24-Hour Studies of the Effects of Somatostatin on the Levels of Plasma Growth Hormone, Glucagon, and Glucose in Normal Subjects and Juvenile Diabetics

Diabetes ◽  
1978 ◽  
Vol 27 (3) ◽  
pp. 300-306 ◽  
Author(s):  
S. E. Christensen ◽  
A. P. Hansen ◽  
J. Weeke ◽  
K. Lundbaek
Keyword(s):  
Growth Hormone ◽  
Normal Subjects ◽  
Plasma Growth Hormone ◽  
Juvenile Diabetics

DIFFERENT EFFECTS OF EXOGENOUS CYCLIC ADENOSINE MONOPHOSPHATE AND ITS DIBUTYRYL DERIVATIVE ON PLASMA GROWTH HORMONE, GLUCOSE, INSULIN AND CORTISOL

1976 ◽  
Vol 83 (1) ◽  
pp. 15-25
Author(s):  
M. Vanderschueren-Lodeweyckx ◽  
W. Proesmans ◽  
E. Eggermont ◽  
R. Eeckels
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Normal Subjects ◽  
Immunoreactive Insulin ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
The Mean

ABSTRACT The effects of the infusion in four different dosages (0.001, 0.005, 0.02 and 0.2 mg/kg/min during 60 min) of cyclic 3′,5′-adenosine monophosphate and of its dibutyryl derivative on plasma growth hormone and on glucose, immunoreactive insulin and cortisol were studied in 38 normal subjects and in 10 patients with idiopathic hypopituitarism. In normal subjects cyclic 3′,5′-adenosine monophosphate provokes an increase in plasma growth hormone levels (only when a dosage of 0.2 mg/kg/min is used) without any changes in plasma glucose, insulin and cortisol. The maximal value of the means is observed 75 min after starting the infusion. Dibutyryl cyclic 3′,5′-adenosine monophosphate (0.2 and 0.02 mg/kg/min) provokes a dose-related rise in plasma growth hormone levels which is always preceded by hyperglycaemia and hyperinsulinaemia. The peak of the mean growth hormone levels occurs at 135 min after initiation of the infusion. In all but one hypopituitary patients the nucleotides do not promote growth hormone secretion. It is concluded that exogenous cyclic 3′,5′-adenosine monophosphate and its dibutyryl derivative may not be considered as analogous and that both compounds may contribute to study growth hormone release in normal subjects and in patients with growth abnormalities.

THE ABSENCE OF INTACT GROWTH HORMONE IN URINE AS JUDGED BY RADIOIMMUNOASSAY

1968 ◽  
Vol 40 (4) ◽  
pp. 493-503 ◽  
Author(s):  
J. GIRARD ◽  
F. C. GREENWOOD
Keyword(s):  
Growth Hormone ◽  
Gel Filtration ◽  
Normal Subjects ◽  
Acromegalic Patient ◽  
Plasma Growth Hormone ◽  
Specific Factors ◽  
Normal Urine

SUMMARY Non-specific factors in urine, measuring as apparent growth hormone, were detected when the radioimmunoassay for plasma growth hormone was applied to urine, dilute urine and fractions therefrom. Varying concentrations of salt and urea were shown to mimic the effect of growth hormone and, like the urine inhibition, were lost on dialysis. Urine from normal subjects and from a hypopituitary dwarf treated with growth hormone, when concentrated, desalted and fractionated by gel filtration gave no evidence for the presence of growth hormone. From recovery experiments it was concluded that growth hormone in normal urine is present at concentrations below 0·1 μg./I. An inhibitor with the immunological characteristics of growth hormone was obtained from a fraction of concentrated urine from an acromegalic patient and was equivalent to 0·24 μg. growth hormone/24 hr. urine.

scholarly journals The dopaminergic regulation of plasma growth hormone secretion in normal subjects.

1986 ◽  
Vol 148 (2) ◽  
pp. 151-158 ◽  
Author(s):  
KUNIHIKO HANEW ◽  
SHUICHI SATO ◽  
ATSUSHI SASAKI ◽  
MEIGAN GOH ◽  
YASUYUKI SHIMIZU ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Subjects ◽  
Plasma Growth Hormone ◽  
Dopaminergic Regulation

Effect of somatostatin on blood glucose, plasma growth hormone, insulin, and free fatty acids in normal subjects and acromegalic patients

Metabolism ◽  
1974 ◽  
Vol 23 (11) ◽  
pp. 1009-1015 ◽  
Author(s):  
M. Peracchi ◽  
E. Reschini ◽  
L. Cantalamessa ◽  
G. Giustina ◽  
F. Cavagnini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Normal Subjects ◽  
Plasma Growth Hormone ◽  
Glucose Plasma

IMMUNOREACTIVE GROWTH HORMONE IN PLASMA AND URINE IN JUVENILE DIABETICS BEFORE AND DURING INITIAL INSULIN TREATMENT

1974 ◽  
Vol 75 (1) ◽  
pp. 50-63 ◽  
Author(s):  
Kristian F. Hanssen
Keyword(s):  
Growth Hormone ◽  
Insulin Treatment ◽  
Juvenile Diabetes ◽  
Control Group ◽  
List Type ◽  
Newly Diagnosed ◽  
Renal Tubular Reabsorption ◽  
Juvenile Diabetics ◽  
The Mean ◽  
Renal Tubular

ABSTRACT Twenty newly diagnosed, but as yet untreated patients of both sexes with classical juvenile diabetes were investigated by determining the mean plasma immunoreactive growth hormone (IRHGH) and urinary IRHGH for a 24 hour period before and during initial insulin treatment. The plasma IRHGH was significantly higher (0.05 > P > 0.01) before than during initial insulin treatment. During initial insulin treatment, the mean plasma IRHGH was significantly higher (0.01 > P > 0.001) than in a control group. The urinary IRHGH was significantly higher (0.01 > P > 0.001) before than during insulin treatment. The increased urinary IRHGH observed before insulin treatment is thought to be partly due to a defective renal tubular reabsorption of growth hormone. No significant correlation was found between the mean blood sugar and plasma or urinary IRHGH either before or during insulin treatment.

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