Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Objectives. In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting. Participants. This cross-sectional analysis included 467 participants (34.8% men). Measurements. Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Regression models and simple regulatory models were used for data analysis. Results. There was an inverse relationship between dietary magnesium and LTL (P<0.001), with a between-extreme-quarter difference of -0.55. Conversely, there was a positive relationship between dietary magnesium and serum tumor necrosis factor (TNF) α, with an interquarter difference of 3.79 pmol/mL (P for trend=0.006). Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNFα increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31–5.36; P=0.003) and 1.98 (95% CI: 1.09–3.59; P=0.008). There was a direct negative effect of dietary magnesium intake on LTL (B=−0.002; P=0.001), which appeared to be indirectly influenced by TNFα (-0.002 to -0.0005). Conclusions. Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα.

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Cross-Sectional Associations Between Exposure To Persistent Organic Pollutants And Leukocyte Telomere Length Among Us Adults: National Health And Nutrition Examination Survey, 2001-2002

ISEE Conference Abstracts ◽

10.1289/isee.2015.2015-282 ◽

2015 ◽

Vol 2015 (1) ◽

pp. 282

Author(s):

Susanna D. Mitro ◽

Linda S. Birnbaum ◽

Belinda L. Needham ◽

Ami R. Zota

Keyword(s):

Telomere Length ◽

Organic Pollutants ◽

National Health ◽

Persistent Organic Pollutants ◽

Leukocyte Telomere Length ◽

Nutrition Examination Survey ◽

Cross Sectional ◽

Health And Nutrition

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Telomere Length in Patients with Transfusion-Dependent Thalassemia

10.21203/rs.2.17677/v3 ◽

2020 ◽

Author(s):

Nithita Nanthatanti ◽

Adisak Tantiworawit ◽

Pokpong Piriyakhuntorn ◽

Thanawat Rattanathammethee ◽

Sasinee Hantrakool ◽

...

Keyword(s):

Iron Overload ◽

Telomere Length ◽

Major Complication ◽

Single Copy ◽

Cross Sectional Study ◽

Hemoglobin Level ◽

Cellular Damage ◽

Repair System ◽

Leukocyte Telomere Length ◽

Cross Sectional

Abstract Background: Thalassemia is a hereditary hemolytic anemia with a severity ranging from mild, non-transfusion dependent to severe chronic anemia requiring lifelong transfusion. Transfusional iron overload is a major complication in patients with transfusion-dependent thalassemia (TDT). Telomeres are sequences of nucleotides forming the end caps of chromosomes that act as a DNA repair system. Iron overload in thalassemia can cause increased oxidative stress which leads to cellular damage and senescence. This may result in telomere length shortening. The degree of telomere length shortening may reflect the severity of thalassemia. Methods: This research aimed to study the leukocyte telomere length in patients with TDT in comparison to non-thalassemic individuals and to identify the clinical and laboratory parameters that are associated with telomere length. We conducted a cross-sectional study in patients with TDT aged ≥18 years. Leukocyte telomere length was measured by real-time quantitative PCR. Results: Sixty-five patients with TDT were enrolled onto the study. There were 37 female patients (54.4%). The median age was 27 (18-57) years, and mean pre-transfusion hemoglobin level was 7.1±1.07 g/dL. The mean telomere to single copy gene (T/S) ratios of patients with TDT and the controls were 0.72±0.18 and 0.99±0.25, respectively (p <0.0001). There was a significant correlation between the T/S ratio and age (p = 0.0002), and hemoglobin level (p = 0.044). There was no correlation between telomere length and other factors. Conclusions: Our study showed that TDT patients had shorter leukocyte telomere length compared with controls. Leukocyte telomere shortening in TDT was an aging-dependent process and associated with lower hemoglobin level.

