89-LB: The Effect of GIP on Plasma Glucose in a Setting of Prandial Insulin Overdose and Physical Activity after Meal Intake in Patients with Type 1 Diabetes

Abstract Aim/Hypothesis It was the aim to prospectively study regimes of “preventive” carbohydrate administration to avoid major reduction in plasma glucose during physical activity. Methods 24 patients with type 1 diabetes (age 41±12 years; 11 women, 13 men; BMI 26.5±4.7 kg/m2; HbA1c 9.1±1.5%; insulin dose 0.64±0.22 IU/kg body weight and day) participated in one experiment without physical activity and in three experiments with a 4 km, 60 min hike starting at 2 p.m.. No “preventive” carbohydrates, 2×10 g or 2×20 g carbohydrates (muesli bars) were taken when starting and after 30 min (randomized order). Plasma glucose was determined. Results Within 30 min after starting physical activity, plasma glucose fell by approximately 70 mg/dl, making additional carbohydrate intake necessary in 70% of the subjects. This drop was not prevented by any regimens of “preventive” carbohydrate intake. After the nadir, plasma glucose rose faster after the 2×20 g carbohydrate regime (the largest amount tested; p=0.0036). With “preventive” administration of carbohydrates, significantly (p<0.05) less additional “therapeutic” carbohydrates needed to be administered in 6 h following the initiation of the hike. Conclusions/Interpretation In conclusion, in the setting of 2 h postprandial exercise in type 1 diabetes, preventive carbohydrate supplementation alone will not completely eliminate the risk of brisk falls in plasma glucose concentrations or hypoglycaemic episodes. Else, higher amounts or repeated administration of carbohydrates may be necessary.

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Abstract #224 Meal Intake is Suppressive of Ketogenesis in Patients with Type 1 Diabetes

Endocrine Practice ◽

10.1016/s1530-891x(20)47070-3 ◽

2018 ◽

Vol 24 ◽

pp. 40

Author(s):

Husam Ghanim ◽

Kelly Green ◽

J.E.A.N.N.E. HEJNA ◽

Nitesh Kuhadiya ◽

M.A.N.A.V. BATRA ◽

...

Keyword(s):

Type 1 Diabetes ◽

Meal Intake

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Mobile Physical Activity for Type 1 Diabetes

Case Medical Research ◽

10.31525/ct1-nct04204733 ◽

2019 ◽

Author(s):

Keyword(s):

Physical Activity ◽

Type 1 Diabetes

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Increasing plasma glucose before the development of type 1 diabetes ‐ the TRIGR study

Pediatric Diabetes ◽

10.1111/pedi.13251 ◽

2021 ◽

Author(s):

Johnny Ludvigsson ◽

David Cuthbertson ◽

Dorothy J. Becker ◽

Olga Kordonouri ◽

Bärbel Aschemeier ◽

...

Keyword(s):

Type 1 Diabetes ◽

Plasma Glucose

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Association between Physical Activity and Sport Participation on Hemoglobin A1c Among Children and Adolescents with Type 1 Diabetes

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18147490 ◽

2021 ◽

Vol 18 (14) ◽

pp. 7490

Author(s):

Kristi M. King ◽

Jason R. Jaggers ◽

Lindsay J. Della ◽

Timothy McKay ◽

Sara Watson ◽

...

Keyword(s):

Physical Activity ◽

Type 1 Diabetes ◽

Medical Records ◽

Hemoglobin A1c ◽

Pediatric Patients ◽

Sport Participation ◽

Multiple Linear Regression Model ◽

Significant Difference ◽

Hba1c Levels

Purpose: To determine associations between physical activity (PA) and sport participation on HbA1c levels in children with type 1 diabetes (T1D). Method: Pediatric patients with T1D were invited to complete a PA and sport participation survey. Data were linked to their medical records for demographic characteristics, diabetes treatment and monitoring plans, and HbA1c levels. Results: Participants consisted of 71 females and 81 males, were 13 ± 3 years old with an average HbA1c level of 8.75 ± 1.81. Children accumulating 60 min of activity 3 days or more a week had significantly lower HbA1c compared to those who accumulated less than 3 days (p < 0.01) of 60 min of activity. However, there was no significant difference in HbA1c values based on sport participation groups. A multiple linear regression model indicated that PA, race, age, duration of diagnosis, and CGM use all significantly predicted HbA1c (p < 0.05). Conclusion: This study demonstrated the significant relationship between daily PA and HbA1c. Those in this sample presented with lower HbA1c values even if accumulating less than the recommended number of days of activity. Further, it was shown that sport participation alone may not be adequate enough to impact HbA1c in a similar manner.

