scholarly journals Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study

Diabetes Care ◽  
2019 ◽  
Vol 42 (4) ◽  
pp. 657-664 ◽  
Author(s):  
Barbara H. Braffett ◽  
Samuel Dagogo-Jack ◽  
Ionut Bebu ◽  
William I. Sivitz ◽  
Mary Larkin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Cardiometabolic Risk ◽  
Insulin Dose ◽  
Cardiometabolic Risk Factors

scholarly journals Risk Factors for Cardiovascular Disease (CVD) in Adults with Type 1 Diabetes: Findings from Prospective Real-life T1D Exchange Registry

2020 ◽  
Vol 105 (5) ◽  
pp. e2032-e2038 ◽  
Author(s):  
Viral N Shah ◽  
Ryan Bailey ◽  
Mengdi Wu ◽  
Nicole C Foster ◽  
Rodica Pop-Busui ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
The United States ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
The Impact

Abstract Context Cardiovascular disease (CVD) is a major cause of mortality in adults with type 1 diabetes. Objective We prospectively evaluated CVD risk factors in a large, contemporary cohort of adults with type 1 diabetes living in the United States. Design Observational study of CVD and CVD risk factors over a median of 5.3 years. Setting The T1D Exchange clinic network. Patients Adults (age ≥ 18 years) with type 1 diabetes and without known CVD diagnosed before or at enrollment. Main Outcome Measure Associations between CVD risk factors and incident CVD were assessed by multivariable logistic regression. Results The study included 8,727 participants (53% female, 88% non-Hispanic white, median age 33 years [interquartile ratio {IQR} = 21, 48], type 1 diabetes duration 16 years [IQR = 9, 26]). At enrollment, median HbA1c was 7.6% (66 mmol/mol) (IQR = 6.9 [52], 8.6 [70]), 33% used a statin, and 37% used blood pressure medication. Over a mean follow-up of 4.6 years, 325 (3.7%) participants developed incident CVD. Ischemic heart disease was the most common CVD event. Increasing age, body mass index, HbA1c, presence of hypertension and dyslipidemia, increasing duration of diabetes, and diabetic nephropathy were associated with increased risk for CVD. There were no significant gender differences in CVD risk. Conclusion HbA1c, hypertension, dyslipidemia and diabetic nephropathy are important risk factors for CVD in adults with type 1 diabetes. A longer follow-up is likely required to assess the impact of other traditional CVD risk factors on incident CVD in the current era.

scholarly journals Echocardiographic parameters according to insulin dose in young patients affected by type 1 diabetes

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244483
Author(s):  
Giacomo Zoppini ◽  
Corinna Bergamini ◽  
Maddalena Trombetta ◽  
Alessandro Mantovani ◽  
Giovanni Targher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Dose Group ◽  
Cardiometabolic Risk ◽  
Insulin Dose ◽  
Young Patients ◽  
High Insulin ◽  
Echocardiographic Parameters ◽  
Systolic And Diastolic Function

Insulin dose has been found to associate to several cardiometabolic risk factors in type 1 diabetes. Changes over time in body weight and composition may partly explain this association. However, no data are available on the relationship between insulin dose and echocardiographic parameters of both systolic and diastolic function in type 1 diabetes. Therefore, the aim of the present study was to examine systolic and diastolic echocardiographic parameters in relation to insulin dose in young patients with type 1 diabetes. The study was carried out on 93 consecutive outpatients with type 1 diabetes with a mean age of 32.8 ± 9.8 years. All patients were examined with a transthoracic echocardiography. Clinical and laboratory data were collected. The median value of daily insulin dose was used to categorized patients in two groups: high and low insulin dose group. Patients belonging to the high insulin dose group showed higher levels of cardiometabolic risk factors such as BMI, triglycerides and TG/HDL cholesterol ratio. Indexes of both systolic and diastolic function were similar in both groups except isovolumetric relaxation time (IVRT), that was significantly prolonged in patients of the high insulin group (94.4 ± 15.0 vs 86.7 ± 13.1 ms, p = 0.008). In the multivariate regression analysis, insulin dose was positively and significantly associated with IVRT. In this study we report an association between insulin dose and impaired active diastolic myocardial relaxation. Future studies are needed to further explore this observation.

Treatment of cardiometabolic risk factors in patients with type 1 diabetes

2020 ◽  
Vol 32 (4) ◽  
pp. 589-594
Author(s):  
Elżbieta Niechciał ◽  
M. Loredana Marcovecchio
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors

Review of cardiometabolic risk factors in a cohort of paediatric type 1 diabetes mellitus patients

2016 ◽  
Vol 186 (2) ◽  
pp. 427-432
Author(s):  
A. Donovan ◽  
N. Finner ◽  
C. O’Connor ◽  
A. Quinn ◽  
C. S. O’Gorman
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors

Risk Factors for Cardiovascular Disease (CVD) in Adults with Type 1 Diabetes (T1D)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 15-LB
Author(s):  
SANJEEV N. MEHTA ◽  
MENGDI WU ◽  
NICOLE C. FOSTER ◽  
RODICA POP-BUSUI ◽  
MICHELLE KATZ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes
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