Risk Groups ◽

Normal Weight ◽

Obese Women ◽

Adipose Tissues ◽

Gene And Protein Expression ◽

Healthy Obese ◽

Metabolically Healthy

IntroductionMetabolic syndrome arises from abnormal adipose function accompanied by insulin resistance. As early factors reflecting/impacting lipid storage dysfunction of adipose tissues, we sought to determine adipokine levels in subcutaneous and visceral adipose tissues (SAT and VAT).Material and methodsGene and protein expression of leptin, adiponectin, and resistin were analyzed in SAT and VAT of normal-weight and overweight/obese women, subclassified according to insulin resistance index, triglyceride, total-, LDL- and HDL-cholesterol levels into metabolically healthy and “at risk” groups.ResultsCompared with normal-weight women, obese women had higher serum leptin levels (P<0.05), as well as increased leptin gene and protein expression in VAT. Conversely, expression levels of leptin were lower in SAT of obese women, and minor in the SAT of “at risk” groups of women, compared with weight-matched healthy groups. In addition, lower adiponectin levels were detected in SAT of metabolically healthy obese women (P<0.01), and lower in SAT and VAT (P<0.05) of “at risk” obese women compared to healthy, obese women. Significant differences in resistin levels were only observed in obese women; resistin gene expression was higher in VAT and SAT of obese, compared to normal-weight women. However, higher gene expression was not consistent with protein expression of resistin.ConclusionsLow adiponectin in both examined adipose tissues and inappropriate leptin expression levels in SAT appear to be important characteristics of obesity-related metabolic syndrome. Intriguingly, this adipokine dysregulation is primary seen in SAT, suggesting that endocrine dysfunction in this abdominal depot may be an early risk sign of metabolic syndrome.

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