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Moderate-Vigorous Physical Activity and the Risk of Hypoglycemia in Active and Inactive Persons Living with Type 1 Diabetes

Canadian Journal of Diabetes ◽

10.1016/j.jcjd.2017.08.078 ◽

2017 ◽

Vol 41 (5) ◽

pp. S27

Author(s):

Andrea Macintosh ◽

Nika Korpesho ◽

Jacqueline Hay ◽

Meaghan Rempel ◽

Kristy Wittmeier ◽

...

Keyword(s):

Physical Activity ◽

Type 1 Diabetes ◽

Vigorous Physical Activity

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Correlation of serum vitamin D level with ketoacidosis in Chinese children with type 1 diabetes mellitus

10.21203/rs.3.rs-323788/v1 ◽

2021 ◽

Author(s):

Jianbo Shu ◽

Xinhui Wang ◽

Mingying Zhang ◽

Xiufang Zhi ◽

Jun Guan ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Plasma Glucose ◽

Serum Vitamin ◽

Chinese Children ◽

Serum Vitamin D ◽

Significant Difference

Abstract Objective: Diabetic ketoacidosis is a common complication in children with type 1 diabetes mellitus. The purposes of the present study were to explore clinical correlates of serum vitamin D level in Chinese children with type 1 diabetes.Methods: A total of 143 inpatients (boys/girls = 60/83) were recruited from Tianjin Children’s Hospital. Their demographic and clinical characteristics were collected. These patients were divided into the non-DKA group(n=43) and DKA group(n=100).Results: The positive ZnT8-ab was significantly higher in DKA patients compared with non-DKA patients (p=0.038). There was a negative correlation between plasma glucose and the concentration of vitamin D(r =−0.188, p=0.024), although there was no significant difference in vitamin D between two groups of T1DM patients with or without DKA (p=0.317). The multiple logistic regression revealed that sex(male) and BMI were independent risk factors to predict the deficiency or insufficiency of Vitamin D in T1DM children. When BMI is lower than 16 kg/m2 according to the cut-off value of the ROC curve, it provides some implications of Vitamin D deficiency or insufficiency in TIDM children ( 95%CI:0.534~0.721, P=0.014). Conclusions: Our results suggested that positive ZnT8-ab was associated with a greater risk of DKA at T1DM onset. Additionally, neither vitamin D levels nor the proportion of patients with different levels of vitamin D differed between the two groups inT1DM children with or without DKA. Furthermore, Vitamin D level was negatively correlated with plasma glucose, lower BMI and male children with T1DM were prone to be deficient or insufficient of Vitamin D.

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Closed-loop glucose control in young people with type 1 diabetes during and after unannounced physical activity: a randomised controlled crossover trial

Diabetologia ◽

10.1007/s00125-017-4395-z ◽

2017 ◽

Vol 60 (11) ◽

pp. 2157-2167 ◽

Cited By ~ 35

Author(s):

Klemen Dovc ◽

Maddalena Macedoni ◽

Natasa Bratina ◽

Dusanka Lepej ◽

Revital Nimri ◽

...

Keyword(s):

Physical Activity ◽

Type 1 Diabetes ◽

Young People ◽

Glucose Control ◽

Closed Loop ◽

Crossover Trial ◽

Randomised Controlled

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Impact of ELKa, the Electronic Device for Prandial Insulin Dose Calculation, on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled Trial

Journal of Diabetes Research ◽

10.1155/2017/1708148 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Agnieszka Kowalska ◽

Katarzyna Piechowiak ◽

Anna Ramotowska ◽

Agnieszka Szypowska

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Metabolic Control ◽

Electronic Device ◽

Intervention Group ◽

Insulin Dosage ◽

Control Group ◽

Prandial Insulin

Background. The ELKa system is composed of computer software, with a database of nutrients, and a dedicated USB kitchen scale. It was designed to automatize the everyday calculations of food exchanges and prandial insulin doses. Aim. To investigate the influence of the ELKa on metabolic control in children with type 1 diabetes mellitus (T1DM). Methods. A randomized, parallel, open-label clinical trial involved 106 patients aged <18 years with T1DM, HbA1C≤10%, undergoing intensive insulin therapy, allocated to the intervention group, who used the ELKa (n=53), or the control group (n=53), who used conventional calculation methods. Results. After the 26-week follow-up, the intention-to-treat analysis showed no differences to all endpoints. In per protocol analysis, 22/53 (41.5%) patients reporting ELKa usage for >50% of meals achieved lower HbA1C levels (P=0.002), lower basal insulin amounts (P=0.049), and lower intrasubject standard deviation of blood glucose levels (P=0.023) in comparison with the control. Moreover, in the intervention group, significant reduction of HbA1C level, by 0.55% point (P=0.002), was noted. No intergroup differences were found in the hypoglycemic episodes, BMI-SDS, bolus insulin dosage, and total daily insulin dosage. Conclusions. The ELKa system improves metabolic control in children with T1DM under regular usage. The trial is registered at ClinicalTrials.gov, number NCT02194517.

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