196-LB: Stem Cell–Derived Islet Replacement Therapy (VC-02) Demonstrates Production of C-Peptide in Patients with Type 1 Diabetes (T1D) and Hypoglycemia Unawareness

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 196-LB
Author(s):  
BART KEYMEULEN ◽  
DANIEL JACOBS-TULLENEERS-THEVISSEN ◽  
EVERT J. KROON ◽  
MANASI S. JAIMAN ◽  
MARK DANIELS ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stem Cell ◽  
Replacement Therapy ◽  
Hypoglycemia Unawareness ◽  
C Peptide

scholarly journals C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?

2017 ◽  
Vol 13 (8) ◽  
pp. 1432-1437 ◽  
Author(s):  
C. W. Pinger ◽  
K. E. Entwistle ◽  
T. M. Bell ◽  
Y. Liu ◽  
D. M. Spence
Keyword(s):  
Type 1 Diabetes ◽  
Replacement Therapy ◽  
C Peptide

C-Peptide has been discussed as a missing component in therapy for people with Type 1 diabetes. Is momentum fading, or do technology models suggest that it is right on schedule?

scholarly journals Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

2021 ◽  
Vol 28 (12) ◽  
pp. 2047-2061.e5 ◽  
Author(s):  
Adam Ramzy ◽  
David M. Thompson ◽  
Kirsten A. Ward-Hartstonge ◽  
Sabine Ivison ◽  
Laura Cook ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
C Peptide

scholarly journals Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device

2021 ◽  
pp. 100466
Author(s):  
A.M. James Shapiro ◽  
David Thompson ◽  
Thomas W. Donner ◽  
Melena D. Bellin ◽  
Willa Hsueh ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stem Cell ◽  
C Peptide ◽  
Insulin Expression

scholarly journals Challenges in stem cell-derived islet replacement therapy can be overcome

2021 ◽  
Vol 30 ◽  
pp. 096368972110453
Author(s):  
Midhat H. Abdulreda ◽  
Per-Olof Berggren
Keyword(s):  
Stem Cells ◽  
Type 1 Diabetes ◽  
Stem Cell ◽  
Anterior Chamber ◽  
Replacement Therapy ◽  
Islet Transplant ◽  
Clinical Islet Transplantation ◽  
The Status ◽  
Transplant Site

In this Commentary, we echo the conclusions of a recent review titled “ The promise of stem cell-derived islet replacement therapy,” which highlighted recent advances in producing glucose responsive “islets” from stem cells and the benefits of their use in islet transplant therapy in type 1 diabetes (T1D). The review also outlined the status of clinical islet transplantation and the challenges that have prevented it from reaching its full therapeutic promise. We agree with the conclusions of the review and suggest that the identified challenges may be overcome by using the eye anterior chamber as an islet transplant site. We anticipate that the combination of stem cell-derived islets and intraocular transplant could help this promising T1D therapy reach full fruition.

1917-P: Alpha-Cell Function in Patients with Type 1 Diabetes Is Compromised with Different Levels of Residual C-Peptide

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1917-P
Author(s):  
LINGYU ZHANG ◽  
YUWEN SHI ◽  
YITING HUANG ◽  
QIZHEN HU ◽  
YAO QIN ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cell Function ◽  
Alpha Cell ◽  
C Peptide ◽  
Alpha Cell Function ◽  
Different Levels
Sign in / Sign up

Export Citation Format

Share Document