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Faculty Opinions recommendation of Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727041882.793531842 ◽

2017 ◽

Author(s):

Jing-Dong Jackie Han

Keyword(s):

Cardiovascular Disease ◽

Telomere Length ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Cross Sectional Study ◽

Leukocyte Telomere Length ◽

Sectional Study ◽

Cross Sectional

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On Cross-Sectional Associations of Leukocyte Telomere Length with Cardiac Systolic, Diastolic and Vascular Function: The Asklepios Study

PLoS ONE ◽

10.1371/journal.pone.0115071 ◽

2014 ◽

Vol 9 (12) ◽

pp. e115071 ◽

Cited By ~ 12

Author(s):

Simon L. I. J. Denil ◽

Ernst R. Rietzschel ◽

Marc L. De Buyzere ◽

Caroline M. Van daele ◽

Patrick Segers ◽

...

Keyword(s):

Telomere Length ◽

Vascular Function ◽

Leukocyte Telomere Length ◽

Cross Sectional

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Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children

Scientific Reports ◽

10.1038/s41598-020-66729-9 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Kim Maasen ◽

Philip T. James ◽

Andrew M. Prentice ◽

Sophie E. Moore ◽

Caroline H. Fall ◽

...

Keyword(s):

Telomere Length ◽

Cross Sectional Study ◽

Leukocyte Telomere Length ◽

Sectional Study ◽

Cross Sectional

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Cross-sectional associations between genetic polymorphisms in metabolic enzymes and longer leukocyte telomere length induced by omethoate

Oncotarget ◽

10.18632/oncotarget.20971 ◽

2017 ◽

Vol 8 (46) ◽

pp. 80638-80644 ◽

Cited By ~ 10

Author(s):

Xiaoran Duan ◽

Yongli Yang ◽

Sihua Wang ◽

Xiaolei Feng ◽

Tuanwei Wang ◽

...

Keyword(s):

Telomere Length ◽

Genetic Polymorphisms ◽

Metabolic Enzymes ◽

Leukocyte Telomere Length ◽

Cross Sectional

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Leukocyte Telomere Length Is Not Reduced in Children and Adults with Cystic Fibrosis but Associates with Clinical Characteristics—A Cross-Sectional Study

Journal of Clinical Medicine ◽

10.3390/jcm10040590 ◽

2021 ◽

Vol 10 (4) ◽

pp. 590

Author(s):

Aleksandra Glapa-Nowak ◽

Shivaprakash Jagalur Mutt ◽

Aleksandra Lisowska ◽

Ewa Sapiejka ◽

Joanna Goździk-Spychalska ◽

...

Keyword(s):

Cystic Fibrosis ◽

Telomere Length ◽

Clinical Characteristics ◽

Inhaled Corticosteroids ◽

Cross Sectional Study ◽

Length Variation ◽

Leukocyte Telomere Length ◽

Cross Sectional ◽

Adult Status ◽

The Moment

We hypothezied that telomere length is considerably altered in cystic fibrosis (CF) patients compared to healthy subjects (HS), and that leukocyte telomere length variation reflects the severity of CF. Relative telomere length (RTL) was assessed by qPCR in 70 children aged 5–10 (34 CF; 36 HS) and 114 adults aged 18–45 (53 CF; 61 HS). Telomere length was similar in CF and HS (median (interquartile range): 0.799 (0.686–0.950) vs. 0.831 (0.707–0.986); p = 0.5283) both in children and adults. In adults, women had longer telomeres than men (0.805 (0.715–0.931) vs. 0.703 (0.574–0.790); p = 0.0002). Patients treated with inhaled corticosteroids had a shorter RTL compared to those without steroid therapy (0.765 (0.664–0.910) vs. 0.943 (0.813–1.191); p = 0.0007) and this finding remained significant after adjusting for gender, age, BMI, and child/adult status (p = 0.0003). Shorter telomeres were independently associated with the presence of comorbidities (0.763 (0.643–0.905) vs. 0.950 (0.783–1.130); p = 0.0006) and antibiotic treatment at the moment of blood sampling (0.762 (0.648–0.908) vs. 0.832 (0.748–1.129); p = 0.0172). RTL correlated with number of multiple-day hospitalizations (rho = −0.251; p = 0.0239), as well as number of hospitalization days (rho = −0.279; p = 0.0113). Leukocyte RTL in children and adults with CF was not shorter than in healthy controls, and did not seem to have any potential as a predictor of CF survival. However, it inversely associated with the investigated clinical characteristics.

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